CN102471275B - Smac模拟物 - Google Patents

Smac模拟物 Download PDF

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Publication number
CN102471275B
CN102471275B CN201080031798.6A CN201080031798A CN102471275B CN 102471275 B CN102471275 B CN 102471275B CN 201080031798 A CN201080031798 A CN 201080031798A CN 102471275 B CN102471275 B CN 102471275B
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cancer
carcinoma
compound
cell
pharmaceutical composition
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CN102471275A (zh
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S.M.康顿
邓一军
M.G.拉波特
S.R.里平
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Medville Co., Ltd.
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TetraLogic Pharmaceuticals Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/07—Tetrapeptides
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    • A61N5/00—Radiation therapy
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080031798.6A 2009-07-02 2010-06-25 Smac模拟物 Active CN102471275B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22266809P 2009-07-02 2009-07-02
US61/222,668 2009-07-02
US12/819,221 2010-06-20
US12/819,221 US8283372B2 (en) 2009-07-02 2010-06-20 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
PCT/US2010/039976 WO2011002684A1 (fr) 2009-07-02 2010-06-25 Mimétique de smac

Publications (2)

Publication Number Publication Date
CN102471275A CN102471275A (zh) 2012-05-23
CN102471275B true CN102471275B (zh) 2014-05-28

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ID=43411387

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CN201080031798.6A Active CN102471275B (zh) 2009-07-02 2010-06-25 Smac模拟物

Country Status (27)

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US (10) US8283372B2 (fr)
EP (1) EP2448923B8 (fr)
JP (1) JP5674780B2 (fr)
KR (1) KR101755218B1 (fr)
CN (1) CN102471275B (fr)
AP (1) AP3619A (fr)
AR (1) AR077629A1 (fr)
AU (1) AU2010266525C1 (fr)
BR (1) BRPI1013958B1 (fr)
CA (1) CA2766162C (fr)
CL (1) CL2011003333A1 (fr)
CO (1) CO6480975A2 (fr)
DK (1) DK2448923T3 (fr)
EA (1) EA022061B1 (fr)
EC (1) ECSP11011557A (fr)
ES (1) ES2565337T3 (fr)
HK (2) HK1169410A1 (fr)
HU (1) HUE026982T2 (fr)
IL (1) IL217237A (fr)
MX (1) MX2011013819A (fr)
MY (1) MY153116A (fr)
NZ (1) NZ597051A (fr)
PE (1) PE20131173A1 (fr)
SG (1) SG177404A1 (fr)
TW (1) TWI485148B (fr)
WO (1) WO2011002684A1 (fr)
ZA (1) ZA201109342B (fr)

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JP5230865B2 (ja) 2004-07-15 2013-07-10 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ結合性化合物
EP1851200B1 (fr) 2005-02-25 2014-01-15 Tetralogic Pharmaceuticals Corporation Inhibiteurs iap dimeriques
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US8283372B2 (en) * 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
UY33236A (es) * 2010-02-25 2011-09-30 Novartis Ag Inhibidores dimericos de las iap
UY33794A (es) 2010-12-13 2012-07-31 Novartis Ag Inhibidores diméricos de las iap
JP2014528409A (ja) * 2011-09-30 2014-10-27 テトラロジック ファーマシューティカルズ コーポレーション 増殖性疾患（がん）の治療において使用するためのＳＭＡＣ模倣体（ビリナパント（ｂｉｒｉｎａｐａｎｔ））
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WO2015017520A1 (fr) * 2013-07-30 2015-02-05 Tetralogic Pharmaceuticals Corp. Procédé de traitement
WO2016079527A1 (fr) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Polythérapie
WO2016097773A1 (fr) 2014-12-19 2016-06-23 Children's Cancer Institute Antagonistes des iap thérapeutiques pour traiter des troubles prolifératifs
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WO2019080928A1 (fr) * 2017-10-27 2019-05-02 南京明德新药研发股份有限公司 Forme cristalline d'un antagoniste d'iap et procédé de préparation correspondant
WO2019089991A1 (fr) * 2017-11-01 2019-05-09 The Regents Of The University Of California Nouveaux agents ciblant des protéines inhibitrices de l'apoptose
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WO2019154053A1 (fr) * 2018-02-09 2019-08-15 广东东阳光药业有限公司 Inhibiteur d'iap et leur utilisation en médecine
JPWO2020027225A1 (ja) 2018-07-31 2021-11-11 ファイメクス株式会社 複素環化合物
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
EP4006037A4 (fr) 2019-07-31 2023-12-13 Fimecs, Inc. Composé hétérocyclique
CN112521372B (zh) * 2019-09-18 2022-07-08 南京华威医药科技集团有限公司 一种细胞凋亡蛋白抑制剂及其制备方法和用途
CN112778398A (zh) * 2019-11-07 2021-05-11 杜心赟 肝靶向药、其药物组合物及其用途
EP4093394A1 (fr) 2020-01-20 2022-11-30 Astrazeneca AB Inhibiteurs de tyrosine kinase du récepteur du facteur de croissance épidermique pour le traitement du cancer
EP4262763A1 (fr) * 2020-12-17 2023-10-25 Council of Scientific & Industrial Research Mimétiques de smac pour le traitement du cancer, leur procédé de préparation et leur composition pharmaceutique
WO2023194547A1 (fr) 2022-04-08 2023-10-12 Medivir Ab Polymorphe h de birinapant
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