CN102036970A - 制备3,6-二氢-1,3,5-三嗪衍生物的方法 - Google Patents

制备3,6-二氢-1,3,5-三嗪衍生物的方法 Download PDF

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Publication number
CN102036970A
CN102036970A CN2009801188956A CN200980118895A CN102036970A CN 102036970 A CN102036970 A CN 102036970A CN 2009801188956 A CN2009801188956 A CN 2009801188956A CN 200980118895 A CN200980118895 A CN 200980118895A CN 102036970 A CN102036970 A CN 102036970A
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CN
China
Prior art keywords
compound
formula
process according
dihydro
synthesis
Prior art date
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Pending
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CN2009801188956A
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English (en)
Chinese (zh)
Inventor
斯特凡尼·奥布格
贝纳德·布代
丹尼尔·克拉沃
马蒂亚斯·赫尔莫里奇
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Poxel SA
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Poxel SA
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Publication of CN102036970A publication Critical patent/CN102036970A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2009801188956A 2008-05-23 2009-04-24 制备3,6-二氢-1,3,5-三嗪衍生物的方法 Pending CN102036970A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08009483.2 2008-05-23
EP08009483 2008-05-23
PCT/EP2009/002997 WO2009141040A2 (en) 2008-05-23 2009-04-24 Process for the synthesis of 3,6-dihydro-1,3,5-triazine derivatives

Publications (1)

Publication Number Publication Date
CN102036970A true CN102036970A (zh) 2011-04-27

Family

ID=40791625

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801188956A Pending CN102036970A (zh) 2008-05-23 2009-04-24 制备3,6-二氢-1,3,5-三嗪衍生物的方法

Country Status (21)

Country Link
US (1) US20110124860A1 (enExample)
EP (1) EP2300444B1 (enExample)
JP (1) JP5458093B2 (enExample)
KR (1) KR101618198B1 (enExample)
CN (1) CN102036970A (enExample)
AU (1) AU2009250149B2 (enExample)
BR (1) BRPI0912512B1 (enExample)
CA (1) CA2725011A1 (enExample)
CY (1) CY1117855T1 (enExample)
DK (1) DK2300444T3 (enExample)
EA (1) EA018921B1 (enExample)
ES (1) ES2571793T3 (enExample)
HR (1) HRP20160414T1 (enExample)
HU (1) HUE027532T2 (enExample)
IL (1) IL209198A (enExample)
MX (1) MX2010012741A (enExample)
PL (1) PL2300444T3 (enExample)
RS (1) RS54736B1 (enExample)
SI (1) SI2300444T1 (enExample)
WO (1) WO2009141040A2 (enExample)
ZA (1) ZA201009160B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105753801A (zh) * 2016-03-25 2016-07-13 浙江工业大学 一种均三嗪类化合物的制备方法
CN114681464A (zh) * 2020-12-28 2022-07-01 南京理工大学 二甲双胍类似物在制备脑缺血再灌注损伤预防和治疗药物中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103228635B (zh) 2010-12-01 2016-03-30 珀科赛尔 利用酒石酸分离三嗪衍生物对映异构体
BR112020006472A2 (pt) 2017-10-02 2020-10-06 Poxel método para tratamento ou prevenção de insuficiência cardíaca com fração de ejeção preservada (icfep)
CN111918655B (zh) 2018-06-06 2024-05-31 博希尔公司 治疗患有慢性肾脏疾病的糖尿病受试者的方法
KR20210003786A (ko) 2018-06-14 2021-01-12 폭셀 당뇨병의 치료에서 사용하기 위한 트리아진 유도체를 포함하는 필름 코팅정

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804113B1 (fr) * 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
BRPI0317188A8 (pt) * 2002-12-17 2018-05-08 Hamari Chemicals Ltd novo derivado de 2,4-diamino-1,3,5-triazina
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
DE102007054416A1 (de) * 2007-11-13 2009-05-14 Studiengesellschaft Kohle Mbh Verfahren zur Herstellung von 3,6-Dihydro-1,3,5- Triazin-Derivaten für die Behandlungen von Erkrankungen, die mit dem Insulinresistenz-Syndrom assoziiert sind

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105753801A (zh) * 2016-03-25 2016-07-13 浙江工业大学 一种均三嗪类化合物的制备方法
CN105753801B (zh) * 2016-03-25 2018-06-01 浙江工业大学 一种均三嗪类化合物的制备方法
CN114681464A (zh) * 2020-12-28 2022-07-01 南京理工大学 二甲双胍类似物在制备脑缺血再灌注损伤预防和治疗药物中的应用
CN114681464B (zh) * 2020-12-28 2024-07-09 南京理工大学 二甲双胍类似物在制备脑缺血再灌注损伤预防和治疗药物中的应用

Also Published As

Publication number Publication date
JP5458093B2 (ja) 2014-04-02
AU2009250149A1 (en) 2009-11-26
US20110124860A1 (en) 2011-05-26
WO2009141040A3 (en) 2010-01-21
BRPI0912512A2 (pt) 2015-07-28
CY1117855T1 (el) 2017-05-17
EA018921B1 (ru) 2013-11-29
IL209198A0 (en) 2011-01-31
HRP20160414T1 (hr) 2016-05-20
AU2009250149B2 (en) 2013-05-23
MX2010012741A (es) 2010-12-21
RS54736B1 (sr) 2016-10-31
KR20110013498A (ko) 2011-02-09
HUE027532T2 (en) 2016-10-28
KR101618198B1 (ko) 2016-05-04
PL2300444T3 (pl) 2016-08-31
DK2300444T3 (en) 2016-05-23
EP2300444A2 (en) 2011-03-30
EP2300444B1 (en) 2016-04-13
JP2011520930A (ja) 2011-07-21
IL209198A (en) 2013-11-28
WO2009141040A2 (en) 2009-11-26
CA2725011A1 (en) 2009-11-26
EA201001828A1 (ru) 2011-04-29
BRPI0912512B1 (pt) 2018-09-11
SI2300444T1 (sl) 2016-10-28
ES2571793T3 (es) 2016-05-26
ZA201009160B (en) 2011-10-26

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Application publication date: 20110427