CN102241742B - 结合血小板生成素受体的肽和化合物 - Google Patents

结合血小板生成素受体的肽和化合物 Download PDF

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Publication number
CN102241742B
CN102241742B CN201110134196.XA CN201110134196A CN102241742B CN 102241742 B CN102241742 B CN 102241742B CN 201110134196 A CN201110134196 A CN 201110134196A CN 102241742 B CN102241742 B CN 102241742B
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China
Prior art keywords
peptide
acid
group
tpo
compound
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Expired - Lifetime
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CN201110134196.XA
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English (en)
Chinese (zh)
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CN102241742A (zh
Inventor
B·R·麦唐纳德
J·K·维斯
E·J·尤尔科
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3 Dimensional Pharmaceuticals Inc
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3 Dimensional Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
CN201110134196.XA 2003-08-28 2004-08-13 结合血小板生成素受体的肽和化合物 Expired - Lifetime CN102241742B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49874003P 2003-08-28 2003-08-28
US60/498,740 2003-08-28
US60/498740 2003-08-28

Related Parent Applications (1)

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CN2004800314520A Division CN1871022B (zh) 2003-08-28 2004-08-13 结合血小板生成素受体的肽和化合物

Publications (2)

Publication Number Publication Date
CN102241742A CN102241742A (zh) 2011-11-16
CN102241742B true CN102241742B (zh) 2014-04-02

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CN201110134196.XA Expired - Lifetime CN102241742B (zh) 2003-08-28 2004-08-13 结合血小板生成素受体的肽和化合物
CN2004800314520A Expired - Lifetime CN1871022B (zh) 2003-08-28 2004-08-13 结合血小板生成素受体的肽和化合物

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CN2004800314520A Expired - Lifetime CN1871022B (zh) 2003-08-28 2004-08-13 结合血小板生成素受体的肽和化合物

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US (1) US7576056B2 (enExample)
EP (1) EP1675606B1 (enExample)
JP (1) JP4848277B2 (enExample)
KR (2) KR101183875B1 (enExample)
CN (2) CN102241742B (enExample)
AR (1) AR045530A1 (enExample)
AU (1) AU2004270656B2 (enExample)
BR (1) BRPI0414008B8 (enExample)
CA (1) CA2537421C (enExample)
CY (1) CY1118965T1 (enExample)
DK (1) DK1675606T3 (enExample)
EA (1) EA009286B1 (enExample)
EC (1) ECSP066396A (enExample)
ES (1) ES2626107T3 (enExample)
HR (1) HRP20170810T1 (enExample)
HU (1) HUE032370T2 (enExample)
IL (1) IL173965A (enExample)
IS (1) IS8300A (enExample)
LT (1) LT1675606T (enExample)
ME (1) ME00313B (enExample)
MX (1) MXPA06002292A (enExample)
NO (1) NO344233B1 (enExample)
NZ (1) NZ545455A (enExample)
PL (1) PL1675606T3 (enExample)
PT (1) PT1675606T (enExample)
RS (2) RS56387B1 (enExample)
SG (1) SG131110A1 (enExample)
SI (1) SI1675606T1 (enExample)
TW (1) TWI348375B (enExample)
UA (1) UA82710C2 (enExample)
WO (1) WO2005023834A2 (enExample)
ZA (1) ZA200602495B (enExample)

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US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
DK1783222T3 (da) 1998-10-23 2012-07-09 Kirin Amgen Inc Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
MXPA05003057A (es) * 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
UA82710C2 (uk) 2003-08-28 2008-05-12 Орто-Макнейл Фармацевтикал, Инк. Пептид, що зв'язується з тромбопоетиновим рецептором (варіанти), та спосіб лікування тромбоциторенії (варіанти)
US7615533B2 (en) 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
AU2007208226A1 (en) * 2006-01-25 2007-08-02 Amgen Inc. Thrombopoietic compounds
TWI458488B (zh) * 2006-02-14 2014-11-01 Janssen Pharmaceutica Nv Ｔｐｏ胜肽化合物及醫藥組成物於治療貧血之用途
CN101374540B (zh) * 2006-02-14 2013-03-06 詹森药业有限公司 Tpo肽化合物和药物组合物在治疗贫血中的用途
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
EP2307041B1 (en) * 2008-06-03 2019-03-13 Janssen Pharmaceutica, N.V. Tpo mimetic peptide for preventing hematological disorder associated with cancer treatment
JP5709113B2 (ja) 2011-06-23 2015-04-30 株式会社島津製作所 分岐型両親媒性ブロックポリマー、それを用いた分子集合体及び薬剤搬送システム
EP3658191A1 (en) * 2017-07-26 2020-06-03 Janssen Pharmaceutica NV Methods of protecting vascular integrity induced by targeted radiation therapy
WO2020209920A2 (en) 2019-01-25 2020-10-15 Janssen Pharmaceutica Nv Methods of mitigating toxic effects of vesicants and caustic gas
JP7664163B2 (ja) 2019-01-25 2025-04-17 ヤンセン ファーマシューティカ エヌ．ベー． 全身照射／化学曝露に対する応答において臓器および血管損傷、造血回復ならびに生存に対する保護を増強する方法
MA54820A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques
CA3234340A1 (en) 2021-10-01 2023-04-06 Janssen Pharmaceutica N.V. Methods of increasing progenitor cell production
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

Citations (2)

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CN1192749A (zh) * 1995-06-07 1998-09-09 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
CN1245504A (zh) * 1996-12-11 2000-02-23 葛兰素集团有限公司 与受体结合的肽和化合物

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UA82710C2 (uk) 2003-08-28 2008-05-12 Орто-Макнейл Фармацевтикал, Инк. Пептид, що зв'язується з тромбопоетиновим рецептором (варіанти), та спосіб лікування тромбоциторенії (варіанти)

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CN1192749A (zh) * 1995-06-07 1998-09-09 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
CN1245504A (zh) * 1996-12-11 2000-02-23 葛兰素集团有限公司 与受体结合的肽和化合物

Also Published As

Publication number Publication date
RS20060141A (sr) 2008-08-07
PT1675606T (pt) 2017-05-22
BRPI0414008B1 (pt) 2018-05-15
ME00313B (me) 2011-05-10
EP1675606A4 (en) 2009-09-30
DK1675606T3 (en) 2017-06-19
AU2004270656A1 (en) 2005-03-17
SI1675606T1 (sl) 2017-07-31
JP4848277B2 (ja) 2011-12-28
EP1675606A2 (en) 2006-07-05
UA82710C2 (uk) 2008-05-12
CN1871022A (zh) 2006-11-29
LT1675606T (lt) 2017-11-10
IL173965A (en) 2015-10-29
MEP48508A (en) 2011-02-10
ES2626107T3 (es) 2017-07-24
IL173965A0 (en) 2006-07-05
KR101183875B1 (ko) 2012-09-27
KR20120078742A (ko) 2012-07-10
TW200517103A (en) 2005-06-01
ZA200602495B (en) 2007-06-27
HRP20170810T1 (hr) 2017-08-11
CA2537421C (en) 2011-09-27
US20050137133A1 (en) 2005-06-23
NO344233B1 (no) 2019-10-14
NO20061346L (no) 2006-05-22
SG131110A1 (en) 2007-04-26
JP2007504132A (ja) 2007-03-01
HUE032370T2 (en) 2017-09-28
WO2005023834A2 (en) 2005-03-17
US7576056B2 (en) 2009-08-18
MXPA06002292A (es) 2006-09-04
KR20070017942A (ko) 2007-02-13
RS56387B1 (sr) 2017-12-29
CN102241742A (zh) 2011-11-16
AU2004270656B2 (en) 2011-03-10
NZ545455A (en) 2009-02-28
BRPI0414008A (pt) 2006-10-24
BRPI0414008B8 (pt) 2021-05-25
TWI348375B (en) 2011-09-11
HK1096873A1 (en) 2007-06-15
CN1871022B (zh) 2011-07-06
WO2005023834A3 (en) 2005-05-06
EA009286B1 (ru) 2007-12-28
AR045530A1 (es) 2005-11-02
CY1118965T1 (el) 2018-01-10
IS8300A (is) 2006-02-14
PL1675606T3 (pl) 2017-08-31
EP1675606B1 (en) 2017-04-05
EA200600477A1 (ru) 2007-02-27
CA2537421A1 (en) 2005-03-17
ECSP066396A (es) 2006-08-30

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