CN102488870B - Compound propolis composition for treating pruritus for dogs and cats and preparation method thereof - Google Patents
Compound propolis composition for treating pruritus for dogs and cats and preparation method thereof Download PDFInfo
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- CN102488870B CN102488870B CN2011104460941A CN201110446094A CN102488870B CN 102488870 B CN102488870 B CN 102488870B CN 2011104460941 A CN2011104460941 A CN 2011104460941A CN 201110446094 A CN201110446094 A CN 201110446094A CN 102488870 B CN102488870 B CN 102488870B
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Abstract
The invention provides a compound propolis composition for treating pruritus for dogs and cats and a preparation method thereof, which relates to the field of animal medicines. The preparation method for the composition comprises the following steps: (1) respectively carrying out ultrafine crushing on all the components in a prescription and screening all the crushed components with a 700-mesh sieve; (2) weighing 15 to 35 parts by weight of propolis, 15 to 35 parts by weight of herba violae, 10 to 35 parts by weight of curcuma rhizome, 15 to 40 parts by weight of coptis, 15 to 35 parts by weight of Poria cocos and 10 to 35 parts by weight of radix sileris and uniformly mixing the components for 5 to 10 min; (3) weighing 10 to 35 parts by weight of honeysuckle flower, 15 to 35 parts by weight of licorice, 15 to 35 parts by weight of radix astragali, 15 to 35 parts by weight of Ligusticum wallichii, 15 to 45 parts by weight of common cnidium fruit, 15 to 35 parts by weight of lithospermum and 15 to 45 parts by weight of phellodendron and uniformly mixing the components for 5 to 10 min; and (4) combining compositions prepared in step (2) and (3) and continuing to uniformly mix the compositions for 10 to 15 min so as to obtain the compound propolis composition. The beneficial effects of the invention are as follows: composition is reasonable; preparation is simple; the compound propolis composition has the advantages of no toxic and side effects, no pollution, no drug residue, no drug resistance, ultrafine crushing, high bioavailability and a very remarkable curative effect, and according to results of clinical practice, the compound propolis composition has special efficacy in treating pruritus for dogs.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment dog cat pruritus and preparation method thereof.
Background technology
Dog cat pruritus is the common a kind of dermatosis of dog cat, clinical main manifestations for spirit, be off one's feed, yellowish urine, feces is dry or half congealed soft, the whole body pruritus is uneasy, the skin pustule, festers etc., and is finally dead because of heart failure.The traditional Chinese medical science thinks that this disease belongs to exopathogen invading into the interior, the damp and hot skin of fighting mutually, and due to QI and blood was weak, treatment should adopt heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, remove that wind is antipruritic, the principle of cool blood and remove dampness, strengthening vital QI to eliminate pathogenic factors.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm dog cat house pet industry.
This disease almost spreads all over all livestock culturing countries of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And western medical treatment is mainly take sterilization, antiinflammatory etc. as main, and Western medicine is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, and clinical practice is very limited.
Therefore research and develop that a kind of to treat the having no side effect of dog cat pruritus, drug residue free, the specific medicament that produces that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability height, successful, have no side effect, have no drug resistance and effective compound bee-glue composition for the treatment of dog cat pruritus of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of dog cat pruritus, by following component by weight mixed preparing form: propolis 15-35 part, Herba Violae 15-35 part, Rhizoma Curcumae 10-35 part, Rhizoma Coptidis 15-40 part, Poria 15-35 part, Radix Saposhnikoviae 10-35 part, Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Astragali 15-35 part, Rhizoma Chuanxiong 15-35 part, Fructus Cnidii 15-45 part, Radix Arnebiae (Radix Lithospermi) 15-35 part, Cortex Phellodendri 15-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Herba Violaes, 25 parts of Rhizoma Curcumae, 25 parts of Rhizoma Coptidis, 25 parts in Poria, 25 parts of Radix Saposhnikoviaes, 25 parts of Flos Loniceraes, 25 parts in Radix Glycyrrhizae, 25 parts of the Radixs Astragali, 25 parts of Rhizoma Chuanxiongs, 30 parts of Fructus Cnidiis, 25 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Cortex Phellodendris.
A kind of preparation method for the treatment of the compound bee-glue composition of dog cat pruritus, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Herba Violae 15-35 part, Rhizoma Curcumae 10-35 part, Rhizoma Coptidis 15-40 part, Poria 15-35 part, Radix Saposhnikoviae 10-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Astragali 15-35 part, Rhizoma Chuanxiong 15-35 part, Fructus Cnidii 15-45 part, Radix Arnebiae (Radix Lithospermi) 15-35 part, Cortex Phellodendri 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, lung, stomach warp, have anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic oxidation, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Flos Lonicerae: sweet, cold, return lung, stomach, heart channel, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Rhizoma Coptidis: bitter, cold, return liver, the heart, spleen, stomach, gallbladder, large intestine channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.
Rhizoma Curcumae: hot, bitter, warm, return liver, spleen channel, have the function of broken silt removing food stagnancy, promoting the circulation of QI to relieve pain; Cure mainly stagnation of QI-blood, tripe abdominal distention and pain, accumulation of food in the stomach and intes tine due to indigestion, traumatic injury etc.
Radix Arnebiae (Radix Lithospermi): sweet, one-tenth, cold, GUIXIN, Liver Channel have the function of removing heat from blood and promoting blood circulation, detoxifcation speckle removing; Cure mainly heat in blood poison Sheng, pyretic toxicity ecchymosis, skin infection, eczema, scald, burn etc.
Cortex Sclerotii Poriae: sweet, light, flat, return kidney, urinary bladder channel, have the function of inducing diuresis to remove edema; Cure mainly edema, dysuria etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Rhizoma Chuanxiong: hot, warm, return gallbladder, liver, pericardium channel, have the function of blood-activating and qi-promoting, wind-expelling pain-stopping; Cure mainly traumatic injury, stagnation of QI-blood, puerperal blood stasis, rheumatic arthralgia etc.
Herba Violae: bitter, hot, cold, Gui Xin, Liver Channel have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain etc.
Radix Saposhnikoviae: hot, sweet, warm, return liver, spleen, urinary bladder channel, have inducing diaphoresis to dispel wind, win function wet, spasmolytic; Cure mainly affection of exogenous wind-cold, anemofrigid-damp arthralgia, rubella pruritus, tetanus etc.
Fructus Cnidii: hot, bitter, warm, return kidney channel, have that warming the kidney to invigorate YANG, dampness dispel the wind, the function of killing parasites for relieving itching; Cure mainly impotence due to deficiency of the kidney, infertility, eczema, pruritus etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of dog cat pruritus, the performance treating both the principal and secondary aspects of a disease effect.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention optimizes this 13 flavor Chinese medicine, and makes them form pure Chinese powder medicine according to optimum ratio according to Chinese veterinarian's traditional theory, and clinical practice proves that treatment dog cat pruritus is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition for the treatment of dog cat pruritus and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of propolis, 150 parts of Herba Violaes, 100 parts of Rhizoma Curcumae, 150 parts of Rhizoma Coptidis, 150 parts in Poria, 100 parts of Radix Saposhnikoviaes, mix 5-10 minute to even;
(3) take by weighing by weight 100 parts of Flos Loniceraes, 150 parts in Radix Glycyrrhizae, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Chuanxiongs, 150 parts of Fructus Cnidiis, 150 parts of Radix Arnebiae (Radix Lithospermi)s, 150 parts of Cortex Phellodendris, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of dog cat pruritus and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of propolis, 250 parts of Herba Violaes, 250 parts of Rhizoma Curcumae, 250 parts of Rhizoma Coptidis, 250 parts in Poria, 250 parts of Radix Saposhnikoviaes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Flos Loniceraes, 250 parts in Radix Glycyrrhizae, 250 parts of the Radixs Astragali, 250 parts of Rhizoma Chuanxiongs, 300 parts of Fructus Cnidiis, 250 parts of Radix Arnebiae (Radix Lithospermi)s, 300 parts of Cortex Phellodendris, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of dog cat pruritus and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of propolis, 350 parts of Herba Violaes, 350 parts of Rhizoma Curcumae, 400 parts of Rhizoma Coptidis, 350 parts in Poria, 350 parts of Radix Saposhnikoviaes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Flos Loniceraes, 350 parts in Radix Glycyrrhizae, 350 parts of the Radixs Astragali, 350 parts of Rhizoma Chuanxiongs, 450 parts of Fructus Cnidiis, 350 parts of Radix Arnebiae (Radix Lithospermi)s, 450 parts of Cortex Phellodendris, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
With the ill dog cat of product feeding of the present invention etc., a day dose is: gavage or lick and lick 5 grams-15 grams by per kilogram of body weight of the present invention, every day 1-2 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment dog cat pruritus:
| Numbering | Group | Case fatality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 12.5 | 61.0 | 26.5 |
| II | The loose group of five tastes sterilization | 6.4 | 80.9 | 12.7 |
| III | Present composition group | 3.5 | 89.8 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of five tastes sterilization aspect the cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment dog cat pruritus and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition for the treatment of dog cat pruritus, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Herba Violae 15-35 part, Rhizoma Curcumae 10-35 part, Rhizoma Coptidis 15-40 part, Poria 15-35 part, Radix Saposhnikoviae 10-35 part, Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Astragali 15-35 part, Rhizoma Chuanxiong 15-35 part, Fructus Cnidii 15-45 part, Radix Arnebiae (Radix Lithospermi) 15-35 part, Cortex Phellodendri 15-45 part.
2. the compound bee-glue composition for the treatment of according to claim 1 dog cat pruritus, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Herba Violaes, 25 parts of Rhizoma Curcumae, 25 parts of Rhizoma Coptidis, 25 parts in Poria, 25 parts of Radix Saposhnikoviaes, 25 parts of Flos Loniceraes, 25 parts in Radix Glycyrrhizae, 25 parts of the Radixs Astragali, 25 parts of Rhizoma Chuanxiongs, 30 parts of Fructus Cnidiis, 25 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Cortex Phellodendris.
3. the preparation method of the compound bee-glue composition of a treatment according to claim 1 dog cat pruritus is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Herba Violae 15-35 part, Rhizoma Curcumae 10-35 part, Rhizoma Coptidis 15-40 part, Poria 15-35 part, Radix Saposhnikoviae 10-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Flos Lonicerae 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Astragali 15-35 part, Rhizoma Chuanxiong 15-35 part, Fructus Cnidii 15-45 part, Radix Arnebiae (Radix Lithospermi) 15-35 part, Cortex Phellodendri 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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