CN101965350A - 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 - Google Patents

作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 Download PDF

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Publication number
CN101965350A
CN101965350A CN2009801083051A CN200980108305A CN101965350A CN 101965350 A CN101965350 A CN 101965350A CN 2009801083051 A CN2009801083051 A CN 2009801083051A CN 200980108305 A CN200980108305 A CN 200980108305A CN 101965350 A CN101965350 A CN 101965350A
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CN
China
Prior art keywords
pyrazolo
pyrimidine
phenyl
amine
formula
Prior art date
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Pending
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CN2009801083051A
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English (en)
Chinese (zh)
Inventor
D·P·科恩凯奇
苏巴·劳·普拉
拉克西米·安南特内利
R·皮利
穆达萨尼·普拉雷迪
布疆加·劳·阿迪巴特拉卡利萨蒂亚
纳纳潘尼·委卡拉筹德利
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Natco Pharma Ltd
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Natco Pharma Ltd
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Publication of CN101965350A publication Critical patent/CN101965350A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801083051A 2008-01-11 2009-01-12 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 Pending CN101965350A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN109/CHE/2008 2008-01-11
IN109CH2008 2008-01-11
PCT/IN2009/000037 WO2009098715A2 (en) 2008-01-11 2009-01-12 Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents

Publications (1)

Publication Number Publication Date
CN101965350A true CN101965350A (zh) 2011-02-02

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Family Applications (1)

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CN2009801083051A Pending CN101965350A (zh) 2008-01-11 2009-01-12 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物

Country Status (18)

Country Link
US (1) US8349847B2 (enExample)
EP (1) EP2247596A2 (enExample)
JP (1) JP2011509290A (enExample)
KR (1) KR20100116607A (enExample)
CN (1) CN101965350A (enExample)
AP (1) AP2010005347A0 (enExample)
AU (1) AU2009211004C1 (enExample)
BR (1) BRPI0906475A2 (enExample)
CA (1) CA2711777A1 (enExample)
CO (1) CO6382174A2 (enExample)
EA (1) EA201070841A1 (enExample)
GE (1) GEP20135780B (enExample)
IL (1) IL206811A0 (enExample)
MA (1) MA32009B1 (enExample)
MX (1) MX2010007523A (enExample)
NZ (1) NZ586642A (enExample)
WO (1) WO2009098715A2 (enExample)
ZA (1) ZA201004823B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746309A (zh) * 2012-07-09 2012-10-24 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307A (zh) * 2012-07-09 2012-10-24 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202A (zh) * 2014-05-21 2014-08-06 马宝花 二环稠合杂环化合物、其制备方法及用途
CN106008527A (zh) * 2016-06-29 2016-10-12 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN115304607A (zh) * 2022-07-06 2022-11-08 华南农业大学 吡唑并嘧啶衍生物的制备方法

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HRP20140754T2 (hr) 2009-06-29 2015-07-17 Incyte Corporation Pirimidinoni kao inhibitori pi3k
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
WO2011130342A1 (en) 2010-04-14 2011-10-20 Incyte Corporation FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2012087881A1 (en) 2010-12-20 2012-06-28 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
LT3196202T (lt) 2011-09-02 2019-07-10 Incyte Holdings Corporation Heterociklilaminai, kaip pi3k slopikliai
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
CN117736209A (zh) 2015-02-27 2024-03-22 因赛特控股公司 Pi3k抑制剂的盐及其制备方法
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
PE20211208A1 (es) 2018-06-01 2021-07-05 Incyte Corp Regimen de dosificacion para el tratamiento de trastornos relacionados con pi3k
US20230121698A1 (en) * 2019-12-23 2023-04-20 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) modulators and uses thereof

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JPS5439096A (en) 1977-08-27 1979-03-24 Lion Dentifrice Co Ltd 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
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US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
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JP4275733B2 (ja) 1996-01-23 2009-06-10 ノバルティス アクチエンゲゼルシャフト ピロロピリミジンおよびその製造法
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DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
AR035885A1 (es) 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
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US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
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ATE323702T1 (de) 2002-08-06 2006-05-15 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
US20040138238A1 (en) 2002-08-08 2004-07-15 Dhanoa Dale S. Substituted aminopyrimidine compounds as neurokinin antagonists

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746309A (zh) * 2012-07-09 2012-10-24 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307A (zh) * 2012-07-09 2012-10-24 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202A (zh) * 2014-05-21 2014-08-06 马宝花 二环稠合杂环化合物、其制备方法及用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
CN106008527A (zh) * 2016-06-29 2016-10-12 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN115304607A (zh) * 2022-07-06 2022-11-08 华南农业大学 吡唑并嘧啶衍生物的制备方法

Also Published As

Publication number Publication date
KR20100116607A (ko) 2010-11-01
WO2009098715A2 (en) 2009-08-13
MX2010007523A (es) 2010-08-18
CA2711777A1 (en) 2009-08-13
IL206811A0 (en) 2010-12-30
CO6382174A2 (es) 2012-02-15
US8349847B2 (en) 2013-01-08
JP2011509290A (ja) 2011-03-24
WO2009098715A3 (en) 2009-10-15
WO2009098715A4 (en) 2009-12-10
NZ586642A (en) 2012-04-27
MA32009B1 (fr) 2011-01-03
US20100298351A1 (en) 2010-11-25
AU2009211004C1 (en) 2013-08-01
GEP20135780B (en) 2013-03-11
EA201070841A1 (ru) 2011-02-28
EP2247596A2 (en) 2010-11-10
AP2010005347A0 (en) 2010-08-31
AU2009211004B2 (en) 2011-09-01
AU2009211004A2 (en) 2011-01-27
AU2009211004A1 (en) 2009-08-13
BRPI0906475A2 (pt) 2015-07-14
ZA201004823B (en) 2011-09-28

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Application publication date: 20110202