CN102639169B - 用于药物输送系统的筒插入组件 - Google Patents

用于药物输送系统的筒插入组件 Download PDF

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CN102639169B
CN102639169B CN201080040968.7A CN201080040968A CN102639169B CN 102639169 B CN102639169 B CN 102639169B CN 201080040968 A CN201080040968 A CN 201080040968A CN 102639169 B CN102639169 B CN 102639169B
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奥兹·卡比里
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Medimop Medical Projects Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system

Abstract

一种筒插入组件，包括：装置(10)，具有形成在装置中的路径(15)；以及筒(12)，能够插入于路径(15)中，筒(12)包括能够连接到激活机构(18)的筒耦接元件(16)，激活机构设置在装置(10)内以操作地使得容纳于筒(12)中的物质被计量出筒(12)之外；其特征在于枢接于装置(10)的门(14)，门包括相对于筒(12)布置的门耦接元件(20)，使得当门(14)处于完全关闭的位置中时，门耦接元件(20)将筒耦接元件(16)与激活机构(18)的耦接元件(22)耦接。

Description

用于药物输送系统的筒插入组件
技术领域
本发明总体上涉及药物输送系统，例如外部药物泵，并且尤其涉及用于将包含待施加给患者的物质的筒插入到药物输送系统中的组件。
背景技术
外部药物泵通常用于为患者输送包含口服时无法消化的大分子的物质，比如胰岛素。典型地，虽然泵通常附接到患者的腹部或胸部或其他部位并且通过皮下插入患者体内的插管(套管，cannula)为患者输送该物质，但是下面所述的发明不限于施加物质的针。
发明内容
本发明试图提供改进的组件以用于将包含待施加给患者的物质的筒插入于药物泵(或者任何一种药物输送系统)中，正如下面所更具体地描述的。要注意的是，术语“筒(cartridge)”包括任何一种用于待施加给患者的物质的储存器或容器(一次性的或非一次性的)，例如但不限于药水瓶、安瓿瓶、瓶器、预充注射器等等，并且不限于任何尺寸或形状。
因此，根据本发明的实施例，提供一种筒插入组件，其包括：具有形成在其内的路径的装置；能够插入该路径内的筒，筒包括能够连接到激活机构的筒耦接元件，激活机构设置在该装置内以操作地使得容纳于筒中的物质被计量出筒之外；以及枢接到该装置的门，门包括相对于筒安装的门耦接元件，使得当门处于完全关闭的位置时，门耦接元件将筒耦接元件与激活机构的耦接元件耦接。
根据本发明的实施例，锁定闩锁从该装置的底座中悬出，其中当筒完全插入该装置中时，锁定闩锁邻接抵靠筒的边缘，从而将该筒锁定在该路径中。
根据本发明的实施例，当筒完全插入该装置中时，筒邻接抵靠设置在该装置中的筒止挡件。
根据本发明的实施例，筒在与筒耦接元件相对的端部处包括隔片(septum)，并且该装置包括空心针，其中，当筒完全插入该装置中时，该针刺穿隔片。
根据本发明的实施例，门在内表面上包括闭合元件，该闭合元件包括一个或多个斜坡元件，其中，关闭门使得斜坡元件滑动并推抵筒耦接元件，以便将筒完全推入该装置中。
根据本发明的实施例，门形成有一个或多个肋，当门完全关闭时，所述肋容纳形成于装置中的一个或多个相应的凹槽中。
根据本发明的实施例，闭合元件包括毂，其中，当门完全关闭时，毂固定地容纳在卡扣件中。
附图说明
从下面结合附图进行的具体描述中将会更充分地了解和理解本发明，附图中：
图1为根据本发明实施例的用于将物质施加给目标的装置的简化图；
图2为图1的装置的简化图，示出了处于打开位置的筒插入组件的门以及准备插入该装置中的筒；
图3为部分地插入装置中的筒的简化图；
图4为部分地插入装置中的筒的简化图，示出了筒插入组件的部件；
图5为完全插入于装置中直至筒插入组件的筒止挡件的筒的简化图，其中门仍然敞开；
图6为完全插入该装置中并且锁定就位的筒的简化图；
图7为将筒锁定就位的锁定闩锁的简化图；
图8为筒插入组件的门的内部的简化图；
图9为部分地关闭筒插入组件的门的简化图；
图10为完全关闭的门的简化图，但是仅仅示出了门的内部部件(比如耦接元件)，而未示出门自身的外部表面；以及
图11为完全关闭的门的简化图，示出了将门卡扣(snap)到装置的本体中的卡扣件。
具体实施方式
现在参照图1和图2，这些图示出了根据本发明的非限制性实施例的将物质(比如胰岛素)施加给目标的装置10。通常，装置10包括筒12(图2)，该筒包含待施加给目标的物质。图2示出了处于打开位置的筒插入组件的门14以及准备插入装置10中的路径15内的筒12。
如图2中所示，筒12包括与激活机构18(见图4，通常包括马达、电池和控制单元)耦接(比如啮合)的筒耦接元件16(比如齿轮)，激活机构使得筒12内所包含的物质被计量出筒12之外以用于最终施加给患者。(在一些实施例中，筒耦接元件16组装到传动螺杆的端部。)激活机构运行以计量筒12中的物质的方法与本发明无关。通过实例，激活机构可用作美国专利申请20090093792和20090093793或PCT专利申请PCT/IL2008/001312(公开号为WO2009/044401)中所描述的类型的外部药物泵，这些申请的内容通过引用结合于此文中。然而，本发明不限于该种药物泵，并且可用于任何类型的合适的物质的施加，不仅仅可通过针刺穿到患者体内，也通过经皮药物输送(其中物质通过装置10被计量到经皮贴片)、通过喷射(其中物质通过装置10被计量到喷嘴)、微型针阵列等。
要注意的是，虽然筒12通常为一次性物品，但是如果需要的话，电子装置、电池、马达以及该系统的其他元件可使用一次以上。
如图3中所示，根据本发明的非限制性实施例，门14包括门耦接元件20(比如齿轮，但是也可以是用于传输旋转运动的任何其他耦接元件，比如摩擦轮)，用于在筒耦接元件16与激活机构18的耦接元件22(图2)之间产生耦接(比如啮合)，下面会更具体地进行描述。
现在参照图4，该图示出了部分地插入装置10中的筒12，示出了筒插入组件的部件。筒12在与筒耦接元件16相对的端部处具有隔片24。该隔片24由空心针26刺穿，因此筒12的内容物从筒12流出到针26内，并且从针26流到出口(未示出)，以用于最终施加给患者。可由刚性材料(例如塑料)或更优选地可由弹性材料(比如弹性体或硅树脂)制成的筒止挡件28被设置成用于阻挡筒12在插入装置10的过程中的运动并且防止筒12的过度插入。筒止挡件28还阻止扭矩旋转筒12，所述扭矩由激活机构18旋转筒的传动螺杆所产生。筒止挡件28邻接抵靠筒12的肩部30。图5示出了完全插入该装置10中直至筒止挡件28的筒12，其中门14仍然敞开。
现在参照图6和图7。装置10的筒插入组件包括从装置10的底座33(图7)中悬出的锁定闩锁32。在将筒12插入装置10中的同时，靠近筒耦接元件16的边缘34下陷并且滑过锁定闩锁32。当筒12完全插入装置10中时，边缘34移动通过锁定闩锁32，并且锁定闩锁32回弹且邻接抵靠边缘34，从而将筒12锁定就位。用户不能从装置10中移除筒12。
现在参照图8，该图示出了门14的内部。上述的门耦接元件20位于门14的内部的中部中。元件20的一侧为铰接元件36，该铰接元件在装置10的本体中枢转地连接(比如通过卡扣)到相应的插座38(见图10)中。元件20的另一侧上为闭合元件40，该闭合元件形成有中心毂42和一个或多个斜坡元件44(在所述的实施例中，两个斜坡元件44在毂42的两侧上延伸)。即使用户还未将筒12完全插入装置10中，但是关闭门14(见图9)的行为使得斜坡元件44滑动并猛击筒耦接元件16。斜坡元件44的斜面轻轻地推动并楔住筒耦接元件16以便完全位于装置10内，从而使得隔片24中由空心针26刺穿，如上面参照图4和5所描述的。
在将筒12锁定就位后，斜坡元件44保持推抵传动螺杆，以便产生药物泵的灌注，其中筒12的内容物溢出并压入针26内且从中滴出。该灌注过程减小了破断力(长期储存后去除活塞的初始力)，并且从流体路径中去除气泡。
门14的内部具有一个或多个肋46，当门14完全关闭时，这些肋容纳在形成于装置10的外壳的端部处的一个或多个相应的凹槽48(图10)中。位于凹槽48中的肋46向在操作装置10的过程中可作用在筒12和门14上的轴向拉出力提供阻力。
图10示出了完全关闭的门14。门耦接元件20在筒的筒耦接元件16与激活机构的耦接元件22之间进行耦接，从而激活机构现在能够使容纳于筒内的物质被计量出筒之外，以用于最终施加给患者。
现在参照图11，当门14完全关闭时，闭合元件40的毂42卡扣并且固定地容纳在卡扣件50内(弯曲的卡扣件)，从而门14适当地固定到装置10的本体。
本技术领域的技术人员会理解的是，本发明不限于上面具体示出和描述的内容。相反地，本发明的范围包括上述特征的组合和子组合、以及本技术领域的技术人员在阅读前面的描述之后可想到的对上述特征的非现有技术的更改和变化。

Claims (22)

1.一种筒插入组件，包括：
装置，具有形成在所述装置中的路径；
筒，能够插入于所述路径中，所述筒包括能够连接到激活机构的筒耦接元件，所述激活机构设置在所述装置内以操作地使得容纳于所述筒中的物质被计量出所述筒之外；
枢接于所述装置的门，所述门包括相对于所述筒布置的门耦接元件，当所述门处于完全关闭的位置中时，所述门耦接元件将所述筒耦接元件与所述激活机构的耦接元件耦接；以及
从所述装置的底座悬出的锁定闩锁，其中，当所述筒完全插入所述装置中时，所述锁定闩锁邻接抵靠所述筒的边缘，从而将所述筒锁定于所述路径中，并且其中，所述门在其内表面上包括闭合元件，所述闭合元件包括一个或多个斜坡元件，其中，关闭所述门使得所述斜坡元件滑动并推抵所述筒耦接元件，以便将所述筒完全推入所述装置中，所述闭合元件进一步包括毂，其中，当所述门完全关闭时，所述毂固定地容纳在卡扣件中。
2.根据权利要求1所述的筒插入组件，其中，当所述筒完全插入所述装置中时，所述筒邻接抵靠被设置在所述装置中的筒止挡件。
3.根据权利要求1所述的筒插入组件，其中，所述筒在与所述筒耦接元件相对的端部处包括隔片，并且所述装置包括空心针，其中，当所述筒完全插入所述装置中时，所述针刺穿所述隔片。
4.根据权利要求1所述的筒插入组件，其中，所述门形成有一个或多个肋，当所述门完全关闭时，所述肋容纳在形成于所述装置中的一个或多个相应的凹槽中。
5.根据权利要求1所述的筒插入组件，其中，所述筒耦接元件、所述门耦接元件、以及所述激活机构的所述耦接元件包括齿轮。
6.一种筒插入组件，包括：
装置，具有形成在所述装置中的路径；
筒，能够插入于所述路径中，所述筒包括能够连接到激活机构的筒耦接元件，所述激活机构设置在所述装置内以操作地使得容纳于所述筒中的物质被计量出所述筒之外；以及
枢接于所述装置的门，所述门包括相对于所述筒布置的门耦接元件，使得当所述门处于完全关闭的位置中时，所述门耦接元件将所述筒耦接元件与所述激活机构的耦接元件耦接。
7.根据权利要求6所述的筒插入组件，进一步包括从所述装置的底座悬出的锁定闩锁，其中，当所述筒完全插入所述装置中时，所述锁定闩锁邻接抵靠所述筒的边缘，从而将所述筒锁定于所述路径中。
8.根据权利要求6所述的筒插入组件，其中，当所述筒完全插入所述装置中时，所述筒邻接抵靠被设置在所述装置中的筒止挡件。
9.根据权利要求6所述的筒插入组件，其中，所述筒在与所述筒耦接元件相对的端部处包括隔片，并且所述装置包括空心针，其中，当所述筒完全插入所述装置中时，所述针刺穿所述隔片。
10.根据权利要求6所述的筒插入组件，其中，所述门在其内表面上包括闭合元件，所述闭合元件包括一个或多个斜坡元件，其中，关闭所述门使得所述斜坡元件滑动并推抵所述筒耦接元件，以便将所述筒完全推入所述装置中。
11.根据权利要求6所述的筒插入组件，其中，所述门形成有一个或多个肋，当所述门完全关闭时，所述肋容纳在形成于所述装置中的一个或多个相应的凹槽中。
12.根据权利要求6所述的筒插入组件，其中，所述门在其内表面上包括闭合元件，所述闭合元件包括毂，其中，当所述门完全关闭时，所述毂固定地容纳在卡扣件中。
13.根据权利要求6所述的筒插入组件，其中，所述耦接元件包括齿轮。
14.一种筒插入组件，包括：
装置，具有形成在所述装置中的路径；
筒，能够插入于所述路径中，所述筒包括能够连接到激活机构的筒耦接元件，所述激活机构设置在所述装置内以操作地使得容纳于所述筒中的物质被计量出所述筒之外；以及
枢接于所述装置的门，所述门包括门耦接元件，所述门耦接元件的尺寸和形状形成为传输旋转运动，所述门耦接元件相对于所述筒布置，使得当所述门处于完全关闭的位置中时，所述门耦接元件将所述筒耦接元件与所述激活机构的耦接元件耦接。
15.根据权利要求14所述的筒插入组件，进一步包括从所述装置的底座悬出的锁定闩锁，其中，当所述筒完全插入所述装置中时，所述锁定闩锁邻接抵靠所述筒的边缘，从而将所述筒锁定于所述路径中。
16.根据权利要求14所述的筒插入组件，其中，当所述筒完全插入所述装置中时，所述筒邻接抵靠被设置在所述装置中的筒止挡件。
17.根据权利要求14所述的筒插入组件，其中，所述筒在与所述筒耦接元件相对的端部处包括隔片，并且所述装置包括空心针，其中，当所述筒完全插入所述装置中时，所述针刺穿所述隔片。
18.根据权利要求14所述的筒插入组件，其中，所述门在其内表面上包括闭合元件，所述闭合元件包括一个或多个斜坡元件，其中，关闭所述门使得所述斜坡元件滑动并推抵所述筒耦接元件，以便将所述筒完全推入所述装置中。
19.根据权利要求14所述的筒插入组件，其中，所述门形成有一个或多个肋，当所述门完全关闭时，所述肋容纳在形成于所述装置中的一个或多个相应的凹槽中。
20.根据权利要求14所述的筒插入组件，其中，所述门在其内表面上包括闭合元件，所述闭合元件包括毂，其中，当所述门完全关闭时，所述毂固定地容纳在卡扣件中。
21.根据权利要求14所述的筒插入组件，其中，所述耦接元件包括齿轮。
22.一种筒插入组件，包括：
装置，具有形成在所述装置中的路径；
筒，能够插入于所述路径中，所述筒包括能够连接到激活机构的筒耦接元件，所述激活机构设置在所述装置内以操作地使得容纳于所述筒中的物质被计量出所述筒之外；
枢接于所述装置的门，所述门包括相对于所述筒布置的门耦接元件，使得当所述门处于完全关闭的位置中时，所述门耦接元件将所述筒耦接元件与所述激活机构的耦接元件耦接；以及
从所述装置的底座悬出的锁定闩锁，其中，当所述筒完全插入所述装置中时，所述锁定闩锁邻接抵靠所述筒的边缘，从而将所述筒锁定于所述路径中，并且其中，当所述筒完全插入所述装置中时，所述筒邻接抵靠被设置在所述装置中的筒止挡件。
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US20120035546A1 (en) 2012-02-09
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US8157769B2 (en) 2012-04-17
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US20130296792A1 (en) 2013-11-07

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