CN102670628B - 治疗病毒感染的方法 - Google Patents

治疗病毒感染的方法 Download PDF

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Publication number
CN102670628B
CN102670628B CN201210080173.XA CN201210080173A CN102670628B CN 102670628 B CN102670628 B CN 102670628B CN 201210080173 A CN201210080173 A CN 201210080173A CN 102670628 B CN102670628 B CN 102670628B
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hiv
patient
cmx157
compound
virus
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Expired - Fee Related
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CN201210080173.XA
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Chinese (zh)
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CN102670628A (zh
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E·R·拉尼尔
M·R·阿尔蒙德
G·R·佩因特
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Chimerix Inc
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Chimerix Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201210080173.XA 2008-01-25 2009-01-23 治疗病毒感染的方法 Expired - Fee Related CN102670628B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2363308P 2008-01-25 2008-01-25
US61/023,633 2008-01-25
US10181008P 2008-10-01 2008-10-01
US61/101,810 2008-10-01
CN2009801097904A CN101977610B (zh) 2008-01-25 2009-01-23 治疗病毒感染的方法

Related Parent Applications (1)

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CN2009801097904A Division CN101977610B (zh) 2008-01-25 2009-01-23 治疗病毒感染的方法

Publications (2)

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CN102670628A CN102670628A (zh) 2012-09-19
CN102670628B true CN102670628B (zh) 2015-11-25

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CN201210080173.XA Expired - Fee Related CN102670628B (zh) 2008-01-25 2009-01-23 治疗病毒感染的方法
CN201510598946.7A Pending CN105055432A (zh) 2008-01-25 2009-01-23 治疗病毒感染的方法
CN2009801097904A Expired - Fee Related CN101977610B (zh) 2008-01-25 2009-01-23 治疗病毒感染的方法

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CN2009801097904A Expired - Fee Related CN101977610B (zh) 2008-01-25 2009-01-23 治疗病毒感染的方法

Country Status (12)

Country Link
US (1) US8993542B2 (cg-RX-API-DMAC7.html)
EP (2) EP2254582B1 (cg-RX-API-DMAC7.html)
JP (1) JP5562255B2 (cg-RX-API-DMAC7.html)
CN (3) CN102670628B (cg-RX-API-DMAC7.html)
AU (1) AU2009206673B2 (cg-RX-API-DMAC7.html)
CA (1) CA2713105C (cg-RX-API-DMAC7.html)
ES (1) ES2572631T3 (cg-RX-API-DMAC7.html)
HK (1) HK1225316A1 (cg-RX-API-DMAC7.html)
IL (2) IL207170A (cg-RX-API-DMAC7.html)
MX (1) MX2010008148A (cg-RX-API-DMAC7.html)
WO (2) WO2009094191A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201005737B (cg-RX-API-DMAC7.html)

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AU2011248620B2 (en) * 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
US9593137B2 (en) 2011-12-22 2017-03-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
WO2014008344A1 (en) * 2012-07-03 2014-01-09 Chimerix, Inc. Method of treating retroviral infections and related dosage regimes
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
WO2014085568A2 (en) 2012-11-27 2014-06-05 Saint Louis University Hbv rnase h purification and enzyme inhbitors
US9629860B2 (en) 2013-03-15 2017-04-25 The Regents Of The University Of California Acyclic nucleoside phosphonate diesters
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
EP3077403A4 (en) * 2013-12-05 2017-08-02 Chimerix, Inc. Branched chain acyclic nucleoside phosphonate esters and methods of synthesis and uses thereof
WO2016044281A1 (en) 2014-09-15 2016-03-24 The Regents Of The University Of California Nucleotide analogs
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
WO2017124895A1 (zh) * 2016-01-19 2017-07-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
BR112018072883B1 (pt) * 2016-05-12 2023-01-17 Merck Sharp & Dohme Llc Sistema de implante subdérmico do agente antiviral 4'-etinil-2-fluoro-2'-desoxiadenosina com polímero eva e seu uso
TW201902507A (zh) 2017-04-14 2019-01-16 美商康特維爾製藥公司 治療病毒感染之組合療法
TW201912153A (zh) * 2017-08-30 2019-04-01 加拿大商愛彼特生物製藥公司 用於治療ｂ型肝炎的化合物、醫藥組合物及方法
AU2023310177A1 (en) 2022-07-21 2025-03-06 Antiva Biosciences, Inc. Compositions and dosage forms for treatment of hpv infection and hpv-induced neoplasia

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