CN101420978B - 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞 - Google Patents

通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞 Download PDF

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CN101420978B
CN101420978B CN2007800127778A CN200780012777A CN101420978B CN 101420978 B CN101420978 B CN 101420978B CN 2007800127778 A CN2007800127778 A CN 2007800127778A CN 200780012777 A CN200780012777 A CN 200780012777A CN 101420978 B CN101420978 B CN 101420978B
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tumor
cells
antibody
cell
her2
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CN101420978A (zh
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霍斯特·林德霍费尔
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Lindes Biotechnology Co ltd
Lingteng Asia Pacific Co ltd
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Trion Pharma GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN2007800127778A 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞 Active CN101420978B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06003057.4 2006-02-15
EP06003057A EP1820513A1 (en) 2006-02-15 2006-02-15 Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
PCT/EP2007/051483 WO2007093630A1 (en) 2006-02-15 2007-02-15 Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies

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CN201310011196XA Division CN103083665A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞
CN2013100120579A Division CN103100084A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞

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CN2013100120579A Pending CN103100084A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞
CN201310011196XA Pending CN103083665A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞

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CN201310011196XA Pending CN103083665A (zh) 2006-02-15 2007-02-15 通过三官能双特异性抗体破坏表达低至中等水平的肿瘤相关靶抗原的肿瘤细胞

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US (1) US9017676B2 (enExample)
EP (4) EP1820513A1 (enExample)
JP (2) JP2009526823A (enExample)
CN (3) CN101420978B (enExample)
AU (1) AU2007216472B2 (enExample)
CA (1) CA2642606C (enExample)
WO (1) WO2007093630A1 (enExample)

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