CN102746240B - 抗感染嘧啶及其用途 - Google Patents

抗感染嘧啶及其用途 Download PDF

Info

Publication number
CN102746240B
CN102746240B CN201210167588.0A CN201210167588A CN102746240B CN 102746240 B CN102746240 B CN 102746240B CN 201210167588 A CN201210167588 A CN 201210167588A CN 102746240 B CN102746240 B CN 102746240B
Authority
CN
China
Prior art keywords
compound
independently selected
alkyl
group
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201210167588.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN102746240A (zh
Inventor
C·A·弗伦特奇
D·K·赫琴森
D·A·贝特本纳
D·A·德戈伊
P·L·唐纳
W·M·卡蒂
A·C·克鲁格
D·刘
Y·刘
K·L·朗格尼克
C·J·马林
C·E·莫特
J·K·普拉特
J·T·兰多尔夫
T·W·罗克威
K·D·斯特沃特
R·瓦格纳
D·M·巴恩斯
S·陈
T·S·弗兰齐克二世
Y·高
A·R·海格特
J·E·亨格维尔德
B·J·科特基
X·楼
G·G·Z·张
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories Ltd
Original Assignee
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of CN102746240A publication Critical patent/CN102746240A/zh
Application granted granted Critical
Publication of CN102746240B publication Critical patent/CN102746240B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201210167588.0A 2007-09-17 2008-09-17 抗感染嘧啶及其用途 Expired - Fee Related CN102746240B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US97288107P 2007-09-17 2007-09-17
US60/972881 2007-09-17
US60/972,881 2007-09-17
US9679208P 2008-09-13 2008-09-13
US61/096,792 2008-09-13
US61/096792 2008-09-13
CN200880113534.8A CN101842360B (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880113534.8A Division CN101842360B (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途

Publications (2)

Publication Number Publication Date
CN102746240A CN102746240A (zh) 2012-10-24
CN102746240B true CN102746240B (zh) 2017-10-03

Family

ID=40308557

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201210167588.0A Expired - Fee Related CN102746240B (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途
CN201410657922.XA Pending CN104628654A (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途
CN200880113534.8A Active CN101842360B (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途
CN201410659529.4A Pending CN104628655A (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201410657922.XA Pending CN104628654A (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途
CN200880113534.8A Active CN101842360B (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途
CN201410659529.4A Pending CN104628655A (zh) 2007-09-17 2008-09-17 抗感染嘧啶及其用途

Country Status (21)

Country Link
US (3) US8188104B2 (OSRAM)
EP (3) EP2639226B1 (OSRAM)
JP (3) JP5734655B2 (OSRAM)
CN (4) CN102746240B (OSRAM)
AT (1) ATE519746T1 (OSRAM)
CA (2) CA2699986C (OSRAM)
CY (3) CY1115514T1 (OSRAM)
DK (3) DK2639226T3 (OSRAM)
ES (3) ES2523864T3 (OSRAM)
HR (2) HRP20110809T1 (OSRAM)
HU (1) HUS1500013I1 (OSRAM)
LT (1) LTC2203431I2 (OSRAM)
LU (1) LU92666I2 (OSRAM)
MX (1) MX2010002902A (OSRAM)
NL (1) NL300729I1 (OSRAM)
NO (1) NO2015011I1 (OSRAM)
PL (3) PL2639226T3 (OSRAM)
PT (3) PT2639226T (OSRAM)
RU (2) RU2539570C2 (OSRAM)
SI (2) SI2368882T1 (OSRAM)
WO (1) WO2009039134A1 (OSRAM)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009039135A1 (en) 2007-09-17 2009-03-26 Abbott Laboratories N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors
PT2639226T (pt) 2007-09-17 2016-12-09 Abbvie Bahamas Ltd Pirimidinas anti-infeciosas e suas utilizações
JP5734654B2 (ja) 2007-09-17 2015-06-17 アッヴィ・バハマズ・リミテッド Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体
ES2383273T3 (es) * 2008-07-23 2012-06-19 F. Hoffmann-La Roche Ag Compuestos heterocíclicos antivíricos
WO2010034671A1 (en) 2008-09-26 2010-04-01 F. Hoffmann-La Roche Ag Pyrine or pyrazine derivatives for treating hcv
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
ES2413080T3 (es) * 2009-03-25 2013-07-15 Abbvie Inc. Compuestos antivirales y usos de los mismos
KR20120011880A (ko) 2009-04-25 2012-02-08 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스성 화합물
AR077004A1 (es) 2009-06-09 2011-07-27 Hoffmann La Roche Compuestos heterociclicos antivirales
BRPI1011744A2 (pt) 2009-06-24 2016-03-22 Hoffmann La Roche composto antiviral heterocíclico.
EP2480533A1 (en) 2009-09-21 2012-08-01 F. Hoffmann-La Roche AG Heterocyclic antiviral compounds
CA2812683C (en) 2009-09-25 2017-10-10 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
KR20120085918A (ko) * 2009-11-21 2012-08-01 에프. 호프만-라 로슈 아게 헤테로환형 항바이러스성 화합물
BR112012014164A2 (pt) * 2009-12-14 2016-05-17 Merck Patent Gmbh inibidores da esfingosina quinase
CA2780526A1 (en) * 2009-12-14 2011-06-23 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
HUE030938T2 (en) 2010-04-19 2017-06-28 Oryzon Genomics Sa Lysine-specific demethylase-1 inhibitors and their use
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
MX2013000623A (es) * 2010-07-16 2013-06-13 Abbvie Inc Proceso para la preparación de compuestos antivirales.
KR101774742B1 (ko) 2010-07-16 2017-09-11 애브비 아일랜드 언리미티드 컴퍼니 촉매 반응용 포스핀 리간드
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
MX341732B (es) 2010-07-29 2016-08-30 Oryzon Genomics S A * Inhibidores de la demetilasa lsd1 basados en arilciclopropilamina y sus usos médicos.
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
WO2012020725A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
EP3981395A1 (en) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
CN102675092B (zh) * 2011-03-14 2014-11-05 江苏中丹药物研究有限公司 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2013057322A1 (en) 2011-10-20 2013-04-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
BR112014009306B1 (pt) 2011-10-20 2021-07-20 Oryzon Genomics S.A. Compostos de (hetero)aril ciclopropilamina como inibidores de lsd1
PT107924A (pt) * 2011-10-21 2014-12-03 Abbvie Inc Tratamento de combinação de daa (eg. com abt-072 ou abt-333) para utilização no tratamento de hcv
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2572329B1 (es) 2011-10-21 2017-08-24 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CN104884440A (zh) 2012-08-21 2015-09-02 艾伯维公司 用于制备抗病毒化合物的方法
WO2014063101A1 (en) * 2012-10-18 2014-04-24 Abbvie Inc. Formulations of pyrimidinedione derivative compounds
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
CN106065009B (zh) * 2014-06-28 2019-03-01 广东东阳光药业有限公司 作为丙型肝炎抑制剂的化合物及其在药物中的应用
WO2016105547A1 (en) 2014-12-24 2016-06-30 Concert Pharmaceuticals, Inc. Deuterated dasabuvir
EA036086B1 (ru) * 2016-03-17 2020-09-24 Фмк Корпорейшн Способ превращения s-энантиомера в его рацемическую форму
CA3022119A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
WO2017202207A1 (zh) * 2016-05-27 2017-11-30 深圳市塔吉瑞生物医药有限公司 一种取代的萘环化合物及药物组合物及其应用
CN110483496B (zh) * 2019-07-17 2021-05-04 杭州市西溪医院 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用
CN111518036A (zh) * 2020-04-29 2020-08-11 杭州勇诚睿生物科技有限公司 一种达沙布韦关键中间体的制备方法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN117466847A (zh) * 2022-07-22 2024-01-30 中国医药工业研究总院有限公司 一种利非斯特中间体苯并呋喃-6-羧酸的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239888A (en) * 1974-11-04 1980-12-16 Pfizer Inc. 1-Phenyluracils
JPS60243017A (ja) * 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
US5084084A (en) * 1989-07-14 1992-01-28 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
AU627906B2 (en) * 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
DE69129998T2 (de) * 1990-02-15 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Pyrimidindionderivate, deren Herstellung und Verwendung
NL9001075A (OSRAM) * 1990-05-04 1991-12-02 Duphar Int Res
EP0489480A1 (en) * 1990-12-05 1992-06-10 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
JPH05213755A (ja) 1992-02-07 1993-08-24 Nikko Kyodo Co Ltd 肝臓障害治療薬
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
US6380387B1 (en) * 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
EP1237878B1 (en) 1999-12-06 2007-03-21 F. Hoffmann-La Roche Ag 4-pyrimidinyl-n-acyl-l-phenylalanines
IL167956A (en) * 2000-02-04 2009-02-11 Sumitomo Chemical Co Isocyanate compounds
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US20040002476A1 (en) * 2002-02-14 2004-01-01 Stuyver Lieven J. Modified fluorinated nucleoside analogues
EA200500721A1 (ru) * 2002-11-28 2005-12-29 Шеринг Акциенгезельшафт Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств
TW200505872A (en) * 2003-06-13 2005-02-16 Lg Life Science Ltd Hepatitis C virus inhibitors
US7511145B2 (en) * 2003-08-01 2009-03-31 Genelabs Technologies, Inc. Bicyclic heteroaryl derivatives
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
JP2008506702A (ja) * 2004-07-14 2008-03-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するための方法
EP1953147A1 (en) * 2005-11-21 2008-08-06 Japan Tobacco, Inc. Heterocyclic compound and medicinal application thereof
JP5734654B2 (ja) 2007-09-17 2015-06-17 アッヴィ・バハマズ・リミテッド Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体
PT2639226T (pt) * 2007-09-17 2016-12-09 Abbvie Bahamas Ltd Pirimidinas anti-infeciosas e suas utilizações
WO2009039135A1 (en) 2007-09-17 2009-03-26 Abbott Laboratories N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors
ES2383273T3 (es) 2008-07-23 2012-06-19 F. Hoffmann-La Roche Ag Compuestos heterocíclicos antivíricos

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase;Raffaele De Francesco et al.;《Antiviral Research》;20031231;第58卷;第1-16页 *
Challenges and successes in developing new therapies for hepatitis C;Raffaele De Francesco et al.;《Nature》;20050818;第436卷;第953-960页 *

Also Published As

Publication number Publication date
NL300729I2 (OSRAM) 2016-01-07
HK1156033A1 (en) 2012-06-01
LTC2203431I2 (lt) 2017-01-25
RU2010114827A (ru) 2011-10-27
RU2014147354A (ru) 2015-07-10
NO2015011I2 (no) 2015-04-22
HK1148273A1 (en) 2011-09-02
NL300729I1 (OSRAM) 2016-01-07
US9139536B2 (en) 2015-09-22
EP2203431A1 (en) 2010-07-07
HUS1500013I1 (hu) 2016-11-28
EP2639226B1 (en) 2016-08-31
PT2639226T (pt) 2016-12-09
SI2368882T1 (sl) 2015-02-27
CY1115893T1 (el) 2017-01-25
CN102746240A (zh) 2012-10-24
DK2639226T3 (en) 2016-12-19
CN101842360A (zh) 2010-09-22
EP2368882A1 (en) 2011-09-28
CN104628655A (zh) 2015-05-20
US20090186912A1 (en) 2009-07-23
PT2203431E (pt) 2011-10-12
CY2015013I1 (el) 2016-04-13
CN104628654A (zh) 2015-05-20
ES2368879T3 (es) 2011-11-23
RU2539570C2 (ru) 2015-01-20
CA2849420C (en) 2016-07-12
PL2368882T3 (pl) 2015-04-30
EP2639226A1 (en) 2013-09-18
HRP20141102T1 (en) 2015-03-13
ES2523864T3 (es) 2014-12-02
ATE519746T1 (de) 2011-08-15
RU2014147354A3 (OSRAM) 2018-07-30
CN101842360B (zh) 2014-12-17
DK2368882T3 (en) 2014-12-01
MX2010002902A (es) 2010-06-02
US20120244119A1 (en) 2012-09-27
US8501238B2 (en) 2013-08-06
US8188104B2 (en) 2012-05-29
SI2203431T1 (sl) 2011-12-30
PT2368882E (pt) 2014-11-27
JP5734655B2 (ja) 2015-06-17
CA2699986C (en) 2014-06-17
JP2010539187A (ja) 2010-12-16
EP2368882B1 (en) 2014-08-13
JP5931683B2 (ja) 2016-06-08
HRP20110809T1 (hr) 2011-12-31
CY2015013I2 (el) 2016-04-13
ES2592961T3 (es) 2016-12-02
JP2015187106A (ja) 2015-10-29
NO2015011I1 (no) 2015-05-04
PL2639226T3 (pl) 2017-02-28
CA2849420A1 (en) 2009-03-26
WO2009039134A1 (en) 2009-03-26
EP2203431B1 (en) 2011-08-10
CY1115514T1 (el) 2016-04-13
PL2203431T3 (pl) 2012-01-31
LU92666I2 (fr) 2015-11-24
CA2699986A1 (en) 2009-03-26
JP2013056886A (ja) 2013-03-28
US20140294766A1 (en) 2014-10-02
DK2203431T3 (da) 2011-11-21

Similar Documents

Publication Publication Date Title
CN102746240B (zh) 抗感染嘧啶及其用途
CN102746239B (zh) 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物
CN101918369B (zh) 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物
AU2014280939B2 (en) Uracil or thymine derivative for treating hepatitis C
HK1177457A (en) Anti-infective pyrimidines and uses thereof
HK1148273B (en) Anti-infective pyrimidines and uses thereof
HK1177457B (en) Anti-infective pyrimidines and uses thereof
HK1189590B (en) Anti-infective pyrimidines and uses thereof
HK1156033B (en) Anti-infective pyrimidines and uses thereof
HK1189590A (en) Anti-infective pyrimidines and uses thereof
AU2013202002A1 (en) Uracil or thymine derivative for treating hepatitis C

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1177457

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: ABBOTT HOSPITAL CO., LTD.

Free format text: FORMER OWNER: ABBOTT GMBH. + CO. KG

Effective date: 20131211

C41 Transfer of patent application or patent right or utility model
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: Bahamas Nassau

Applicant after: AbbVie Inc.

Address before: Bahamas Nassau

Applicant before: Abbott Laboratories Ltd.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: ABBOTT HOSPITAL CO., LTD. TO: ABBVIE BAHAMAS B.V.

TA01 Transfer of patent application right

Effective date of registration: 20131211

Address after: Bahamas Nassau

Applicant after: Abbott Laboratories Ltd.

Address before: Illinois State

Applicant before: ABBOTT LABORATORIES

GR01 Patent grant
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1177457

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20171003

Termination date: 20200917