KR101618198B1 - 3,6-디히드로-1,3,5-트리아진 유도체의 제조방법 - Google Patents

3,6-디히드로-1,3,5-트리아진 유도체의 제조방법 Download PDF

Info

Publication number
KR101618198B1
KR101618198B1 KR1020107028733A KR20107028733A KR101618198B1 KR 101618198 B1 KR101618198 B1 KR 101618198B1 KR 1020107028733 A KR1020107028733 A KR 1020107028733A KR 20107028733 A KR20107028733 A KR 20107028733A KR 101618198 B1 KR101618198 B1 KR 101618198B1
Authority
KR
South Korea
Prior art keywords
formula
compound
base
dihydro
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020107028733A
Other languages
English (en)
Korean (ko)
Other versions
KR20110013498A (ko
Inventor
스테파니 오부르
베르나르 부데
다니엘 크라보
마티아스 헬름라이히
Original Assignee
뽁셀 에스아에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 뽁셀 에스아에스 filed Critical 뽁셀 에스아에스
Publication of KR20110013498A publication Critical patent/KR20110013498A/ko
Application granted granted Critical
Publication of KR101618198B1 publication Critical patent/KR101618198B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020107028733A 2008-05-23 2009-04-24 3,6-디히드로-1,3,5-트리아진 유도체의 제조방법 Expired - Fee Related KR101618198B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08009483.2 2008-05-23
EP08009483 2008-05-23

Publications (2)

Publication Number Publication Date
KR20110013498A KR20110013498A (ko) 2011-02-09
KR101618198B1 true KR101618198B1 (ko) 2016-05-04

Family

ID=40791625

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107028733A Expired - Fee Related KR101618198B1 (ko) 2008-05-23 2009-04-24 3,6-디히드로-1,3,5-트리아진 유도체의 제조방법

Country Status (21)

Country Link
US (1) US20110124860A1 (enExample)
EP (1) EP2300444B1 (enExample)
JP (1) JP5458093B2 (enExample)
KR (1) KR101618198B1 (enExample)
CN (1) CN102036970A (enExample)
AU (1) AU2009250149B2 (enExample)
BR (1) BRPI0912512B1 (enExample)
CA (1) CA2725011A1 (enExample)
CY (1) CY1117855T1 (enExample)
DK (1) DK2300444T3 (enExample)
EA (1) EA018921B1 (enExample)
ES (1) ES2571793T3 (enExample)
HR (1) HRP20160414T1 (enExample)
HU (1) HUE027532T2 (enExample)
IL (1) IL209198A (enExample)
MX (1) MX2010012741A (enExample)
PL (1) PL2300444T3 (enExample)
RS (1) RS54736B1 (enExample)
SI (1) SI2300444T1 (enExample)
WO (1) WO2009141040A2 (enExample)
ZA (1) ZA201009160B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5758010B2 (ja) 2010-12-01 2015-08-05 ポクセルＰｏｘｅｌ 酒石酸によるトリアジン誘導体エナンチオマーの分離
CN105753801B (zh) * 2016-03-25 2018-06-01 浙江工业大学 一种均三嗪类化合物的制备方法
WO2019069230A1 (en) 2017-10-02 2019-04-11 Poxel METHODS OF TREATING CARDIAC INSUFFICIENCY WITH PRESERVED EJECTION FRACTION
TWI846700B (zh) 2018-06-06 2024-07-01 瑞士商梅萬特科學公司 治療患有慢性腎臟病之糖尿病患者之方法
MX2020013567A (es) 2018-06-14 2021-05-27 Poxel Tableta recubierta con pelicula que comprende un derivado de triazina para su uso en el tratamiento de la diabetes.
CN114681464B (zh) * 2020-12-28 2024-07-09 南京理工大学 二甲双胍类似物在制备脑缺血再灌注损伤预防和治疗药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804113B1 (fr) * 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
EP1574503B1 (en) * 2002-12-17 2013-03-13 Hamari Chemicals, Ltd. 2,4-Diamino-1,3,5-triazine derivative
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
DE102007054416A1 (de) * 2007-11-13 2009-05-14 Studiengesellschaft Kohle Mbh Verfahren zur Herstellung von 3,6-Dihydro-1,3,5- Triazin-Derivaten für die Behandlungen von Erkrankungen, die mit dem Insulinresistenz-Syndrom assoziiert sind

Also Published As

Publication number Publication date
ZA201009160B (en) 2011-10-26
EP2300444B1 (en) 2016-04-13
WO2009141040A2 (en) 2009-11-26
SI2300444T1 (sl) 2016-10-28
BRPI0912512B1 (pt) 2018-09-11
HRP20160414T1 (hr) 2016-05-20
BRPI0912512A2 (pt) 2015-07-28
EA201001828A1 (ru) 2011-04-29
IL209198A (en) 2013-11-28
AU2009250149A1 (en) 2009-11-26
DK2300444T3 (en) 2016-05-23
RS54736B1 (sr) 2016-10-31
WO2009141040A3 (en) 2010-01-21
ES2571793T3 (es) 2016-05-26
AU2009250149B2 (en) 2013-05-23
EP2300444A2 (en) 2011-03-30
CA2725011A1 (en) 2009-11-26
IL209198A0 (en) 2011-01-31
JP2011520930A (ja) 2011-07-21
MX2010012741A (es) 2010-12-21
JP5458093B2 (ja) 2014-04-02
CN102036970A (zh) 2011-04-27
KR20110013498A (ko) 2011-02-09
EA018921B1 (ru) 2013-11-29
HUE027532T2 (en) 2016-10-28
US20110124860A1 (en) 2011-05-26
CY1117855T1 (el) 2017-05-17
PL2300444T3 (pl) 2016-08-31

Similar Documents

Publication Publication Date Title
KR101618198B1 (ko) 3,6-디히드로-1,3,5-트리아진 유도체의 제조방법
TWI496781B (zh) 製備｛４，６－二胺基－２－［１－（２－氟苯甲基）－１Ｈ－吡唑并［３，４－ｂ］吡啶－３－基］嘧啶－５－基｝甲基胺基甲酸甲酯之方法及其使用作為醫藥活性化合物之純化
EP1760073A1 (en) Sulfonamide compound
RU2509763C2 (ru) Способ получения промежуточных соединений нафталин-2-ил-пиразол-3-она, используемых в синтезе ингибиторов сигма рецептора
KR20120098815A (ko) 메틸-｛4,6-디아미노-2-［1-(2-플루오로벤질)-1ｈ-피라졸로［3,4-ｂ］피리디노-3-일］피리미디노-5-일｝카르바메이트의 제조 방법 및 제약 물질로서의 그의 사용을 위한 그의 정제
KR101624340B1 (ko) 신규 클로로겐산 유도체 및 이를 유효성분으로 포함하는 염증성 질환 치료용 조성물
WO2017189339A1 (en) Process for the preparation of n-[(5-pyrimidinyl)methyl]-2-pyridinamines
JP2011503124A (ja) ３，６−ジヒドロ−１，３，５−トリアジン誘導体の製造方法
SK14802002A3 (sk) Nový spôsob prípravy medziproduktu torsemidu
KR20040072665A (ko) [1,4,5]-옥사디아제핀 유도체의 제조방법
EP1982983B1 (en) Improved process for producing moxonidine
WO2004082685A1 (en) Process for the preparation of donepezil and derivatives thereof
HU197878B (en) Process for producing guanidino-benzoic acid esters and pharmaceutical compositions containing them
JP4636525B2 (ja) トランス−４−アミノ−１−シクロヘキサンカルボン酸エチルエステルの塩およびその製造方法
US7019009B2 (en) Acyl derivatives of 5-(2-(4-(1,2 benzisothiazole-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one having neuroleptic activity
EP3794001B1 (en) Intermediates and processes for the preparation of linagliptin and its salts
JP4502280B2 (ja) スルファミンカルボン酸誘導体の製造方法
RU2649006C2 (ru) Способ синтеза гидразина, который можно применять при лечении вируса папилломы
US7189855B2 (en) Process for production of phenoxy-substituted 2-pyridone compounds
AU2005298824B2 (en) A process for the preparation of [1,4,5]-oxadiazepane derivatives

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20190422

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20220429

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20220429

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301