AR071483A1 - Derivados de la 1,3- dihidro -2h - pirrolo (3,2-b) piridin-2- ona, su preparacion y sus aplicaciones en terapeutica - Google Patents
Derivados de la 1,3- dihidro -2h - pirrolo (3,2-b) piridin-2- ona, su preparacion y sus aplicaciones en terapeuticaInfo
- Publication number
- AR071483A1 AR071483A1 ARP090101356A ARP090101356A AR071483A1 AR 071483 A1 AR071483 A1 AR 071483A1 AR P090101356 A ARP090101356 A AR P090101356A AR P090101356 A ARP090101356 A AR P090101356A AR 071483 A1 AR071483 A1 AR 071483A1
- Authority
- AR
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- Prior art keywords
- group
- atom
- hydrogen atom
- alk
- hydroxy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
Procedimiento de preparacion y aplicacion en terapéutica. Como antagonistas de los receptores V1a de la arginina-vasopresina y de los receptores V1b de la AVP. Reivindicacion 1: Compuesto que responde a la formula (1): en la que: X representa un radical bivalente alquileno C1-5 no sustituido o sustituido una o varias veces en un átomo de carbono con un átomo de fluor o con un alquilo C1-3; R1 representa: un grupo -NR8R9; un radical piperidin-3-ilo o piperidin-4-ilo no sustituido o sustituido una o varias veces con un alquilo C1-4 o un cicloalquilo C3-5, pudiendo estar los átomos de carbono sustituidos igualmente con uno o varios átomos de fluor; R2 representa un átomo de hidrogeno, un átomo de. halogeno, un grupo Alk o un grupo OAlk; R3 representa un átomo de hidrogeno, un átomo de halogeno un grupo Alk o un grupo OAlk; R4 representa un átomo de hidrogeno, un átomo de halogeno un grupo Alk, un hidroxi o un grupo OAlk; R5 representa un átomo de hidrogeno, un átomo de halogeno, un grupo Alk, un hidroxi o un grupo OAlk; R6 representa un átomo de hidrogeno, un átomo de halogeno, un grupo Alk, un hidroxi o un grupo OAlk; R7 representa un átomo de hidrogeno, un átomo de halogeno, un grupo Alk, un hidroxi o un grupo OAlk; R8 y R9 representan cada uno independientemente un átomo de hidrogeno o un alquilo C1-4; o bien R8 y R9 junto con el átomo de nitrogeno al que están unidos constituyen un radical heterocíclico elegido entre: azetidin-1-ilo, pirrolidin-1-ilo, piperidin-1-ilo, morfolin-4-ilo, tiomorfolin-4-ilo, piperazin-1-ilo o perhidroazepin-1-ilo, estando dicho radical heterocíclico no sustituido o sustituido una o varias veces con un amino, un hidroxi un alquilo C1-4, un cicloalquilo C3-5, un alcoxi C1-4, pudiendo estar los átomos de carbono sustituidos igualmente con uno o varios átomos de fluor; Alk representa un alquilo C1-4 no sustituido o sustituido una o varias veces con un átomo de fluor, en el estado de base o de sal de adicion a un ácido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0802195A FR2930249B1 (fr) | 2008-04-21 | 2008-04-21 | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
Publications (1)
Publication Number | Publication Date |
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AR071483A1 true AR071483A1 (es) | 2010-06-23 |
Family
ID=39869969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101356A AR071483A1 (es) | 2008-04-21 | 2009-04-17 | Derivados de la 1,3- dihidro -2h - pirrolo (3,2-b) piridin-2- ona, su preparacion y sus aplicaciones en terapeutica |
Country Status (10)
Country | Link |
---|---|
US (1) | US8324214B2 (es) |
EP (1) | EP2294068B1 (es) |
JP (1) | JP2011518213A (es) |
AR (1) | AR071483A1 (es) |
AT (1) | ATE531715T1 (es) |
CL (1) | CL2009000946A1 (es) |
FR (1) | FR2930249B1 (es) |
TW (1) | TW200948811A (es) |
UY (1) | UY31776A (es) |
WO (1) | WO2009133314A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002342045C1 (en) * | 2001-10-12 | 2009-07-30 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl vasopressin Vla antagonists |
CN104922117A (zh) | 2005-03-22 | 2015-09-23 | 阿泽范药品公司 | 用于治疗月经前病症的β-内酰氨基链烷酸 |
FR2930249B1 (fr) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
US9376424B2 (en) | 2010-07-01 | 2016-06-28 | Azevan Pharmaceuticals, Inc. | Methods for treating post traumatic stress disorder |
FI3122743T3 (fi) | 2014-03-28 | 2023-03-02 | Azevan Pharmaceuticals Inc | Koostumuksia ja menetelmiä hermostoa rappeuttavien sairauksien hoitamiseksi |
JP2020534274A (ja) | 2017-09-15 | 2020-11-26 | アゼヴァン ファーマシューティカルズ,インコーポレイテッド | 脳損傷を治療するための組成物及び方法 |
WO2019126082A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | 6-azaindole compounds |
Family Cites Families (16)
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FR2665441B1 (fr) | 1990-07-31 | 1992-12-04 | Sanofi Sa | Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant. |
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
FR2708606B1 (fr) | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
FR2714378B1 (fr) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
FR2740136B1 (fr) | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
FR2757157B1 (fr) | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2804115B1 (fr) | 2000-01-25 | 2002-03-08 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
FR2804114B1 (fr) | 2000-01-25 | 2002-03-08 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
FR2805536B1 (fr) | 2000-02-25 | 2002-08-23 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
FR2810320B1 (fr) | 2000-06-19 | 2002-08-23 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
KR100894244B1 (ko) | 2001-07-13 | 2009-04-20 | 교와 핫꼬 케미칼 가부시키가이샤 | 에테르 화합물의 제조법 |
FR2827604B1 (fr) * | 2001-07-17 | 2003-09-19 | Sanofi Synthelabo | Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
JP5125501B2 (ja) * | 2005-01-28 | 2013-01-23 | 大正製薬株式会社 | 1,3−ジヒドロ−2h−インドール−2−オン化合物、及び芳香族複素環が縮合したピロリジン−2−オン化合物 |
DE102006040915A1 (de) | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
FR2930249B1 (fr) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
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2008
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EP2294068B1 (fr) | 2011-11-02 |
WO2009133314A1 (fr) | 2009-11-05 |
JP2011518213A (ja) | 2011-06-23 |
ATE531715T1 (de) | 2011-11-15 |
US8324214B2 (en) | 2012-12-04 |
TW200948811A (en) | 2009-12-01 |
FR2930249B1 (fr) | 2010-05-14 |
FR2930249A1 (fr) | 2009-10-23 |
UY31776A (es) | 2009-12-14 |
CL2009000946A1 (es) | 2010-04-09 |
EP2294068A1 (fr) | 2011-03-16 |
US20110071160A1 (en) | 2011-03-24 |
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