JP2010532657A - クレブシエラ属の抗原 - Google Patents

クレブシエラ属の抗原 Download PDF

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Publication number
JP2010532657A
JP2010532657A JP2010504730A JP2010504730A JP2010532657A JP 2010532657 A JP2010532657 A JP 2010532657A JP 2010504730 A JP2010504730 A JP 2010504730A JP 2010504730 A JP2010504730 A JP 2010504730A JP 2010532657 A JP2010532657 A JP 2010532657A
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Japan
Prior art keywords
seq
amino acids
antigen
nucleic acid
klebsiella
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JP2010504730A
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Japanese (ja)
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JP2010532657A5 (enExample
Inventor
シャーミラ バクシ
トマス シップス
マルクス ハナー
ジュッタ ピカロ
クリスティーナ サッケ
エスター ナージ
アーバン ランドバーグ
ダグマー ツィーレル
アンドリアス メインケ
ビルギット ノイジス
ウルリケ シュティーアシュナイダー
ガバイン アレクサンダー ボン
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インターセル アーゲー
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Publication of JP2010532657A publication Critical patent/JP2010532657A/ja
Publication of JP2010532657A5 publication Critical patent/JP2010532657A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0266—Klebsiella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010504730A 2007-05-02 2008-04-29 クレブシエラ属の抗原 Pending JP2010532657A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107344 2007-05-02
PCT/EP2008/055214 WO2008135446A2 (en) 2007-05-02 2008-04-29 Klebsiella antigens

Publications (2)

Publication Number Publication Date
JP2010532657A true JP2010532657A (ja) 2010-10-14
JP2010532657A5 JP2010532657A5 (enExample) 2011-07-14

Family

ID=39708006

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504730A Pending JP2010532657A (ja) 2007-05-02 2008-04-29 クレブシエラ属の抗原

Country Status (7)

Country Link
US (3) US8236326B2 (enExample)
EP (5) EP2497779A1 (enExample)
JP (1) JP2010532657A (enExample)
CN (1) CN102015754A (enExample)
AU (1) AU2008248755A1 (enExample)
CA (1) CA2685805A1 (enExample)
WO (1) WO2008135446A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2685805A1 (en) * 2007-05-02 2008-11-13 Intercell Ag Klebsiella antigens
US9150621B2 (en) * 2008-08-28 2015-10-06 The University Of Queensland Mutant bacterial glycoproteins and uses thereof
AU2013203774A1 (en) 2012-01-27 2013-08-15 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Compositions and methods for immunization against bacteria expressing a carbapenemase
KR101605846B1 (ko) * 2013-11-20 2016-03-23 한국과학기술연구원 클렙시엘라 뉴모니아에 특이적으로 결합하는 단일가닥 핵산 앱타머 및 이를 이용한 클렙시엘라 뉴모니아 검출 방법
EP3485907B1 (en) * 2015-01-12 2023-06-28 Evaxion Biotech ApS Treatment and prophylaxis of k. pneumoniae infection
US11000582B2 (en) 2015-07-10 2021-05-11 Epitopix, Llc Proteins and immunizing compositions containing klebsiella proteins and methods of use
US20170073397A1 (en) * 2015-08-24 2017-03-16 Medimmune, Llc MrkA Polypeptides, Antibodies, and Uses Thereof
US20180312576A1 (en) * 2015-10-28 2018-11-01 Arsanis Biosciences Gmbh Antibodies targeting a mannan-based o-antigen of k. pneumoniae
BR112019002039A2 (pt) 2016-08-05 2019-05-07 Medimmune, Llc anticorpos anti-o2 e uso dos mesmos
US10759848B2 (en) 2016-08-12 2020-09-01 Arsanis Biosciences Gmbh Klebsiella pneumoniae O3 specific antibodies
CA3039686A1 (en) 2016-10-19 2018-04-26 Medimmune, Llc Anti-o1 antibodies and uses thereof
CN110540595B (zh) * 2018-12-20 2021-04-06 湖北工业大学 一种肺炎克雷伯菌抗体乳胶微球免疫层析检测试纸的制备方法
CN110540599B (zh) * 2018-12-20 2021-04-06 湖北工业大学 基于肺炎克雷伯菌表面蛋白抗体的肺炎克雷伯菌Elisa检测试剂盒及制备方法
CN110540600B (zh) * 2018-12-20 2021-01-29 湖北工业大学 基于肺炎克雷伯菌表面蛋白的乳胶微球免疫层析试纸的制备方法
CN111150839A (zh) * 2019-12-17 2020-05-15 中国科学院深圳先进技术研究院 一种用于免疫接种的组合物及其制备方法
CN112505324A (zh) * 2020-11-06 2021-03-16 杭州迅耀生物科技有限公司 一种新型冠状病毒检测方法
CN116033922B (zh) * 2021-08-25 2025-08-19 北京三诺佳邑生物技术有限责任公司 特异性识别肺炎克雷伯菌o1抗原的抗体及其应用
CN115838431A (zh) * 2022-07-08 2023-03-24 中国人民解放军陆军军医大学 一种用作肺炎克雷伯菌疫苗抗原的融合蛋白KP-Ag2及其应用
WO2025177313A1 (en) * 2024-02-23 2025-08-28 Bharat Serums And Vaccines Limited Antibodies against klebsiella pneumoniae and implementations thereof

Citations (1)

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US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics

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EP0464533B1 (de) 1990-06-28 1998-07-29 Hoechst Aktiengesellschaft Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
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Also Published As

Publication number Publication date
US20140212448A1 (en) 2014-07-31
WO2008135446A2 (en) 2008-11-13
EP2360177A1 (en) 2011-08-24
US8637052B2 (en) 2014-01-28
EP2497779A1 (en) 2012-09-12
US20130011403A1 (en) 2013-01-10
EP2489673A3 (en) 2012-09-12
EP2152731A2 (en) 2010-02-17
US20130230526A9 (en) 2013-09-05
CN102015754A (zh) 2011-04-13
WO2008135446A3 (en) 2009-03-12
AU2008248755A1 (en) 2008-11-13
CA2685805A1 (en) 2008-11-13
EP2338902A1 (en) 2011-06-29
US20110236410A1 (en) 2011-09-29
EP2489673A2 (en) 2012-08-22
US8236326B2 (en) 2012-08-07
EP2338902A8 (en) 2011-08-03

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