CN1023700C - 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备 - Google Patents

芳族及杂环甲酰胺衍生物抗肿瘤剂的制备 Download PDF

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Publication number
CN1023700C
CN1023700C CN89103540A CN89103540A CN1023700C CN 1023700 C CN1023700 C CN 1023700C CN 89103540 A CN89103540 A CN 89103540A CN 89103540 A CN89103540 A CN 89103540A CN 1023700 C CN1023700 C CN 1023700C
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CN
China
Prior art keywords
hydrogen
alkyl
product
methyl
acid
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Expired - Fee Related
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CN89103540A
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English (en)
Chinese (zh)
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CN1037898A (zh
Inventor
安东·弗朗兹·约瑟夫·弗里利
罗德尼·考伦·斯纽尔
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Graft Or Block Polymers (AREA)
CN89103540A 1988-05-24 1989-05-24 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备 Expired - Fee Related CN1023700C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
US198,034 1988-05-24

Publications (2)

Publication Number Publication Date
CN1037898A CN1037898A (zh) 1989-12-13
CN1023700C true CN1023700C (zh) 1994-02-09

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
CN89103540A Expired - Fee Related CN1023700C (zh) 1988-05-24 1989-05-24 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备

Country Status (25)

Country Link
EP (1) EP0343893B1 (https=)
JP (1) JPH0678331B2 (https=)
KR (1) KR910006864B1 (https=)
CN (1) CN1023700C (https=)
AT (1) ATE79114T1 (https=)
AU (1) AU601905B2 (https=)
CA (1) CA1328871C (https=)
DD (1) DD283815A5 (https=)
DE (1) DE68902358T2 (https=)
DK (1) DK249389A (https=)
ES (1) ES2043012T3 (https=)
FI (1) FI892498A7 (https=)
GR (1) GR3005844T3 (https=)
HU (1) HU202507B (https=)
IE (1) IE891667L (https=)
IL (1) IL90337A0 (https=)
MX (1) MX173140B (https=)
MY (1) MY106035A (https=)
NO (1) NO172389C (https=)
NZ (1) NZ229234A (https=)
PL (1) PL154875B1 (https=)
PT (1) PT90622B (https=)
SU (1) SU1681728A3 (https=)
YU (1) YU47019B (https=)
ZA (1) ZA893862B (https=)

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JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
BR9610422A (pt) * 1995-08-30 1999-07-13 Searle & Co Derivados de meta-guanidina uréia tiouréia ou ácido aminobenzóico azacíclico como antagonistas de integrina
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
NZ503491A (en) 1997-11-10 2002-08-28 Bristol Myers Squibb Co 2-substituted amino-1,3-benzothiazole derivatives useful as protein tyrosine kinase inhibitors
EP0928793B1 (en) * 1998-01-02 2002-05-15 F. Hoffmann-La Roche Ag Thiazole derivatives
WO1999052861A1 (de) * 1998-04-09 1999-10-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik
AU8181701A (en) * 2000-06-21 2002-01-02 Hoffmann La Roche Benzothiazole derivatives
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
AU2004238508B2 (en) * 2003-05-13 2009-11-19 F. Hoffmann-La Roche Ag Imidazo-benzothiazoles
JP4444290B2 (ja) * 2003-05-19 2010-03-31 エフ．ホフマン−ラ ロシュ アーゲー アデノシン受容体リガンドとしてのベンゾチアゾール誘導体
PL1628662T3 (pl) * 2003-05-21 2007-07-31 Hoffmann La Roche Pochodne benzotiazolu i ich zastosowanie w leczeniu chorób związanych z receptorem adenozynowym A2A
HRP20080318T3 (en) * 2003-05-30 2008-07-31 F. Hoffmann - La Roche Ag Benzothiazole derivatives and use thereof in the treatment of diseases related to the adenosine a2a receptor
CN1856490A (zh) * 2003-07-28 2006-11-01 詹森药业有限公司 苯并咪唑、苯并噻唑和苯并噁唑衍生物及其作为lta4h调节剂的应用
CN1956983B (zh) 2004-05-24 2010-05-26 弗·哈夫曼-拉罗切有限公司 4-羟基-4-甲基-哌啶-1-甲酸(4-甲氧基-7-吗啉-4-基-苯并噻唑-2-基)-酰胺
EP1773795A1 (en) * 2004-07-22 2007-04-18 F.Hoffmann-La Roche Ag Substituted benzothiazoles
CN1989139B (zh) * 2004-07-22 2010-05-12 弗·哈夫曼-拉罗切有限公司 苯并噻唑衍生物
JP4633123B2 (ja) 2004-11-05 2011-02-16 エフ．ホフマン−ラ ロシュ アーゲー イソニコチン酸誘導体の製造方法
DE602006012815D1 (de) 2005-03-23 2010-04-22 Hoffmann La Roche Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
AU2006298829B2 (en) 2005-09-27 2011-03-03 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists
EP1994017A2 (en) * 2006-03-15 2008-11-26 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
WO2010008847A2 (en) * 2008-06-24 2010-01-21 Takeda Pharmaceutical Company Limited Pi3k/m tor inhibitors
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
AP2014007595A0 (en) * 2011-09-30 2014-04-30 Kineta Inc Anti-viral compounds
KR101996343B1 (ko) 2012-01-27 2019-07-05 고쿠리츠 다이가쿠 호진 교토 다이가쿠 전능성 줄기세포의 심근분화 유도방법
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
JP6333830B2 (ja) * 2013-09-13 2018-05-30 国立大学法人京都大学 多能性幹細胞の心筋分化を促進する化合物
EP3150705B1 (en) 2014-05-30 2019-05-15 Kyoto University Method for inducing myocardial differentiation of pluripotent stem cells using low-molecular compound
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
ZA893862B (en) 1991-01-30
CA1328871C (en) 1994-04-26
EP0343893B1 (en) 1992-08-05
IE891667L (en) 1989-11-24
EP0343893A1 (en) 1989-11-29
AU3509889A (en) 1989-11-30
MX16158A (es) 1993-06-01
NO892059D0 (no) 1989-05-23
DE68902358D1 (de) 1992-09-10
FI892498A0 (fi) 1989-05-23
MX173140B (es) 1994-02-02
KR910006864B1 (ko) 1991-09-09
MY106035A (en) 1995-03-31
NZ229234A (en) 1990-09-26
PL154875B1 (en) 1991-09-30
PT90622A (pt) 1989-11-30
JPH0678331B2 (ja) 1994-10-05
JPH0217181A (ja) 1990-01-22
YU105989A (en) 1990-08-31
SU1681728A3 (ru) 1991-09-30
NO172389C (no) 1993-07-14
DK249389D0 (da) 1989-05-23
PT90622B (pt) 1994-10-31
AU601905B2 (en) 1990-09-20
IL90337A0 (en) 1989-12-15
FI892498A7 (fi) 1989-11-25
GR3005844T3 (https=) 1993-06-07
ES2043012T3 (es) 1993-12-16
PL279613A1 (en) 1989-11-27
CN1037898A (zh) 1989-12-13
HUT51606A (en) 1990-05-28
ATE79114T1 (de) 1992-08-15
DD283815A5 (de) 1990-10-24
HU202507B (en) 1991-03-28
NO172389B (no) 1993-04-05
NO892059L (no) 1989-11-27
DE68902358T2 (de) 1992-12-10
YU47019B (sh) 1994-11-15
KR890017248A (ko) 1989-12-15
DK249389A (da) 1989-11-27

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