CN102970978B - 活性药物成分的颗粒加工方法 - Google Patents

活性药物成分的颗粒加工方法 Download PDF

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Publication number
CN102970978B
CN102970978B CN201180024407.2A CN201180024407A CN102970978B CN 102970978 B CN102970978 B CN 102970978B CN 201180024407 A CN201180024407 A CN 201180024407A CN 102970978 B CN102970978 B CN 102970978B
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active pharmaceutical
ingredient
active
particle size
cavitation
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Chinese (zh)
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CN102970978A (zh
Inventor
M·吉尔
C·卡塞拉
R·门东萨
F·加斯帕尔
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Hovione Inter AG
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Hovione Inter AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180024407.2A 2010-04-21 2011-04-21 活性药物成分的颗粒加工方法 Active CN102970978B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT105058 2010-04-21
PT105058A PT105058B (pt) 2010-04-21 2010-04-21 Processo para processamento de partículas de ingredientes activos farmacêuticos
PCT/GB2011/000631 WO2011131947A2 (en) 2010-04-21 2011-04-21 A process for particle processing of active pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
CN102970978A CN102970978A (zh) 2013-03-13
CN102970978B true CN102970978B (zh) 2017-05-10

Family

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CN201180024407.2A Active CN102970978B (zh) 2010-04-21 2011-04-21 活性药物成分的颗粒加工方法

Country Status (13)

Country Link
US (1) US9956144B2 (cg-RX-API-DMAC7.html)
EP (1) EP2560620B1 (cg-RX-API-DMAC7.html)
JP (2) JP6347608B2 (cg-RX-API-DMAC7.html)
CN (1) CN102970978B (cg-RX-API-DMAC7.html)
BR (1) BR112012026941A2 (cg-RX-API-DMAC7.html)
CA (1) CA2796978C (cg-RX-API-DMAC7.html)
IL (1) IL222596B (cg-RX-API-DMAC7.html)
MX (1) MX338594B (cg-RX-API-DMAC7.html)
PL (1) PL2560620T3 (cg-RX-API-DMAC7.html)
PT (1) PT105058B (cg-RX-API-DMAC7.html)
RU (1) RU2597790C2 (cg-RX-API-DMAC7.html)
SG (1) SG185003A1 (cg-RX-API-DMAC7.html)
WO (1) WO2011131947A2 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
BR112012026941A2 (pt) 2016-07-12
SG185003A1 (en) 2012-11-29
MX338594B (es) 2016-04-25
EP2560620B1 (en) 2020-09-16
CN102970978A (zh) 2013-03-13
WO2011131947A3 (en) 2012-01-05
JP6857467B2 (ja) 2021-04-14
JP6347608B2 (ja) 2018-06-27
JP2017019845A (ja) 2017-01-26
IL222596B (en) 2019-03-31
PL2560620T3 (pl) 2021-04-06
WO2011131947A2 (en) 2011-10-27
US20130203717A1 (en) 2013-08-08
PT105058A (pt) 2011-10-21
EP2560620A2 (en) 2013-02-27
CA2796978C (en) 2019-07-02
MX2012012215A (es) 2013-05-09
RU2597790C2 (ru) 2016-09-20
JP2013525338A (ja) 2013-06-20
CA2796978A1 (en) 2011-10-27
US9956144B2 (en) 2018-05-01
IL222596A0 (en) 2012-12-31
PT105058B (pt) 2013-04-17
RU2012149459A (ru) 2014-05-27

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