CN101970476B - 具有超延迟时效特征的胰岛素衍生物 - Google Patents

具有超延迟时效特征的胰岛素衍生物 Download PDF

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Publication number
CN101970476B
CN101970476B CN200980101942.6A CN200980101942A CN101970476B CN 101970476 B CN101970476 B CN 101970476B CN 200980101942 A CN200980101942 A CN 200980101942A CN 101970476 B CN101970476 B CN 101970476B
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China
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pro
exendin
lys
asp
arg
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Expired - Fee Related
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CN200980101942.6A
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English (en)
Chinese (zh)
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CN101970476A (zh
Inventor
P·哈伯曼
G·赛普克
R·库尔勒
G·米勒
M·佐默费尔德
N·特纳格尔斯
G·钱克
U·沃纳
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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Priority claimed from DE102008003566A external-priority patent/DE102008003566A1/de
Priority claimed from DE200810025007 external-priority patent/DE102008025007A1/de
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Publication of CN101970476A publication Critical patent/CN101970476A/zh
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980101942.6A 2008-01-09 2009-01-06 具有超延迟时效特征的胰岛素衍生物 Expired - Fee Related CN101970476B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE102008003566A DE102008003566A1 (de) 2008-01-09 2008-01-09 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003566.1 2008-01-09
US4466208P 2008-04-14 2008-04-14
US61/044,662 2008-04-14
DE102008025007.4 2008-05-24
DE200810025007 DE102008025007A1 (de) 2008-05-24 2008-05-24 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
PCT/EP2009/000018 WO2009087082A2 (de) 2008-01-09 2009-01-06 Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil

Publications (2)

Publication Number Publication Date
CN101970476A CN101970476A (zh) 2011-02-09
CN101970476B true CN101970476B (zh) 2014-08-27

Family

ID=40473425

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980101942.6A Expired - Fee Related CN101970476B (zh) 2008-01-09 2009-01-06 具有超延迟时效特征的胰岛素衍生物

Country Status (20)

Country Link
US (1) US8633156B2 (enExample)
EP (1) EP2229406B1 (enExample)
JP (1) JP5695909B2 (enExample)
KR (1) KR20100111683A (enExample)
CN (1) CN101970476B (enExample)
AR (1) AR070119A1 (enExample)
AU (1) AU2009203810B2 (enExample)
BR (1) BRPI0907119A2 (enExample)
CA (1) CA2711752A1 (enExample)
CL (1) CL2009000018A1 (enExample)
CO (1) CO6290770A2 (enExample)
IL (1) IL206843A0 (enExample)
MA (1) MA31997B1 (enExample)
NZ (1) NZ586589A (enExample)
PA (1) PA8811501A1 (enExample)
PE (1) PE20091305A1 (enExample)
TW (1) TWI433681B (enExample)
UY (1) UY31597A1 (enExample)
WO (1) WO2009087082A2 (enExample)
ZA (1) ZA201003927B (enExample)

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HUE068164T2 (hu) 2008-10-17 2024-12-28 Sanofi Aventis Deutschland Egy inzulin és egy GLP-1 agonista kombinációja
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KR20150116912A (ko) 2008-12-15 2015-10-16 질랜드 파마 에이/에스 글루카곤 유사체
JP5635530B2 (ja) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
PT2454282E (pt) 2009-07-13 2015-06-23 Zealand Pharma As Análogos de glucagão acilados
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
CA2780460C (en) 2009-11-13 2018-09-04 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
AR081975A1 (es) 2010-06-23 2012-10-31 Zealand Pharma As Analogos de glucagon
KR20230051307A (ko) 2010-06-24 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
MA34383B1 (fr) 2010-06-24 2013-07-03 Zealand Pharma As Analogues de glucagon
RS55378B1 (sr) 2010-08-30 2017-03-31 Sanofi Aventis Deutschland Upotreba ave0010 za proizvodnju leka za tretman diabetes mellitus tipa 2
US20120283169A1 (en) 2010-11-08 2012-11-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
MX2013008005A (es) 2011-01-20 2013-08-21 Zealand Pharma As Combinacion de analogos de glucagon acilados con analogos de insulina.
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
UA113626C2 (xx) * 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
BR112014004726A2 (pt) 2011-08-29 2017-04-04 Sanofi Aventis Deutschland combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
AR090937A1 (es) 2012-05-03 2014-12-17 Zealand Pharma As Compuestos agonista duales de gip-glp-1 y metodos para usarlos
BR112015001451B1 (pt) 2012-07-23 2022-03-29 Zealand Pharma A/S Composto, construção de ácido nucleico, vetor de expressão, célula hospedeira, composição farmacêutica, utilização de um composto ou de seu sal ou solvato farmaceuticamente aceitável
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
TWI641381B (zh) 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
MX368436B (es) 2013-10-17 2019-10-03 Zealand Pharma As Analogos de glucagon acilados.
KR102310392B1 (ko) 2013-11-06 2021-10-13 질랜드 파마 에이/에스 글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물
CA2929459C (en) 2013-11-06 2022-05-03 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
EP3091995B1 (en) 2014-01-09 2024-03-20 Sanofi Stabilized pharmaceutical formulations of insulin aspart
WO2015104311A1 (en) 2014-01-09 2015-07-16 Sanofi Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
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TWI684458B (zh) 2014-05-30 2020-02-11 南韓商韓美藥品股份有限公司 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物
ES2883345T3 (es) 2014-10-29 2021-12-07 Zealand Pharma As Compuestos agonistas del GIP y métodos
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
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Also Published As

Publication number Publication date
CO6290770A2 (es) 2011-06-20
AU2009203810B2 (en) 2013-07-25
CL2009000018A1 (es) 2009-06-05
WO2009087082A2 (de) 2009-07-16
WO2009087082A3 (de) 2009-09-24
EP2229406B1 (de) 2015-04-22
TW200942257A (en) 2009-10-16
US8633156B2 (en) 2014-01-21
EP2229406A2 (de) 2010-09-22
IL206843A0 (en) 2010-12-30
BRPI0907119A2 (pt) 2015-07-14
ZA201003927B (en) 2011-04-28
JP5695909B2 (ja) 2015-04-08
AU2009203810A1 (en) 2009-07-16
NZ586589A (en) 2012-04-27
TWI433681B (zh) 2014-04-11
CA2711752A1 (en) 2009-07-16
JP2011509269A (ja) 2011-03-24
HK1148542A1 (en) 2011-09-09
CN101970476A (zh) 2011-02-09
MA31997B1 (fr) 2011-01-03
UY31597A1 (es) 2009-08-31
AR070119A1 (es) 2010-03-17
KR20100111683A (ko) 2010-10-15
PE20091305A1 (es) 2009-09-26
US20110173722A1 (en) 2011-07-14
PA8811501A1 (es) 2009-09-17

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