CL2009000946A1 - Compuestos derivados de 1,3-dihidro-2h-pirrolo[3,2-b]piridin-2-ona; procedimiento de preparacion de estos; composicion farmaceutica que los comprende; utiles para el tratamiento ees, afecciones del snc, dismenorrea primaria y secundaria, del snc, dismenorrea primaria y secundaria, entre otras. - Google Patents

Compuestos derivados de 1,3-dihidro-2h-pirrolo[3,2-b]piridin-2-ona; procedimiento de preparacion de estos; composicion farmaceutica que los comprende; utiles para el tratamiento ees, afecciones del snc, dismenorrea primaria y secundaria, del snc, dismenorrea primaria y secundaria, entre otras.

Info

Publication number
CL2009000946A1
CL2009000946A1 CL2009000946A CL2009000946A CL2009000946A1 CL 2009000946 A1 CL2009000946 A1 CL 2009000946A1 CL 2009000946 A CL2009000946 A CL 2009000946A CL 2009000946 A CL2009000946 A CL 2009000946A CL 2009000946 A1 CL2009000946 A1 CL 2009000946A1
Authority
CL
Chile
Prior art keywords
primary
cns
secondary dysmenorrhea
pyrrolo
pyridin
Prior art date
Application number
CL2009000946A
Other languages
English (en)
Inventor
Cedric Couturier
Loic Foulon
Claudine Serradeil-Legal
Gerard Valette
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CL2009000946A1 publication Critical patent/CL2009000946A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

Compuestos derivados de 1,3-dihidro-2h-pirrolo[3,2-b]piridin-2-ona; procedimiento de preparación; composición farmacéutica, útiles para el tratamiento de afecciones cardiovasculares, afecciones del SNC, dismenorrea primaria y secundaria, entre otras.
CL2009000946A 2008-04-21 2009-04-20 Compuestos derivados de 1,3-dihidro-2h-pirrolo[3,2-b]piridin-2-ona; procedimiento de preparacion de estos; composicion farmaceutica que los comprende; utiles para el tratamiento ees, afecciones del snc, dismenorrea primaria y secundaria, del snc, dismenorrea primaria y secundaria, entre otras. CL2009000946A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0802195A FR2930249B1 (fr) 2008-04-21 2008-04-21 Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
CL2009000946A1 true CL2009000946A1 (es) 2010-04-09

Family

ID=39869969

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000946A CL2009000946A1 (es) 2008-04-21 2009-04-20 Compuestos derivados de 1,3-dihidro-2h-pirrolo[3,2-b]piridin-2-ona; procedimiento de preparacion de estos; composicion farmaceutica que los comprende; utiles para el tratamiento ees, afecciones del snc, dismenorrea primaria y secundaria, del snc, dismenorrea primaria y secundaria, entre otras.

Country Status (10)

Country Link
US (1) US8324214B2 (es)
EP (1) EP2294068B1 (es)
JP (1) JP2011518213A (es)
AR (1) AR071483A1 (es)
AT (1) ATE531715T1 (es)
CL (1) CL2009000946A1 (es)
FR (1) FR2930249B1 (es)
TW (1) TW200948811A (es)
UY (1) UY31776A (es)
WO (1) WO2009133314A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4494015B2 (ja) * 2001-10-12 2010-06-30 アゼヴァン ファーマスーティカルズ，インコーポレイテッド β−ラクタミル・バソプレッシンＶ１ａ拮抗剤
WO2006102283A2 (en) 2005-03-22 2006-09-28 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids for treating premenstrual disorders
FR2930249B1 (fr) 2008-04-21 2010-05-14 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
PL2587919T3 (pl) 2010-07-01 2018-05-30 Azevan Pharmaceuticals, Inc. Sposoby leczenia zespołu stresu pourazowego
MY184878A (en) * 2014-03-28 2021-04-29 Azevan Pharmaceuticals Inc Compositions and methods for treating neurodegenerative diseases
CN111295373A (zh) 2017-09-15 2020-06-16 阿泽凡药物公司 用于治疗脑损伤的组合物和方法
EA202091508A1 (ru) 2017-12-19 2020-09-14 Бристол-Маерс Сквибб Компани 6-азаиндольные соединения

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665441B1 (fr) 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2686878B1 (fr) * 1992-01-30 1995-06-30 Sanofi Elf Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant.
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
FR2740136B1 (fr) 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2757157B1 (fr) 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2804115B1 (fr) 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2804114B1 (fr) 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2805536B1 (fr) 2000-02-25 2002-08-23 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2810320B1 (fr) 2000-06-19 2002-08-23 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
WO2003006407A1 (fr) 2001-07-13 2003-01-23 Kyowa Yuka Co., Ltd. Procédé de production de composé d'éther
FR2827604B1 (fr) * 2001-07-17 2003-09-19 Sanofi Synthelabo Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
JP5125501B2 (ja) * 2005-01-28 2013-01-23 大正製薬株式会社 １，３−ジヒドロ−２ｈ−インドール−２−オン化合物、及び芳香族複素環が縮合したピロリジン−２−オン化合物
DE102006040915A1 (de) 2006-08-26 2008-03-20 Abbott Gmbh & Co. Kg Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
FR2930249B1 (fr) 2008-04-21 2010-05-14 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.

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AR071483A1 (es) 2010-06-23
US20110071160A1 (en) 2011-03-24
FR2930249A1 (fr) 2009-10-23
ATE531715T1 (de) 2011-11-15
FR2930249B1 (fr) 2010-05-14
JP2011518213A (ja) 2011-06-23
UY31776A (es) 2009-12-14
US8324214B2 (en) 2012-12-04
EP2294068B1 (fr) 2011-11-02
EP2294068A1 (fr) 2011-03-16
TW200948811A (en) 2009-12-01
WO2009133314A1 (fr) 2009-11-05

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