CN102307876B - 吗啡-6-葡萄糖苷酸或其一种衍生物的合成 - Google Patents

吗啡-6-葡萄糖苷酸或其一种衍生物的合成 Download PDF

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Publication number
CN102307876B
CN102307876B CN200980156211.1A CN200980156211A CN102307876B CN 102307876 B CN102307876 B CN 102307876B CN 200980156211 A CN200980156211 A CN 200980156211A CN 102307876 B CN102307876 B CN 102307876B
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CN
China
Prior art keywords
bis
morphin
formula
group
compound
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Expired - Fee Related
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CN200980156211.1A
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English (en)
Chinese (zh)
Other versions
CN102307876A (zh
Inventor
阿兰.德鲁巴拉
伊莎贝尔.里波切
克莱尔.特里坎特
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Sanofi Aventis France
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Sanofi Aventis France
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Publication of CN102307876A publication Critical patent/CN102307876A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200980156211.1A 2008-12-10 2009-12-08 吗啡-6-葡萄糖苷酸或其一种衍生物的合成 Expired - Fee Related CN102307876B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0806948 2008-12-10
FR0806948A FR2939436B1 (fr) 2008-12-10 2008-12-10 Synthese de morphine-6-glucuronide ou de l'un de ses derives
PCT/FR2009/052445 WO2010067007A2 (fr) 2008-12-10 2009-12-08 Synthese de morphine-6-glucuronide ou de l'un de ses derives

Publications (2)

Publication Number Publication Date
CN102307876A CN102307876A (zh) 2012-01-04
CN102307876B true CN102307876B (zh) 2014-12-10

Family

ID=40996840

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980156211.1A Expired - Fee Related CN102307876B (zh) 2008-12-10 2009-12-08 吗啡-6-葡萄糖苷酸或其一种衍生物的合成

Country Status (30)

Country Link
US (1) US8258298B2 (https=)
EP (1) EP2376496B1 (https=)
JP (1) JP5619768B2 (https=)
KR (1) KR20110091534A (https=)
CN (1) CN102307876B (https=)
AR (1) AR074513A1 (https=)
AU (1) AU2009326906B2 (https=)
BR (1) BRPI0923238A2 (https=)
CA (1) CA2746428A1 (https=)
CL (1) CL2011001398A1 (https=)
CO (1) CO6390060A2 (https=)
CR (1) CR20110307A (https=)
EA (1) EA201170790A1 (https=)
EC (1) ECSP11011100A (https=)
ES (1) ES2470666T3 (https=)
FR (1) FR2939436B1 (https=)
HN (1) HN2011001597A (https=)
IL (1) IL213379A0 (https=)
MA (1) MA32950B1 (https=)
MX (1) MX337925B (https=)
MY (1) MY152276A (https=)
NI (1) NI201100116A (https=)
NZ (1) NZ593342A (https=)
PE (1) PE20110836A1 (https=)
SG (1) SG172069A1 (https=)
TN (1) TN2011000243A1 (https=)
TW (1) TW201033218A (https=)
UA (1) UA103643C2 (https=)
WO (1) WO2010067007A2 (https=)
ZA (1) ZA201104657B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) * 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
WO1993003051A1 (en) * 1991-08-06 1993-02-18 Salford Ultrafine Chemicals And Research Limited A process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
WO1999064430A2 (en) * 1998-06-06 1999-12-16 Cenes Limited Morphine-6-glucuronide synthesis
WO2005063263A1 (fr) * 2003-12-22 2005-07-14 Syntem Nouveaux derives de la morphine-6-glucuronide, compositions pharmaceutiques les contenant, leur procede de preparation et leurs utilisations
CN1720054A (zh) * 2002-03-19 2006-01-11 布雷恩及比扬德生物科技公司 阿朴吗啡和其类似物的糖苷和原酸酯糖苷衍生物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
DE69815336T2 (de) 1997-04-14 2004-05-06 Ufc Ltd. Morphin-derivate
GB9914382D0 (en) * 1999-06-21 1999-08-18 Ufc Limited New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
KR20040014544A (ko) * 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) * 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
WO1993003051A1 (en) * 1991-08-06 1993-02-18 Salford Ultrafine Chemicals And Research Limited A process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
WO1999064430A2 (en) * 1998-06-06 1999-12-16 Cenes Limited Morphine-6-glucuronide synthesis
CN1720054A (zh) * 2002-03-19 2006-01-11 布雷恩及比扬德生物科技公司 阿朴吗啡和其类似物的糖苷和原酸酯糖苷衍生物及其用途
WO2005063263A1 (fr) * 2003-12-22 2005-07-14 Syntem Nouveaux derives de la morphine-6-glucuronide, compositions pharmaceutiques les contenant, leur procede de preparation et leurs utilisations

Also Published As

Publication number Publication date
SG172069A1 (en) 2011-07-28
ECSP11011100A (es) 2011-07-29
WO2010067007A3 (fr) 2011-07-07
HN2011001597A (es) 2013-09-09
ES2470666T3 (es) 2014-06-24
CO6390060A2 (es) 2012-02-29
MY152276A (en) 2014-09-15
UA103643C2 (ru) 2013-11-11
PE20110836A1 (es) 2011-11-25
TW201033218A (en) 2010-09-16
FR2939436A1 (fr) 2010-06-11
JP5619768B2 (ja) 2014-11-05
EA201170790A1 (ru) 2011-12-30
NZ593342A (en) 2013-07-26
KR20110091534A (ko) 2011-08-11
CR20110307A (es) 2011-09-21
EP2376496A2 (fr) 2011-10-19
AR074513A1 (es) 2011-01-19
AU2009326906A1 (en) 2011-06-30
FR2939436B1 (fr) 2010-12-17
AU2009326906B2 (en) 2016-05-26
CA2746428A1 (fr) 2010-06-17
TN2011000243A1 (fr) 2012-12-17
CN102307876A (zh) 2012-01-04
JP2012511551A (ja) 2012-05-24
ZA201104657B (en) 2012-09-26
HK1163096A1 (en) 2012-09-07
WO2010067007A2 (fr) 2010-06-17
BRPI0923238A2 (pt) 2016-01-26
US20110275820A1 (en) 2011-11-10
CL2011001398A1 (es) 2011-10-28
MA32950B1 (fr) 2012-01-02
IL213379A0 (en) 2011-07-31
EP2376496B1 (fr) 2014-03-12
MX2011006264A (es) 2011-11-04
NI201100116A (es) 2011-12-14
MX337925B (es) 2016-03-28
US8258298B2 (en) 2012-09-04

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Granted publication date: 20141210

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