PE20140860A1 - Compuestos de pirazol como antagonistas de crth2 - Google Patents
Compuestos de pirazol como antagonistas de crth2Info
- Publication number
- PE20140860A1 PE20140860A1 PE2013001586A PE2013001586A PE20140860A1 PE 20140860 A1 PE20140860 A1 PE 20140860A1 PE 2013001586 A PE2013001586 A PE 2013001586A PE 2013001586 A PE2013001586 A PE 2013001586A PE 20140860 A1 PE20140860 A1 PE 20140860A1
- Authority
- PE
- Peru
- Prior art keywords
- independently
- compounds
- benzyl
- carbonyl
- fluoro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DE PIRAZOL DE FORMULA (Ia) O (Ib) DONDE: Ra Y Rb SON INDEPENDIENTEMENTE H, HIDROXI, ALCOXI C1-C6, ENTRE OTROS, O Ra Y Rb JUNTOS CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN GRUPO CARBONILO; Rc Y Rd SON INDEPENDIENTEMENTE H, HALOGENO, HALOALQUILO C1-6, ENTRE OTROS O Rc Y Rd JUNTOS CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN GRUPO CARBONILO, ENTRE OTROS; Y1, Y2, Y3, Y4 E Y5 SON INDEPENDIENTEMENTE N Y CRY, DONDE RY ES H, HIDROXI, CIANO, ENTRE OTROS; Z ES O, S, Y NRZ, DONDE RZ ES H, ALQUILO C1-C6 O BENCILO; R1 Y R2 ES INDEPENDIENTEMENTE H, FENILO, NAFTILO, ENTRE OTROS; n ES UN NUIMERO ENTERO ENTRE 0 A 3; R3 SI ESTA PRESENTE ES HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO (1-(2-FLUORO-4-[(1H-INDOL-2-CARBONIL)AMINO]BENCIL)-3,5-DIMETIL-1H-PIRAZOL-4-IL)ACETICO; ACIDO (1-{4-[(5-FLUORO-3-METILBENZOFURAN-2-CARBONIL)AMINO]BENCIL}-3,5-DIMETIL-1H-PIRAZOL-4-IL)ACETICO; ENTRE OTROS. REFERIDO ADEMAS A FORMULACIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS EN COMBINACION CON UNA O MAS SUSTANCIAS ACTIVAS TAL COMO BETAMIMETICOS, ANTICOLINERGICOS, CORTICOSTEROIDES, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151876 | 2011-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140860A1 true PE20140860A1 (es) | 2014-07-20 |
Family
ID=43799503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013001586A PE20140860A1 (es) | 2011-01-24 | 2012-01-20 | Compuestos de pirazol como antagonistas de crth2 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8759386B2 (es) |
| EP (1) | EP2668181B1 (es) |
| JP (1) | JP5695216B2 (es) |
| KR (2) | KR102251939B1 (es) |
| CN (4) | CN104628705B (es) |
| AP (1) | AP3343A (es) |
| AR (1) | AR084916A1 (es) |
| AU (1) | AU2012210718B2 (es) |
| BR (1) | BR112013017570B1 (es) |
| CA (1) | CA2825458C (es) |
| CL (1) | CL2013001945A1 (es) |
| CO (1) | CO6801731A2 (es) |
| CY (1) | CY1116012T1 (es) |
| DK (1) | DK2668181T3 (es) |
| EA (1) | EA022559B1 (es) |
| EC (1) | ECSP13012832A (es) |
| ES (1) | ES2529452T3 (es) |
| GE (1) | GEP20156332B (es) |
| HK (3) | HK1210467A1 (es) |
| HR (1) | HRP20150069T1 (es) |
| IL (1) | IL226920A (es) |
| MA (1) | MA34838B1 (es) |
| MX (1) | MX342830B (es) |
| MY (1) | MY163012A (es) |
| PE (1) | PE20140860A1 (es) |
| PH (1) | PH12018501531A1 (es) |
| PL (1) | PL2668181T3 (es) |
| PT (1) | PT2668181E (es) |
| RS (1) | RS53785B1 (es) |
| SG (1) | SG192096A1 (es) |
| SI (1) | SI2668181T1 (es) |
| TN (1) | TN2013000280A1 (es) |
| TW (1) | TWI527809B (es) |
| UA (1) | UA109696C2 (es) |
| UY (1) | UY33873A (es) |
| WO (1) | WO2012101043A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
| WO2012130633A1 (en) * | 2011-03-25 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as crth2 antagonists |
| US20140148492A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Bicyclosubstituted pyrazole compounds for treating hair loss |
| US20140148484A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Pyrazole compounds for treating hairloss |
| CN112188888A (zh) * | 2018-03-23 | 2021-01-05 | 帕拉丁科技公司 | 用于胃肠道特异性递送的黑皮质素受体特异性肽配制品和方法 |
| AR117472A1 (es) | 2018-12-21 | 2021-08-11 | Celgene Corp | Inhibidores de tienopiridina de ripk2 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| ATE271049T1 (de) * | 1999-11-10 | 2004-07-15 | Takeda Chemical Industries Ltd | Fünfgliedrige n-heterocyclen mit hypoglykämischer und hypolipidemischer wirkung |
| PT1471057E (pt) | 2003-04-25 | 2006-05-31 | Actimis Pharmaceuticals Inc | Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2 |
| US20070060596A1 (en) * | 2003-10-24 | 2007-03-15 | Giblin Gerard M P | Heterocyclyl compounds |
| CA2587664A1 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
| JP4950542B2 (ja) * | 2006-04-07 | 2012-06-13 | 岩手東芝エレクトロニクス株式会社 | 固体撮像装置およびその製造方法 |
| DE602007010781D1 (de) | 2006-06-06 | 2011-01-05 | Glaxo Group Ltd | N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid-derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration |
| AU2007327004A1 (en) * | 2006-11-27 | 2008-06-05 | Pfizer Products Inc. | Pyrazole analogs |
| US8314116B2 (en) * | 2007-09-25 | 2012-11-20 | Actimis Pharmaceuticals, Inc. | 2-S-benzyl substituted pyrimidines as CRTH2 antagonists |
| JP5524847B2 (ja) | 2007-09-25 | 2014-06-18 | アクチミス ファーマシューティカルズ インコーポレーテッド | Ｃｒｔｈ２アンタゴニストとしてのアルキルチオピリミジン |
| JP2011088826A (ja) * | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
| WO2010003120A2 (en) * | 2008-07-03 | 2010-01-07 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
| EP2393492A1 (en) * | 2009-02-09 | 2011-12-14 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| ES2545865T3 (es) * | 2010-01-27 | 2015-09-16 | Boehringer Ingelheim International Gmbh | Compuestos de pirazol como antagonistas de CRTH2 |
| EP2598145A1 (en) * | 2010-07-28 | 2013-06-05 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
-
2012
- 2012-01-19 US US13/353,621 patent/US8759386B2/en active Active
- 2012-01-19 TW TW101102302A patent/TWI527809B/zh not_active IP Right Cessation
- 2012-01-20 CN CN201410837969.4A patent/CN104628705B/zh not_active Expired - Fee Related
- 2012-01-20 MY MYPI2013002719A patent/MY163012A/en unknown
- 2012-01-20 AU AU2012210718A patent/AU2012210718B2/en not_active Ceased
- 2012-01-20 KR KR1020187033824A patent/KR102251939B1/ko active IP Right Grant
- 2012-01-20 GE GEAP201213204A patent/GEP20156332B/en unknown
- 2012-01-20 EA EA201300857A patent/EA022559B1/ru not_active IP Right Cessation
- 2012-01-20 CN CN201710440429.6A patent/CN107011332B/zh not_active Expired - Fee Related
- 2012-01-20 BR BR112013017570-2A patent/BR112013017570B1/pt not_active IP Right Cessation
- 2012-01-20 PE PE2013001586A patent/PE20140860A1/es active IP Right Grant
- 2012-01-20 AP AP2013006942A patent/AP3343A/xx active
- 2012-01-20 RS RS20150037A patent/RS53785B1/en unknown
- 2012-01-20 UA UAA201310232A patent/UA109696C2/uk unknown
- 2012-01-20 CA CA2825458A patent/CA2825458C/en active Active
- 2012-01-20 JP JP2013549819A patent/JP5695216B2/ja not_active Expired - Fee Related
- 2012-01-20 PT PT127006955T patent/PT2668181E/pt unknown
- 2012-01-20 PL PL12700695T patent/PL2668181T3/pl unknown
- 2012-01-20 CN CN201280006303.3A patent/CN103339125B/zh not_active Expired - Fee Related
- 2012-01-20 MX MX2013008082A patent/MX342830B/es active IP Right Grant
- 2012-01-20 CN CN201510362688.2A patent/CN104961732B/zh not_active Expired - Fee Related
- 2012-01-20 WO PCT/EP2012/050830 patent/WO2012101043A1/en active Application Filing
- 2012-01-20 SG SG2013056106A patent/SG192096A1/en unknown
- 2012-01-20 KR KR1020137019577A patent/KR101923365B1/ko active IP Right Grant
- 2012-01-20 MA MA36130A patent/MA34838B1/fr unknown
- 2012-01-20 SI SI201230126T patent/SI2668181T1/sl unknown
- 2012-01-20 ES ES12700695.5T patent/ES2529452T3/es active Active
- 2012-01-20 EP EP12700695.5A patent/EP2668181B1/en active Active
- 2012-01-20 DK DK12700695.5T patent/DK2668181T3/da active
- 2012-01-23 AR ARP120100213A patent/AR084916A1/es active IP Right Grant
- 2012-01-24 UY UY0001033873A patent/UY33873A/es unknown
-
2013
- 2013-06-13 IL IL226920A patent/IL226920A/en active IP Right Grant
- 2013-06-28 TN TNP2013000280A patent/TN2013000280A1/fr unknown
- 2013-06-28 CL CL2013001945A patent/CL2013001945A1/es unknown
- 2013-07-26 CO CO13177740A patent/CO6801731A2/es active IP Right Grant
- 2013-08-15 EC ECSP13012832 patent/ECSP13012832A/es unknown
- 2013-12-10 HK HK15111230.0A patent/HK1210467A1/xx not_active IP Right Cessation
- 2013-12-10 HK HK16103130.7A patent/HK1215247A1/zh not_active IP Right Cessation
- 2013-12-10 HK HK13113692.9A patent/HK1186183A1/xx not_active IP Right Cessation
-
2015
- 2015-01-20 HR HRP20150069AT patent/HRP20150069T1/hr unknown
- 2015-02-02 CY CY20151100103T patent/CY1116012T1/el unknown
-
2018
- 2018-07-18 PH PH12018501531A patent/PH12018501531A1/en unknown
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