BR112012024673B1 - Composição farmacêutica anestésica termogelificante e uso da mesma para a preparação de um medicamento para o tratamento de dor - Google Patents

Composição farmacêutica anestésica termogelificante e uso da mesma para a preparação de um medicamento para o tratamento de dor Download PDF

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Publication number
BR112012024673B1
BR112012024673B1 BR112012024673-9A BR112012024673A BR112012024673B1 BR 112012024673 B1 BR112012024673 B1 BR 112012024673B1 BR 112012024673 A BR112012024673 A BR 112012024673A BR 112012024673 B1 BR112012024673 B1 BR 112012024673B1
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BR
Brazil
Prior art keywords
pharmaceutical composition
weight
composition according
poloxamer
amount
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BR112012024673-9A
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English (en)
Portuguese (pt)
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BR112012024673A2 (pt
Inventor
Mark Sundberg
Arne Brodin
Nils Kallberg
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Palette Life Sciences AB
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Application filed by Palette Life Sciences AB filed Critical Palette Life Sciences AB
Publication of BR112012024673A2 publication Critical patent/BR112012024673A2/pt
Publication of BR112012024673B1 publication Critical patent/BR112012024673B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402Anaestetics, analgesics, e.g. lidocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112012024673-9A 2010-04-01 2011-03-31 Composição farmacêutica anestésica termogelificante e uso da mesma para a preparação de um medicamento para o tratamento de dor BR112012024673B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1050321 2010-04-01
SE1050321-7 2010-04-01
US32541810P 2010-04-19 2010-04-19
US61/325,418 2010-04-19
PCT/EP2011/055009 WO2011121074A1 (en) 2010-04-01 2011-03-31 Thermogelling anaesthetic compositions

Publications (2)

Publication Number Publication Date
BR112012024673A2 BR112012024673A2 (pt) 2017-08-08
BR112012024673B1 true BR112012024673B1 (pt) 2021-06-29

Family

ID=44502740

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012024673-9A BR112012024673B1 (pt) 2010-04-01 2011-03-31 Composição farmacêutica anestésica termogelificante e uso da mesma para a preparação de um medicamento para o tratamento de dor

Country Status (29)

Country Link
US (3) US8834927B2 (enExample)
EP (1) EP2552487B1 (enExample)
JP (2) JP5972862B2 (enExample)
KR (1) KR101792200B1 (enExample)
CN (1) CN102858374B (enExample)
AU (1) AU2011234492B2 (enExample)
BR (1) BR112012024673B1 (enExample)
CA (1) CA2795154C (enExample)
CL (1) CL2012002706A1 (enExample)
CY (1) CY1118396T1 (enExample)
DK (1) DK2552487T3 (enExample)
EA (1) EA023396B1 (enExample)
ES (1) ES2608850T3 (enExample)
HR (1) HRP20161663T1 (enExample)
HU (1) HUE031107T2 (enExample)
IL (1) IL222224A (enExample)
LT (1) LT2552487T (enExample)
MX (1) MX2012011262A (enExample)
MY (1) MY163215A (enExample)
NZ (1) NZ602538A (enExample)
PH (1) PH12012501886A1 (enExample)
PL (1) PL2552487T3 (enExample)
PT (1) PT2552487T (enExample)
RS (1) RS55544B1 (enExample)
SG (1) SG184071A1 (enExample)
SI (1) SI2552487T1 (enExample)
SM (2) SMT201700050T1 (enExample)
WO (1) WO2011121074A1 (enExample)
ZA (1) ZA201206988B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ602538A (en) * 2010-04-01 2014-03-28 Pharmanest Ab Thermogelling anaesthetic compositions
WO2014134586A2 (en) * 2013-02-28 2014-09-04 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compostions
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
GB201305622D0 (en) * 2013-03-27 2013-05-15 Sas Ltd Composition
CA2961660A1 (en) * 2014-10-01 2016-04-07 Als Mountain Llc Pharmaceutical composition comprising aspirin, metformin, and serotonin with non-ionic surfactant
JP6678946B2 (ja) 2015-03-25 2020-04-15 テルモ株式会社 ゲル状局所麻酔剤およびそれを用いたゲル状局所麻酔製剤
JP6853785B2 (ja) 2015-11-12 2021-03-31 テルモ株式会社 徐放性局所投与剤
CN105769839B (zh) * 2016-05-17 2019-06-11 山西远扬医药科技有限公司 一种复方利多卡因药物组合物及其制备方法
CN107149697B (zh) * 2017-03-24 2020-07-31 王科 一种皮肤表面麻醉敷料、其制备方法及使用方法
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
CN108309928A (zh) * 2018-03-22 2018-07-24 兆科(广州)眼科药物有限公司 一种妇科术后止痛药物组合物及其制备方法
IT201800004036A1 (it) * 2018-03-28 2019-09-28 Teres Srl Gel transdermico
WO2019217536A1 (en) * 2018-05-08 2019-11-14 University Of Connecticut Long-acting local anesthetic formulation
CN111840553A (zh) * 2019-04-15 2020-10-30 湖州依诺唯新药物制剂有限公司 脂性药物制剂及其应用
JP7646175B2 (ja) * 2019-11-28 2025-03-17 東洋製薬化成株式会社 リドカイン含有外用医薬組成物
CA3168712A1 (en) * 2020-02-25 2021-09-02 The University Of North Carolina At Chapel Hill Eutectic based anesthetic compositions and applications thereof
WO2022055927A1 (en) * 2020-09-11 2022-03-17 Ps Therapy Ltd. Topical compositions and methods of use
JP2025504173A (ja) * 2022-02-04 2025-02-06 インタクト セラピューティクス, インコーポレイテッド メサラミン薬学的製剤およびその使用法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248014B (it) * 1991-06-07 1995-01-05 Inverni Della Beffa Spa Preparazioni oftalmiche a rilascio protratto
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
US6217900B1 (en) 1997-04-30 2001-04-17 American Home Products Corporation Vesicular complexes and methods of making and using the same
JP3782551B2 (ja) * 1997-06-24 2006-06-07 鉄郎 高山 鎮痛組成物
US6528086B2 (en) 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
KR100416646B1 (ko) 2000-08-14 2004-02-05 구주제약주식회사 리도카인을 함유한 조루치료용 마이크로에멀젼 하이드로겔 제형의 약학 조성물
GB0120701D0 (en) 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Pharmaceutical formulations
GB0120702D0 (en) 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Anaesthetic formulations
RS54275B1 (sr) * 2002-07-29 2016-02-29 Transform Pharmaceuticals, Inc. Vodeni 2,6-diizopropilfenol farmaceutski sastavi
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
AU2003900887A0 (en) * 2003-02-27 2003-03-13 Novasel Australia Pty Ltd Poloxamer emulsion preparations
ES2237298B1 (es) * 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
US20050084508A1 (en) 2003-07-22 2005-04-21 Vancaillie Thierry G. Topical anesthesia formulation for bodily cavities
US20080154210A1 (en) 2004-05-28 2008-06-26 Oryxe Mixture for Transdermal Delivery of Low and High Molecular Weight Compounds
US20070190124A1 (en) 2004-06-07 2007-08-16 Jie Zhang Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs
AU2006201233B2 (en) 2006-03-24 2010-10-07 Alan Hewitt Topical anesthesia formulation for bodily cavities
US20070298005A1 (en) 2006-06-22 2007-12-27 Marie-Josee Thibault Injectable composition for treatment of skin defects or deformations
WO2008015190A2 (en) 2006-07-31 2008-02-07 Laboratoires Besins International Treatment and prevention of excessive scarring
JP5301205B2 (ja) * 2008-05-28 2013-09-25 東興薬品工業株式会社 ゲル軟膏組成物
NZ602538A (en) * 2010-04-01 2014-03-28 Pharmanest Ab Thermogelling anaesthetic compositions

Also Published As

Publication number Publication date
CL2012002706A1 (es) 2013-02-01
AU2011234492B2 (en) 2014-02-27
EA023396B1 (ru) 2016-05-31
JP2013523693A (ja) 2013-06-17
RS55544B1 (sr) 2017-05-31
IL222224A0 (en) 2012-12-31
ES2608850T3 (es) 2017-04-17
US20130116328A1 (en) 2013-05-09
PT2552487T (pt) 2016-12-30
LT2552487T (lt) 2016-12-27
NZ602538A (en) 2014-03-28
JP2016185950A (ja) 2016-10-27
PL2552487T3 (pl) 2017-04-28
SG184071A1 (en) 2012-10-30
HRP20161663T1 (hr) 2017-01-13
MY163215A (en) 2017-08-30
EP2552487A1 (en) 2013-02-06
ZA201206988B (en) 2014-04-30
US20140329906A1 (en) 2014-11-06
KR20130081653A (ko) 2013-07-17
PH12012501886A1 (en) 2012-12-17
WO2011121074A1 (en) 2011-10-06
US8828437B2 (en) 2014-09-09
AU2011234492A1 (en) 2012-10-18
EP2552487B1 (en) 2016-10-19
HUE031107T2 (en) 2017-06-28
CA2795154A1 (en) 2011-10-06
CA2795154C (en) 2017-04-18
BR112012024673A2 (pt) 2017-08-08
DK2552487T3 (en) 2017-02-06
MX2012011262A (es) 2013-02-11
SMT201700050B (it) 2017-03-08
IL222224A (en) 2015-10-29
EA201290789A1 (ru) 2013-04-30
KR101792200B1 (ko) 2017-10-31
SI2552487T1 (sl) 2017-02-28
CN102858374B (zh) 2015-12-09
US20140155434A1 (en) 2014-06-05
SMT201700050T1 (it) 2017-03-08
US8834927B2 (en) 2014-09-16
CY1118396T1 (el) 2017-06-28
US9254263B2 (en) 2016-02-09
JP5972862B2 (ja) 2016-08-17
CN102858374A (zh) 2013-01-02

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/03/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, , QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.