CN102089279A - 用于治疗炎症的联芳基pde4抑制剂 - Google Patents

用于治疗炎症的联芳基pde4抑制剂 Download PDF

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CN102089279A
CN102089279A CN2008801251758A CN200880125175A CN102089279A CN 102089279 A CN102089279 A CN 102089279A CN 2008801251758 A CN2008801251758 A CN 2008801251758A CN 200880125175 A CN200880125175 A CN 200880125175A CN 102089279 A CN102089279 A CN 102089279A
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alkyl
nhc
amino
salt
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J·辛格
M·E.·格尼
A·布尔金
V·桑达纳亚卡
A·吉谢廖夫
A·莫塔
G·舒尔茨
G·哈泰干
T·哈根
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Decode Genetics ehf
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012408A (zh) * 2012-11-28 2013-04-03 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
CN110041253A (zh) * 2018-01-17 2019-07-23 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
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CN117756794A (zh) * 2023-12-18 2024-03-26 和径医药科技（上海）有限公司 一种含氮杂环类化合物及其制备方法和应用
CN118994115A (zh) * 2024-07-29 2024-11-22 宁波大学 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2644069A1 (en) 2006-02-28 2007-09-07 Helicon Therapeutics, Inc. Therapeutic piperazines as pde4 inhibitors
EP2222639A1 (en) 2007-11-21 2010-09-01 Decode Genetics EHF Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders
WO2010059838A2 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects
JP5860459B2 (ja) 2010-06-30 2016-02-16 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激薬
WO2012018980A2 (en) 2010-08-04 2012-02-09 Yun Michael Shim Compositions and methods for treating inflammatory diseases
ES2572803T3 (es) 2010-11-09 2016-06-02 Ironwood Pharmaceuticals, Inc. Estimuladores de GCs
ES2586908T3 (es) * 2010-12-24 2016-10-19 Merck Sharp & Dohme B.V. Derivados de azetidina N-sustituidos
CN102617457A (zh) * 2011-01-28 2012-08-01 天津药物研究院 一种制备罗氟司特的新方法
CN103012255B (zh) * 2011-09-21 2014-06-11 天津康鸿医药科技发展有限公司 罗氟司特晶型化合物、其制备方法、组合物及应用
CN102603676B (zh) * 2012-02-20 2014-02-12 徐江平 一种能避免呕吐反应的磷酸二酯酶4抑制剂
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9073875B2 (en) 2012-11-20 2015-07-07 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
EP3345902B1 (en) 2013-03-14 2019-10-30 Dart Neuroscience (Cayman) Ltd. Substituted pyridine and pyrazine compounds as pde4 inhibitors
JP2017513926A (ja) 2014-03-14 2017-06-01 ウォックハート リミテッド ナトリウム（２ｓ，５ｒ）−６−（ベンジルオキシ）−７−オキソ−１，６−ジアザビシクロ［３．２．１］オクタン−２−カルボキシレートを調製する方法
SI3209655T1 (sl) 2014-10-24 2020-11-30 Landos Biopharma, Inc. Terapevtiki na osnovi C-podobne lantionin sintetaze 2
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2018006795A1 (zh) * 2016-07-05 2018-01-11 广州再极医药科技有限公司 芳香乙炔或芳香乙烯类化合物、其中间体、制备方法、药物组合物及应用
EA202091325A1 (ru) 2017-11-30 2020-08-28 Лэндос Байофарма, Инк. Способы лечения с помощью лигандов лантионин c-подобного белка 2 и подготовленных с их помощью клеток
CN109988144B (zh) 2017-12-29 2024-07-05 广州再极医药科技有限公司 芳香乙烯或芳香乙基类衍生物、其制备方法、中间体、药物组合物及应用
JP2022531129A (ja) * 2019-04-23 2022-07-06 テトラ ディスカバリー パートナーズ インコーポレイテッド Ｐｄｅ４ｄ阻害剤としての３－ヒドロキシ－２－フェニル－６－（ピラゾール－４－イルメチル）ピリジン誘導体
WO2021127472A1 (en) 2019-12-20 2021-06-24 Landos Biopharma, Inc. Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same
US20240101552A1 (en) 2020-09-18 2024-03-28 Shanghai Pharmaceuticals Holding Co., Ltd. Carbonyl heterocyclic compound and application thereof
KR102514860B1 (ko) * 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물
CN119819277B (zh) * 2025-03-17 2025-05-27 昆明医科大学 一种基于BINAM的β-环糊精衍生物手性固定相及其制备方法和应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3778430D1 (en) * 1986-06-20 1992-05-27 Idemitsu Kosan Co Polycarbonate.
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
CA2144669A1 (en) * 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
EP0793662A1 (en) * 1994-11-23 1997-09-10 Neurogen Corporation Aminomethyl aryl compounds; dopamine receptor subtype selective ligands
US5594141A (en) * 1994-11-23 1997-01-14 Neurogen Corporation Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
WO1997003967A1 (en) * 1995-07-22 1997-02-06 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
GB9604926D0 (en) * 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
FR2754260B1 (fr) * 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4321737B2 (ja) * 1997-12-17 2009-08-26 塩野義製薬株式会社 新規ピリジン化合物
EP1066257A2 (en) * 1998-03-26 2001-01-10 Sugen, Inc. Heterocylic classes of compounds for the modulating tyrosine protein kinase
EP1112262B1 (en) * 1998-09-09 2004-08-04 Inflazyme Pharmaceuticals Ltd. Substituted gamma-phenyl-delta-lactones and analogs thereof and uses related thereto
EP1227086B1 (en) * 1999-10-22 2006-03-29 Takeda Pharmaceutical Company Limited 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
PL373912A1 (en) * 2001-03-07 2005-09-19 Incyte San Diego, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
US6747048B2 (en) * 2002-05-08 2004-06-08 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
US7960369B2 (en) * 2002-11-08 2011-06-14 Takeda Pharmaceutical Company Limited Receptor function regulator
CN1791580A (zh) * 2003-03-24 2006-06-21 麦克公司 联芳基取代的6元杂环钠通道阻滞剂
CN1798738A (zh) * 2003-04-03 2006-07-05 麦克公司 作为钠通道阻滞剂的联芳基取代吡唑
US7557143B2 (en) * 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
WO2005030206A1 (en) * 2003-09-24 2005-04-07 Imclone Systems Incorporated Aryl-1,3-azole derivatives and methods for inhibiting heparnase activity
DE602004031667D1 (de) * 2003-11-10 2011-04-14 Merck & Co Inc Substituierte trialzole als blocker des natriumkanals
CA2546601A1 (en) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
BRPI0418148A (pt) * 2003-12-25 2007-04-17 Takeda Pharmaceutical composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto
AP2007003980A0 (en) * 2004-11-23 2007-06-30 Pfizer Prod Inc Dibenzylamine compounds and derivatives
KR101316992B1 (ko) * 2004-12-23 2013-10-11 갈데르마 리써어치 앤드 디벨로프먼트 Ｒａｒ 수용체를 조절하는 신규 리간드, 및 인간 의학 및화장품에서의 그의 용도
KR20070107022A (ko) * 2005-01-07 2007-11-06 신타 파마슈티칼스 코프. 염증 및 면역 관련 용도를 위한 화합물
DK2774925T3 (en) * 2005-11-08 2017-02-27 Vertex Pharma Heterocyclic modulators of ATP binding cassette transporters
NZ569327A (en) * 2005-12-28 2011-09-30 Vertex Pharma 1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis
WO2007079186A2 (en) * 2005-12-30 2007-07-12 Merck & Co., Inc. 1, 3-oxazolidin-2-one derivatives useful as cetp inhibitors
UA93548C2 (uk) * 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
EP2036887A1 (en) * 2006-06-28 2009-03-18 Sanwa Kagaku Kenkyusho Co., Ltd Novel 6-5 bicycic heterocyclic derivative and medical use thereof
CN102516115B (zh) * 2006-08-09 2016-05-11 史密丝克莱恩比彻姆公司 作为阿片样物质受体的拮抗剂或反向激动剂的新型化合物
EP2132197A2 (en) * 2007-03-21 2009-12-16 Almirall, S.A. Substituted pyrimidines as adenosine receptor antagonists
EP2222639A1 (en) * 2007-11-21 2010-09-01 Decode Genetics EHF Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders
FR2932180B1 (fr) * 2008-06-04 2012-08-10 Centre Nat Rech Scient Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline

Cited By (10)

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CN103012408A (zh) * 2012-11-28 2013-04-03 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
CN103012408B (zh) * 2012-11-28 2015-02-04 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
CN110041253A (zh) * 2018-01-17 2019-07-23 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
CN110041253B (zh) * 2018-01-17 2022-03-29 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
CN113912593A (zh) * 2020-07-10 2022-01-11 启元生物(杭州)有限公司 一种氘代吡啶酮类化合物及其应用
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺
CN117756794A (zh) * 2023-12-18 2024-03-26 和径医药科技（上海）有限公司 一种含氮杂环类化合物及其制备方法和应用
CN117756794B (zh) * 2023-12-18 2024-07-16 和径医药科技（上海）有限公司 一种含氮杂环类化合物及其制备方法和应用
CN118994115A (zh) * 2024-07-29 2024-11-22 宁波大学 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用
CN118994115B (zh) * 2024-07-29 2025-09-09 宁波大学 治疗甲基苯丙胺成瘾及认知障碍的新化合物制备和应用

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Application publication date: 20110608