HK1186183A1 - 作為 拮抗劑的吡唑化合物 - Google Patents

作為 拮抗劑的吡唑化合物

Info

Publication number
HK1186183A1
HK1186183A1 HK13113692.9A HK13113692A HK1186183A1 HK 1186183 A1 HK1186183 A1 HK 1186183A1 HK 13113692 A HK13113692 A HK 13113692A HK 1186183 A1 HK1186183 A1 HK 1186183A1
Authority
HK
Hong Kong
Prior art keywords
crth2
pyrazole compounds
antagonists
pyrazole
compounds
Prior art date
Application number
HK13113692.9A
Other languages
English (en)
Inventor
Ralf Anderskewitz
Domnic Martyres
Thorsten Oost
Wolfgang Rist
Peter Seither
Original Assignee
勃林格殷格翰國際有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43799503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1186183(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 勃林格殷格翰國際有限公司 filed Critical 勃林格殷格翰國際有限公司
Publication of HK1186183A1 publication Critical patent/HK1186183A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK13113692.9A 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物 HK1186183A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11151876 2011-01-24
PCT/EP2012/050830 WO2012101043A1 (en) 2011-01-24 2012-01-20 Pyrazole compounds as crth2 antagonists

Publications (1)

Publication Number Publication Date
HK1186183A1 true HK1186183A1 (zh) 2014-03-07

Family

ID=43799503

Family Applications (3)

Application Number Title Priority Date Filing Date
HK13113692.9A HK1186183A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物
HK15111230.0A HK1210467A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物
HK16103130.7A HK1215247A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK15111230.0A HK1210467A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物
HK16103130.7A HK1215247A1 (zh) 2011-01-24 2013-12-10 作為 拮抗劑的吡唑化合物

Country Status (36)

Country Link
US (1) US8759386B2 (zh)
EP (1) EP2668181B1 (zh)
JP (1) JP5695216B2 (zh)
KR (2) KR102251939B1 (zh)
CN (4) CN104961732B (zh)
AP (1) AP3343A (zh)
AR (1) AR084916A1 (zh)
AU (1) AU2012210718B2 (zh)
BR (1) BR112013017570B1 (zh)
CA (1) CA2825458C (zh)
CL (1) CL2013001945A1 (zh)
CO (1) CO6801731A2 (zh)
CY (1) CY1116012T1 (zh)
DK (1) DK2668181T3 (zh)
EA (1) EA022559B1 (zh)
EC (1) ECSP13012832A (zh)
ES (1) ES2529452T3 (zh)
GE (1) GEP20156332B (zh)
HK (3) HK1186183A1 (zh)
HR (1) HRP20150069T1 (zh)
IL (1) IL226920A (zh)
MA (1) MA34838B1 (zh)
MX (1) MX342830B (zh)
MY (1) MY163012A (zh)
PE (1) PE20140860A1 (zh)
PH (1) PH12018501531A1 (zh)
PL (1) PL2668181T3 (zh)
PT (1) PT2668181E (zh)
RS (1) RS53785B1 (zh)
SG (1) SG192096A1 (zh)
SI (1) SI2668181T1 (zh)
TN (1) TN2013000280A1 (zh)
TW (1) TWI527809B (zh)
UA (1) UA109696C2 (zh)
UY (1) UY33873A (zh)
WO (1) WO2012101043A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
US9206164B2 (en) * 2011-03-25 2015-12-08 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
US20140148484A1 (en) * 2012-11-23 2014-05-29 Boehringer Ingelheim International Gmbh Pyrazole compounds for treating hairloss
WO2014079803A1 (en) 2012-11-23 2014-05-30 Boehringer Ingelheim International Gmbh Bicyclosubstituted pyrazole compounds for treating hairloss
CN112188888A (zh) * 2018-03-23 2021-01-05 帕拉丁科技公司 用于胃肠道特异性递送的黑皮质素受体特异性肽配制品和方法
KR20210106506A (ko) 2018-12-21 2021-08-30 셀진 코포레이션 Ripk2의 티에노피리딘 억제제

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
SI1228067T1 (en) 1999-11-10 2005-02-28 Takeda Chemical Industries, Ltd. 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
PT1471057E (pt) 2003-04-25 2006-05-31 Actimis Pharmaceuticals Inc Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2
WO2005040128A1 (en) 2003-10-24 2005-05-06 Glaxo Group Limited Heterocyclyl compounds
AU2005318465A1 (en) * 2004-12-21 2006-06-29 Devgen N.V. Compounds with Kv4 ion channel activity
JP4950542B2 (ja) * 2006-04-07 2012-06-13 岩手東芝エレクトロニクス株式会社 固体撮像装置およびその製造方法
US20090149524A1 (en) 2006-06-06 2009-06-11 Paul John Beswick N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration
MX2009005526A (es) * 2006-11-27 2009-06-05 Pfizer Prod Inc Analogos de pirazol.
CN101874024A (zh) * 2007-09-25 2010-10-27 艾克提麦斯医药品有限公司 作为crth2拮抗剂的2-s-苄基取代的嘧啶
SI2205569T1 (sl) 2007-09-25 2012-06-29 Actimis Pharmaceuticals Inc Alkiltio pirimidini kot crth2 antagonisti
JP2011088826A (ja) * 2008-01-31 2011-05-06 Astellas Pharma Inc 芳香族カルボン酸化合物
US20110190227A1 (en) * 2008-07-03 2011-08-04 Amira Pharmaceuticals, Inc. Antagonists of Prostaglandin D2 Receptors
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
US20120129820A1 (en) * 2009-02-09 2012-05-24 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
CN104829535A (zh) * 2010-01-27 2015-08-12 贝林格尔·英格海姆国际有限公司 作为crth2拮抗剂的吡唑化合物
JP2013535457A (ja) * 2010-07-28 2013-09-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器系及び炎症性疾患の治療用医薬組成物
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists

Also Published As

Publication number Publication date
HK1215247A1 (zh) 2016-08-19
EP2668181B1 (en) 2014-11-05
HK1210467A1 (zh) 2016-04-22
TN2013000280A1 (en) 2014-11-10
CL2013001945A1 (es) 2013-10-25
NZ611695A (en) 2015-04-24
KR20180129962A (ko) 2018-12-05
KR101923365B1 (ko) 2018-11-30
US8759386B2 (en) 2014-06-24
GEP20156332B (en) 2015-07-27
RS53785B1 (en) 2015-06-30
EA201300857A1 (ru) 2013-12-30
TWI527809B (zh) 2016-04-01
CN104961732B (zh) 2017-07-11
MA34838B1 (fr) 2014-01-02
CY1116012T1 (el) 2017-01-25
BR112013017570A2 (pt) 2016-10-18
MX342830B (es) 2016-10-14
CN104961732A (zh) 2015-10-07
JP5695216B2 (ja) 2015-04-01
EA022559B1 (ru) 2016-01-29
AU2012210718A1 (en) 2013-07-04
CN104628705B (zh) 2017-04-12
US20130023576A1 (en) 2013-01-24
DK2668181T3 (da) 2015-01-19
CN107011332A (zh) 2017-08-04
KR102251939B1 (ko) 2021-05-14
KR20140005931A (ko) 2014-01-15
CN103339125B (zh) 2015-07-15
MX2013008082A (es) 2013-09-13
PE20140860A1 (es) 2014-07-20
SG192096A1 (en) 2013-08-30
PL2668181T3 (pl) 2015-04-30
CA2825458A1 (en) 2012-08-02
BR112013017570B1 (pt) 2022-01-11
UA109696C2 (xx) 2015-09-25
CN107011332B (zh) 2020-03-13
EP2668181A1 (en) 2013-12-04
SI2668181T1 (sl) 2015-02-27
AR084916A1 (es) 2013-07-10
ES2529452T3 (es) 2015-02-20
AP2013006942A0 (en) 2013-06-30
IL226920A (en) 2016-11-30
PH12018501531A1 (en) 2019-04-08
CO6801731A2 (es) 2013-11-29
PT2668181E (pt) 2015-02-05
MY163012A (en) 2017-07-31
AU2012210718B2 (en) 2016-06-02
ECSP13012832A (es) 2013-09-30
WO2012101043A1 (en) 2012-08-02
HRP20150069T1 (hr) 2015-02-27
JP2014502986A (ja) 2014-02-06
CA2825458C (en) 2021-01-26
CN103339125A (zh) 2013-10-02
UY33873A (es) 2012-07-31
AP3343A (en) 2015-07-31
CN104628705A (zh) 2015-05-20
TW201245184A (en) 2012-11-16

Similar Documents

Publication Publication Date Title
IL286152A (en) Modified imidazopyridinyl-aminopyridine compounds
AP3360A (en) Pyrazole compounds as CRTH2 antagonists
EP2627178A4 (en) QUINAZOLINONE-LIKE COMPOUNDS AS CRTH2 ANTAGONISTS
AP3391A (en) 2-Amino-4-arylthiazole compounds as TROA1 antagonists
EP2698368A4 (en) NEW PYRAZOLE DERIVATIVE
EP2738170A4 (en) HETEROCYCLIC COMPOUND
GB201118652D0 (en) New compounds
GB201118654D0 (en) New compounds
GB201118675D0 (en) New compounds
EP2709609A4 (en) HETEROCYCLIC COMPOUNDS
HK1191862A1 (zh) 吡唑衍生物
GB201106814D0 (en) New compounds
HK1186183A1 (zh) 作為 拮抗劑的吡唑化合物
EP2771012A4 (en) NEW CONNECTIONS
ZA201303800B (en) Pyrazole compounds
HK1191946A1 (zh) 新型六氫吡咯並咪唑酮化合物
GB201119590D0 (en) New compounds I
GB201102024D0 (en) Novel heterocyclic compounds 3
GB201101823D0 (en) Novel heterocyclic compounds 4
GB201101822D0 (en) Novel heterocyclic compounds 2
GB201101821D0 (en) Novel heterocyclic compounds 1

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230120