CN102590423A - 川芎茶调颗粒制剂指纹图谱的测定方法 - Google Patents
川芎茶调颗粒制剂指纹图谱的测定方法 Download PDFInfo
- Publication number
- CN102590423A CN102590423A CN2012100446526A CN201210044652A CN102590423A CN 102590423 A CN102590423 A CN 102590423A CN 2012100446526 A CN2012100446526 A CN 2012100446526A CN 201210044652 A CN201210044652 A CN 201210044652A CN 102590423 A CN102590423 A CN 102590423A
- Authority
- CN
- China
- Prior art keywords
- peak
- weight portions
- preparation
- root
- ligusticum wallichii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 92
- 238000002360 preparation method Methods 0.000 title claims abstract description 88
- 241000112528 Ligusticum striatum Species 0.000 title claims abstract description 42
- 238000002156 mixing Methods 0.000 title abstract description 13
- 238000001228 spectrum Methods 0.000 title abstract description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims abstract description 37
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 36
- 238000012360 testing method Methods 0.000 claims abstract description 35
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000000605 extraction Methods 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 18
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000019253 formic acid Nutrition 0.000 claims abstract description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000010992 reflux Methods 0.000 claims abstract description 14
- 239000000945 filler Substances 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 11
- 238000010828 elution Methods 0.000 claims abstract description 9
- 238000005303 weighing Methods 0.000 claims abstract description 9
- 239000002904 solvent Substances 0.000 claims abstract description 8
- 238000001704 evaporation Methods 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 239000000284 extract Substances 0.000 claims description 32
- 230000014759 maintenance of location Effects 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 29
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 26
- 241000125175 Angelica Species 0.000 claims description 24
- 235000017965 Asarum canadense Nutrition 0.000 claims description 24
- 235000000385 Costus speciosus Nutrition 0.000 claims description 24
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 24
- 244000246386 Mentha pulegium Species 0.000 claims description 24
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 24
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 24
- 241000951473 Schizonepeta Species 0.000 claims description 24
- 241000606265 Valeriana jatamansi Species 0.000 claims description 24
- 235000014687 Zingiber zerumbet Nutrition 0.000 claims description 24
- 235000001050 hortel pimenta Nutrition 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 24
- 230000008569 process Effects 0.000 claims description 16
- 239000000341 volatile oil Substances 0.000 claims description 16
- 238000003556 assay Methods 0.000 claims description 11
- 235000014347 soups Nutrition 0.000 claims description 11
- 235000018927 edible plant Nutrition 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 7
- 239000007901 soft capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 5
- 239000007902 hard capsule Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 2
- 238000004811 liquid chromatography Methods 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- -1 butyl alcohols Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 25
- 239000000523 sample Substances 0.000 abstract description 15
- 238000004128 high performance liquid chromatography Methods 0.000 abstract description 13
- 238000001514 detection method Methods 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000012528 membrane Substances 0.000 abstract description 2
- 239000012488 sample solution Substances 0.000 abstract description 2
- 239000000741 silica gel Substances 0.000 abstract description 2
- 229910002027 silica gel Inorganic materials 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000001471 micro-filtration Methods 0.000 abstract 1
- 238000010183 spectrum analysis Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 description 31
- 239000000203 mixture Substances 0.000 description 16
- 239000013558 reference substance Substances 0.000 description 16
- 238000003908 quality control method Methods 0.000 description 13
- 239000012071 phase Substances 0.000 description 12
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 239000002253 acid Substances 0.000 description 10
- 238000009472 formulation Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000470 constituent Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 206010063659 Aversion Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010028748 Nasal obstruction Diseases 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000012850 discrimination method Methods 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- WITLAWYGGVAFLU-UHFFFAOYSA-N 3-(6-methoxy-1,3-benzodioxol-5-yl)-8,8-dimethylpyrano[2,3-f]chromen-4-one Chemical compound C1=CC(C)(C)OC2=CC=C(C(C(C3=CC=4OCOC=4C=C3OC)=CO3)=O)C3=C21 WITLAWYGGVAFLU-UHFFFAOYSA-N 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- QMNWISYXSJWHRY-YLNUDOOFSA-N astragaloside IV Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)[C@H]4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)C[C@H]3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-YLNUDOOFSA-N 0.000 description 2
- QMNWISYXSJWHRY-BCBPIKMJSA-N astragaloside IV Natural products CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@H](O)[C@@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O QMNWISYXSJWHRY-BCBPIKMJSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- PFKIBRPYVNVMRU-UHFFFAOYSA-N cyclosieversioside F Natural products CC(C)(O)C1COC(C)(C1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O PFKIBRPYVNVMRU-UHFFFAOYSA-N 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000001303 quality assessment method Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011122 softwood Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000008574 Intracranial Hemorrhages Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 240000007711 Peperomia pellucida Species 0.000 description 1
- 235000012364 Peperomia pellucida Nutrition 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- AOZUYISQWWJMJC-UHFFFAOYSA-N acetic acid;methanol;hydrate Chemical compound O.OC.CC(O)=O AOZUYISQWWJMJC-UHFFFAOYSA-N 0.000 description 1
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002460 anti-migrenic effect Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000007887 hard shell capsule Substances 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 201000005671 spondyloarthropathy Diseases 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000005556 structure-activity relationship Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
时间(min) | A(%) | B(%) |
0 | 2-8 | 98-92 |
85 | 25-30 | 75-70 |
100 | 42-48 | 58-52 |
105 | 48-52 | 52-48 |
135 | 62-68 | 38-32 |
时间(min) | A(%) | B(%) |
0 | 5 | 95 |
85 | 28 | 72 |
100 | 45 | 55 |
105 | 50 | 50 |
135 | 65 | 35 |
时间(min) | A(%) | B(%) |
0 | 5 | 95 |
85 | 28 | 72 |
100 | 45 | 55 |
105 | 50 | 50 |
135 | 65 | 35 |
峰1 | Rt=0.11, | 峰12 | Rt=0.65, |
峰2 | Rt=0.17, | 峰13 | Rt=0.72, |
峰3 | Rt=0.23, | 峰14 | Rt=0.74, |
峰4 | Rt=0.26, | 峰15 | Rt=0.75, |
峰5 | Rt=0.30, | 峰16 | Rt=0.79, |
峰6 | Rt=0.38, | 峰17 | Rt=0.87, |
峰7 | Rt=0.46, | 峰18 | Rt=0.94, |
峰8 | Rt=0.47, | 峰19 | Rt=0.98, |
峰9 | Rt=0.49, | 峰20 | Rt=1.00, |
峰10 | Rt=0.52, | 峰21 | Rt=1.01, |
峰11 | Rt=0.58, | 峰22 | Rt=1.04。 |
峰2 | Rt=0.17, | 峰12 | Rt=0.65, |
峰3 | Rt=0.23, | 峰13 | Rt=0.72, |
峰6 | Rt=0.38, | 峰16 | Rt=0.79, |
峰8 | Rt=0.47, | 峰18 | Rt=0.94, |
峰9 | Rt=0.49, | 峰19 | Rt=0.98, |
峰10 | Rt=0.52, | 峰20 | Rt=1.00, |
峰11 | Rt=0.58, | 峰21 | Rt=1.01, |
峰22 | Rt=1.04。 |
峰1 | Rt=0.11, | 峰12 | Rt=0.65, |
峰2 | Rt=0.17, | 峰13 | Rt=0.72, |
峰3 | Rt=0.23, | 峰14 | Rt=0.74, |
峰4 | Rt=0.26, | 峰15 | Rt=0.75, |
峰5 | Rt=0.30, | 峰16 | Rt=0.79, |
峰6 | Rt=0.38, | 峰17 | Rt=0.87, |
峰7 | Rt=0.46, | 峰18 | Rt=0.94, |
峰8 | Rt=0.47, | 峰19 | Rt=0.98, |
峰9 | Rt=0.49, | 峰20 | Rt=1.00, |
峰10 | Rt=0.52, | 峰21 | Rt=1.01, |
峰11 | Rt=0.58, | 峰22 | Rt=1.04。 |
峰2 | Rt=0.17, | 峰12 | Rt=0.65, |
峰3 | Rt=0.23, | 峰13 | Rt=0.72, |
峰6 | Rt=0.38, | 峰16 | Rt=0.79, |
峰8 | Rt=0.47, | 峰18 | Rt=0.94, |
峰9 | Rt=0.49, | 峰19 | Rt=0.98, |
峰10 | Rt=0.52, | 峰20 | Rt=1.00, |
峰11 | Rt=0.58, | 峰21 | Rt=1.01, |
峰22 | Rt=1.04。 |
时间(min) | 乙腈(%) | 0.05%甲酸(%) |
0 | 5 | 95 |
85 | 28 | 72 |
100 | 45 | 55 |
105 | 50 | 50 |
135 | 65 | 35 |
编号 | 相似度 | 编号 | 相似度 |
S1 | 0.982 | S6 | 0.989 |
S2 | 0.995 | S7 | 0.993 |
S3 | 0.988 | S8 | 0.991 |
S4 | 0.981 | S9 | 0.952 |
S5 | 0.915 | S10 | 0.969 |
Claims (14)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210044652.6A CN102590423B (zh) | 2012-02-27 | 2012-02-27 | 川芎茶调颗粒制剂指纹图谱的测定方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210044652.6A CN102590423B (zh) | 2012-02-27 | 2012-02-27 | 川芎茶调颗粒制剂指纹图谱的测定方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102590423A true CN102590423A (zh) | 2012-07-18 |
CN102590423B CN102590423B (zh) | 2014-04-16 |
Family
ID=46479354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210044652.6A Active CN102590423B (zh) | 2012-02-27 | 2012-02-27 | 川芎茶调颗粒制剂指纹图谱的测定方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102590423B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108459129A (zh) * | 2017-02-17 | 2018-08-28 | 华润三九医药股份有限公司 | 一种防己茯苓汤组合物的质量控制方法 |
CN113552276A (zh) * | 2021-07-06 | 2021-10-26 | 贵州健兴药业有限公司 | 一种川芎茶调滴丸的检测方法 |
CN116678978A (zh) * | 2023-06-27 | 2023-09-01 | 中国中医科学院中药研究所 | 川芎茶调散指纹图谱及化学成分含量测定方法的建立 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050142229A1 (en) * | 2003-12-29 | 2005-06-30 | Jiao Gong | Pharmaceutical activity and manufacturing method of the four-plant-derived coronary blood flow enhancing agent |
CN1739612A (zh) * | 2005-09-08 | 2006-03-01 | 王衡新 | 疏风止痛的中药制剂及其制备方法和质量控制方法 |
-
2012
- 2012-02-27 CN CN201210044652.6A patent/CN102590423B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050142229A1 (en) * | 2003-12-29 | 2005-06-30 | Jiao Gong | Pharmaceutical activity and manufacturing method of the four-plant-derived coronary blood flow enhancing agent |
CN1739612A (zh) * | 2005-09-08 | 2006-03-01 | 王衡新 | 疏风止痛的中药制剂及其制备方法和质量控制方法 |
Non-Patent Citations (2)
Title |
---|
吴清: "《230种中药颗粒剂和胶囊剂制备关键技术》", 31 January 2009, article "川芎茶调冲剂" * |
李棣华 等: "山西产柴胡中皂苷类成分HPLC指纹图谱初步研究", 《辽宁中医药大学学报》, vol. 13, no. 5, 31 May 2011 (2011-05-31), pages 89 - 90 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108459129A (zh) * | 2017-02-17 | 2018-08-28 | 华润三九医药股份有限公司 | 一种防己茯苓汤组合物的质量控制方法 |
CN108459129B (zh) * | 2017-02-17 | 2020-06-05 | 华润三九医药股份有限公司 | 一种防己茯苓汤组合物的质量控制方法 |
CN113552276A (zh) * | 2021-07-06 | 2021-10-26 | 贵州健兴药业有限公司 | 一种川芎茶调滴丸的检测方法 |
CN116678978A (zh) * | 2023-06-27 | 2023-09-01 | 中国中医科学院中药研究所 | 川芎茶调散指纹图谱及化学成分含量测定方法的建立 |
CN116678978B (zh) * | 2023-06-27 | 2023-11-17 | 中国中医科学院中药研究所 | 川芎茶调散指纹图谱及化学成分含量测定方法的建立 |
Also Published As
Publication number | Publication date |
---|---|
CN102590423B (zh) | 2014-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107153098A (zh) | 一种中药组合物的指纹图谱的测定方法 | |
CN103207255B (zh) | 一种脑心通胶囊的含量检测方法 | |
CN107478749B (zh) | 一种桃红四物汤的药物制剂的检测方法 | |
CN102100818B (zh) | 藿香正气片的检测方法 | |
CN101961381A (zh) | 一种丹参配方颗粒的制备方法及其检测方法 | |
CN104713956A (zh) | 一种黄芪川芎提取物指纹图谱的测定方法 | |
CN104569252B (zh) | 一种中药组合物的指纹图谱的建立方法 | |
CN106290599B (zh) | 一种中药组合物的含量测定方法 | |
CN103800438A (zh) | 川芎茶调制剂和制法 | |
CN102590423B (zh) | 川芎茶调颗粒制剂指纹图谱的测定方法 | |
CN102539599B (zh) | 一种强肝药物的检测方法 | |
CN102441057A (zh) | 一种养血清脑颗粒的hplc指纹图谱检测方法 | |
CN101690757B (zh) | 一种牛黄上清制剂的制备方法 | |
CN108226325A (zh) | 葶苈生脉口服液组合物指纹图谱的建立方法 | |
CN100381813C (zh) | 复方丹参滴丸质量控制方法 | |
CN103211907A (zh) | 四物汤复方配方颗粒及其制备方法和检测方法 | |
CN103604898B (zh) | 益心舒制剂的指纹图谱检测方法 | |
CN100402059C (zh) | 舒筋定痛制剂的质量控制方法 | |
CN100522205C (zh) | 小儿鼻炎颗粒的检测方法 | |
CN102688336A (zh) | 一种牛黄上清组合物及其制备方法 | |
CN101339166B (zh) | 妇科调经胶囊的检测方法 | |
CN101647997B (zh) | 感冒疏风胶囊及其制备方法和质量控制方法 | |
CN101642492B (zh) | 治疗慢性盆腔炎的药物及其制备方法 | |
CN100412546C (zh) | 一种复方丹参滴丸指纹图谱的测定方法 | |
CN100515476C (zh) | 复方金蒲胶囊及其制备方法、质量控制方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Liyan Inventor after: Liang Bin Inventor after: Li Menglin Inventor after: Xie Yu Inventor after: Tang Jingwen Inventor after: Pan Mei Inventor after: Mei Jixiong Inventor before: Liang Bin Inventor before: Li Menglin Inventor before: Zhang Liyan Inventor before: Xie Yu Inventor before: Tang Jingwen Inventor before: Pan Mei Inventor before: Mei Jixiong |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LIANG BIN LI MENGLIN ZHANG LIYAN XIE YU TANG JINGWEN PAN MEI MEI JIXIONG TO: ZHANG LIYAN LIANG BIN LI MENGLIN XIE YU TANG JINGWEN PAN MEI MEI JIXIONG |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Determination of fingerprint of Chuanxiong chatiao granules Effective date of registration: 20210113 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021520000001 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210723 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021520000001 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Determination of fingerprint of Chuanxiong chatiao granules Effective date of registration: 20210819 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021520000011 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220601 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021520000011 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Determination method of fingerprint of Chuanxiong chadiao granule preparation Effective date of registration: 20220719 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2022520000033 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230523 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2022520000033 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for determining the fingerprint of Chuanxiong Chadiao Granules Effective date of registration: 20230530 Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2023520000021 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2023520000021 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for determining the fingerprint spectrum of Chuanxiong Tea Tiao Granules Granted publication date: 20140416 Pledgee: Bank of Communications Co.,Ltd. Guizhou Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2024520000019 |