CN102015754A - 克雷伯菌（Klebsiella）抗原 - Google Patents

克雷伯菌（Klebsiella）抗原 Download PDF

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Publication number
CN102015754A
CN102015754A CN2008800222372A CN200880022237A CN102015754A CN 102015754 A CN102015754 A CN 102015754A CN 2008800222372 A CN2008800222372 A CN 2008800222372A CN 200880022237 A CN200880022237 A CN 200880022237A CN 102015754 A CN102015754 A CN 102015754A
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CN
China
Prior art keywords
seq
amino acids
klebsiella
antigen
pneumoniae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008800222372A
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English (en)
Chinese (zh)
Inventor
S·巴克施
T·希普斯
M·哈内
J·皮卡洛
C·萨特格
E·纳吉
U·伦德伯格
D·齐勒
A·迈因克
B·诺伊杰斯
U·斯特施内德
A·范格贝恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valneva Austria GmbH
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Intercell Austria AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Intercell Austria AG filed Critical Intercell Austria AG
Publication of CN102015754A publication Critical patent/CN102015754A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0266—Klebsiella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2008800222372A 2007-05-02 2008-04-29 克雷伯菌（Klebsiella）抗原 Pending CN102015754A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07107344 2007-05-02
EP07107344.9 2007-05-02
PCT/EP2008/055214 WO2008135446A2 (en) 2007-05-02 2008-04-29 Klebsiella antigens

Publications (1)

Publication Number Publication Date
CN102015754A true CN102015754A (zh) 2011-04-13

Family

ID=39708006

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800222372A Pending CN102015754A (zh) 2007-05-02 2008-04-29 克雷伯菌（Klebsiella）抗原

Country Status (7)

Country Link
US (3) US8236326B2 (enExample)
EP (5) EP2152731A2 (enExample)
JP (1) JP2010532657A (enExample)
CN (1) CN102015754A (enExample)
AU (1) AU2008248755A1 (enExample)
CA (1) CA2685805A1 (enExample)
WO (1) WO2008135446A2 (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921086A (zh) * 2015-08-24 2018-04-17 免疫医疗有限责任公司 MrkA多肽、抗体及其用途
CN109689090A (zh) * 2016-08-05 2019-04-26 免疫医疗有限责任公司 抗o2抗体及其用途
CN109843917A (zh) * 2016-10-19 2019-06-04 免疫医疗有限责任公司 抗o1抗体及其用途
CN110540599A (zh) * 2018-12-20 2019-12-06 湖北工业大学 基于肺炎克雷伯菌表面蛋白抗体的肺炎克雷伯菌Elisa检测试剂盒及制备方法
CN110540600A (zh) * 2018-12-20 2019-12-06 湖北工业大学 基于肺炎克雷伯菌表面蛋白的乳胶微球免疫层析试纸的制备方法
CN110540595A (zh) * 2018-12-20 2019-12-06 湖北工业大学 一种肺炎克雷伯菌抗体乳胶微球免疫层析检测试纸的制备方法
CN111150839A (zh) * 2019-12-17 2020-05-15 中国科学院深圳先进技术研究院 一种用于免疫接种的组合物及其制备方法
CN112505324A (zh) * 2020-11-06 2021-03-16 杭州迅耀生物科技有限公司 一种新型冠状病毒检测方法
CN115838431A (zh) * 2022-07-08 2023-03-24 中国人民解放军陆军军医大学 一种用作肺炎克雷伯菌疫苗抗原的融合蛋白KP-Ag2及其应用
CN116033922A (zh) * 2021-08-25 2023-04-28 北京三诺佳邑生物技术有限责任公司 特异性识别肺炎克雷伯菌o1抗原的抗体及其应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2152731A2 (en) * 2007-05-02 2010-02-17 Intercell AG Klebsiella antigens
AU2009287339B2 (en) * 2008-08-28 2015-11-26 The University Of Queensland Mutant bacterial glycoproteins and uses thereof
WO2013112696A1 (en) * 2012-01-27 2013-08-01 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Compositions and methods for immunization against bacteria expressing a carbapenemase
KR101605846B1 (ko) * 2013-11-20 2016-03-23 한국과학기술연구원 클렙시엘라 뉴모니아에 특이적으로 결합하는 단일가닥 핵산 앱타머 및 이를 이용한 클렙시엘라 뉴모니아 검출 방법
EP4279080A3 (en) * 2015-01-12 2024-02-21 Evaxion Biotech A/S Treatment and prophylaxis of k. pneumoniae infection
CA2991907A1 (en) * 2015-07-10 2017-01-19 Douglas T. Burkhardt Proteins and immunizing compositions containing klebsiella proteins and methods of use
MX2018005015A (es) * 2015-10-28 2019-06-24 Arsanis Biosciences Gmbh Anticuerpos dirigidos a un antigeno-o de manano de la k. pneumoniae.
EP3497124A1 (en) 2016-08-12 2019-06-19 ARSANIS Biosciences GmbH Klebsiella pneumoniae o3 specific antibodies

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US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
WO1991018088A1 (en) 1990-05-23 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Adeno-associated virus (aav)-based eucaryotic vectors
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DK0464533T3 (da) 1990-06-28 1999-04-26 Gen Hospital Corp Fusionsproteiner med immunglobulindele, deres fremstilling og anvendelse
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RS50101B (sr) 1996-02-24 2009-01-22 Boehringer Ingelheim International Gmbh., Farmaceutski preparati za imunomodulaciju
JP2001504448A (ja) 1996-08-30 2001-04-03 フュルステ，イェンス，ペーター 核酸の鏡面対称選択および進化
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US6958239B2 (en) 1996-11-21 2005-10-25 Oligos Etc Inc. Three component chimeric antisense oligonucleotides
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
DE19803453A1 (de) 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
AT408721B (de) 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
AT409085B (de) 2000-01-28 2002-05-27 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
WO2001078767A2 (en) 2000-04-14 2001-10-25 Cistem Biotechnologies Gmbh Pharmaceutical preparations comprising modified peptides
AT410173B (de) 2000-06-08 2003-02-25 Cistem Biotechnologies Gmbh Antigene zusammensetzung
RU2413520C2 (ru) 2000-06-08 2011-03-10 Интерселл Аг Вакцинная композиция, содержащая иммуностимулирующие олигодезоксинуклеотиды
CA2418854A1 (en) 2000-08-17 2002-02-21 Jorg Fritz A vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide or a derivative thereof
AT410635B (de) 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
EP1390495B1 (en) 2001-05-21 2007-07-04 Intercell AG Immunostimulatory oligodeoxynucleic molecules
WO2003047602A1 (en) 2001-12-07 2003-06-12 Intercell Ag Immunostimulatory oligodeoxynucleotides
WO2005103073A2 (en) * 2004-04-27 2005-11-03 Intercell Ag Td antigens
EP2152731A2 (en) * 2007-05-02 2010-02-17 Intercell AG Klebsiella antigens
DE102012005675A1 (de) 2012-03-21 2013-09-26 Daimler Ag Kraftfahrzeugantriebsstrangvorrichtung mit einem Mehrgruppengetriebe

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921086A (zh) * 2015-08-24 2018-04-17 免疫医疗有限责任公司 MrkA多肽、抗体及其用途
CN109689090A (zh) * 2016-08-05 2019-04-26 免疫医疗有限责任公司 抗o2抗体及其用途
US12312397B2 (en) 2016-08-05 2025-05-27 Medimmune, Llc Anti-O2 antibodies and uses thereof
CN109689090B (zh) * 2016-08-05 2023-12-26 免疫医疗有限责任公司 抗o2抗体及其用途
CN109843917B (zh) * 2016-10-19 2023-10-03 免疫医疗有限责任公司 抗o1抗体及其用途
CN109843917A (zh) * 2016-10-19 2019-06-04 免疫医疗有限责任公司 抗o1抗体及其用途
US12018068B2 (en) 2016-10-19 2024-06-25 Medimmune, Llc Anti-O1 antibodies and uses thereof
CN110540599A (zh) * 2018-12-20 2019-12-06 湖北工业大学 基于肺炎克雷伯菌表面蛋白抗体的肺炎克雷伯菌Elisa检测试剂盒及制备方法
CN110540600A (zh) * 2018-12-20 2019-12-06 湖北工业大学 基于肺炎克雷伯菌表面蛋白的乳胶微球免疫层析试纸的制备方法
CN110540595A (zh) * 2018-12-20 2019-12-06 湖北工业大学 一种肺炎克雷伯菌抗体乳胶微球免疫层析检测试纸的制备方法
CN111150839A (zh) * 2019-12-17 2020-05-15 中国科学院深圳先进技术研究院 一种用于免疫接种的组合物及其制备方法
CN112505324A (zh) * 2020-11-06 2021-03-16 杭州迅耀生物科技有限公司 一种新型冠状病毒检测方法
CN116033922A (zh) * 2021-08-25 2023-04-28 北京三诺佳邑生物技术有限责任公司 特异性识别肺炎克雷伯菌o1抗原的抗体及其应用
CN115838431A (zh) * 2022-07-08 2023-03-24 中国人民解放军陆军军医大学 一种用作肺炎克雷伯菌疫苗抗原的融合蛋白KP-Ag2及其应用

Also Published As

Publication number Publication date
EP2338902A8 (en) 2011-08-03
EP2360177A1 (en) 2011-08-24
WO2008135446A3 (en) 2009-03-12
WO2008135446A2 (en) 2008-11-13
US20110236410A1 (en) 2011-09-29
EP2497779A1 (en) 2012-09-12
CA2685805A1 (en) 2008-11-13
US20130011403A1 (en) 2013-01-10
EP2489673A3 (en) 2012-09-12
US8637052B2 (en) 2014-01-28
EP2152731A2 (en) 2010-02-17
US20130230526A9 (en) 2013-09-05
JP2010532657A (ja) 2010-10-14
US8236326B2 (en) 2012-08-07
EP2338902A1 (en) 2011-06-29
AU2008248755A1 (en) 2008-11-13
EP2489673A2 (en) 2012-08-22
US20140212448A1 (en) 2014-07-31

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Application publication date: 20110413