CN102917691A - 用于生产干燥、稳定的止血组合物的方法 - Google Patents

用于生产干燥、稳定的止血组合物的方法 Download PDF

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Publication number
CN102917691A
CN102917691A CN201180027072XA CN201180027072A CN102917691A CN 102917691 A CN102917691 A CN 102917691A CN 201180027072X A CN201180027072X A CN 201180027072XA CN 201180027072 A CN201180027072 A CN 201180027072A CN 102917691 A CN102917691 A CN 102917691A
Authority
CN
China
Prior art keywords
component
dry
hemostatic composition
thrombin
final container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201180027072XA
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English (en)
Chinese (zh)
Inventor
A·格斯尔
A·E·奥萨瓦
C·J·赖布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44626885&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102917691(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of CN102917691A publication Critical patent/CN102917691A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
CN201180027072XA 2010-06-01 2011-06-01 用于生产干燥、稳定的止血组合物的方法 Pending CN102917691A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35021410P 2010-06-01 2010-06-01
US61/350,214 2010-06-01
PCT/EP2011/059114 WO2011151400A1 (en) 2010-06-01 2011-06-01 Process for making dry and stable hemostatic compositions

Publications (1)

Publication Number Publication Date
CN102917691A true CN102917691A (zh) 2013-02-06

Family

ID=44626885

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180027072XA Pending CN102917691A (zh) 2010-06-01 2011-06-01 用于生产干燥、稳定的止血组合物的方法

Country Status (12)

Country Link
US (1) US9408945B2 (enExample)
EP (1) EP2575776B1 (enExample)
JP (3) JP6289096B2 (enExample)
KR (1) KR101865427B1 (enExample)
CN (1) CN102917691A (enExample)
AU (1) AU2011260274B2 (enExample)
BR (1) BR112012030457B1 (enExample)
CA (1) CA2801120C (enExample)
CO (1) CO6660509A2 (enExample)
ES (1) ES2682302T3 (enExample)
MX (1) MX352875B (enExample)
WO (1) WO2011151400A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104005179A (zh) * 2014-06-13 2014-08-27 东华大学 一种聚己内酯-角蛋白复合纳米纤维管的制备方法
CN105358071A (zh) * 2013-06-21 2016-02-24 弗罗桑医疗设备公司 真空膨胀的干组合物和用于保留该干组合物的注射器
CN109529098A (zh) * 2018-12-03 2019-03-29 广州润虹医药科技股份有限公司 一种外科医用粘合剂
CN109661234A (zh) * 2016-09-06 2019-04-19 株式会社Bmi韩国 包含交联的透明质酸衍生物基质的止血组合物
CN111465417A (zh) * 2017-11-28 2020-07-28 多林体森株式会社 止血用组合物以及包含上述止血用组合物的容器

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EP2575770B1 (en) 2010-06-01 2017-03-22 Baxter International Inc Process for making dry and stable hemostatic compositions
KR101814841B1 (ko) 2010-06-01 2018-01-03 백스터 인터내셔널 인코포레이티드 건조 및 안정한 지혈 조성물의 제조 방법
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RU2602301C1 (ru) * 2015-12-08 2016-11-20 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации Способ получения фибринной пасты
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ES2684403B1 (es) * 2017-03-31 2019-07-09 Farm Rovi Lab Sa Procedimiento para el llenado gravimetrico en condiciones esteriles de solidos en un contenedor farmaceutico y contenedor farmaceutico utilizable en el mismo
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WO2019107887A2 (ko) * 2017-11-28 2019-06-06 (주)다림티센 지혈용 조성물 및 이를 포함하는 용기
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US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
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JP7625189B2 (ja) * 2020-08-20 2025-02-03 青葉化成株式会社 液状医療材料
US20220313948A1 (en) 2021-03-31 2022-10-06 Ethicon, Inc. Systems, devices and methods for dispensing flowable hemostats that incorporate safety mechanisms for preventing air embolisms
EP4412534A1 (en) 2021-10-08 2024-08-14 Guangzhou Bioseal Biotech Co., Ltd. Systems, devices and methods of using hydraulic forces for delivering flowable, therapeutic compositions to surgical sites
CA3236089A1 (en) 2021-11-29 2023-06-01 Baxter International Inc. Improved hemostat reconstitution methods and devices
CA3244889A1 (en) 2022-03-08 2023-09-14 Equashield Medical Ltd FLUID TRANSFER STATION IN A ROBOTIC PHARMACEUTICAL PREPARATION SYSTEM
KR102721257B1 (ko) * 2024-02-07 2024-10-24 주식회사 엘앤씨이에스 가교 젤라틴 기반 흡수성 체내용 지혈 조성물

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