CN103083665A - 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞 - Google Patents

通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞 Download PDF

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CN103083665A
CN103083665A CN201310011196XA CN201310011196A CN103083665A CN 103083665 A CN103083665 A CN 103083665A CN 201310011196X A CN201310011196X A CN 201310011196XA CN 201310011196 A CN201310011196 A CN 201310011196A CN 103083665 A CN103083665 A CN 103083665A
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tumor
antibody
her2
neu
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霍斯特·林德霍费尔
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Lindhofer Horst Dr
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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CN201310011196XA 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞 Pending CN103083665A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06003057.4 2006-02-15
EP06003057A EP1820513A1 (en) 2006-02-15 2006-02-15 Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies

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CN2007800127778A Division CN101420978B (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞

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CN2007800127778A Active CN101420978B (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞
CN2013100120579A Pending CN103100084A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞
CN201310011196XA Pending CN103083665A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞

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CN2013100120579A Pending CN103100084A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞

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US (1) US9017676B2 (enExample)
EP (4) EP1820513A1 (enExample)
JP (2) JP2009526823A (enExample)
CN (3) CN101420978B (enExample)
AU (1) AU2007216472B2 (enExample)
CA (1) CA2642606C (enExample)
WO (1) WO2007093630A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115141805A (zh) * 2022-08-22 2022-10-04 中山大学孙逸仙纪念医院 一种模拟人体肿瘤微环境的cic细胞及制备方法、分选方法

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