CN1027507C - 新的磺酰化合物的制备方法 - Google Patents

新的磺酰化合物的制备方法 Download PDF

Info

Publication number
CN1027507C
CN1027507C CN91103408A CN91103408A CN1027507C CN 1027507 C CN1027507 C CN 1027507C CN 91103408 A CN91103408 A CN 91103408A CN 91103408 A CN91103408 A CN 91103408A CN 1027507 C CN1027507 C CN 1027507C
Authority
CN
China
Prior art keywords
formula
compound
methyl
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN91103408A
Other languages
English (en)
Chinese (zh)
Other versions
CN1056691A (zh
Inventor
迪特尔·弗洛克齐
赫尔曼·阿姆殊勒
福尔克·菲加拉
库特·克莱姆
罗尔夫·博默
迪特里希·黑夫纳
吉多·哈瑙尔
曼弗里德·埃尔策
克里斯蒂安·舒特
乌尔里希·基利安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of CN1056691A publication Critical patent/CN1056691A/zh
Application granted granted Critical
Publication of CN1027507C publication Critical patent/CN1027507C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heat Treatment Of Steel (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN91103408A 1990-05-16 1991-05-16 新的磺酰化合物的制备方法 Expired - Fee Related CN1027507C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH165890 1990-05-16
CH1658/90 1990-05-16

Publications (2)

Publication Number Publication Date
CN1056691A CN1056691A (zh) 1991-12-04
CN1027507C true CN1027507C (zh) 1995-01-25

Family

ID=4215610

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91103408A Expired - Fee Related CN1027507C (zh) 1990-05-16 1991-05-16 新的磺酰化合物的制备方法

Country Status (23)

Country Link
US (1) US5346904A (https=)
EP (1) EP0528922B1 (https=)
JP (1) JP3238397B2 (https=)
CN (1) CN1027507C (https=)
AT (1) ATE181330T1 (https=)
AU (1) AU651592B2 (https=)
CA (1) CA2082923C (https=)
CS (1) CS144791A3 (https=)
DE (3) DE4191109D2 (https=)
DK (1) DK0528922T3 (https=)
ES (1) ES2134777T3 (https=)
FI (1) FI925005L (https=)
GR (1) GR3031098T3 (https=)
HU (2) HUT62895A (https=)
IE (1) IE911625A1 (https=)
IL (1) IL98133A (https=)
MY (1) MY105344A (https=)
NO (1) NO924414L (https=)
NZ (1) NZ238141A (https=)
PT (1) PT97680B (https=)
WO (1) WO1991017991A1 (https=)
YU (1) YU85691A (https=)
ZA (1) ZA913627B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0612247A1 (de) * 1991-11-15 1994-08-31 Byk Gulden Lomberg Chemische Fabrik GmbH Verwendung von sulfonylverbindungen
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
EE03829B1 (et) * 1996-11-11 2002-08-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim
JP2001514640A (ja) * 1997-03-07 2001-09-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のテトラゾール
CA2291153A1 (en) * 1997-06-03 1998-12-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
DE69828284T2 (de) 1997-06-30 2005-12-08 Nippon Kayaku K.K. Naphthyridinderivate oder salze davon
EP1212089B1 (en) 1999-08-21 2006-03-22 ALTANA Pharma AG Synergistic combination of roflumilast and salmeterol
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8196556B2 (en) * 2009-09-17 2012-06-12 Delphi Technologies, Inc. Apparatus and method for setting mechanical lash in a valve-deactivating hydraulic lash adjuster
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
US4087530A (en) * 1974-02-05 1978-05-02 Sandoz Ltd. Substituted 6-phenyl-octahydrobenzo [c] [1,6] naphthyridines
DE2503156A1 (de) * 1974-02-05 1975-08-07 Sandoz Ag Verfahren zur herstellung neuer heterocyclischer verbindungen
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin

Also Published As

Publication number Publication date
AU7870191A (en) 1991-12-10
EP0528922A1 (de) 1993-03-03
MY105344A (en) 1994-09-30
HU9203557D0 (en) 1993-03-29
ZA913627B (en) 1992-01-29
DE4191109A1 (https=) 1993-04-01
CS144791A3 (en) 1992-03-18
NO924414D0 (no) 1992-11-16
DE59109135D1 (de) 1999-07-22
JPH05507081A (ja) 1993-10-14
CN1056691A (zh) 1991-12-04
DK0528922T3 (da) 1999-11-22
IL98133A (en) 1994-11-11
NZ238141A (en) 1993-07-27
PT97680A (pt) 1992-02-28
DE4191109D2 (en) 1993-04-01
CA2082923C (en) 2001-12-18
WO1991017991A1 (de) 1991-11-28
NO924414L (no) 1992-11-16
IE911625A1 (en) 1991-11-20
HUT62895A (en) 1993-06-28
YU85691A (sh) 1994-06-24
PT97680B (pt) 1998-09-30
ATE181330T1 (de) 1999-07-15
CA2082923A1 (en) 1991-11-17
GR3031098T3 (en) 1999-12-31
FI925005A7 (fi) 1992-11-05
FI925005A0 (fi) 1992-11-05
FI925005L (fi) 1992-11-05
EP0528922B1 (de) 1999-06-16
AU651592B2 (en) 1994-07-28
US5346904A (en) 1994-09-13
ES2134777T3 (es) 1999-10-16
JP3238397B2 (ja) 2001-12-10
IL98133A0 (en) 1992-06-21

Similar Documents

Publication Publication Date Title
CN1027507C (zh) 新的磺酰化合物的制备方法
CN1056611C (zh) 吡唑并吡啶和吡咯并吡啶,其用途和用于制备它们的中间体
CN1052005C (zh) 咪唑并吡啶、其制法和药用
PL188908B1 (pl) Nowe pochodne benzimidazolu i ich zastosowanie dowytwarzania leków do leczenia stanów alergicznych
CN1101385C (zh) 取代的苯并咪唑衍生物及其制法和药物用途
CN1042633C (zh) 咪唑并(1,2－a)吡啶类的氨基甲酸烷氧基烷基酯
CN1065459A (zh) 哌啶衍生物及其制备方法和治疗应用
CN1064275A (zh) 咪唑并吡啶paf/h1拮抗剂
CN1268122A (zh) 用作nos抑制剂的支化烷氧基取代的2－氨基吡啶
CN87101183A (zh) 抗肿瘤试剂活性的增进剂及其制备方法
CN1128030A (zh) 具有中枢神经系统活性的杂环胺
JP2002501920A (ja) セロトニン−１ａ受容体作動薬としてのオキサゾール誘導体
JPS601300B2 (ja) 第三アミンの製造方法
JPH08283262A (ja) ４−インドリルピペラジニル誘導体
JP2002527515A (ja) 精神障害の処置のための３−テトラヒドロピリジン−４−イルインドール類
JPH0692406B2 (ja) キサンチン誘導体、その製造方法およびそれらの医薬としての用途
CN1307563A (zh) N－苯基－n′－苯丙基哌嗪衍生物及其制备方法
CN1014992B (zh) 喹唑啉二酮和吡啶并嘧啶二酮的制备方法
US6057340A (en) Oxazole derivatives as serotonin-1A receptor agonists
CN100342851C (zh) 包含西布曲明甲磺酸盐半水合物晶体的药物组合物
CN1247593C (zh) 噻庚英并[3,2－b]二氢吡啶和相关组合物及方法
AU621479B2 (en) New benzothiazolinone derivatives, process for manufacturing them, and pharmaceutical compositions which contain them
CN1039998C (zh) 取代的环烷基乙酰胺及其制法、药物和用途
CN1040756C (zh) 杂环化合物的制备方法
JPH0472829B2 (https=)

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee