CN1032206C - 制备四氢叶酸盐的方法 - Google Patents

制备四氢叶酸盐的方法 Download PDF

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Publication number
CN1032206C
CN1032206C CN89104352A CN89104352A CN1032206C CN 1032206 C CN1032206 C CN 1032206C CN 89104352 A CN89104352 A CN 89104352A CN 89104352 A CN89104352 A CN 89104352A CN 1032206 C CN1032206 C CN 1032206C
Authority
CN
China
Prior art keywords
acid
thf
thfa
salt
tetrahydrofolic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN89104352A
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English (en)
Chinese (zh)
Other versions
CN1038813A (zh
Inventor
汉斯·鲁道尔夫·米勒
马汀·乌尔曼
约瑟夫·孔第
冈特·米尔代尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Eprova AG
Original Assignee
Eprova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova AG filed Critical Eprova AG
Publication of CN1038813A publication Critical patent/CN1038813A/zh
Application granted granted Critical
Publication of CN1032206C publication Critical patent/CN1032206C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN89104352A 1988-06-29 1989-06-26 制备四氢叶酸盐的方法 Expired - Lifetime CN1032206C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3821875A DE3821875C1 (enExample) 1988-06-29 1988-06-29
DEP3821875.5 1988-06-29

Publications (2)

Publication Number Publication Date
CN1038813A CN1038813A (zh) 1990-01-17
CN1032206C true CN1032206C (zh) 1996-07-03

Family

ID=6357486

Family Applications (1)

Application Number Title Priority Date Filing Date
CN89104352A Expired - Lifetime CN1032206C (zh) 1988-06-29 1989-06-26 制备四氢叶酸盐的方法

Country Status (20)

Country Link
US (1) US5006655A (enExample)
EP (1) EP0348641B1 (enExample)
JP (1) JPH0826022B2 (enExample)
KR (1) KR960003613B1 (enExample)
CN (1) CN1032206C (enExample)
AT (1) ATE124042T1 (enExample)
AU (1) AU624620B2 (enExample)
CA (1) CA1339675C (enExample)
DD (1) DD284018A5 (enExample)
DE (2) DE3821875C1 (enExample)
DK (1) DK175118B1 (enExample)
ES (1) ES2075010T3 (enExample)
FI (1) FI93960C (enExample)
HU (1) HU203237B (enExample)
IE (1) IE68942B1 (enExample)
NO (1) NO167665C (enExample)
NZ (1) NZ229254A (enExample)
PH (1) PH27148A (enExample)
PT (1) PT90999B (enExample)
ZA (1) ZA894896B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102361558B (zh) * 2009-01-24 2015-09-02 安密诺普特凌公司 包含外消旋氨基蝶呤的药物组合物

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CH673459A5 (enExample) * 1987-05-15 1990-03-15 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
CA2021042A1 (en) * 1989-07-21 1991-01-22 Fabrizio Marazza Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid
DK0432441T3 (da) * 1989-12-11 1996-07-29 American Cyanamid Co Fremgangsmåde til fremstilling af optisk rene diastereoisomere af tetrahydrofolatforbindelser
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (enExample) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5153309A (en) * 1990-07-27 1992-10-06 The United States Of America As Represented By The Department Of Health And Human Services Process of making tetrahydropteroylpoly-l-glutamic acid derivatives
CH681303A5 (enExample) * 1991-01-16 1993-02-26 Eprova Ag
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
CH682664A5 (en) * 1991-10-15 1993-10-29 Eprova Ag Stable salts of 5,10-methylene tetrahydrofolate.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683690A5 (de) * 1991-12-21 1994-04-29 Sapec Fine Chemicals Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten.
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
RU2109015C1 (ru) * 1993-07-16 1998-04-20 Эй Си Эс Добфар С.п.А. Способ получения (6s)-изомеров производных фолиевой кислоты
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
US5997915A (en) * 1996-01-31 1999-12-07 South Alabama Medical Science Foundation Compositions for human and animal consumption containing reduced folates and methods for making and using same
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) * 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
KR100415826B1 (ko) * 2000-11-28 2004-01-31 신준식 구척 및 천수근을 주성분으로 함유하는 약학적 제제
ITMI20020132A1 (it) * 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
TWI372055B (en) * 2007-09-10 2012-09-11 Univ Chang Gung The medical composition having the amount of dna damaging agent and the amount of tea polyphenols
CN101407518A (zh) * 2007-10-11 2009-04-15 南京莱尔生物化工有限公司 (6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
JP5532506B2 (ja) 2008-10-01 2014-06-25 日本電気硝子株式会社 ガラスロール
JP5435267B2 (ja) 2008-10-01 2014-03-05 日本電気硝子株式会社 ガラスロール、ガラスロールの製造装置、及びガラスロールの製造方法
JP5691148B2 (ja) 2008-10-01 2015-04-01 日本電気硝子株式会社 ガラスロール、ガラスロールの製造装置、及びガラスロールの製造方法
JP5532507B2 (ja) 2008-10-01 2014-06-25 日本電気硝子株式会社 ガラスロール及びガラスロールの処理方法
CN102516247A (zh) * 2010-12-15 2012-06-27 连云港金康医药科技有限公司 A型l-5-甲基四氢叶酸钙盐多晶型及其制备方法
DE102011081172B4 (de) 2011-08-18 2013-05-08 Schott Ag Verpackungseinheit für ein auf einen Wickelkern gerolltes Glas
CN103102350A (zh) * 2011-11-11 2013-05-15 重庆华邦胜凯制药有限公司 一种左亚叶酸盐的制备方法
CN104557937B (zh) * 2012-01-20 2017-03-08 连云港金康和信药业有限公司 (6s)‑5‑甲基四氢叶酸盐晶型及其制备方法
CN102584826B (zh) * 2012-01-20 2015-04-29 连云港金康医药科技有限公司 (6s)-5-甲基四氢叶酸盐晶型及其制备方法
WO2014018873A2 (en) * 2012-07-27 2014-01-30 Chemic Laboratories Inc. Compositions comprising folic acid derivatives. their preparations and methods of use
EP2837631A1 (en) * 2013-08-14 2015-02-18 Merck & Cie New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
CN105399747A (zh) * 2015-10-30 2016-03-16 天津药物研究院药业有限责任公司 左旋5，10-亚甲基四氢叶酸的制备方法
CN108033962B (zh) * 2017-01-20 2019-08-30 连云港金康和信药业有限公司 一种合成(6s)-5-甲基四氢叶酸盐的方法

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* Cited by examiner, † Cited by third party
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US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
JPS5838285A (ja) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd ５−メチル−（６ｒｓ）−５，６，７，８−テトラヒドロ−ｌ−葉酸のマグネシウム塩またはその遊離酸の製法
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (enExample) * 1987-05-15 1990-03-15 Eprova Ag

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102361558B (zh) * 2009-01-24 2015-09-02 安密诺普特凌公司 包含外消旋氨基蝶呤的药物组合物

Also Published As

Publication number Publication date
AU3716189A (en) 1990-01-04
AU624620B2 (en) 1992-06-18
IE68942B1 (en) 1996-07-24
KR900000367A (ko) 1990-01-30
DE3821875C1 (enExample) 1990-02-15
PH27148A (en) 1993-04-02
FI93960B (fi) 1995-03-15
JPH0826022B2 (ja) 1996-03-13
FI93960C (fi) 1995-06-26
US5006655A (en) 1991-04-09
HUT50822A (en) 1990-03-28
EP0348641A2 (de) 1990-01-03
EP0348641A3 (de) 1991-04-24
ES2075010T3 (es) 1995-10-01
DK237789D0 (da) 1989-05-16
NO892697D0 (no) 1989-06-28
KR960003613B1 (en) 1996-03-20
ATE124042T1 (de) 1995-07-15
IE891652L (en) 1989-12-29
FI893158L (fi) 1989-12-30
NO167665C (no) 1991-11-27
JPH0248577A (ja) 1990-02-19
CN1038813A (zh) 1990-01-17
NO167665B (no) 1991-08-19
PT90999A (pt) 1990-11-07
ZA894896B (en) 1990-03-28
EP0348641B1 (de) 1995-06-21
FI893158A0 (fi) 1989-06-28
DE58909305D1 (de) 1995-07-27
DD284018A5 (de) 1990-10-31
NZ229254A (en) 1990-10-26
DK237789A (da) 1989-12-30
DK175118B1 (da) 2004-06-07
NO892697L (no) 1990-01-02
PT90999B (pt) 1995-03-31
CA1339675C (en) 1998-02-17
HU203237B (en) 1991-06-28

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C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C17 Cessation of patent right
CX01 Expiry of patent term