CN102686207B - 含水的粉状组合物 - Google Patents
含水的粉状组合物 Download PDFInfo
- Publication number
- CN102686207B CN102686207B CN201080059489.XA CN201080059489A CN102686207B CN 102686207 B CN102686207 B CN 102686207B CN 201080059489 A CN201080059489 A CN 201080059489A CN 102686207 B CN102686207 B CN 102686207B
- Authority
- CN
- China
- Prior art keywords
- water
- powder composition
- carrier
- weight
- silica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 101
- 239000000203 mixture Substances 0.000 title claims abstract description 71
- 239000000843 powder Substances 0.000 title claims abstract description 61
- 239000007788 liquid Substances 0.000 claims abstract description 47
- 239000002245 particle Substances 0.000 claims abstract description 41
- 239000000758 substrate Substances 0.000 claims abstract description 20
- 239000011257 shell material Substances 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 5
- 239000011258 core-shell material Substances 0.000 claims abstract description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 76
- -1 deodorizer Substances 0.000 claims description 38
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims description 38
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- 239000008187 granular material Substances 0.000 claims description 35
- 239000000377 silicon dioxide Substances 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 31
- 229910021485 fumed silica Inorganic materials 0.000 claims description 19
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- 235000012239 silicon dioxide Nutrition 0.000 claims description 12
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 230000003078 antioxidant effect Effects 0.000 claims description 7
- 239000007844 bleaching agent Substances 0.000 claims description 7
- 230000000035 biogenic effect Effects 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 230000000507 anthelmentic effect Effects 0.000 claims description 5
- 230000001166 anti-perspirative effect Effects 0.000 claims description 5
- 239000003213 antiperspirant Substances 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- 230000000843 anti-fungal effect Effects 0.000 claims description 4
- 229940121375 antifungal agent Drugs 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 229910002011 hydrophilic fumed silica Inorganic materials 0.000 claims description 4
- 238000010008 shearing Methods 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 abstract description 21
- 239000008346 aqueous phase Substances 0.000 abstract description 4
- 238000011010 flushing procedure Methods 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 17
- 125000000217 alkyl group Chemical group 0.000 description 17
- 241001597008 Nomeidae Species 0.000 description 16
- 150000002148 esters Chemical class 0.000 description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 15
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 229910002092 carbon dioxide Inorganic materials 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 9
- 239000006185 dispersion Substances 0.000 description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 239000000654 additive Substances 0.000 description 8
- 230000000996 additive effect Effects 0.000 description 8
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 8
- 239000001569 carbon dioxide Substances 0.000 description 8
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 7
- 229940088594 vitamin Drugs 0.000 description 7
- 229930003231 vitamin Natural products 0.000 description 7
- 239000011782 vitamin Substances 0.000 description 7
- 235000013343 vitamin Nutrition 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 6
- 125000001475 halogen functional group Chemical group 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000003607 modifier Substances 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 5
- 239000000314 lubricant Substances 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 150000003863 ammonium salts Chemical class 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 238000002242 deionisation method Methods 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 4
- 229910044991 metal oxide Inorganic materials 0.000 description 4
- AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229960001295 tocopherol Drugs 0.000 description 4
- 239000011732 tocopherol Substances 0.000 description 4
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical group CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 3
- 235000013980 iron oxide Nutrition 0.000 description 3
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 3
- 229910052629 lepidolite Inorganic materials 0.000 description 3
- 239000006193 liquid solution Substances 0.000 description 3
- 150000004706 metal oxides Chemical class 0.000 description 3
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 3
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 3
- 229960000601 octocrylene Drugs 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229930003799 tocopherol Natural products 0.000 description 3
- 235000010384 tocopherol Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 235000003840 Amygdalus nana Nutrition 0.000 description 2
- 244000296825 Amygdalus nana Species 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N Benzylformate Chemical compound O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- 241000195940 Bryophyta Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 108010087806 Carnosine Proteins 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- BTJXBZZBBNNTOV-UHFFFAOYSA-N Linalyl benzoate Chemical compound CC(C)=CCCC(C)(C=C)OC(=O)C1=CC=CC=C1 BTJXBZZBBNNTOV-UHFFFAOYSA-N 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 235000011432 Prunus Nutrition 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- 229910004298 SiO 2 Inorganic materials 0.000 description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- 125000005210 alkyl ammonium group Chemical group 0.000 description 2
- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- UBNYRXMKIIGMKK-UHFFFAOYSA-N amiloxate Chemical compound COC1=CC=C(C=CC(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-UHFFFAOYSA-N 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- QFWSIJKSJPEHCF-BTVCFUMJSA-N azane;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound N.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O QFWSIJKSJPEHCF-BTVCFUMJSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000012965 benzophenone Substances 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 235000011929 mousse Nutrition 0.000 description 2
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 2
- 239000011824 nuclear material Substances 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical compound CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 description 2
- 229960003493 octyltriethoxysilane Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011164 primary particle Substances 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- 235000014774 prunus Nutrition 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910000077 silane Inorganic materials 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- HDDLVZWGOPWKFW-UHFFFAOYSA-N trimethyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound COC(=O)CC(O)(C(=O)OC)CC(=O)OC HDDLVZWGOPWKFW-UHFFFAOYSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 1
- AALXZHPCKJILAZ-UHFFFAOYSA-N (4-propan-2-ylphenyl)methyl 2-hydroxybenzoate Chemical compound C1=CC(C(C)C)=CC=C1COC(=O)C1=CC=CC=C1O AALXZHPCKJILAZ-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- YKSSSKBJDZDZTD-XVNBXDOJSA-N (E)-isoeugenyl benzyl ether Chemical compound COC1=CC(\C=C\C)=CC=C1OCC1=CC=CC=C1 YKSSSKBJDZDZTD-XVNBXDOJSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 1
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 1
- LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 description 1
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 description 1
- AKWFJQNBHYVIPY-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO AKWFJQNBHYVIPY-UHFFFAOYSA-N 0.000 description 1
- NCKMMSIFQUPKCK-UHFFFAOYSA-N 2-benzyl-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1CC1=CC=CC=C1 NCKMMSIFQUPKCK-UHFFFAOYSA-N 0.000 description 1
- KXTAOXNYQGASTA-UHFFFAOYSA-N 2-benzylidenepropanedioic acid Chemical compound OC(=O)C(C(O)=O)=CC1=CC=CC=C1 KXTAOXNYQGASTA-UHFFFAOYSA-N 0.000 description 1
- ZIYRDJLAJYTELF-UHFFFAOYSA-N 2-bromo-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1Br ZIYRDJLAJYTELF-UHFFFAOYSA-N 0.000 description 1
- JUNWNQWKUFETAN-UHFFFAOYSA-N 2-ethylhexyl 3-(3-phenylphenyl)prop-2-enoate Chemical compound CCCCC(CC)COC(=O)C=CC1=CC=CC(C=2C=CC=CC=2)=C1 JUNWNQWKUFETAN-UHFFFAOYSA-N 0.000 description 1
- OUCGLXKNITVPJS-UHFFFAOYSA-N 2-ethylhexyl 3-phenylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C=CC1=CC=CC=C1 OUCGLXKNITVPJS-UHFFFAOYSA-N 0.000 description 1
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QBNUACHIKOJLLH-UHFFFAOYSA-N 3-(2,4-dichlorophenoxy)phenol Chemical compound OC1=CC=CC(OC=2C(=CC(Cl)=CC=2)Cl)=C1 QBNUACHIKOJLLH-UHFFFAOYSA-N 0.000 description 1
- QQQNPVHFBDPNNA-UHFFFAOYSA-N 3-(3-phenylphenyl)prop-2-enoic acid Chemical compound OC(=O)C=CC1=CC=CC(C=2C=CC=CC=2)=C1 QQQNPVHFBDPNNA-UHFFFAOYSA-N 0.000 description 1
- FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 1
- YDIYEOMDOWUDTJ-UHFFFAOYSA-N 4-(dimethylamino)benzoic acid Chemical compound CN(C)C1=CC=C(C(O)=O)C=C1 YDIYEOMDOWUDTJ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- LJXVZFDPCUEGLM-UHFFFAOYSA-N C(CCCCC)[Si](OC)(OC)OC.[F] Chemical class C(CCCCC)[Si](OC)(OC)OC.[F] LJXVZFDPCUEGLM-UHFFFAOYSA-N 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- FVJBRFUOWISBKS-UHFFFAOYSA-N C1=C(C)C=CC(C(C)C)=C1O.C1(=CC=CC=C1)NC(NC1=CC=CC=C1)=O Chemical compound C1=C(C)C=CC(C(C)C)=C1O.C1(=CC=CC=C1)NC(NC1=CC=CC=C1)=O FVJBRFUOWISBKS-UHFFFAOYSA-N 0.000 description 1
- HEOMGVQTHRQEBY-UHFFFAOYSA-N COC1=CC=C(CC(C(=O)O)(C(=O)O)CCC)C=C1 Chemical compound COC1=CC=C(CC(C(=O)O)(C(=O)O)CCC)C=C1 HEOMGVQTHRQEBY-UHFFFAOYSA-N 0.000 description 1
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 description 1
- 235000015511 Liquidambar orientalis Nutrition 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229910003849 O-Si Inorganic materials 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229910003872 O—Si Inorganic materials 0.000 description 1
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 229920002593 Polyethylene Glycol 800 Polymers 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000004870 Styrax Substances 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- RJDOZRNNYVAULJ-UHFFFAOYSA-L [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[F-].[F-].[Mg++].[Mg++].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[K+] Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[F-].[F-].[Mg++].[Mg++].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[K+] RJDOZRNNYVAULJ-UHFFFAOYSA-L 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 239000011795 alpha-carotene Substances 0.000 description 1
- 235000003903 alpha-carotene Nutrition 0.000 description 1
- ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229960001422 aluminium chlorohydrate Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 229910052916 barium silicate Inorganic materials 0.000 description 1
- HMOQPOVBDRFNIU-UHFFFAOYSA-N barium(2+);dioxido(oxo)silane Chemical compound [Ba+2].[O-][Si]([O-])=O HMOQPOVBDRFNIU-UHFFFAOYSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 229910052626 biotite Inorganic materials 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
- RDSNYYQDMRAFHN-UHFFFAOYSA-N butyl 2-acetamidopropanoate Chemical compound CCCCOC(=O)C(C)NC(C)=O RDSNYYQDMRAFHN-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000012241 calcium silicate Nutrition 0.000 description 1
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 description 1
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 description 1
- 235000000431 campesterol Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- MXOAEAUPQDYUQM-UHFFFAOYSA-N chlorphenesin Chemical compound OCC(O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940114081 cinnamate Drugs 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940019836 cyclamen aldehyde Drugs 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- SSLNXNMYNJKQTO-UHFFFAOYSA-N diethoxy-octyl-(2,2,2-trifluoroethoxy)silane Chemical compound FC(CO[Si](OCC)(OCC)CCCCCCCC)(F)F SSLNXNMYNJKQTO-UHFFFAOYSA-N 0.000 description 1
- OUWSNHWQZPEFEX-UHFFFAOYSA-N diethyl glutarate Chemical compound CCOC(=O)CCCC(=O)OCC OUWSNHWQZPEFEX-UHFFFAOYSA-N 0.000 description 1
- YSAVZVORKRDODB-WDSKDSINSA-N diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- XHEDLZYGAQSNTR-UHFFFAOYSA-N ethene;hexanedioic acid Chemical compound C=C.C=C.OC(=O)CCCCC(O)=O XHEDLZYGAQSNTR-UHFFFAOYSA-N 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 229940077441 fluorapatite Drugs 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940068939 glyceryl monolaurate Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- RSKGMYDENCAJEN-UHFFFAOYSA-N hexadecyl(trimethoxy)silane Chemical compound CCCCCCCCCCCCCCCC[Si](OC)(OC)OC RSKGMYDENCAJEN-UHFFFAOYSA-N 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- 229910001947 lithium oxide Inorganic materials 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- AUYPHISUPZUIJS-UHFFFAOYSA-N n-decyl-2-hydroxybenzamide Chemical compound CCCCCCCCCCNC(=O)C1=CC=CC=C1O AUYPHISUPZUIJS-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- YZUUTMGDONTGTN-UHFFFAOYSA-N nonaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCO YZUUTMGDONTGTN-UHFFFAOYSA-N 0.000 description 1
- KPMKEVXVVHNIEY-RITPCOANSA-N norcamphor Chemical compound C1C[C@@H]2C(=O)C[C@H]1C2 KPMKEVXVVHNIEY-RITPCOANSA-N 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 239000004482 other powder Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- MDHYEMXUFSJLGV-UHFFFAOYSA-N phenethyl acetate Chemical compound CC(=O)OCCC1=CC=CC=C1 MDHYEMXUFSJLGV-UHFFFAOYSA-N 0.000 description 1
- 229910052628 phlogopite Inorganic materials 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 229910052615 phyllosilicate Inorganic materials 0.000 description 1
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 description 1
- CGIHFIDULQUVJG-VNTMZGSJSA-N phytantriol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(O)[C@H](O)CO CGIHFIDULQUVJG-VNTMZGSJSA-N 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229930193551 sterin Natural products 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 229910052917 strontium silicate Inorganic materials 0.000 description 1
- QSQXISIULMTHLV-UHFFFAOYSA-N strontium;dioxido(oxo)silane Chemical compound [Sr+2].[O-][Si]([O-])=O QSQXISIULMTHLV-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- RBNWAMSGVWEHFP-UHFFFAOYSA-N trans-p-Menthane-1,8-diol Chemical compound CC(C)(O)C1CCC(C)(O)CC1 RBNWAMSGVWEHFP-UHFFFAOYSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 238000004627 transmission electron microscopy Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- OYGYKEULCAINCL-UHFFFAOYSA-N triethoxy(hexadecyl)silane Chemical compound CCCCCCCCCCCCCCCC[Si](OCC)(OCC)OCC OYGYKEULCAINCL-UHFFFAOYSA-N 0.000 description 1
- YUYCVXFAYWRXLS-UHFFFAOYSA-N trimethoxysilane Chemical compound CO[SiH](OC)OC YUYCVXFAYWRXLS-UHFFFAOYSA-N 0.000 description 1
- FQAZRHVERGEKOS-UHFFFAOYSA-N tripropan-2-yl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(C)OC(=O)CC(O)(C(=O)OC(C)C)CC(=O)OC(C)C FQAZRHVERGEKOS-UHFFFAOYSA-N 0.000 description 1
- ODHUFJLMXDXVRC-UHFFFAOYSA-N tripropyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CCCOC(=O)CC(O)(C(=O)OCCC)CC(=O)OCCC ODHUFJLMXDXVRC-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- WXETUDXXEZHSCS-MAVITOTKSA-N vertofix coeur Chemical compound C[C@@H]1CC[C@@]2(C(/CC3)=C\C(C)=O)[C@@H]3C(C)(C)[C@@H]1C2 WXETUDXXEZHSCS-MAVITOTKSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229940105296 zinc peroxide Drugs 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0233—Distinct layers, e.g. core/shell sticks
- A61K8/0237—Striped compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
Abstract
粉状组合物，其包含：a)至少一种核壳颗粒形式的粉末，所述核包含液态水或液态水相，并且所述壳包含疏水性或疏水化的颗粒；和b)至少一种包含载体和分别位于所述载体之中和/或之上的以下物质的粉末以下物质：b1)至少部分可溶于水的液体和/或b2)水反应性基质。由上述粉状组合物制备乳膏状组合物的方法，其中所述粉状组合物通过能量输入而活化，所述能量输入的形式是压力、剪切、温度、振动和/或添加溶剂，并且所述能量输入足以从所述核-壳材料释放所述液态水或所述液态水相，然后，a）所述液态水或液态水相从所述载体溶解或冲洗所述至少部分可溶于水的液体，和/或b）所述液态水或液态水相活化所述载体之中和/或之上的水反应性基质，然后从所述载体溶解或冲洗经活化而得的产物。
Description
技术领域
本发明涉及含水的粉状组合物和由此粉状组合物制备乳膏状(creamy)组合物的方法。
背景技术
水含量高的固体化妆品制剂，例如粉剂，是本领域已知的。一些专利申请的依据是久为人知的事实：在疏水性粉末例如疏水性二氧化硅粉末的存在下，水可被分散成小液滴并被疏水性材料包围，由此防止液滴重新结合。以此方式形成称为"干水"的水含量高的粉状物质(Fine Particles series no.11,Evonik Degussa)。基于"干水"的化妆品制剂在Seifen,Fette,
Wachse
8(2003)，第1-8页中有述。这些是当擦在皮肤上时液化的自由流动的精细粉剂。基于此原理的含水的可液化的粉状组合物还在数项专利申请和专利中公开。
US 4274883公开了疏水性二氧化硅的水分散体，其由0.1-50份疏水性二氧化硅、在特定的情况中不超过3份湿润剂和99.9-50份水组成。它通过剧烈混合疏水性二氧化硅与水以已知的"干-水-相"为中间步骤进行制备。在还可使用湿润剂的特定的情况中，不产生"干-水-相"。疏水性二氧化硅的分散体可在没有额外的步骤或材料的情况下与橡胶胶乳混合。
DE-A-1467023公开了使用包含化妆品配料替代纯水制备干水的用途。
EP-A-1206928公开了含水的粉状组合物，其包含包有疏水性颗粒的水凝胶核。
JP 2000-309505公开了通过涂擦液化的化妆品粉剂，其包含2重量%-20重量%的比表面积至少60m2/g的疏水性二氧化硅和水包油型乳液组合物。
EP-A-1235554公开了化妆品或药物粉剂至液体组合物，其包含其中含有水和水溶性聚合物的疏水性包覆的二氧化硅颗粒，所述组合物包含小于1%的油。
EP-A-1386599公开了制备包含包有疏水性粉末的含水组分的干水的方法，用以形成能够在涂擦使用时液化的粉末状态，其包括将疏水性粉末和含水组分加入中空的容器在其内形成疏水性封闭空间，然后在疏水性中空容器中高速搅拌形成精细的小水滴，而后使精细小液滴的表面均一地吸附疏水性粉末。
WO 01/85138A2公开了包封系统，其包含：含有至少5重量%水的含水液体的核，以及包围所述核形成稳定包封颗粒的包封剂，所述包封剂包含至少一层接触并包围所述核的疏水性颗粒，所述核和疏水性颗粒提供体积加权平均粒径为0.05-25微米的被包封的系统，至少25%的被包封的颗粒是球形并且可支撑其本身的重量。
EP-A-855177公开了美白粉剂，其包含0.1重量%-7重量%的比表面积至少80m2/g并且疏水度至少50%的三甲基硅氧基化的二氧化硅、5重量%-40重量%的多元醇、50重量%-94重量%水和0.01重量%-5重量%的美白成分。
WO 2005/058256公开了乳膏状或糊状稠度的化妆品制剂，其包含50重量%-95重量%水、疏水化的二氧化硅粉末、至少一种化妆品相关的活性成分，或者水溶性或在含水介质中可分散或乳化的添加剂，以及粘度调节剂。通过随着混合连续地向至少一种化妆品相关的活性成分的溶液或分散体添加疏水化的二氧化硅粉末并且继续混合直至达到糊状稠度，制备上述制剂。
虽然现有技术包括例如包封水的构思，此构思的问题是，取决于添加剂的性质例如添加剂的极性和链长，可添加的同时保持稳定粉末的添加剂的量为0重量%-3重量%。配方局限于0重量%-3重量%的添加剂，并且限制添加剂，减小最初构思的可行性。即使在已尝试此构思的工业的指导下，仍然不能克服关于添加剂种类或添加剂量的限制。
发明详述
因此，本发明一个目的是提供克服过去困难的构思。该构思不应局限于化妆品用途，而是应该还可用于其它工业如个人护理或家用护理。
本发明提供粉状组合物，其包含：
a)至少一种核壳颗粒形式的粉末，所述核包含液态水或液态水相，并且所述壳包含疏水性或疏水化的颗粒，和
b)至少一种包含载体和以下物质的粉末，以下物质分别位于所述载体之中和/或之上：
b1)至少部分可溶于水的液体和/或
b2)水反应性基质。
所述可溶于水的液体和水反应性基质通过毛细作用/吸收/吸附可逆地结合至载体，并且可被核壳颗粒的液态水或液态水相从载体部分或完全地冲洗或溶解。载体本身可以是水溶性的或者非水溶性的。
作为本发明的组合物的组成部分的核壳颗粒是指包含液态水或液态水相的粉状材料，但是其中疏水性或疏水化的颗粒的壳阻止单个水滴的聚集。该壳在通过压力、剪切、温度、振动和/或添加一种或多种溶剂或者一种或多种表面活性剂活化时能够从核释放液态水相或液态水。这些种类的核壳颗粒称为“干水”。水相可以是水溶液、水分散体或水乳液。
疏水性颗粒应理解为疏水性颗粒本身，而疏水化的颗粒是通过使亲水性颗粒的表面与疏水性表面改性剂反应而得的那些。通常在颗粒表面的反应基团如羟基与表面改性剂的反应基团之间形成共价键。
“疏水性”通常是指与水仅略有相互作用或无相互作用并且对水的亲和性小或为零。甲醇润湿性可用来定量衡量疏水性。本发明的壳颗粒的甲醇润湿性应为至少40，优选50-80，更优选60–70。为了测定甲醇润湿性，在每种情况中，将0.2g(±0.005g)疏水性或疏水化的颗粒称入透明离心管中。将8.0ml份的含有10体积%、20体积%、30体积%、40体积%、50体积%、60体积%、70体积%或80体积%甲醇的甲醇/水混合物加入每个样品中。摇动管30秒，然后在2500min-1下离心5分钟。甲醇润湿性定义为相对于沉积物体积100%，甲醇的体积百分比。该值越高，疏水性越高。
本发明中可使用的核壳颗粒的疏水性或疏水化的壳包括例如无机粉末，例如滑石、高岭土、云母、绢云母、白云石、金云母、合成云母、锂云母（lepidolite）、黑云母、锂云母（lithia mica）、蛭石、碳酸镁、碳酸钙、硅酸铝、硅酸钡、硅酸钙、硅酸镁、硅酸锶、钨酸金属盐、镁、二氧化硅、沸石、硫酸钡、煅烧硫酸钙、磷酸钙、氟磷灰石、羟磷灰石、二氧化钛、热解法二氧化钛、氧化铝和热解法氧化铝。
在这些形成三维网状物的疏水化的二氧化硅颗粒中，聚集的结构是优选的壳材料。所述二氧化硅可以是沉淀二氧化硅或热解法二氧化硅，优选后者。热解法二氧化硅通过火焰水解或火焰氧化法获得。它的纯度高于99重量%，通常高于99.8重量%。热解法二氧化硅通常形成聚集初始颗粒的三维网状物。热解法二氧化硅初始颗粒在它们的表面具有羟基并且无孔。
沉淀和热解法二氧化硅颗粒以及适合用作壳颗粒的其它颗粒是需要在下一步骤中被疏水化的亲水性颗粒。此步骤的工序是本领域技术人员已知的。
适合的表面改性剂可以是以下硅烷，其可单独地或作为混合物使用。
有机硅烷(RO)3Si(CnH2n+1)和(RO)3Si(CnH2n-1)，其中R=烷基，例如甲基、乙基、正丙基、异丙基、丁基，并且n=1-20。
有机硅烷R'x(RO)ySi(CnH2n+1)和R'x(RO)ySi(CnH2n-1)，其中R=烷基，例如甲基、乙基、正丙基、异丙基、丁基；R'=烷基，例如甲基、乙基、正丙基、异丙基、丁基；R'=环烷基；n=1-20；x+y=3、x=1、2；y=1、2。
卤代有机硅烷X3Si(CnH2n+1)和X3Si(CnH2n-1)，其中X=Cl、Br；n=1-20。
卤代有机硅烷X2(R')Si(CnH2n+1)和X2(R')Si(CnH2n-1)，其中X=Cl、Br，R'=烷基，例如甲基、乙基、正丙基、异丙基、丁基；R'=环烷基；n=1-20。
卤代有机硅烷X(R')2Si(CnH2n+1)和X(R')2Si(CnH2n-1)，其中X=Cl、Br；R'=烷基，例如甲基、乙基、正丙基、异丙基、丁基；R'=环烷基；n=1-20。
有机硅烷(RO)3Si(CH2)m-R'，其中R=烷基，例如甲基、乙基、丙基；m=0–20，R'=甲基、芳基例如-C6H5、取代的苯基、C4F9、OCF2-CHF-CF3、C6F13、OCF2CHF2、Sx-(CH2)3Si(OR)3。
有机硅烷(R")x(RO)ySi(CH2)m-R'，其中R"=烷基、x+y=3；环烷基，x=1、2，y=1、2；m=0.1-20；R'=甲基、芳基例如C6H5、取代的苯基、C4F9、OCF2-CHF-CF3、C6F13、OCF2CHF2、Sx-(CH2)3Si(OR)3、SH、NR'R''R″′，其中R'=烷基、芳基；R''=H、烷基、芳基；R'''=H、烷基、芳基、苄基、C2H4NR″″R″″′，其中R″″=H、烷基，R″″′=H、烷基。
卤代有机硅烷X3Si(CH2)m-R'，其中X=Cl、Br；m=0-20；R'=甲基、芳基例如C6H5、取代的苯基、C4F9、OCF2-CHF-CF3、C6F13、O-CF2-CHF2、Sx-(CH2)3Si(OR)3，其中R=甲基、乙基、丙基、丁基，并且x=1或2、SH。
卤代有机硅烷RX2Si(CH2)mR'，其中X=Cl、Br；m=0-20；R'=甲基、芳基例如C6H5、取代的苯基、C4F9、OCF2-CHF-CF3、C6F13、O-CF2-CHF2、-OOC(CH3)C=CH2、-Sx-(CH2)3Si(OR)3，其中R=甲基、乙基、丙基、丁基，并且x=1或2，SH。
卤代有机硅烷R2XSi(CH2)mR'，其中X=Cl、Br；m=0-20；R'=甲基、芳基例如C6H5、取代的苯基、C4F9、OCF2-CHF-CF3、C6F13、O-CF2-CHF2、-Sx-(CH2)3Si(OR)3，其中R=甲基、乙基、丙基、丁基并且x=1或2，SH。
硅氮烷R'R2SiNHSiR2R'，其中R、R'=烷基、乙烯基、芳基。
环聚硅氧烷D3、D4、D5及它们的同系物，其中D3、D4和D5是指含有3、4或5个-O-Si(CH3)2型单元的环聚硅氧烷，例如，八甲基环四硅氧烷=D4。
Y-O[[-SiRR’-O]m-[SiR”R”’-O]n]u-Y型聚硅氧烷或硅油，其中R=烷基；R'=烷基、芳基、H；R''=烷基、芳基；R'''=烷基、芳基、H；Y=CH3、H、CzH2z+1其中z=1-20，Si(CH3)3、Si(CH3)2H、Si(CH3)2OH、Si(CH3)2(OCH3)、Si(CH3)2(CzH2z+1)并且z=1-20，m=0、1、2、3、…，n=0、1、2、3、…，u=0、1、2、3、…。
可优选以下化合物作为表面改性剂：辛基三甲氧基硅烷、辛基三乙氧基硅烷、六甲基二硅氮烷、十六烷基三甲氧基硅烷、十六烷基三乙氧基硅烷、二甲基聚硅氧烷、九氟己基三甲氧基硅烷、十三氟辛基三甲氧基硅烷、十三氟辛基三乙氧基硅烷。可特别优选使用六甲基二硅氮烷、辛基三乙氧基硅烷和二甲基聚硅氧烷。
本发明的粉状组合物的壳颗粒可以是BET表面积优选为30m2/g-500m2/g，更优选100m2/g-350m2/g的疏水化的二氧化硅颗粒。由于与表面改性剂反应，这些颗粒可包含0.1重量%-15重量%，通常0.5重量%-5重量%的碳。
可用作壳材料的典型实例是：
R104(八甲基环四硅氧烷；150m2/g；55)；
R106(八甲基环四硅氧烷；250m2/g；50)；
R202(聚二甲基硅氧烷；100m2/g；75)；
R805(辛基硅烷；150m2/g；60)；
R812(六甲基二硅氮烷；260m2/g；60)；R812S (六甲基二硅氮烷；220m2/g；65)；R8200(六甲基二硅氮烷；150m2/g；65)。
括号内的说明是指表面改性剂、以及按照本说明书给出的方法测得的近似BET表面积和近似甲醇润湿性。
特别有用的壳颗粒材料是通过使BET表面积为270-330m2/g的亲水性热解法二氧化硅颗粒与六甲基二硅氮烷反应获得的疏水化的二氧化硅颗粒。所得的疏水化的二氧化硅颗粒的BET表面积为200-290m2/g，碳含量为2重量%-4重量%，甲醇润湿性为至少50，更优选50-70。
还可有益地使用紧密或颗粒形式的疏水化的热解法二氧化硅颗粒。
要讨论的核壳颗粒的另一部分是核。所述核包含液态水，并且是液态水本身的形式，或者液态水溶液形式、包含液态水的乳液或水分散体。在液态水溶液或乳液的情况中溶解或乳化的材料，或者在水分散体的情况中固体材料，应选自既不显著降低所述核的表面张力也不润湿所述壳的疏水性或疏水化的颗粒的那些材料。对于液态水溶液，这是指该溶液不应包含大于10重量%的被溶解的材料，优选包含不大于3重量%的被溶解的材料。液态水本身是最优选的核材料。
所述核可由包含至多10重量%的化合物的液态水相组成，可使用在化妆品、个人护理或家庭护理中典型使用的化合物，只要它们既不降低所述核的表面张力也不润湿所述壳的疏水性或疏水化的颗粒。与包含至少部分可溶于水的液体和/或水反应性基质的载体一起讨论典型实例。
所述核壳颗粒的水含量通常占所述核壳颗粒的75重量%-95重量%。
本发明的粉状组合物包含紧邻核壳颗粒的粉末，其由至少另一种其它粉末组成，其定义为包含分别位于载体之中和/或之上的至少部分可溶于水的液体或水反应性基质的载体。
在所述核壳颗粒通过压力、剪切、温度、振动和/或添加一种或多种溶剂或者一种或多种表面活性剂活化的情况中，所述可溶于水的液体能够部分或完全地从载体被该核壳颗粒的核材料冲洗或者溶解。这意味着可溶于水的液体部分或完全地从载体被所述核的水或水相溶解。或者，可溶于水的液体可部分或完全地从载体被所述核的水或水相冲洗。
同样适用于水反应性基质。水反应性基质是不溶于水或者仅可少量溶解的材料。当被水或水相活化时，它被转化成基本上或完全可溶的反应产物。
所述载体优选选自二氧化硅、二氧化硅-金属氧化物的混合氧化物如二氧化硅-氧化铝混合氧化物、二氧化硅-二氧化钛混合氧化物、层状硅酸盐、淀粉、中空玻璃球、尼龙、糖、环糊精和多糖。
在本发明的一个特别的实施方案中，所述载体选自热解法二氧化硅或沉淀二氧化硅，利用亲水性和疏水化的形式获得良好的结果。
在本发明的另一个特定的实施方案中，所述载体是沉淀二氧化硅，所述沉淀二氧化硅具有以下特征：
a)BET表面积为50-1000m2/g，优选100-700m2/g，更优选150-500m2/g，
b)通过激光衍射测得的粒度d50为2-100μm，优选3-20μm，更优选4-10μm，和
c)DBP(邻苯二甲酸二丁基酯)吸收为200-400，优选250-350gDBP/100g二氧化硅)。
对干燥后的物质，按照ISO 5794-1附录D测定BET表面积，按照ASTM690-1992测定粒度d50，按照ASTM D 2414测定DBP吸收。
具体的沉淀二氧化硅包括BET表面积为400-500m2/g，粒度d50为4-6μm并且DBP吸收为300-350g DBP/100g二氧化硅的材料。此外，另一种材料的BET表面积为150-250m2/g，粒度d50为4-7μm并且DBP吸收为250-300g DBP/100g二氧化硅。典型的实例是均来自Evonik Degussa的
500LS和
22LS。
至少部分可溶于水的液体和/或水反应性基质与载体的重量比取决于多种因素，例如可溶于水的液体的粘度、载体的结构包括孔径、孔体积和BET表面积。通常为10-90，优选60-75。
包含至少部分水溶性液体和/或水反应性基质的载体与核壳颗粒的重量比通常为1:1-1:9。
通过例如透射电子显微镜测定的载体和核壳颗粒的平均粒度通常可彼此独立地为2-20μm。可优选核壳颗粒的平均粒度是载体平均粒度的50%-150%。
核壳颗粒的核的水相和/或分别在载体之中和/或之上的至少部分可溶于水的液体和/或水反应性基质包含以下材料中的至少一种：紫外光保护过滤物质(UV light protection filters)、抗氧化剂、增湿物质（moisturizingsubstances）、除臭剂、止汗剂活性化合物、生物源物质（biogenic substances）、驱虫剂活性化合物、漂白剂抗氧化剂、漂白剂、抗细菌物质、抗真菌物质、调味剂、芳香剂、酸、碱、酶或它们的混合物。
根据本发明，紫外光保护过滤物质是有机物质，其在室温下呈液态或者结晶并且能够吸收紫外线，再以波长较长的辐射形式释放吸收的能量，例如热。紫外光过滤物质可以是油溶性或水溶性的。油溶性物质是例如：
-3-亚苄基樟脑和3-亚苄基降樟脑及它们的衍生物，
-4-氨基苯甲酸衍生物，优选4-(二甲基氨基)苯甲酸(2-乙基己基)酯、4-(二甲基氨基)苯甲酸(2-辛基)酯和4-(二甲基氨基)苯甲酸戊基酯，
-肉桂酸酯，优选4-甲氧基肉桂酸(2-乙基己基)酯、4-甲氧基肉桂酸丙基酯、4-甲氧基肉桂酸异戊基酯、2-氰基-3,3-苯基肉桂酸(2-乙基己基)酯(氰双苯丙烯酸辛酯，octocrylene)
-水杨酸酯，优选水杨酸(2-乙基己基)酯、水杨酸(4-异丙基苄基)酯、水杨酸(3,3,5-环己基)酯
-二苯甲酮衍生物，优选2-羟基-4-甲氧基二苯甲酮、2-羟基-4-甲氧基-4'-甲基二苯甲酮、2,2'-二羟基-4-甲氧基二苯甲酮
-苄基丙二酸酯（esters of benzalmalonic acid），优选4-甲氧基苄基丙二酸二(2-乙基己基)酯
-三嗪衍生物，例如2,4,6-三苯胺基-(对甲酰基-2'-乙基-1'-己氧基)-1,3,5-三嗪、辛基三嗪酮和二辛基丁酰胺基三嗪酮
-丙烷-1,3-二酮，例如1-(4-叔丁基苯基)-3-(4'-甲氧基苯基)丙烷-1,3-二酮
可用的水溶性物质是：
-2-苯基苯并咪唑-5-磺酸及其碱金属盐、碱土金属盐、铵盐、烷基铵盐、烷醇铵盐和葡糖铵盐
-二苯甲酮的磺酸衍生物，优选2-羟基-4-甲氧基二苯甲酮-5-磺酸及其盐
-3-亚苄基樟脑的磺酸衍生物，例如，4-(2-氧代-3-亚冰片基甲基)苯磺酸和2-甲基-5-(2-氧代-3-亚冰片基)磺酸及其盐。
典型的UV-A滤过剂是苯甲酰基甲烷衍生物，例如，1-(4'-叔丁基苯基)-3-(4'-甲氧基苯基)丙烷-1,3-二酮、4-叔丁基-4'-甲氧基二苯甲酰基甲烷、1-苯基-3-(4'-异丙基苯基)-丙烷-1,3-二酮。
当然，UV-A和UV-B过滤物质还可混合使用。特别有利的组合包括，苯甲酰基甲烷的衍生物如4-叔丁基-4'-甲氧基二苯甲酰基甲烷和2-氰基-3,3-苯基肉桂酸(2-乙基-己基)酯(氰双苯丙烯酸辛酯)与肉桂酸酯优选4-甲氧基肉桂酸(2-乙基己基)酯和/或4-甲氧基肉桂酸丙基酯和/或4-甲氧基肉桂酸异戊基酯组合。这样的组合有利地与水溶性过滤物质例如2-苯基苯并咪唑-5-磺酸及其碱金属盐、碱土金属盐、铵盐、烷基铵盐、烷醇铵盐和葡糖铵盐组合。
除了上述有机物质之外，不溶性光保护色素，即精细分散的金属氧化物粉末的原样或者疏水化的形式和盐也可用于此目的。适合的金属氧化物粉末或疏水化的金属氧化物粉末的实例可以是二氧化钛粉末、氧化锌粉末和/或含有元素Si、Ti、Al、Zn、Fe、B、Zr和/或Ce的这些混合氧化物粉末。
典型的实例是：被包覆的二氧化钛例如UV-Titan M212、M 262和X 111(Kemira)；
TiO2P25、PF2、T 805和T 817(Evonik Degussa)、微二氧化钛MT-150W、MT-100AQ、MT-100SA、MT-100HD、MT-100TV(Tayca)、Eusolex TM T2000(Merck)、氧化锌中性H&R和氧化锌NDM(Haarmann&Reimer)以及Z-Cote和Z-Cote HP1(BASF)。
还可使用分散体，例如，TEGO Sun TAQ 40，40重量%浓度的疏水化的二氧化钛水分散体(Evonik Goldschmidt)。
作为本发明的粉状组合物的组成部分的典型抗氧化剂可以是：
-氨基酸如甘氨酸、组氨酸、酪氨酸或色氨酸及它们的衍生物，
-咪唑如尿刊酸)及它们的衍生物，
-肽，例如D,L-肌肽、D-肌肽、L-肌肽及它们的衍生物，
-类胡萝卜素、胡萝卜素、α-胡萝卜素、β-胡萝卜素、番茄红素及它们的衍生物，
-绿原酸及它们的衍生物，
-脂酮酸及它们的衍生物
-螯合剂如α-羟基-脂肪酸、棕榈酸、植酸，
-α-羟基酸如柠檬酸、乳酸、苹果酸
-不饱和脂肪酸及它们的衍生物如γ-亚麻酸、亚油酸、油酸，
-叶酸及它们的衍生物，
-泛醌和泛醇及它们的衍生物，
-维生素C及衍生物如棕榈酸抗坏血酸基酯、磷酸抗坏血酸基酯、乙酸抗坏血酸基酯，
-生育酚及衍生物如维生素E、乙酸维生素E，
-维生素A及衍生物如棕榈酸维生素A
-甘露糖及它们的衍生物，
-超氧化物岐化酶。
保湿性物质可选自乙二醇、丁二醇、2,3-丁二醇、丙二醇、二丙二醇、三丙二醇、己二醇、丙三醇、二丙三醇、葡萄糖、果糖、乳糖、蔗糖、麦芽糖、甘露醇、甘露糖、PEG-4至PEG-800、如PEG-4、PEG-6、PEG-7、PEG-8、PEG-9、PEG-10、PEG-12、PEG-14、PEG-16、PEG-18、PEG-20、山梨糖醇、聚甘油山梨糖醇、脲、木糖醇及它们的混合物。
除臭剂和止汗剂活性的化合物可以是选自以下的至少一种：
-收敛剂金属盐，例如水合氯化铝、羟基乳酸铝、水合氯化铝锆和锌盐
-抑菌剂，例如壳聚糖、苯氧基乙醇、葡萄糖酸氯己定或5-氯-2-(2,4-二氯苯氧基)-苯酚
-酶抑制剂，例如
i)柠檬酸三烷基酯，例如柠檬酸三甲酯、柠檬酸三丙基酯、柠檬酸三异丙基酯、柠檬酸三丁基酯和柠檬酸三乙基酯；
ii)固醇硫酸酯或磷酸酯，例如羊毛固醇、胆固醇、菜油固醇、豆固醇及谷固醇硫酸酯和磷酸酯，
iii)二元羧酸及其酯，例如，戊二酸、戊二酸单乙基酯、戊二酸二乙基酯、己二酸、己二酸单乙基酯、己二酸二乙酯、丙二酸和丙二酸二乙酯，
iv)羟基羧酸及其酯，例如柠檬酸、苹果酸、酒石酸或酒石酸二乙酯；或者
v)4-羟基苯甲酸及其盐和酯，N-(4-氯苯基)-N'-(3,4-二氯苯基)脲、2,4,4'-三氯-2'-羟基-二苯基醚(Triclosan)、4-氯-3,5-二甲基-苯酚、2,2'-亚甲基-双(6-溴-4-氯苯酚)、3-甲基-4-(1-甲基乙基)-苯酚、2-苄基-4-氯苯酚、3-(4-氯苯氧基)-1,2-丙二醇、丁基甲酸(3-碘-2-丙炔基)酯、氯己定、3,4,4'-三氯二苯基脲百里酚、百里香油、丁香酚、丁香油、薄荷醇、薄荷油、法尼醇、苯氧基乙醇、甘油单己酸酯、甘油单辛酸酯、甘油单月桂酸酯、双甘油单己酸酯(DMC)、水杨酸N-烷基酰胺例如水杨酸N-辛基酰胺或水杨酸N-癸基酰胺。
-吸收剂或除臭剂如乙酸苄酯、乙酸(对叔丁基环己基)酯、乙酸芳樟酯、乙酸苯乙基酯、苯甲酸芳樟酯、甲酸苄酯、丙酸烯丙基环己基酯、丙酸苏合香脂和水杨酸苄基酯、苄基乙基醚、柠檬醛、香茅醛、香茅氧基乙醛、兔耳草醛、羟基香茅醛、紫罗兰酮、甲基柏木酮、茴香脑、香茅醇、丁香酚、异丁香酚、牛儿醇、芳樟醇、苯基乙醇、萜品醇或萜烯。
生物源物质可选自生育酚、生育酚乙酸酯、生育酚棕榈酸酯、抗坏血酸、(脱氧)核糖核酸及其分裂产物、β-葡聚糖、视黄醇、红没药醇、尿囊素、植烷三醇、泛醇、泛酸、水果酸(fruit acids)、α-羟基酸、氨基酸、神经酰胺、假神经酰胺、精油、植物提取物例如李属提取物(prunus extract)、bambara坚果提取物和复合维生素中的至少一种。
驱虫剂活性化合物可选自N,N-二乙基-间-甲苯酰胺、1,2-戊二醇、3-(N-正丁基-N-乙酰基-氨基)-丙酸乙基酯，和乙酰氨基丙酸丁基酯。
适合于本发明的漂白剂的实例是氢醌、过氧化锌、脲过氧化物、过氧化氢和/或有机过氧化物。
在本发明的一个具体的实施方案中，所述核壳颗粒的核是水，所述壳由疏水化的热解法二氧化硅颗粒组成，所述疏水化的热解法二氧化硅颗粒由BET表面积为30-500m2/g的亲水性的热解法二氧化硅反应而得。
此外，在本发明的一个有利的实施方案中，所述疏水化的热解法二氧化硅颗粒是通过使BET表面积270-330m2/g的亲水性热解法二氧化硅与六甲基二硅氮烷反应而得的，得到的疏水化的热解法二氧化硅颗粒，其BET表面积为200-290m2/g，碳含量为2重量%-4重量%并且甲醇润湿性为至少50。
该具体的实施方案还可包含作为载体的沉淀二氧化硅，其BET表面积为400-500m2/g，经激光衍射测得的粒度d50为4-6μm，并且DBP(邻苯二甲酸二丁基酯)吸收为300–350g DBP/100g二氧化硅。
该具体的实施方案还可包含作为载体的沉淀二氧化硅，其BET表面积为150-250m2/g，经激光衍射测得的粒度d50为4-7μm，并且DBP(邻苯二甲酸二丁基酯)吸收为250-300g DBP/100g二氧化硅。
另外，该具体的实施方案还可包含分别位于所述载体之中和/或之上的作为至少部分可溶于水的液体和/或水反应性基质的紫外光保护过滤物质、抗氧化剂、增湿物质、除臭剂、止汗剂活性化合物、生物源物质、驱虫剂活性化合物、漂白剂抗氧化剂、漂白剂、抗细菌物质、抗真菌物质、调味剂、芳香剂、酸、碱、酶或它们的混合物。
本发明的另一目的是由本发明的粉状组合物制备乳膏状组合物的方法。此粉状组合物通过能量输入而活化，所述能量输入的形式是压力、剪切、温度、振动和/或添加溶剂，该能量输入足以从核-壳材料释放液态水或液态水相，然后，
a)所述液态水或液态水相从所述载体溶解或冲洗至少部分可溶于水的液体，和/或
b)所述液态水或液态水相活化所述载体之中和/或之上的水反应性基质，然后从所述载体溶解或冲洗经活化而得的产物。
“乳膏状”应理解为是指从更似液体组合物至更似凝胶组合物至乳膏状组合物。
已概括地描述本发明，可参照仅以说明而非限制为目的提供的某些具体实施例进一步理解本发明。
实施例
实施例1：现有技术的粉状-乳膏状-粉状粉底（powder foundation）
为了制备干水制剂，将77.5重量%的去离子(DI)水与10.48重量%的来自The Dow Chemical Company的Carbowax
聚乙二醇400NF、5.27重量%的来自Chemsil Silicones,Inc.的
DM-20(20cPs)、1.75重量%的来自Kobo的铁氧化物色素AC-5Red R516P、AC-5 Yellow LL-100P、AC-5Black BL-100P和AC-5TiO2CR-50一起加入#KSB5ER4型KitchenAid混合机中。将R812S以5.0重量%加在水/PEG/二甲聚硅氧烷/色素混合物上。在混合机上紧密加盖，在最高挡(液化)以9,700RPM混合混合物1分钟。在1分钟的混合过程中，从左至右以50-60度角倾斜整个混合机保持10秒。
在约30分钟后，产品是在底部具有明显分离的乳膏/摩丝状。由于在与疏水性二氧化硅混合时没有形成稳定分离的小液滴，添加PEG和二甲聚硅氧烷的方法失败。认为润滑剂大幅降低水的表面张力以至它能够克服液滴与R812S之间的界面张力。
实施例2：本发明的粉状-乳膏状-粉状粉底
为了按照本发明制备新的粉状-乳膏状粉底制剂，通过将42.9重量%的来自The Dow Chemical Company的PEG
聚乙二醇400NF、21.4重量%的来自Chemsil Silicones的
DM-20(20cPs)、28.6重量%去离子(DI)水和7.1重量%的来自Kobo的AC-5铁氧化物色素混合产生PEG/二甲聚硅氧烷/色素/DI水稀释液。然后采用金属刮刀通过手工低剪切混合，在3-4加料步骤中将此溶液加入
22LS中。所得的粉末产品是由70重量%润滑剂/色素溶液液体和30重量%载体组成的混合物。现将此粉末产品称为液体/载体。
通过添加5重量%的
R812S、20重量%铁氧化物AC-5色素和75重量%的DI水制得干水。在混合机上紧密加盖，在最高挡(液化)以9,700RPM混合混合物1分钟。在1分钟混合的过程中，从左至右以50-60度角倾斜整个混合机保持约10秒。
然后将35重量%的液体/载体与65重量%干水混合物温和混合(翻滚、搅拌或调入)以制备最终的粉状-乳膏状粉底。
然后将此粉末储藏在塑料容器中。能够产生粉状组合物并且保持粉状。
实施例3：现有技术的粉状-乳膏状维生素油膏（rub）
称量13.71重量%的润滑剂聚乙二醇(来自的The Dow ChemicalCompany的PEG
聚乙二醇400NF)、2.75重量%维生素E(JEENInternational Corp.)、78.54重量%的DI水和5.0重量%
R812S并置于KSB5ER4型KitchenAid混合机中，以其最高速度(9,700rpm,液化)混合1分钟。在1分钟混合的过程中，从左至右以45度角倾斜混合机在每侧保持约10秒。
在约半小时后，最终产品呈在底部具有明显分离的乳膏状/摩丝状。
由于在与疏水性二氧化硅一起混合时没有形成稳定分离的液滴，添加润滑剂和维生素的方法失败。认为润滑剂和维生素大幅降低水的表面张力以至它能够克服液滴与
R812S之间的界面张力。
实施例4：本发明的粉状-乳膏状维生素油膏
配制71.4重量%聚乙二醇(来自The Dow Chemical Company的PEG聚乙二醇400NF)、14.3重量%维生素E(来自JEEN InternationalCorp.)和14.3重量%DI水的液体混合物。然后该液体混合物用来制备64.0重量%液体混合物，以36.0重量%
22LS为载体。在3-4加料步骤中，将液体混合物缓慢加入
22LS中，利用低剪切混合(在此情况中手工混合)直至混合均一。
然后将所得的粉末(30重量%)温和地混合(翻滚、搅拌或调入)入70重量%干水中。
然后将粉末储藏在塑料容器中。
表1：实施例1–4的配方的成分[重量%]
Claims (17)
1.粉状组合物，其包含：
a)至少一种核壳颗粒形式的粉末，所述核包含液态水或液态水相，并且所述壳包含疏水性或疏水化的颗粒，和
b)至少一种包含载体和以下物质的粉末，以下物质分别位于所述载体之中和/或之上：
b1)至少部分可溶于水的液体和/或
b2)水反应性基质，所述水反应性基质不溶于水，并且当被水或水相活化时，所述水反应性基质被转化成可溶于水的反应产物，
其中，所述载体的形式为沉淀二氧化硅，所述沉淀二氧化硅具有以下特征：
i)BET表面积为50-1000m2/g，
ii)经激光衍射测得的粒度d50为3-20μm，并且
iii)邻苯二甲酸二丁基酯DBP吸收为200-400g DBP/100g二氧化硅。
2.权利要求1的粉状组合物，其中所述壳颗粒包含或由疏水化的二氧化硅颗粒组成。
3.权利要求2的粉状组合物，其中所述疏水化的二氧化硅颗粒是聚集的热解法二氧化硅颗粒。
4.权利要求2的粉状组合物，其中所述疏水化的二氧化硅颗粒的BET表面积为30m2/g-500m2/g。
5.权利要求2的粉状组合物，其中所述疏水化的二氧化硅颗粒是通过使BET表面积270-330m2/g的亲水性热解法二氧化硅与六甲基二硅氮烷反应而得的，得到的疏水化的热解法二氧化硅颗粒的BET表面积为200-290m2/g，碳含量为2重量%-4重量%，并且甲醇润湿性为至少50。
6.权利要求1的粉状组合物，其中所述核由包含90重量%以上的水的液态水相组成。
7.权利要求1的粉状组合物，其中所述核壳颗粒的水含量为75重量%-95重量%。
8.权利要求1的粉状组合物，其中所述包含至少部分可溶于水的液体和/或水反应性基质的载体与所述核壳颗粒的重量比为1:1-1:9。
9.权利要求1的粉状组合物，其中所述载体和所述核壳颗粒的平均粒度为2-20μm。
10.权利要求9的粉状组合物，其中所述核壳颗粒的平均粒度是所述载体的平均粒度的50%-150%。
11.权利要求1的粉状组合物，其中a)所述核壳颗粒的核的水相和/或b)分别位于所述载体之中和/或之上的所述至少部分可溶于水的液体和/或水反应性基质包含选自如下的至少一种材料：紫外光保护过滤物质、抗氧化剂、增湿物质、除臭剂、止汗剂活性化合物、生物源物质、驱虫剂活性化合物、漂白剂、抗细菌物质、抗真菌物质、调味剂、芳香剂、酸、碱、酶或它们的混合物。
12.权利要求1的粉状组合物，其中所述核壳颗粒的核是水，并且所述壳由疏水化的热解法二氧化硅颗粒组成，所述疏水化的热解法二氧化硅颗粒由BET表面积为30-500m2/g的亲水性的热解法二氧化硅反应而得。
13.权利要求12的粉状组合物，其中所述疏水化的热解法二氧化硅颗粒是通过使BET表面积为270-330m2/g的亲水性热解法二氧化硅与六甲基二硅氮烷反应而得的，得到的疏水化的热解法二氧化硅颗粒的BET表面积为200-290m2/g，碳含量为2重量%-4重量%，并且甲醇润湿性为至少50。
14.权利要求12的粉状组合物，其中所述载体的形式是沉淀二氧化硅，该沉淀二氧化硅的BET表面积为400-500m2/g，经激光衍射测得的粒度d50为4-6μm，并且邻苯二甲酸二丁基酯DBP吸收为300-350g DBP/100g二氧化硅。
15.权利要求12的粉状组合物，其中所述载体的形式是沉淀二氧化硅，该沉淀二氧化硅的BET表面积为150-250m2/g，经激光衍射测得的粒度d50为4-7μm，并且邻苯二甲酸二丁基酯DBP吸收为250-300g DBP/100g二氧化硅。
16.权利要求12-15中任一项的粉状组合物，其还包含分别位于所述载体之中和/或之上的作为至少部分可溶于水的液体和/或水反应性基质的紫外光保护过滤物质、抗氧化剂、增湿物质、除臭剂、止汗剂活性化合物、生物源物质、驱虫剂活性化合物、漂白剂、抗细菌物质、抗真菌物质、调味剂、芳香剂、酸、碱、酶或它们的混合物。
17.由权利要求1的粉状组合物制备乳膏状组合物的方法，其中所述粉状组合物通过能量输入而活化，所述能量输入的形式是压力、剪切、温度、振动和/或添加溶剂，并且所述能量输入足以从所述核-壳材料释放所述液态水或所述液态水相，然后，
a)所述液态水或液态水相从所述载体溶解或冲洗所述至少部分可溶于水的液体，和/或
b)所述液态水或液态水相活化所述载体之中和/或之上的水反应性基质，然后从所述载体溶解或冲洗经活化而得的产物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29020509P | 2009-12-26 | 2009-12-26 | |
| US61/290,205 | 2009-12-26 | ||
| PCT/EP2010/068324 WO2011076518A1 (en) | 2009-12-26 | 2010-11-26 | Water containing powder composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102686207A CN102686207A (zh) | 2012-09-19 |
| CN102686207B true CN102686207B (zh) | 2014-05-28 |
Family
ID=43828151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080059489.XA Active CN102686207B (zh) | 2009-12-26 | 2010-11-26 | 含水的粉状组合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8647653B2 (zh) |
| EP (1) | EP2515829B1 (zh) |
| JP (1) | JP5746210B2 (zh) |
| KR (1) | KR101431932B1 (zh) |
| CN (1) | CN102686207B (zh) |
| BR (1) | BR112012018812B1 (zh) |
| CA (1) | CA2785753C (zh) |
| MX (1) | MX2012007285A (zh) |
| WO (1) | WO2011076518A1 (zh) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2982147B1 (fr) * | 2011-11-07 | 2014-03-21 | Oreal | Composition a phase huileuse continue contenant au moins un filtre uv organique lipophile et des particules d'aerogel de silice hydrophobes. |
| FR2982148B1 (fr) * | 2011-11-07 | 2014-08-01 | Oreal | Composition solide solaire a base de filtre uv organique lipophile et de particules d'aerogel de silice hydrophobes |
| DE102011088841A1 (de) | 2011-12-16 | 2013-06-20 | Henkel Ag & Co. Kgaa | Haarkosmetika |
| DE102011088818A1 (de) | 2011-12-16 | 2013-06-20 | Henkel Ag & Co. Kgaa | Pulverförmige Haarkosmetika |
| DE102011088815A1 (de) | 2011-12-16 | 2013-06-20 | Henkel Ag & Co. Kgaa | Pulverförmige Kosmetika |
| DE102012211912A1 (de) * | 2012-07-09 | 2014-01-09 | Henkel Ag & Co. Kgaa | Mittel und Verfahren zur temporären Verformung keratinhaltiger Fasern |
| JP6022268B2 (ja) * | 2012-09-07 | 2016-11-09 | 日本メナード化粧品株式会社 | 粉末化粧料 |
| SG11201503249QA (en) * | 2012-10-26 | 2015-05-28 | Pibed Ltd | Multi-component encapsulated reactive formulations |
| FR2999423B1 (fr) * | 2012-12-14 | 2015-03-13 | Oreal | Composition cosmetique sous forme de poudre comprenant un polymere epaississant (meth)acrylique, un polymere fixant, des particules insolubles dans l'eau |
| US20140227333A1 (en) * | 2013-02-12 | 2014-08-14 | Ecolab Usa Inc. | Dry active oxygen technology |
| KR101540587B1 (ko) * | 2013-03-26 | 2015-07-31 | 한국콜마주식회사 | 소수 처리된 다공성 실리카에 담지된 유기 자외선 차단제를 함유한 습식 성형 색조 화장료 및 이의 제조방법 |
| JP5809185B2 (ja) * | 2013-03-28 | 2015-11-10 | 富士フイルム株式会社 | 溶液製膜方法 |
| EP3057562B1 (en) * | 2013-10-15 | 2018-08-08 | Unilever NV | Cosmetic composition with increased opacity |
| CN105636573B (zh) * | 2013-10-15 | 2020-02-28 | 荷兰联合利华有限公司 | 具有提高的不透明度的化妆品组合物 |
| CN105658195B (zh) * | 2013-10-15 | 2020-09-15 | 荷兰联合利华有限公司 | 具有提高的不透明度的化妆品组合物 |
| WO2015091759A1 (en) * | 2013-12-18 | 2015-06-25 | Pusch Roland | A method for producing wet clay using divided clay and dry water |
| US9474699B2 (en) | 2014-03-31 | 2016-10-25 | Johnson & Johnson Consumer Inc. | Compostions and methods for enhancing the topical application of a basic benefit agent |
| US9468606B2 (en) | 2014-03-31 | 2016-10-18 | Johnson & Johnson Consumer Inc. | Compostions and methods for enhancing the topical application of an acidic benefit agent |
| AU2015277745B2 (en) * | 2014-06-16 | 2020-04-16 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for enhancing the topical application of a color cosmetic |
| WO2015195304A1 (en) | 2014-06-17 | 2015-12-23 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for enhancing the topical application of a benefit agent including powder to liquid particles and a second powder |
| DE102014222801A1 (de) * | 2014-11-07 | 2016-05-12 | Henkel Ag & Co. Kgaa | Mittel und Verfahren zur temporären Verformung keratinhaltiger Fasern |
| DE102014222802A1 (de) * | 2014-11-07 | 2016-05-12 | Henkel Ag & Co. Kgaa | Mittel und Verfahren zur temporären Verformung keratinhaltiger Fasern |
| EP3034551A1 (en) * | 2014-12-17 | 2016-06-22 | Akzo Nobel Chemicals International B.V. | Powder mixture comprising organic peroxide |
| US9431536B1 (en) | 2015-03-16 | 2016-08-30 | Taiwan Semiconductor Manufacturing Co., Ltd. | Semiconductor device structure with raised source/drain having cap element |
| KR101647736B1 (ko) * | 2015-10-23 | 2016-08-11 | (주)씨앤씨인터내셔널 | 발색 및 사용감이 개선된 지속형 파우더 에센스 조성물 및 이의 제조방법 |
| US20170144124A1 (en) * | 2015-11-24 | 2017-05-25 | Evonik Corporation | Powdery Composition Containing Emulsion |
| CN105967537A (zh) * | 2016-05-06 | 2016-09-28 | 西北工业大学 | 一种制备液体橡皮泥的方法及橡皮泥成形方法 |
| CN106189374A (zh) * | 2016-07-05 | 2016-12-07 | 承德人和矿业有限责任公司 | 一种复合粉体及其制备方法 |
| ES2776901T3 (es) | 2016-07-29 | 2020-08-03 | Evonik Degussa Gmbh | Procedimiento para la producción de un material termoaislante que contiene ácido silícico hidrófobo |
| BR112019004612B1 (pt) * | 2016-09-14 | 2022-09-06 | Noxell Corporation | Composição cosmética de tensionamento |
| RU2759942C2 (ru) | 2017-01-18 | 2021-11-18 | Эвоник Оперейшенс ГмбХ | Гранулированный теплоизоляционный материал и способ его получения |
| WO2018210605A1 (de) | 2017-05-17 | 2018-11-22 | Evonik Degussa Gmbh | Kernhydrophobe wärmedämmplatte mit gehärteter oberfläche |
| DE102017209782A1 (de) | 2017-06-09 | 2018-12-13 | Evonik Degussa Gmbh | Verfahren zur Wärmedämmung eines evakuierbaren Behälters |
| ES2840899T3 (es) | 2017-08-25 | 2021-07-07 | Evonik Operations Gmbh | Granulado de aislamiento térmico con hidrofobicidad reducida |
| JP6968632B2 (ja) | 2017-09-07 | 2021-11-17 | 扶桑化学工業株式会社 | 疎水性シリカ粉末 |
| EP3467052B1 (de) | 2017-10-06 | 2022-04-13 | Evonik Operations GmbH | Wässrige dispersion enthaltend siliziumdioxid und trimethyl 1,6-hexamethylendiamin |
| KR101982484B1 (ko) * | 2017-10-27 | 2019-05-27 | 코스맥스 주식회사 | 소수성 실리카의 혼합물을 포함하는 분말 화장료 조성물 |
| WO2019170264A1 (de) | 2018-03-05 | 2019-09-12 | Evonik Degussa Gmbh | Verfahren zur herstellung eines aerogelmaterials |
| EP3597615A1 (en) | 2018-07-17 | 2020-01-22 | Evonik Operations GmbH | Granular mixed oxide material and thermal insulating composition on its basis |
| EP3823939A1 (en) | 2018-07-17 | 2021-05-26 | Evonik Operations GmbH | Thermal insulating composition based on fumed silica granulates, processes for its preparation and uses thereof |
| US11987528B2 (en) | 2018-07-18 | 2024-05-21 | Kingspan Insulation Limited | Process for hydrophobizing shaped insulation-material bodies based on silica at ambient pressure |
| EP3663365A1 (de) | 2018-12-07 | 2020-06-10 | Evonik Operations GmbH | Hydrophiles siliziumdioxid und silanol haltige wässrige dispersion und lackzubereitung |
| KR20220004180A (ko) | 2019-05-07 | 2022-01-11 | 에보니크 오퍼레이션즈 게엠베하 | 표면 처리된 알루미나로 코팅된 리튬-이온 배터리 세퍼레이터 |
| FI4010411T3 (fi) | 2019-08-08 | 2023-08-30 | Evonik Operations Gmbh | Mekaanisilta ominaisuuksiltaan aikaisempaa parempia pmma-pohjaisia valupolymeereja |
| US11590474B1 (en) * | 2019-08-14 | 2023-02-28 | JEA Holdings, LLC | Stable solid particulate system for controlling humidity to a selected range |
| EP4041697B1 (en) | 2019-10-07 | 2024-07-10 | Kingspan Insulation Limited | Silica-based thermal-insulation sheet coated with intumescent composition |
| TW202135363A (zh) | 2020-01-14 | 2021-09-16 | 德商贏創運營有限公司 | 用於金屬電極之保護層及含彼之鋰電池 |
| US20230002627A1 (en) | 2020-01-14 | 2023-01-05 | Evonik Operations Gmbh | Silica-based hydrophobic granular material with an increased polarity |
| ES2914063T3 (es) | 2020-01-14 | 2022-06-07 | Evonik Operations Gmbh | Sílice pirógena con actividad superficial modificada |
| MX2022010516A (es) | 2020-02-28 | 2022-09-21 | Evonik Operations Gmbh | Cuerpo moldeado para aislamiento termico basado en silice. |
| EP3954743A1 (de) | 2020-08-12 | 2022-02-16 | Evonik Operations GmbH | Verwendung von siliziumdioxid zur verbesserung der leitfähigkeit von beschichtungen |
| CN111956524A (zh) * | 2020-08-21 | 2020-11-20 | 中国药科大学 | 一种基于“干水”技术的烟酰胺与抗坏血酸或其衍生物的组合物 |
| EP4043398B1 (en) | 2021-02-11 | 2023-06-28 | Evonik Operations GmbH | Silica with reduced tribo-charge for toner applications |
| EP4291528A1 (en) | 2021-02-11 | 2023-12-20 | Evonik Operations GmbH | Fumed silica powder with reduced silanol group density |
| BR112023023514A2 (pt) | 2021-05-14 | 2024-01-30 | Evonik Operations Gmbh | Pó de alumina pirogênica com teor de umidade reduzido |
| CN113460986B (zh) * | 2021-07-26 | 2023-07-28 | 山东大学 | 一步法制备核壳结构羟基磷灰石微球的方法及其应用 |
| CN118401223A (zh) * | 2021-12-15 | 2024-07-26 | 联合利华知识产权控股有限公司 | 皮肤护理组合物 |
| CA3219241A1 (en) | 2022-11-15 | 2024-05-15 | Evonik Operations Gmbh | Curable composition for production of coatings for thermal, electrical and/or acoustic insulation |
| WO2024110694A1 (en) * | 2022-11-22 | 2024-05-30 | Aalto-Korkeakoulusäätiö Sr | Method to produce capsules consisting of aqueous solution droplets encapsulated with very low amounts of hydrophobic silica particles and a material consisting of salt particles or organic particles coated with precipitated silica microparticles |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1382034A (zh) * | 1999-08-24 | 2002-11-27 | 株式会社高丝 | 含水粉末组合物及其制造方法和含该粉末组合物的化妆料 |
| CN1803605A (zh) * | 2005-01-12 | 2006-07-19 | 德古萨股份公司 | 热解法制造的二氧化硅粉末 |
| CN101087579A (zh) * | 2004-12-24 | 2007-12-12 | 德古萨有限责任公司 | 具有高水含量的粉状物质的存储方法 |
| CN101205068A (zh) * | 2006-12-15 | 2008-06-25 | 德古萨有限责任公司 | 热解法二氧化硅分散体的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1467023A1 (de) | 1964-02-28 | 1969-01-23 | Degussa | Verfahren zur Inkorporierung von Wasser in feinst verteilter Kieselsaeure |
| DE2844052A1 (de) | 1978-10-10 | 1980-04-30 | Degussa | Waessrige dispersion einer hydrophoben kieselsaeure |
| CA2226996C (en) | 1997-01-24 | 2006-08-15 | Kose Corporation | Whitening cosmetic composition comprising polyhydric alcohol |
| JPH11130614A (ja) * | 1997-10-29 | 1999-05-18 | Kose Corp | 粉末化粧料 |
| FR2776537B1 (fr) * | 1998-03-30 | 2000-05-05 | Rhodia Chimie Sa | Composition comprenant un liquide absorbe sur un support a base de silice precipitee |
| JP2000309505A (ja) | 1999-02-26 | 2000-11-07 | Shiseido Co Ltd | 粉末化粧料 |
| US6290941B1 (en) | 1999-11-23 | 2001-09-18 | Color Access, Inc. | Powder to liquid compositions |
| US6413548B1 (en) | 2000-05-10 | 2002-07-02 | Aveka, Inc. | Particulate encapsulation of liquid beads |
| TWI314865B (zh) | 2001-01-18 | 2009-09-21 | Shiseido Co Ltd | |
| EP1694287A1 (de) | 2003-12-01 | 2006-08-30 | Degussa AG | Verstreichbare kosmetische zubereitung mit hohem wassergehalt |
| JP4808456B2 (ja) | 2004-09-27 | 2011-11-02 | 株式会社コーセー | 粉末状化粧料 |
| DE102005055226A1 (de) | 2004-12-24 | 2006-07-13 | Degussa Ag | Lagerung pulverförmiger Stoffe mit hohem Wassergehalt |
| US20070154426A1 (en) * | 2006-01-05 | 2007-07-05 | Hansen Angela M | Powdered water cosmetic compositions and related methods |
| US20070218024A1 (en) * | 2006-03-17 | 2007-09-20 | Tatyana Zamyatin | Dry water cosmetic compositions that change color upon application |
| US20090298952A1 (en) * | 2008-05-07 | 2009-12-03 | Brimmer Karen S | Platable soluble dyes |
| DE102008035867A1 (de) * | 2008-08-01 | 2010-02-04 | Evonik Degussa Gmbh | Neuartige Fällungskieselsäuren für Trägeranwendungen |
| FR2942715B1 (fr) | 2009-03-04 | 2013-10-25 | J2Ni | Composition cosmetique pour lutter contre le vieillissement de la peau, constituee et distribuee sous la forme d'une poudre se transformant en creme lors de son application |
| DE102011077298A1 (de) * | 2011-06-09 | 2012-12-13 | Evonik Degussa Gmbh | Kern-Hülle-Partikel mit einem hohen Gehalt an Glycerin, ihre Herstellung und Verwendung |
-
2010
- 2010-11-26 MX MX2012007285A patent/MX2012007285A/es active IP Right Grant
- 2010-11-26 EP EP10784508.3A patent/EP2515829B1/en active Active
- 2010-11-26 KR KR1020127016449A patent/KR101431932B1/ko active IP Right Grant
- 2010-11-26 BR BR112012018812-7A patent/BR112012018812B1/pt active IP Right Grant
- 2010-11-26 JP JP2012545192A patent/JP5746210B2/ja active Active
- 2010-11-26 CN CN201080059489.XA patent/CN102686207B/zh active Active
- 2010-11-26 CA CA2785753A patent/CA2785753C/en active Active
- 2010-11-26 US US13/519,515 patent/US8647653B2/en active Active
- 2010-11-26 WO PCT/EP2010/068324 patent/WO2011076518A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1382034A (zh) * | 1999-08-24 | 2002-11-27 | 株式会社高丝 | 含水粉末组合物及其制造方法和含该粉末组合物的化妆料 |
| CN101087579A (zh) * | 2004-12-24 | 2007-12-12 | 德古萨有限责任公司 | 具有高水含量的粉状物质的存储方法 |
| CN1803605A (zh) * | 2005-01-12 | 2006-07-19 | 德古萨股份公司 | 热解法制造的二氧化硅粉末 |
| CN101205068A (zh) * | 2006-12-15 | 2008-06-25 | 德古萨有限责任公司 | 热解法二氧化硅分散体的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8647653B2 (en) | 2014-02-11 |
| CN102686207A (zh) | 2012-09-19 |
| BR112012018812B1 (pt) | 2020-12-15 |
| KR101431932B1 (ko) | 2014-08-19 |
| CA2785753A1 (en) | 2011-06-30 |
| WO2011076518A1 (en) | 2011-06-30 |
| CA2785753C (en) | 2016-12-06 |
| US20130022656A1 (en) | 2013-01-24 |
| EP2515829B1 (en) | 2016-08-10 |
| EP2515829A1 (en) | 2012-10-31 |
| JP5746210B2 (ja) | 2015-07-08 |
| MX2012007285A (es) | 2012-07-30 |
| JP2013515689A (ja) | 2013-05-09 |
| KR20120091389A (ko) | 2012-08-17 |
| BR112012018812A2 (pt) | 2020-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102686207B (zh) | 含水的粉状组合物 | |
| TWI361706B (en) | Pulverulent cosmetic formulation having a high water content | |
| EP3267964B1 (en) | Peg free stable low viscosity oil-in-water emulsion and use thereof | |
| US20090047225A1 (en) | Storage of pulverulent substances having a high water content | |
| US8454941B2 (en) | O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof | |
| US20050255134A1 (en) | Brushable cosmetic preparation having a high water content | |
| EP3423028B1 (de) | Verfahren zur herstellung von riechstoffkapseln mit verbesserter tensidstabilität | |
| CN108697594A (zh) | 包含光子颗粒、至少一种吸收剂和至少一种表面活性剂的组合物 | |
| US7731982B2 (en) | O/W emulsifier, O/W emulsion and applications thereof | |
| CN100579503C (zh) | 具有高水含量的粉状物质的存储方法 | |
| CN101309664B (zh) | O/w乳液化妆品组合物 | |
| EP3177263B1 (en) | Soap based sunscreen composition | |
| US20170144124A1 (en) | Powdery Composition Containing Emulsion | |
| KR102340304B1 (ko) | 자외선 차단용 실리카 나노입자 조성물 및 그 제조방법 | |
| KR20210075074A (ko) | 이산화티탄 분산액 | |
| DE102017215011A1 (de) | Schweißhemmende und/oder deodorierende kosmetische Mittel mit verbesserter Lagerstabilität | |
| KR20120067377A (ko) | 자외선 흡수제 포접 점토광물 및 이를 함유하는 화장료 | |
| WO2024038046A1 (en) | Process for producing microparticles | |
| CN103442688A (zh) | 含有(甲基)丙烯酰氨基(c1-c4)烷基磺酸的交联均聚物和至少部分中和的丙烯酸的均聚物的遮光乳液 | |
| CN111372557A (zh) | 用于个人护理的1,3-亚丙基醚衍生的化合物 | |
| CN1813051A (zh) | O/w乳化剂、o/w乳液及其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Essen, Germany Patentee after: Evonik Operations Limited Address before: Essen, Germany Patentee before: EVONIK DEGUSSA GmbH |