CN102378684A - 变色消费产品 - Google Patents
变色消费产品 Download PDFInfo
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- CN102378684A CN102378684A CN2009801585946A CN200980158594A CN102378684A CN 102378684 A CN102378684 A CN 102378684A CN 2009801585946 A CN2009801585946 A CN 2009801585946A CN 200980158594 A CN200980158594 A CN 200980158594A CN 102378684 A CN102378684 A CN 102378684A
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- 239000000606 toothpaste Substances 0.000 claims abstract description 18
- 229940034610 toothpaste Drugs 0.000 claims abstract description 18
- 230000008859 change Effects 0.000 claims abstract description 11
- 239000000344 soap Substances 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims description 116
- 239000010410 layer Substances 0.000 claims description 77
- 239000000049 pigment Substances 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 239000004094 surface-active agent Substances 0.000 claims description 15
- -1 asccharin Chemical compound 0.000 claims description 14
- 210000000214 mouth Anatomy 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000013047 polymeric layer Substances 0.000 claims description 12
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 11
- 239000000080 wetting agent Substances 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 229940091249 fluoride supplement Drugs 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 4
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 4
- 229960002799 stannous fluoride Drugs 0.000 claims description 4
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 239000011775 sodium fluoride Substances 0.000 claims description 3
- 235000013024 sodium fluoride Nutrition 0.000 claims description 3
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 claims description 2
- MPPQGYCZBNURDG-UHFFFAOYSA-N 2-propionyl-6-dimethylaminonaphthalene Chemical compound C1=C(N(C)C)C=CC2=CC(C(=O)CC)=CC=C21 MPPQGYCZBNURDG-UHFFFAOYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 241000628997 Flos Species 0.000 claims description 2
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims description 2
- 239000003599 detergent Substances 0.000 claims description 2
- 238000004851 dishwashing Methods 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000010445 mica Substances 0.000 claims description 2
- 229910052618 mica group Inorganic materials 0.000 claims description 2
- 229940074371 monofluorophosphate Drugs 0.000 claims description 2
- 239000011698 potassium fluoride Substances 0.000 claims description 2
- 235000003270 potassium fluoride Nutrition 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- 239000001119 stannous chloride Substances 0.000 claims description 2
- 235000011150 stannous chloride Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 4
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 239000000440 bentonite Substances 0.000 claims 2
- 229910000278 bentonite Inorganic materials 0.000 claims 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 claims 2
- 239000000975 dye Substances 0.000 claims 2
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- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 claims 2
- 229940099402 potassium metaphosphate Drugs 0.000 claims 2
- 235000019983 sodium metaphosphate Nutrition 0.000 claims 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 229920000049 Carbon (fiber) Polymers 0.000 claims 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- 240000001238 Gaultheria procumbens Species 0.000 claims 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims 1
- 229960005164 acesulfame Drugs 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000004917 carbon fiber Substances 0.000 claims 1
- 239000004927 clay Substances 0.000 claims 1
- 229910052570 clay Inorganic materials 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims 1
- 229910000271 hectorite Inorganic materials 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims 1
- 239000001683 mentha spicata herb oil Substances 0.000 claims 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 229920005787 opaque polymer Polymers 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 235000019477 peppermint oil Nutrition 0.000 claims 1
- 239000010672 sassafras oil Substances 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 229960001462 sodium cyclamate Drugs 0.000 claims 1
- 235000019721 spearmint oil Nutrition 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 15
- 210000003296 saliva Anatomy 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000006260 foam Substances 0.000 description 12
- 235000011180 diphosphates Nutrition 0.000 description 9
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
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Abstract
本发明涉及含有具有装饰层的多层膜且可赋予显著变色的个人护理产品。本发明适用于包括牙膏型的产品、肥皂和其他直接用水(或唾液)稀释的其他产品。
Description
发明背景
感官信号在传达关键益处给消费者方面起重要作用。例如,在使用牙膏时,在使用期间通常没有产品如约起作用或做任何事情的即时信号。诸如泡沫体从白色变为蓝色的目视指示(visual cue)可显著改进该感知,但该领域报道说这类技术当前可能无法实行。
此外,存在用以控制该变色出现的速率的需要,从而可将该信号用以确保消费者的顺从性(例如,确保儿童适当刷洗)。
发明概述
本发明包括包含膜的组合物。所述膜由第一屏蔽聚合物层、中间装饰层和第二屏蔽聚合物层构成。第一屏蔽层和第二屏蔽层遮蔽所述中间装饰层的至少一部分。
还包括在口腔护理、个人护理或家庭护理方案中使用所述组合物的方法。
发明详述
从始至终使用的范围用作描述在该范围内的各个和每一个值的简写。可选择在该范围内的任何值作为该范围的端点。此外,本文引用的所有参考文献通过全文引用结合到本文中。在本公开中的定义与引用的参考文献中的定义相冲突的情况下,以本公开为准。
本发明广泛涵盖口腔护理组合物、个人护理组合物和家庭护理组合物。口腔护理组合物包括诸如牙膏的组合物,个人护理组合物包括诸如洗液和淋浴胶的组合物,且家庭护理组合物包括诸如通用清洁液和盘碟洗涤剂的此类组合物。在本文的其他地方公开了其他示例性组合物。
本发明还涵盖包含膜的口腔护理组合物。所述膜包括至少第一屏蔽聚合物层和第二屏蔽聚合物层及置于第一屏蔽层与第二屏蔽层之间的中间装饰聚合物层。所述口腔护理组合物可以任何形式,包括牙膏、凝胶、漱口液、锭剂、牙线、牙带、牙条、糖膏或牙护漆(varnish)。
屏蔽层(存在至少两个屏蔽层)用来遮蔽装饰层的可视外观,使得在与口腔接触之前和/或在口腔中机械操作之前,装饰层的真实可视外观看不出来。“遮蔽”旨在包括存在于装饰层上和/或随后的缺乏改变膜和/或总组合物的可视外观的屏蔽层。例如,屏蔽层可为不透明的且在视觉上屏蔽装饰层;屏蔽层可为半透明或透明但有色的,使得缺乏屏蔽层导致膜的察觉到的变色;屏蔽层甚至可为澄明的,如果装饰层含有在暴露于口腔时(通过除去屏蔽层)变色的组分,诸如pH或热敏剂。或者,屏蔽层可屏蔽在释放时改变总组合物美观性的在装饰层中的混配剂,这类化合物或试剂在视觉上可能可以辨别或不在装饰层内。
屏蔽层可能不连续或者它们可对于装饰层的全部面积提供覆盖。该膜可含有多于一个装饰层。
下图进一步举例说明该材料,其可通过连续流延(casting)膜浆液或此项技术中的任何其他方式来制备。
在一个实施方案中,所述屏蔽层至少包含羟丙基甲基纤维素(HPMC)、甘油和氧化钛。在另一实施方案中,所述屏蔽层至少包含HPMC、甘油和氧化钛。在另一实施方案中,所述中间装饰聚合物层至少包含HPMC、甘油和颜料。在某些实施方案中,所述装饰中间层的颜料为红色、蓝色、绿色或其混合色,但任何颜色都适宜。组合物可包含多于两个屏蔽层。
在一个实施方案中,聚合物层中的任一个都可包含羟丙基纤维素(HPC)。任何所述聚合物层都尤其可包含颜料、FD&C颜料和色淀颜料和各种赋予颜色的化合物中的一种或多种。
所述口腔护理组合物可包含各种成分,例如至少一种研磨剂、至少一种氟化物源、至少一种用以增加泡沫量的试剂、至少一种表面活性剂、至少一种维生素、至少一种聚合物、至少一种调味剂、至少一种酶、至少一种润湿剂和/或至少一种防腐剂及其组合。
本发明还涵盖告知使用者刷牙完成的方法,其包括施用如本文所述的口腔护理组合物,所述口腔护理组合物包括第一屏蔽聚合物层、至少一个中间装饰聚合物层和第二屏蔽聚合物层,其中第一不透明层和第二不透明层对于牙齿共同掩蔽所述至少一个中间装饰层的至少一部分;刷洗牙齿和口腔护理组合物以产生泡沫体;观察所述口腔护理组合物的清晰变色。在某些实施方案中,所述变色发生在所述总组合物中或在通过使用所述组合物产生的泡沫体中。
例如,当制剂以正常方式使用时,膜迅速溶解,使得着色剂或颜料变得愈加突出。泡沫体从白色变色以在1分钟内装饰。该效应还可以通过随着牙膏被分配和薄膜溶解时牙膏在水中的1∶3浆液从白色的改变来装饰。颜色改变的程度可通过增加或减少配方中膜的量来容易地改变。
在某些实施方案中,研磨剂以约1-20%重量的量存在于所述组合物中。在某些实施方案中,氟化物源以约0.01-5%重量的量存在。在某些实施方案中,用以增加泡沫体的量的试剂以约1-90%重量的量存在。在某些实施方案中,调味剂以约0.01-5%重量的量存在。在某些实施方案中,牙带或牙条进一步包含以约0.01-5%重量的量的至少一种润湿剂。
所述口腔护理组合物还可包含一种或多种氟离子源。在本发明的组合物中可使用广泛的各种产生氟离子的物质作为可溶性氟化物的来源。合适的产生氟离子的物质的实例见于Briner等的美国专利3,535,421号;Parran,Jr.等的美国专利4,885,155号;和Widder等的美国专利3,678,154号中,这些专利以引用的方式结合到本文中。
代表性氟离子源包括但不限于氟化亚锡、氟化钠、氟化钾、单氟磷酸钠、氟硅酸钠、单氟磷酸钠(MFP)、氟硅酸铵以及氟化锡(诸如氟化亚锡)和氯化亚锡及其组合。一些特定的实施方案包括氟化亚锡或氟化钠以及其混合物。
在某些实施方案中,本发明的口腔护理组合物也还可以含有足以供应约25ppm-5,000ppm的氟化物离子的量的提供氟化物离子或氟的成分的来源。
在一个实施方案中,氟化物离子源可以基于组合物的重量计的约0.01%-3.0%的水平加到本发明的组合物中,或在另一实施方案中,其可以约0.03%-1.0%的水平加入。
本发明的口腔护理组合物还可包含用以增加在刷洗附着到口腔的牙条或牙带时产生的泡沫体的量的试剂。
增加泡沫体量的试剂的说明性实例包括但不限于聚氧化乙烯和包括但不限于海藻酸盐聚合物的一些聚合物。
所述聚氧化乙烯可增加由本发明的口腔护理组合物产生的泡沫体的量和泡沫体的厚度。聚氧化乙烯通常还被称为聚乙二醇(“PEG”)或聚环氧乙烷。适于本发明的聚氧化乙烯将具有约200,000-约7,000,000的分子量。在一个实施方案中,所述分子量将为约600,000-约2,000,000,且在另一实施方案中,所述分子量将为约800,000-约1,000,000。Polyox为由Union Carbide生产的高分子量聚氧化乙烯的商品名称。
所述聚氧化乙烯可以基于本发明的口腔组合物的口腔护理载体组分的重量计算约1%-90%、在一个实施方案中约5%-50%且在另一实施方案中约10%-20%的量存在。
本发明的口腔护理牙带或牙条中任选包含的另一试剂为表面活性剂或相容性表面活性剂的混合物。合适的表面活性剂为贯穿广泛的pH范围的相当稳定的表面活性剂,例如阴离子表面活性剂、阳离子表面活性剂、非离子表面活性剂或两性离子表面活性剂。
合适的表面活性剂更全面地描述在例如Agricola等的美国专利3,959,458号;Haefele的美国专利3,937,807号;和Gieske等的美国专利4,051,234号中,这些专利通过引用结合到本文中。
在某些实施方案中,本文有用的阴离子表面活性剂包括在烷基中具有10-18个碳原子的硫酸烷基酯的水溶性盐和具有10-18个碳原子的脂肪酸的磺化甘油单酯的水溶性盐。十二烷基硫酸钠、月桂酰肌氨酸钠和椰油甘油单酯磺酸钠为该类型的阴离子表面活性剂的实例。还可使用阴离子表面活性剂的混合物。
在另一实施方案中,本发明有用的阳离子表面活性剂可广泛定义为具有含有约8-18个碳原子的一个长烷基链的脂族季铵化合物的衍生物,诸如十二烷基三甲基氯化铵、氯化十六烷基吡啶十六烷基三甲基溴化铵、二异丁基苯氧基乙基二甲基苄基氯化铵、椰油烷基三烷基亚硝酸铵、氟化十六基吡啶及其混合物。
说明性的阳离子表面活性剂为在Briner等的美国专利3,535,421号中描述的季铵氟化物,该专利通过引用结合到本文中。一些阳离子表面活性剂还可用作所述组合物中的杀菌剂。
可用于本发明的组合物中的示例性非离子表面活性剂可宽泛地定义为通过烯化氧基团(性质上为亲水性的)与有机疏水性化合物(其性质上可为脂族或烷基芳族化合物)的缩合生成的化合物。合适非离子表面活性剂的实例包括但不限于普流罗尼克(Pluronics)、烷基酚的聚环氧乙烷缩合物、来源于环氧乙烷与环氧丙烷和乙二胺的反应产物的缩合的产物、脂族醇的环氧乙烷缩合物、长链叔胺氧化物、长链叔膦氧化物、长链二烷基亚砜和这类物质的混合物。
在某些实施方案中,可用于本发明的两性离子合成表面活性剂可宽泛地描述为脂族季铵、和锍化合物的衍生物,其中所述脂族基团可为直链或支链的且其中脂族取代基之一含有约8-18个碳原子且一个含有阴离子水增溶性基团,例如羧基、磺酸盐、硫酸盐、磷酸盐或膦酸盐。适于包含到所述组合物中的表面活性剂的说明性实例包括但不限于烷基硫酸钠、月桂酰肌氨酸钠、可可酰氨基丙基甜菜碱和聚山梨醇酯20及其组合。
所述表面活性剂或相容性表面活性剂的混合物可以基于总组合物的重量计的约0.1%-约5.0%、在另一实施方案中以约0.3%-约3.0%重量且在另一实施方案中以约0.5%-约2.0%重量存在于本发明的组合物中。表面活性剂在单个牙条或牙带中的配量(即,单剂量)为约0.001-0.05%重量、0.003-0.03%%重量且在另一实施方案中约0.005-0.02%重量。
用于实施本发明的调味剂包括但不限于精油以及各种调味醛、酯、醇和类似物质。所述精油的实例包括留兰香、薄荷、冬青、黄樟、丁香、鼠尾草、桉树、牛至属植物、肉桂、柠檬、酸橙、葡萄柚和橙的油。也可使用诸如薄荷醇、香芹酮和茴香脑的化学品。一些实施方案使用薄荷和留兰香的油。
所述调味剂以约0.1%重量-约5%重量和约0.5%重量-约1.5%重量的浓度掺入到所述口腔组合物中。
本发明的口腔护理组合物还可任选包含能够络合在细菌的细胞壁中见到的钙的一种或多种螯合剂。这种钙的结合削弱了细菌细胞壁并加强了细菌的裂解。
适合用作本发明中的螯合剂的另一组试剂为可溶性焦磷酸盐。本发明的组合物中使用的焦磷酸盐可为任何碱金属焦磷酸盐。在某些实施方案中,盐包括四碱金属焦磷酸盐、二碱金属二酸焦磷酸盐、三碱金属单酸焦磷酸盐及其混合物,其中所述碱金属为钠或钾。所述盐可以其水合形式和非水合形式二者使用。可用于本发明的组合物中的焦磷酸盐的有效量通常足以提供至少1.0%的焦磷酸盐离子、约1.5%-约6%、约3.5%-约6%的焦磷酸盐离子。在单个牙条或牙带中的螯合剂的配量(即,单剂量)为约0.01-0.6%重量且在另一实施方案中约0.035-0.06%重量。
本发明的口腔护理牙条或牙带组合物任选还包含一种或多种聚合物。这类物质在本领域中是众所周知的,其以其游离酸或部分或完全中和的水溶性碱金属(例如钾和钠)或铵盐的形式使用。一些实施方案包括马来酸酐或酸与另一可聚合的烯属不饱和单体(例如分子量(M.W.)为约30,000-约1,000,000的甲基乙烯基醚(甲氧基乙烯))的1∶4至4∶1共聚物。这些共聚物例如作为GAF Chemicals Corporation的Gantrez AN 139(M.W.500,000)、AN 119(M.W.250,000)和S-97Pharmaceutical Grade(M.W.70,000)购得。
其他聚合物包括诸如以下的聚合物:马来酸酐与丙烯酸乙酯、甲基丙烯酸羟乙酯、N-乙烯基-2-吡咯烷酮或乙烯的1∶1共聚物,后者例如作为Monsanto EMA 1103号(M.W.10,000)和EMA Grade 61购得;和丙烯酸与甲基丙烯酸甲酯或甲基丙烯酸羟乙酯、丙烯酸甲酯或丙烯酸乙酯、异丁基乙烯醚或N-乙烯基-2-吡咯烷酮的1∶1共聚物。
合适的通常是含有活性碳-碳烯属双键和至少一个羧基的聚合烯属或烯系不饱和羧酸,即,含有由于存在于单体分子中相对于羧基的α-β位中或作为末端亚甲基的一部分而易于在聚合中起作用的烯属双键的酸。这类酸的说明性例子有丙烯酸、甲基丙烯酸、乙基丙烯酸、α-氯丙烯酸、巴豆酸、β-丙烯酰氧基(acryloxy)丙酸、山梨酸、α-氯山梨酸、肉桂酸、β-苯乙烯基丙烯酸、粘康酸、衣康酸、柠康酸、中康酸、戊烯二酸、乌头酸、α-苯基丙烯酸、2-苄基丙烯酸、2-环己基丙烯酸、当归酸(angelic)、伞形酸(umbellic)、富马酸、马来酸和酸酐。可与这类羧基单体共聚合的其他不同的烯属单体包括乙酸乙烯酯、氯乙烯、马来酸二甲酯等。共聚物含有对于水溶性来说足够的羧酸盐。
另一类聚合剂包括含有被取代的丙烯酰胺的均聚物和/或不饱和磺酸及其盐的均聚物的组合物,特别是其中聚合物基于选自丙烯酰氨基烷磺酸(诸如2-丙烯酰胺-2-甲基丙烷磺酸)的不饱和磺酸,其分子量为1,000-2,000,000,描述在Zahid的1989年6月27日的美国专利4,842,847号中,该文献以引用的方式结合到本文中。
另一类有用的聚合剂包括聚氨基酸,特别是含有诸如天冬氨酸、谷氨酸和磷酸丝氨酸的阴离子表面活性氨基酸部分的那些聚氨基酸,如在以引用的方式结合到本文中的Sikes等的美国专利4,866,161号中所公开的。
本发明的口腔护理组合物还可任选包含一种或多种酶。有用的酶包括可得到的蛋白酶、葡聚糖水解酶、糖苷内切酶、淀粉酶、齿斑葡聚糖酶(mutanases)、脂肪酶和粘多糖酶或其相容性混合物中的一种。在某些实施方案中,所述酶为蛋白酶、葡聚糖酶、糖苷内切酶和齿斑葡聚糖酶。在另一实施方案中,所述酶为木瓜酶、糖苷内切酶或葡聚糖酶与变聚糖酶的混合物。适用于本发明的其他酶公开在Dring等的美国专利5,000,939号;美国专利4,992,420号;美国专利4,355,022号;美国专利4,154,815号;美国专利4,058,595号;美国专利3,991,177号;和美国专利3,696,191号中,所有专利都以引用的方式结合到本文中。在本发明中若干相容性酶的混合物的酶构成(在一个实施方案中)约0.002%-约2.0%、或(在另一实施方案中)约0.05%-约1.5%、或(在又一实施方案中)约0.1%-约0.5%。
水也可存在于本发明的口腔组合物中。在商业口腔组合物的制备中使用的水应为去离子且不含有机杂质的。水通常构成所述组合物的余量且占所述口腔组合物重量的约10%-50%、约20%-40%或约10%-15%。该水量包括所加入的游离水加上与诸如山梨糖醇或本发明的任何组分的其他物质一起引入的量。
在制备口腔护理组合物的过程中,有时必需加入一些增稠物质以提供所需的稠度。在某些实施方案中,所述增稠剂为羧乙烯聚合物、角叉菜胶、羟乙基纤维素和纤维素醚的水溶性盐,诸如羧甲基纤维素钠和羧甲基羟乙基纤维素钠。还可以掺入诸如卡拉牙胶、阿拉伯胶和黄蓍胶的天然树胶。可将胶状硅酸镁铝或细分散的硅粉用作增稠组合物的组分以进一步改进组合物的质地。可使用以总组合物的重量计的0.5%-5.0%的量的增稠剂。
在所述口腔组合物的一些实施方案中,还希望掺入润湿剂以防止组合物在暴露于空气时硬化。一些润湿剂也可以赋予洁牙剂组合物所需的甜味或香味。润湿剂(基于纯润湿剂)通常占所述洁牙剂组合物重量的(在一个实施方案中)约15%-70%或(在另一实施方案中)约30%-65%。
合适的润湿剂包括可食用的多元醇,诸如甘油、山梨糖醇、木糖醇、丙二醇以及其他多元醇和这些润湿剂的混合物。甘油和山梨糖醇的混合物可在某些实施方案中用作本文中的牙膏组合物的润湿剂组分。
除了上述组分以外,本发明的实施方案可含有多种任选的洁牙剂组分,其中一些描述如下。任选的组分例如包括(但不限于)胶粘剂、起泡剂(sudsing agent)、调味剂、甜味剂、其他防牙菌斑剂、研磨剂和着色剂。这些和其他任选的组分进一步描述在Majeti的美国专利5,004,597号;Agricola等的美国专利3,959,458号;和Haefele的美国专利3,937,807号中,所有专利都以引用的方式结合到本文中。
本发明在其方法方面包括向口腔施用安全且有效量的本文所述的组合物。使这些量(例如约20mm2-2000mm2的牙条或牙带)在口中保持约15秒-约12小时。另外,可仅使口腔护理牙条或牙带留下以清洁牙齿或者可将其与牙刷一起使用。
实验性实施例
实施例1:崩解试验
在各种实施方案中,本发明的组合物进行崩解试验。在一个优选的崩解试验中,将1克包含膜片段样品的组合物置于2英寸(50.8mm)磁性星状棒的顶端上。将该搅拌棒置于透明容器中,诸如处于30℃下的含有300ml水的500ml烧杯中。随后针对破损膜片段和未破损的膜片段的存在分析包含搅拌棒的水。该分析可包括迫使水穿过小于膜形状的最初长尺寸的一半的筛孔。如果有任何碎片没有破碎,该试验将显示出。
实施例2:变色配方
实施例2说明显示多层变色配方(白色→蓝色)的说明性实施方案。
表1:不透明的白色层1
表2:蓝色层2
表3:不透明的白色层3
实施例3-制备实施例2的多层变色配方
将层1流延1mil,随后在90℃烘箱中干燥10分钟。将层2以1mil流延在层1上,随后以相同方式干燥。将层3以1mil流延且将最终组合物在100℃下另外干燥10分钟。膜看上去为白色至灰白色。此时切割成小碎片并以牙膏(配方如下)配制。
实施例4:具有变色膜的全牙膏
实施例4说明显示多层变色配方的全牙膏的说明性实施方案。
表4:具有变色膜的全牙膏
当全制剂以正常方式使用时,膜迅速溶解,使得着色剂变得愈加突出。在该说明性实施例中,泡沫体在1分钟内从白色变为深蓝色。该效应可以通过随着牙膏被分配和膜溶解时牙膏在水中的1∶3浆液从白色到蓝色的改变来说明。颜色改变的程度可通过增加或减少配方中膜的量来容易地改变。
其他颜色或效应可通过替代上述实施例中的颜料来容易地取代。
实施例5:红色变色牙膏
用氧化铁或D&C红#30替代层2中的蓝色颜料。
实施例6:绿色变色牙膏
用颜料绿7替代层2中的蓝色颜料。
实施例7:缓慢释放金色闪光的牙膏
用在TiO2涂覆的云母上的基于氧化铁的着色剂(自各种制造商购得,诸如自Presperse以Timeron商品名称购得)替代层2中的蓝色颜料。
实施例8:缓慢释放麻刺感觉的牙膏
用麻刺感觉物(Tingle Sensate)(得自IFF)替代层2中的5%配方甘油。
实施例9:蓝色变色牙膏
用色淀颜料替代中间层中的颜料
表5:蓝色变色洁牙剂的组分。
颜色改变可为从白色组合物到彩色组合物。然而,应当理解的是颜色改变也可为从一种颜色到另一种颜色。在一些实施方案中,随后的颜色可代替先前的颜色。在其他实施方案中,随后的不同颜色可由与第一颜料组合的第二颜料的组合产生。
例如,可将诸如淡绿色基底的不同颜色基底与牙膏中的白色-蓝色-白色三层膜组合。该颜色将从绿色改变为蓝色。
在另一实施例中,代替上文阐述的白色-彩色-白色膜,该三层膜可在外层(即,层1和层3)中具有一种颜色,而在中间层中具有另一颜色。例如,组合物可具有黄色-蓝色-黄色膜模式。该三层膜看起来为黄色,但所得泡沫体将变色为蓝色或绿色(在混合黄色层与蓝色层时)。
在其他说明性实施方案中,供选择的膜制剂将确保使用中的稳定性和可溶解性。调整溶解和释放可通过增加相应层的厚度来容易地进行。
已经引用了许多参考文献,其全部公开内容通过引用结合到本文中。
Claims (33)
1.包含膜的组合物,所述膜包括:
第一屏蔽聚合物层、
中间装饰聚合物层和
第二屏蔽聚合物层,
其中所述第一屏蔽层和所述第二屏蔽层遮蔽中间装饰层的至少一部分且适于在使用所述组合物时露出所述中间装饰层。
2.权利要求1的组合物,其中所述组合物为口腔护理组合物。
3.权利要求1的组合物,其中所述膜的所述第一屏蔽层和所述第二屏蔽层中的至少一个为基本上不透明的。
4.权利要求1的组合物,其中所述膜的所述第一屏蔽层和所述第二屏蔽层中的至少一个为基本上半透明的。
5.权利要求1的组合物,其中所述膜还包含包涵物。
6.权利要求5的组合物,其中所述包涵物选自珠光粒子、反光粒子、云母、不透明的聚合物珠粒、闪光剂和碎片。
7.权利要求1的组合物,其中所述第一屏蔽层和所述第二屏蔽层中的至少一个在暴露于口腔时溶解。
8.权利要求1的组合物,其中所述第一屏蔽层和所述第二屏蔽层中的至少一个为脆性的。
9.权利要求1的组合物,其中所述膜还包括另一装饰层。
10.权利要求9的组合物,其中至少一个装饰层包含选自颜料、FD&C染料和色淀颜料的至少一个成员。
11.权利要求1的组合物,其中所述膜还包括另一屏蔽层。
12.权利要求11的组合物,其中至少一个屏蔽层包含选自颜料、FD&C染料和色淀颜料的至少一个成员。
13.权利要求1的组合物,其中所述屏蔽层中的至少一个还包含选自氧化钛、氧化锌、滑石、锂蒙脱石、粘土、碳纤维、乳浊颜料、FD&C和色淀颜料的组分。
14.权利要求1的组合物,其中所述膜含有活性剂。
15.权利要求1的组合物,其以牙膏或凝胶形式。
16.权利要求1的口腔护理组合物,其中所述聚合物层中的至少一个包含HPMC和丙二醇。
17.权利要求1的口腔护理组合物,其中所述聚合物层中的至少一个包含羟丙基纤维素。
18.权利要求1的组合物,其还包含至少一种研磨剂。
19.权利要求1的组合物,其还包含选自研磨二氧化硅、偏磷酸钠、偏磷酸钾、磷酸三钙、二水合磷酸二钙、硅酸铝、煅烧氧化铝、斑脱土和含硅材料的成员。
20.权利要求1的组合物,其还包含至少一种氟离子源。
21.权利要求1的组合物,其还包含选自氟化钠、氟化钾、氟硅酸钠、单氟磷酸钠(MFP)、氟硅酸铵、氟化亚锡的氟离子源和氯化亚锡。
22.权利要求1的组合物,其还包含至少一种表面活性剂。
23.权利要求1的组合物,其还包含至少一种维生素、至少一种聚合物、至少一种调味剂、至少一种酶、至少一种润湿剂和/或至少一种防腐剂及其组合。
24.权利要求1的组合物,其还包含选自海藻酸钠和聚氧化乙烯的试剂。
25.权利要求1的组合物,其还包含选自冬青油、薄荷油、留兰香油、黄樟油、丁香油、阿司帕甜、乙酰舒泛、糖精、右旋糖、果糖和环拉酸钠的试剂。
26.从口腔表面除去斑块的方法,其包括使所述口腔的表面与权利要求1的组合物接触和相对于所述口腔的表面机械操作所述组合物直到除去膜的第一屏蔽层和第二屏蔽层中的至少一个并露出至少一部分装饰层。
27.权利要求19的方法,其中机械操作通过选自咀嚼、牙线清洁、刷牙、摩擦、擦抹和漱洗的动作来实现。
28.权利要求19的方法,其中所述装饰层的露出通过整个组合物的颜色的改变来指示。
29.权利要求24的方法,其中所述研磨剂为选自研磨二氧化硅、偏磷酸钠、偏磷酸钾、磷酸三钙、二水合磷酸二钙、硅酸铝、煅烧氧化铝、斑脱土或其他含硅材料或其组合的一个成员。
30.权利要求1的组合物,其中所述组合物为个人护理产品。
31.权利要求30的组合物,其中所述个人护理组合物选自淋浴胶、洗液、乳膏、液体皂和条皂。
32.权利要求1的组合物,其中所述组合物为家庭护理组合物。
33.权利要求32的组合物,其中所述家庭护理组合物选自盘碟洗涤剂和通用清洁剂。
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- 2009-04-02 US US13/262,513 patent/US8647648B2/en active Active
- 2009-04-02 CA CA2757118A patent/CA2757118C/en not_active Expired - Fee Related
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- 2009-04-02 CN CN200980158594.6A patent/CN102378684B/zh not_active Expired - Fee Related
- 2009-04-02 MX MX2011009428A patent/MX2011009428A/es active IP Right Grant
- 2009-04-02 AU AU2009343766A patent/AU2009343766B2/en not_active Ceased
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- 2009-04-02 JP JP2012503398A patent/JP2012522780A/ja active Pending
- 2009-04-02 RU RU2011144363/15A patent/RU2482836C1/ru not_active IP Right Cessation
- 2009-04-02 WO PCT/US2009/039324 patent/WO2010114551A1/en active Application Filing
- 2009-04-02 EP EP09789571.8A patent/EP2414158B1/en active Active
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2010
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- 2010-03-31 AR ARP100101107A patent/AR076049A1/es unknown
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CN102958495A (zh) * | 2010-06-30 | 2013-03-06 | 高露洁-棕榄公司 | 香料在刷牙期间从多层膜释放 |
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CN102958567B (zh) * | 2010-06-30 | 2015-09-02 | 高露洁-棕榄公司 | 用于递送香料的多层膜 |
CN104837476A (zh) * | 2012-12-14 | 2015-08-12 | 高露洁-棕榄公司 | 用于口腔护理的可研磨薄膜 |
CN104837476B (zh) * | 2012-12-14 | 2017-11-07 | 高露洁-棕榄公司 | 用于口腔护理的可研磨薄膜 |
CN104853731B (zh) * | 2012-12-21 | 2018-07-17 | 高露洁-棕榄公司 | 不染色的牙膏 |
CN105828802A (zh) * | 2013-12-23 | 2016-08-03 | 高露洁-棕榄公司 | 用于口腔使用的薄膜组合物 |
CN105848729A (zh) * | 2013-12-23 | 2016-08-10 | 高露洁-棕榄公司 | 包含聚乙酸乙烯酯和颜料的含成膜物的组合物 |
CN105828802B (zh) * | 2013-12-23 | 2020-08-04 | 高露洁-棕榄公司 | 用于口腔使用的薄膜组合物 |
CN109106612A (zh) * | 2018-10-10 | 2019-01-01 | 广州市飞雪材料科技有限公司 | 一种牙膏用变色磨擦粒子及其制备方法 |
CN109106612B (zh) * | 2018-10-10 | 2019-07-26 | 广州市飞雪材料科技有限公司 | 一种牙膏用变色磨擦粒子及其制备方法 |
WO2020073677A1 (zh) * | 2018-10-10 | 2020-04-16 | 广州市飞雪材料科技有限公司 | 一种牙膏用变色磨擦粒子及其制备方法 |
Also Published As
Publication number | Publication date |
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CN102378684B (zh) | 2015-09-23 |
EP2414158A1 (en) | 2012-02-08 |
ZA201106910B (en) | 2014-03-26 |
US20140161735A1 (en) | 2014-06-12 |
AU2009343766B2 (en) | 2013-02-14 |
PL2414158T3 (pl) | 2016-04-29 |
AR076049A1 (es) | 2011-05-11 |
TW201102095A (en) | 2011-01-16 |
RU2482836C1 (ru) | 2013-05-27 |
BRPI0924629A2 (pt) | 2016-03-01 |
AU2009343766A1 (en) | 2011-09-15 |
EP2414158B1 (en) | 2015-11-04 |
WO2010114551A1 (en) | 2010-10-07 |
CA2757118A1 (en) | 2010-10-07 |
US9138384B2 (en) | 2015-09-22 |
MX2011009428A (es) | 2011-09-28 |
US20120070478A1 (en) | 2012-03-22 |
SG174151A1 (en) | 2011-10-28 |
JP2012522780A (ja) | 2012-09-27 |
TWI393573B (zh) | 2013-04-21 |
CA2757118C (en) | 2014-06-10 |
US8647648B2 (en) | 2014-02-11 |
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