JP5597729B2 - 薬剤供給装置 - Google Patents
薬剤供給装置 Download PDFInfo
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- JP5597729B2 JP5597729B2 JP2012557005A JP2012557005A JP5597729B2 JP 5597729 B2 JP5597729 B2 JP 5597729B2 JP 2012557005 A JP2012557005 A JP 2012557005A JP 2012557005 A JP2012557005 A JP 2012557005A JP 5597729 B2 JP5597729 B2 JP 5597729B2
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- 239000003814 drug Substances 0.000 title claims description 33
- 229940079593 drug Drugs 0.000 title claims description 26
- 230000004913 activation Effects 0.000 claims description 24
- 230000008878 coupling Effects 0.000 claims description 22
- 238000010168 coupling process Methods 0.000 claims description 22
- 238000005859 coupling reaction Methods 0.000 claims description 22
- 239000012528 membrane Substances 0.000 claims description 13
- 238000012377 drug delivery Methods 0.000 claims description 10
- 230000009916 joint effect Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 description 34
- 239000007924 injection Substances 0.000 description 34
- 238000001802 infusion Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 1
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- 238000007906 compression Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3271—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position
- A61M5/3272—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position having projections following labyrinth paths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/19—Constructional features of carpules, syringes or blisters
- A61M2205/192—Avoiding coring, e.g. preventing formation of particles during puncture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
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- Health & Medical Sciences (AREA)
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- Hematology (AREA)
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
本発明の主要な局面に従い、薬剤供給装置は、対向する近位端部および遠位端部を有する管状ハウジングと、管状ハウジング内に摺動可能および同軸に配置され、近位環状接触部材を含む管状起動部材と、管状起動部材の遠位端部に配置され、管状起動部材を起動されてない位置から近位方向に移動させるための第1の弾性部材とを備え、環状接触部材はハウジングの近位端部に接して起動位置にあり、環状接触部材はハウジングの近位端部から所定の距離にあり、さらに、管状起動部材内に同軸に配置されかつ管状ハウジングに固定的に取付けられる容器ホルダと、摺動可能なストッパを収納する前記容器ホルダ内に配置される薬剤容器と、容器ホルダとハウジングの遠位端部において管状延長部との間で回転可能に配置され、管状起動部材の対応する第1の共同作用手段に相互作用的に接続される第1の共同作用手段を含む管状作動部材と、プランジャーロッドおよび第2の弾性部材とを備え、前記プランジャーロッドの近位端部はストッパに接し、管状作動部材の対応する第2の共同作用手段に相互作用的に接続される第2の共同作用手段を含み、さらに供給部材を備え、容器は膜を有するカートリッジであり、供給部材は、容器ホルダに固定的に接続される保持部材、保持部材内で同軸に移動可能なハブ、対向する近位端部および遠位端部を有しかつハブに固定的に取付けられる針、ならびにハブおよび保持部材に相互作用的に接続されるキャップを含み、キャップは環状接触部材の近位端面と当接する遠位端面を含み、前記キャップが手で操作されると、ハブは遠位に動かされ、それにより針の遠位端部は膜を刺通し、キャップは保持部材から外れ、管状起動部材は第1の弾性部材からの力によって、起動されない位置から起動される位置に動かされる。
装置を予め組立てることにより、針は初期状態では膜を刺通せず、薬剤と供給部材の材料とがある時間接触するとその間の反応に伴って起こり得る不必要な問題を避けることができる。
本願において、「遠位部/端部」の用語が用いられた場合、これは薬剤注入装置の部分/端部、またはその部材の部分/端部を指すものであり、これ/これらは患者の注入部位から最も遠い位置にある。これに対応して、「近位部/端部」の用語が用いられた場合、これは薬剤注入装置の部分/端部またはその部材の部分/端部を指すものであり、これ/これらは患者の薬剤注入場所から最も近い位置にある。
上記の第1の共同作用手段は、管状起動部材30の内面の遠位端部上の少なくとも1つの内側に延在する突出部35(図12参照)、および管状作動部材100の外面上の少なくとも1つの溝101、102、103であり、前記半径方向内側に延在する突出部35は、少なくとも1つの溝内で案内されるよう適合されて、管状起動部材が軸方向に移動した場合に、管状作動部材100を回転させる。
予め張力がかけられた状態では、少なくとも1つの突出部92は張り出し部106に当接し、管状起動部材30の内面の突出部35は位置101にある。
Claims (7)
- 薬剤供給装置であって、
対向する近位端部および遠位端部を有する管状ハウジング(20)と、
管状ハウジング(20)内に摺動可能および同軸に配置され、近位環状接触部材(31)を含む管状起動部材(30)と、
前記管状起動部材(30)の遠位端部に配置され、前記管状起動部材を起動されない位置から近位方向に起動位置まで移動させるための第1の弾性部材(34)とを備え、
前記近位環状接触部材は、前記管状起動部材が前記起動されない位置にあるときには前記管状ハウジング(20)の近位端部に接し、前記管状起動部材が前記起動位置にあるときには前記管状ハウジングの近位端部から所定の距離離れた位置にあり、さらに
前記管状起動部材(30)内に同軸に配置され、前記管状ハウジング(20)に固定的に取付けられる容器ホルダ(50)と、
前記容器ホルダ(50)内に配置されるとともに、摺動可能なストッパ(83)を収納する薬剤容器(80)と、
前記容器ホルダ(50)と前記管状ハウジング(20)の遠位端部における管状延長部(22)との間で回転可能に配置され、前記管状起動部材(30)の対応する第1の共同作用手段に相互作用的に接続される第1の共同作用手段を含む管状作動部材(100)と、
プランジャーロッド(90)および第2の弾性部材(91)とを備え、前記プランジャーロッドの近位端部は前記ストッパ(83)に接し、前記プランジャーロッドは前記管状作動部材(100)の対応する第2の共同作用手段に相互作用的に接続される第2の共同作用手段を含み、さらに
供給部材を備え、
前記薬剤容器(80)は膜(82)を有するカートリッジであり、前記供給部材は、前記容器ホルダに固定的に接続される保持部材(70)、保持部材内に同軸に移動可能なハブ(60)、対向する近位端部および遠位端部を有し、かつ前記ハブに固定的に取付けられる針、ならびに前記ハブおよび前記保持部材に相互作用的に接続されるキャップ(10)を含み、該キャップは前記環状接触部材の近位端面に当接する遠位端面を含み、前記キャップが手で操作されると、前記ハブは遠位に動かされ、それにより前記針の遠位端部は前記膜を刺通し、前記キャップは前記保持部材から外れ、前記管状起動部材は、前記第1の弾性部材からの力によって、前記起動されない位置から前記起動位置に動かされる、薬剤供給装置。 - 前記第1の共同作用手段は、前記管状起動部材(30)の内面の遠位端部上の少なくとも1つの内側に延在する突出部(35)と前記管状作動部材(100)の外面上の少なくとも1つの溝とであり、前記半径方向内側に延在する突出部(35)は少なくとも1つの溝内に案内されるよう適合され、前記管状起動部材が軸方向に動かされると、前記管状作動部材(100)を回転させる、請求項1に記載の薬剤供給装置。
- 前記第2の共同作用手段は、前記管状作動部材(100)の内面上の少なくとも1つの張り出し部(106)と、プランジャーロッド(90)の外面上の少なくとも1つの突出部(92)とであり、前記少なくとも1つの突出部(92)は前記少なくとも1つの張り出し部(106)に当接して、前記プランジャーロッドおよび前記第2の弾性部材を予め張力がかけられた状態に保持する、請求項1または2に記載の薬剤供給装置。
- 前記管状起動部材(30)に相互作用的に接続されるロッキング手段をさらに備える、請求項1に記載の薬剤供給装置。
- 前記ロッキング手段は、前記管状作動部材(100)の少なくとも1つの溝上の柔軟なタング(104)であり、前記半径方向内側に延在する突出部(35)がタング(104)上に移動させられると、半径方向内側に延在する突出部(35)はロックされる、請求項4に記載の薬剤供給装置。
- 前記ハブ(60)は、前記保持部材(70)の対応する第1の結合手段(71)と相互作用的に接続される第1の結合手段(63)と、前記キャップ(10)の対応する第2の結合手段(12)と相互作用的に接続される第2の結合手段(62)とを含む、請求項1から5のいずれかに記載の薬剤供給装置。
- 前記キャップ(10)は、前記保持部材(70)の対応する第3の結合手段(73)に相互作用的に接続される第3の結合手段(13)をさらに含む、請求項6に記載の薬剤供給装置。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31181710P | 2010-03-09 | 2010-03-09 | |
SE1050217-7 | 2010-03-09 | ||
US61/311,817 | 2010-03-09 | ||
SE1050217 | 2010-03-09 | ||
PCT/SE2011/050101 WO2011112136A1 (en) | 2010-03-09 | 2011-02-01 | Medicament delivery device |
Publications (2)
Publication Number | Publication Date |
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JP2013521858A JP2013521858A (ja) | 2013-06-13 |
JP5597729B2 true JP5597729B2 (ja) | 2014-10-01 |
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Application Number | Title | Priority Date | Filing Date |
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JP2012557005A Active JP5597729B2 (ja) | 2010-03-09 | 2011-02-01 | 薬剤供給装置 |
Country Status (9)
Country | Link |
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US (1) | US9061104B2 (ja) |
EP (1) | EP2544741B1 (ja) |
JP (1) | JP5597729B2 (ja) |
CN (1) | CN102869399B (ja) |
AU (1) | AU2011224884B2 (ja) |
DK (1) | DK2544741T3 (ja) |
ES (1) | ES2572477T3 (ja) |
TW (1) | TWI421110B (ja) |
WO (1) | WO2011112136A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113018580A (zh) * | 2021-03-24 | 2021-06-25 | 安徽医科大学第二附属医院 | 进药机构及胰岛素泵 |
Families Citing this family (79)
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WO2003068290A2 (en) | 2002-02-11 | 2003-08-21 | Antares Pharma, Inc. | Intradermal injector |
WO2006079064A1 (en) | 2005-01-24 | 2006-07-27 | Antares Pharma, Inc. | Prefilled needle assisted jet injector |
WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
US9656019B2 (en) | 2007-10-02 | 2017-05-23 | Medimop Medical Projects Ltd. | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
US10420880B2 (en) | 2007-10-02 | 2019-09-24 | West Pharma. Services IL, Ltd. | Key for securing components of a drug delivery system during assembly and/or transport and methods of using same |
US7967795B1 (en) | 2010-01-19 | 2011-06-28 | Lamodel Ltd. | Cartridge interface assembly with driving plunger |
US9345836B2 (en) | 2007-10-02 | 2016-05-24 | Medimop Medical Projects Ltd. | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
CN101868273B (zh) | 2007-10-02 | 2014-10-15 | 莱蒙德尔有限公司 | 外部药泵 |
EP2268342B1 (en) | 2008-03-10 | 2015-09-16 | Antares Pharma, Inc. | Injector safety device |
WO2010017285A2 (en) | 2008-08-05 | 2010-02-11 | Antares Pharma, Inc. | Multiple dosage injector |
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US20130144218A1 (en) | 2013-06-06 |
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