CN103328005A - 基于将到抗体的佐剂直接靶向抗原呈递细胞的新型疫苗佐剂 - Google Patents

基于将到抗体的佐剂直接靶向抗原呈递细胞的新型疫苗佐剂 Download PDF

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CN103328005A
CN103328005A CN2011800489046A CN201180048904A CN103328005A CN 103328005 A CN103328005 A CN 103328005A CN 2011800489046 A CN2011800489046 A CN 2011800489046A CN 201180048904 A CN201180048904 A CN 201180048904A CN 103328005 A CN103328005 A CN 103328005A
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antigen
antigens
cancer
composition
virus
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G·祖拉夫斯基
J·F·班彻罗
A-L·弗拉玛
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Baylor Research Institute
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
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CN2011800489046A 2010-08-13 2011-08-12 基于将到抗体的佐剂直接靶向抗原呈递细胞的新型疫苗佐剂 Pending CN103328005A (zh)

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US37376310P 2010-08-13 2010-08-13
US61/373763 2010-08-13
PCT/US2011/047633 WO2012021834A1 (en) 2010-08-13 2011-08-12 Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells

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CN103328005A true CN103328005A (zh) 2013-09-25

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US (1) US20120039916A1 (https=)
EP (1) EP2603235A4 (https=)
JP (1) JP2013535508A (https=)
KR (1) KR20130108295A (https=)
CN (1) CN103328005A (https=)
AR (1) AR082686A1 (https=)
AU (1) AU2011289234B2 (https=)
BR (1) BR112013002940A2 (https=)
CA (1) CA2807585A1 (https=)
MX (1) MX2013001527A (https=)
RU (1) RU2013110889A (https=)
TW (1) TWI506035B (https=)
WO (1) WO2012021834A1 (https=)
ZA (1) ZA201301013B (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
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CN104689313A (zh) * 2015-03-04 2015-06-10 中国科学院海洋研究所 大菱鲆cd83分子作为疫苗佐剂的应用
CN106170299A (zh) * 2014-01-22 2016-11-30 小利兰斯坦福大学托管委员会 用于抗体和抗体负载树突状细胞介导治疗的方法和组合物
CN106456736A (zh) * 2014-06-02 2017-02-22 贝勒研究院 用于治疗过敏和炎性疾病的方法和组合物
CN107098970A (zh) * 2007-05-03 2017-08-29 新加坡科技研究局 结合细胞内prl‑1多肽或prl‑3多肽的抗体
CN108430498A (zh) * 2015-11-10 2018-08-21 耶鲁大学 用于治疗自身免疫疾病和癌症的组合物及方法
CN108727503A (zh) * 2017-04-18 2018-11-02 武汉博沃生物科技有限公司 VZV重组gE-鞭毛素融合蛋白及其制备方法和应用
CN111432833A (zh) * 2017-11-29 2020-07-17 自适应噬菌体治疗公司 使用二十面体噬菌体的疫苗接种方法
CN111801100A (zh) * 2018-02-28 2020-10-20 豪夫迈·罗氏有限公司 用于治疗和预防肝癌的7-取代的磺亚氨酰基嘌呤酮化合物和衍生物
US11110178B2 (en) 2016-07-07 2021-09-07 The Board Of Trustees Of The Leland Standford Junior University Antibody adjuvant conjugates
CN113811547A (zh) * 2019-03-27 2021-12-17 国家医疗保健研究所 具有cd40激活特性的重组蛋白
US11400164B2 (en) 2019-03-15 2022-08-02 Bolt Biotherapeutics, Inc. Immunoconjugates targeting HER2

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TW201247706A (en) * 2011-03-08 2012-12-01 Baylor Res Inst Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
WO2013033104A1 (en) * 2011-08-29 2013-03-07 Baylor Research Institute CONTROLLING ALLERGY AND ASTHMA BY ACTIVATING HUMAN DCs VIA DECTIN-1 OR DECTIN-1 AND TOLL-LIKE RECEPTOR 2 (TLR2)
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CN105899539B (zh) 2014-01-10 2021-11-09 博笛生物科技有限公司 用于免疫疗法的化合物和组合物
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CN106659774A (zh) 2014-05-16 2017-05-10 贝勒研究院 用于治疗自身免疫和炎性病症的方法和组合物
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Cited By (15)

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CN107098970B (zh) * 2007-05-03 2021-11-23 新加坡科技研究局 结合细胞内prl-1多肽或prl-3多肽的抗体
CN107098970A (zh) * 2007-05-03 2017-08-29 新加坡科技研究局 结合细胞内prl‑1多肽或prl‑3多肽的抗体
CN106170299A (zh) * 2014-01-22 2016-11-30 小利兰斯坦福大学托管委员会 用于抗体和抗体负载树突状细胞介导治疗的方法和组合物
CN106456736A (zh) * 2014-06-02 2017-02-22 贝勒研究院 用于治疗过敏和炎性疾病的方法和组合物
CN104689313A (zh) * 2015-03-04 2015-06-10 中国科学院海洋研究所 大菱鲆cd83分子作为疫苗佐剂的应用
CN108430498A (zh) * 2015-11-10 2018-08-21 耶鲁大学 用于治疗自身免疫疾病和癌症的组合物及方法
US11110178B2 (en) 2016-07-07 2021-09-07 The Board Of Trustees Of The Leland Standford Junior University Antibody adjuvant conjugates
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