CN102858374B - 热胶凝麻醉剂组合物 - Google Patents

热胶凝麻醉剂组合物 Download PDF

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Publication number
CN102858374B
CN102858374B CN201180016573.8A CN201180016573A CN102858374B CN 102858374 B CN102858374 B CN 102858374B CN 201180016573 A CN201180016573 A CN 201180016573A CN 102858374 B CN102858374 B CN 102858374B
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China
Prior art keywords
pharmaceutical composition
composition according
lidocaine
composition
poloxamer
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CN201180016573.8A
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English (en)
Chinese (zh)
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CN102858374A (zh
Inventor
M·松德贝里
A·布罗丁
N·科尔贝里
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Parett Life Sciences
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Pharmanest AB
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180016573.8A 2010-04-01 2011-03-31 热胶凝麻醉剂组合物 Active CN102858374B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1050321-7 2010-04-01
SE1050321 2010-04-01
US32541810P 2010-04-19 2010-04-19
US61/325,418 2010-04-19
PCT/EP2011/055009 WO2011121074A1 (en) 2010-04-01 2011-03-31 Thermogelling anaesthetic compositions

Publications (2)

Publication Number Publication Date
CN102858374A CN102858374A (zh) 2013-01-02
CN102858374B true CN102858374B (zh) 2015-12-09

Family

ID=44502740

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CN201180016573.8A Active CN102858374B (zh) 2010-04-01 2011-03-31 热胶凝麻醉剂组合物

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US (3) US8834927B2 (enExample)
EP (1) EP2552487B1 (enExample)
JP (2) JP5972862B2 (enExample)
KR (1) KR101792200B1 (enExample)
CN (1) CN102858374B (enExample)
AU (1) AU2011234492B2 (enExample)
BR (1) BR112012024673B1 (enExample)
CA (1) CA2795154C (enExample)
CL (1) CL2012002706A1 (enExample)
CY (1) CY1118396T1 (enExample)
DK (1) DK2552487T3 (enExample)
EA (1) EA023396B1 (enExample)
ES (1) ES2608850T3 (enExample)
HR (1) HRP20161663T1 (enExample)
HU (1) HUE031107T2 (enExample)
IL (1) IL222224A (enExample)
LT (1) LT2552487T (enExample)
MX (1) MX2012011262A (enExample)
MY (1) MY163215A (enExample)
NZ (1) NZ602538A (enExample)
PH (1) PH12012501886A1 (enExample)
PL (1) PL2552487T3 (enExample)
PT (1) PT2552487T (enExample)
RS (1) RS55544B1 (enExample)
SG (1) SG184071A1 (enExample)
SI (1) SI2552487T1 (enExample)
SM (2) SMT201700050T1 (enExample)
WO (1) WO2011121074A1 (enExample)
ZA (1) ZA201206988B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011121074A1 (en) * 2010-04-01 2011-10-06 Pharmanest Ab Thermogelling anaesthetic compositions
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
EP2961380B1 (en) * 2013-02-28 2020-04-08 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compositions
GB201305622D0 (en) * 2013-03-27 2013-05-15 Sas Ltd Composition
CA2961660A1 (en) * 2014-10-01 2016-04-07 Als Mountain Llc Pharmaceutical composition comprising aspirin, metformin, and serotonin with non-ionic surfactant
JP6678946B2 (ja) 2015-03-25 2020-04-15 テルモ株式会社 ゲル状局所麻酔剤およびそれを用いたゲル状局所麻酔製剤
EP3375456B1 (en) 2015-11-12 2023-05-03 Terumo Kabushiki Kaisha Sustained-release topically administered agent
CN105769839B (zh) * 2016-05-17 2019-06-11 山西远扬医药科技有限公司 一种复方利多卡因药物组合物及其制备方法
CN107149697B (zh) * 2017-03-24 2020-07-31 王科 一种皮肤表面麻醉敷料、其制备方法及使用方法
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
CN108309928A (zh) * 2018-03-22 2018-07-24 兆科（广州）眼科药物有限公司 一种妇科术后止痛药物组合物及其制备方法
IT201800004036A1 (it) * 2018-03-28 2019-09-28 Teres Srl Gel transdermico
WO2019217536A1 (en) * 2018-05-08 2019-11-14 University Of Connecticut Long-acting local anesthetic formulation
CN111840553A (zh) * 2019-04-15 2020-10-30 湖州依诺唯新药物制剂有限公司 脂性药物制剂及其应用
JP7646175B2 (ja) * 2019-11-28 2025-03-17 東洋製薬化成株式会社 リドカイン含有外用医薬組成物
EP4110293A4 (en) * 2020-02-25 2024-07-10 The University of North Carolina at Chapel Hill EUTECTIC-BASED ANESTHESIC COMPOSITIONS AND CORRESPONDING APPLICATIONS
WO2022055927A1 (en) * 2020-09-11 2022-03-17 Ps Therapy Ltd. Topical compositions and methods of use
WO2023150345A1 (en) * 2022-02-04 2023-08-10 Intact Therapeutics, Inc. Mesalamine pharmaceutical formulations and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1188407A (zh) * 1996-04-12 1998-07-22 阿斯特拉公司 具有麻醉作用的新型药物组合物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248014B (it) * 1991-06-07 1995-01-05 Inverni Della Beffa Spa Preparazioni oftalmiche a rilascio protratto
US6217900B1 (en) * 1997-04-30 2001-04-17 American Home Products Corporation Vesicular complexes and methods of making and using the same
JP3782551B2 (ja) * 1997-06-24 2006-06-07 鉄郎 高山 鎮痛組成物
US6528086B2 (en) 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
KR100416646B1 (ko) 2000-08-14 2004-02-05 구주제약주식회사 리도카인을 함유한 조루치료용 마이크로에멀젼 하이드로겔 제형의 약학 조성물
GB0120701D0 (en) 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Pharmaceutical formulations
GB0120702D0 (en) 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Anaesthetic formulations
BR0313060A (pt) * 2002-07-29 2005-06-28 Transform Pharmaceuticals Inc Composições farmacêuticas aquosas de 2,6-diisopropilfenol
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
AU2003900887A0 (en) 2003-02-27 2003-03-13 Novasel Australia Pty Ltd Poloxamer emulsion preparations
ES2237298B1 (es) * 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
US20050084508A1 (en) 2003-07-22 2005-04-21 Vancaillie Thierry G. Topical anesthesia formulation for bodily cavities
US20080154210A1 (en) 2004-05-28 2008-06-26 Oryxe Mixture for Transdermal Delivery of Low and High Molecular Weight Compounds
US20070190124A1 (en) 2004-06-07 2007-08-16 Jie Zhang Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs
AU2006201233B2 (en) 2006-03-24 2010-10-07 Alan Hewitt Topical anesthesia formulation for bodily cavities
US20070298005A1 (en) 2006-06-22 2007-12-27 Marie-Josee Thibault Injectable composition for treatment of skin defects or deformations
CA2659344C (en) 2006-07-31 2015-03-17 Laboratoires Besins International Treatment and prevention of excessive scarring
JP5301205B2 (ja) * 2008-05-28 2013-09-25 東興薬品工業株式会社 ゲル軟膏組成物
WO2011121074A1 (en) * 2010-04-01 2011-10-06 Pharmanest Ab Thermogelling anaesthetic compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1188407A (zh) * 1996-04-12 1998-07-22 阿斯特拉公司 具有麻醉作用的新型药物组合物

Also Published As

Publication number Publication date
EP2552487A1 (en) 2013-02-06
SI2552487T1 (sl) 2017-02-28
LT2552487T (lt) 2016-12-27
US20140155434A1 (en) 2014-06-05
CL2012002706A1 (es) 2013-02-01
PH12012501886A1 (en) 2012-12-17
NZ602538A (en) 2014-03-28
BR112012024673A2 (pt) 2017-08-08
KR20130081653A (ko) 2013-07-17
HUE031107T2 (en) 2017-06-28
WO2011121074A1 (en) 2011-10-06
EA023396B1 (ru) 2016-05-31
JP5972862B2 (ja) 2016-08-17
RS55544B1 (sr) 2017-05-31
MX2012011262A (es) 2013-02-11
CA2795154A1 (en) 2011-10-06
JP2013523693A (ja) 2013-06-17
PL2552487T3 (pl) 2017-04-28
SMT201700050T1 (it) 2017-03-08
CY1118396T1 (el) 2017-06-28
BR112012024673B1 (pt) 2021-06-29
EA201290789A1 (ru) 2013-04-30
DK2552487T3 (en) 2017-02-06
US20130116328A1 (en) 2013-05-09
MY163215A (en) 2017-08-30
ES2608850T3 (es) 2017-04-17
PT2552487T (pt) 2016-12-30
CA2795154C (en) 2017-04-18
IL222224A (en) 2015-10-29
KR101792200B1 (ko) 2017-10-31
SG184071A1 (en) 2012-10-30
EP2552487B1 (en) 2016-10-19
US8834927B2 (en) 2014-09-16
JP2016185950A (ja) 2016-10-27
ZA201206988B (en) 2014-04-30
US8828437B2 (en) 2014-09-09
AU2011234492B2 (en) 2014-02-27
HRP20161663T1 (hr) 2017-01-13
AU2011234492A1 (en) 2012-10-18
US9254263B2 (en) 2016-02-09
CN102858374A (zh) 2013-01-02
IL222224A0 (en) 2012-12-31
SMT201700050B (it) 2017-03-08
US20140329906A1 (en) 2014-11-06

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Address after: Solna, Sweden

Patentee after: Parett Life Sciences

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Patentee before: PHARMANEST AB