AP3343A - Pyrazole compounds as CRTH2 antagonists - Google Patents
Pyrazole compounds as CRTH2 antagonistsInfo
- Publication number
- AP3343A AP3343A AP2013006942A AP2013006942A AP3343A AP 3343 A AP3343 A AP 3343A AP 2013006942 A AP2013006942 A AP 2013006942A AP 2013006942 A AP2013006942 A AP 2013006942A AP 3343 A AP3343 A AP 3343A
- Authority
- AP
- ARIPO
- Prior art keywords
- pyrazole compounds
- crth2 antagonists
- crth2
- antagonists
- pyrazole
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151876 | 2011-01-24 | ||
| PCT/EP2012/050830 WO2012101043A1 (en) | 2011-01-24 | 2012-01-20 | Pyrazole compounds as crth2 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2013006942A0 AP2013006942A0 (en) | 2013-06-30 |
| AP3343A true AP3343A (en) | 2015-07-31 |
Family
ID=43799503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2013006942A AP3343A (en) | 2011-01-24 | 2012-01-20 | Pyrazole compounds as CRTH2 antagonists |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8759386B2 (xx) |
| EP (1) | EP2668181B1 (xx) |
| JP (1) | JP5695216B2 (xx) |
| KR (2) | KR102251939B1 (xx) |
| CN (4) | CN104961732B (xx) |
| AP (1) | AP3343A (xx) |
| AR (1) | AR084916A1 (xx) |
| AU (1) | AU2012210718B2 (xx) |
| BR (1) | BR112013017570B1 (xx) |
| CA (1) | CA2825458C (xx) |
| CL (1) | CL2013001945A1 (xx) |
| CO (1) | CO6801731A2 (xx) |
| CY (1) | CY1116012T1 (xx) |
| DK (1) | DK2668181T3 (xx) |
| EA (1) | EA022559B1 (xx) |
| EC (1) | ECSP13012832A (xx) |
| ES (1) | ES2529452T3 (xx) |
| GE (1) | GEP20156332B (xx) |
| HK (3) | HK1186183A1 (xx) |
| HR (1) | HRP20150069T1 (xx) |
| IL (1) | IL226920A (xx) |
| MA (1) | MA34838B1 (xx) |
| MX (1) | MX342830B (xx) |
| MY (1) | MY163012A (xx) |
| PE (1) | PE20140860A1 (xx) |
| PH (1) | PH12018501531A1 (xx) |
| PL (1) | PL2668181T3 (xx) |
| PT (1) | PT2668181E (xx) |
| RS (1) | RS53785B1 (xx) |
| SG (1) | SG192096A1 (xx) |
| SI (1) | SI2668181T1 (xx) |
| TN (1) | TN2013000280A1 (xx) |
| TW (1) | TWI527809B (xx) |
| UA (1) | UA109696C2 (xx) |
| UY (1) | UY33873A (xx) |
| WO (1) | WO2012101043A1 (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
| US9206164B2 (en) * | 2011-03-25 | 2015-12-08 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
| US20140148484A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Pyrazole compounds for treating hairloss |
| WO2014079803A1 (en) | 2012-11-23 | 2014-05-30 | Boehringer Ingelheim International Gmbh | Bicyclosubstituted pyrazole compounds for treating hairloss |
| CN112188888A (zh) * | 2018-03-23 | 2021-01-05 | 帕拉丁科技公司 | 用于胃肠道特异性递送的黑皮质素受体特异性肽配制品和方法 |
| KR20210106506A (ko) | 2018-12-21 | 2021-08-30 | 셀진 코포레이션 | Ripk2의 티에노피리딘 억제제 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010057118A2 (en) * | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| SI1228067T1 (en) | 1999-11-10 | 2005-02-28 | Takeda Chemical Industries, Ltd. | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
| PT1471057E (pt) | 2003-04-25 | 2006-05-31 | Actimis Pharmaceuticals Inc | Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2 |
| WO2005040128A1 (en) | 2003-10-24 | 2005-05-06 | Glaxo Group Limited | Heterocyclyl compounds |
| AU2005318465A1 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with Kv4 ion channel activity |
| JP4950542B2 (ja) * | 2006-04-07 | 2012-06-13 | 岩手東芝エレクトロニクス株式会社 | 固体撮像装置およびその製造方法 |
| US20090149524A1 (en) | 2006-06-06 | 2009-06-11 | Paul John Beswick | N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration |
| MX2009005526A (es) * | 2006-11-27 | 2009-06-05 | Pfizer Prod Inc | Analogos de pirazol. |
| CN101874024A (zh) * | 2007-09-25 | 2010-10-27 | 艾克提麦斯医药品有限公司 | 作为crth2拮抗剂的2-s-苄基取代的嘧啶 |
| SI2205569T1 (sl) | 2007-09-25 | 2012-06-29 | Actimis Pharmaceuticals Inc | Alkiltio pirimidini kot crth2 antagonisti |
| JP2011088826A (ja) * | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
| US20110190227A1 (en) * | 2008-07-03 | 2011-08-04 | Amira Pharmaceuticals, Inc. | Antagonists of Prostaglandin D2 Receptors |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| US20120129820A1 (en) * | 2009-02-09 | 2012-05-24 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| CN104829535A (zh) * | 2010-01-27 | 2015-08-12 | 贝林格尔·英格海姆国际有限公司 | 作为crth2拮抗剂的吡唑化合物 |
| JP2013535457A (ja) * | 2010-07-28 | 2013-09-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系及び炎症性疾患の治療用医薬組成物 |
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
-
2012
- 2012-01-19 US US13/353,621 patent/US8759386B2/en active Active
- 2012-01-19 TW TW101102302A patent/TWI527809B/zh not_active IP Right Cessation
- 2012-01-20 CN CN201510362688.2A patent/CN104961732B/zh not_active Expired - Fee Related
- 2012-01-20 MX MX2013008082A patent/MX342830B/es active IP Right Grant
- 2012-01-20 ES ES12700695.5T patent/ES2529452T3/es active Active
- 2012-01-20 CN CN201280006303.3A patent/CN103339125B/zh not_active Expired - Fee Related
- 2012-01-20 GE GEAP201213204A patent/GEP20156332B/en unknown
- 2012-01-20 BR BR112013017570-2A patent/BR112013017570B1/pt not_active IP Right Cessation
- 2012-01-20 DK DK12700695.5T patent/DK2668181T3/da active
- 2012-01-20 PL PL12700695T patent/PL2668181T3/pl unknown
- 2012-01-20 RS RS20150037A patent/RS53785B1/en unknown
- 2012-01-20 PT PT127006955T patent/PT2668181E/pt unknown
- 2012-01-20 EA EA201300857A patent/EA022559B1/ru not_active IP Right Cessation
- 2012-01-20 EP EP12700695.5A patent/EP2668181B1/en active Active
- 2012-01-20 MY MYPI2013002719A patent/MY163012A/en unknown
- 2012-01-20 AP AP2013006942A patent/AP3343A/xx active
- 2012-01-20 AU AU2012210718A patent/AU2012210718B2/en not_active Ceased
- 2012-01-20 KR KR1020187033824A patent/KR102251939B1/ko active IP Right Grant
- 2012-01-20 WO PCT/EP2012/050830 patent/WO2012101043A1/en active Application Filing
- 2012-01-20 KR KR1020137019577A patent/KR101923365B1/ko active IP Right Grant
- 2012-01-20 SG SG2013056106A patent/SG192096A1/en unknown
- 2012-01-20 CN CN201710440429.6A patent/CN107011332B/zh not_active Expired - Fee Related
- 2012-01-20 SI SI201230126T patent/SI2668181T1/sl unknown
- 2012-01-20 PE PE2013001586A patent/PE20140860A1/es active IP Right Grant
- 2012-01-20 MA MA36130A patent/MA34838B1/fr unknown
- 2012-01-20 CN CN201410837969.4A patent/CN104628705B/zh not_active Expired - Fee Related
- 2012-01-20 JP JP2013549819A patent/JP5695216B2/ja not_active Expired - Fee Related
- 2012-01-20 UA UAA201310232A patent/UA109696C2/uk unknown
- 2012-01-20 CA CA2825458A patent/CA2825458C/en active Active
- 2012-01-23 AR ARP120100213A patent/AR084916A1/es active IP Right Grant
- 2012-01-24 UY UY0001033873A patent/UY33873A/es unknown
-
2013
- 2013-06-13 IL IL226920A patent/IL226920A/en active IP Right Grant
- 2013-06-28 TN TNP2013000280A patent/TN2013000280A1/fr unknown
- 2013-06-28 CL CL2013001945A patent/CL2013001945A1/es unknown
- 2013-07-26 CO CO13177740A patent/CO6801731A2/es active IP Right Grant
- 2013-08-15 EC ECSP13012832 patent/ECSP13012832A/es unknown
- 2013-12-10 HK HK13113692.9A patent/HK1186183A1/xx not_active IP Right Cessation
- 2013-12-10 HK HK15111230.0A patent/HK1210467A1/xx not_active IP Right Cessation
- 2013-12-10 HK HK16103130.7A patent/HK1215247A1/zh not_active IP Right Cessation
-
2015
- 2015-01-20 HR HRP20150069AT patent/HRP20150069T1/hr unknown
- 2015-02-02 CY CY20151100103T patent/CY1116012T1/el unknown
-
2018
- 2018-07-18 PH PH12018501531A patent/PH12018501531A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010057118A2 (en) * | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
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