CN101778843A - 制备奥美沙坦酯的方法 - Google Patents

制备奥美沙坦酯的方法 Download PDF

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Publication number
CN101778843A
CN101778843A CN200880102268A CN200880102268A CN101778843A CN 101778843 A CN101778843 A CN 101778843A CN 200880102268 A CN200880102268 A CN 200880102268A CN 200880102268 A CN200880102268 A CN 200880102268A CN 101778843 A CN101778843 A CN 101778843A
Authority
CN
China
Prior art keywords
olmesartan medoxomil
base
trityl
steps
olmesartan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880102268A
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English (en)
Chinese (zh)
Inventor
R·托普拉克卡萨尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07114000A external-priority patent/EP2022790A1/en
Priority claimed from EP07114004A external-priority patent/EP2036904A1/en
Application filed by Lek Pharmaceuticals dd filed Critical Lek Pharmaceuticals dd
Publication of CN101778843A publication Critical patent/CN101778843A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880102268A 2007-08-08 2008-08-07 制备奥美沙坦酯的方法 Pending CN101778843A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07114004.0 2007-08-08
EP07114000.8 2007-08-08
EP07114000A EP2022790A1 (en) 2007-08-08 2007-08-08 A process for the preparation or purification of olmesartan medoxomil
EP07114004A EP2036904A1 (en) 2007-08-08 2007-08-08 A process for the preparation of olmesartan medoxomil
PCT/EP2008/060400 WO2009019304A1 (en) 2007-08-08 2008-08-07 A process for the preparation of olmesartan medoxomil

Publications (1)

Publication Number Publication Date
CN101778843A true CN101778843A (zh) 2010-07-14

Family

ID=39789494

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880102268A Pending CN101778843A (zh) 2007-08-08 2008-08-07 制备奥美沙坦酯的方法
CN200880102267.4A Expired - Fee Related CN101778842B (zh) 2007-08-08 2008-08-07 制备或纯化奥美沙坦酯的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880102267.4A Expired - Fee Related CN101778842B (zh) 2007-08-08 2008-08-07 制备或纯化奥美沙坦酯的方法

Country Status (9)

Country Link
US (2) US8592474B2 (enExample)
EP (2) EP2176253B1 (enExample)
JP (2) JP5685082B2 (enExample)
CN (2) CN101778843A (enExample)
AT (1) ATE528305T1 (enExample)
BR (2) BRPI0815134A2 (enExample)
CA (2) CA2707365A1 (enExample)
SI (1) SI2176253T1 (enExample)
WO (2) WO2009019304A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102351849A (zh) * 2011-10-26 2012-02-15 齐鲁天和惠世制药有限公司 一种奥美沙坦酯的制备方法
CN103304550A (zh) * 2012-03-16 2013-09-18 湖南欧亚生物有限公司 一种奥美沙坦酯的制备方法
CN103435602A (zh) * 2013-07-31 2013-12-11 山东省医学科学院药物研究所 一种奥美沙坦酯的制备方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104817546A (zh) * 2015-05-20 2015-08-05 浙江华海药业股份有限公司 一种奥美沙坦酯母液回收的方法
CN107311990B (zh) * 2017-07-25 2021-09-03 浙江华海致诚药业有限公司 一种奥美沙坦酯的制备方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019304A1 (en) * 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation of olmesartan medoxomil
US8735598B2 (en) 2008-06-09 2014-05-27 Daiichi Sankyo Company, Limited Method for producing 1-biphenylmethylimidazole compound
EP2426126B1 (en) 2009-04-28 2014-11-19 Daiichi Sankyo Company, Limited Method for producing olmesartan medoxomil
SG175296A1 (en) * 2009-04-28 2011-11-28 Daiichi Sankyo Co Ltd Novel solvate crystals
WO2011007368A2 (en) * 2009-07-14 2011-01-20 Cadila Healthcare Limited An improved process for preparation of olmesartan
AU2010277221A1 (en) * 2009-07-31 2012-03-15 Ranbaxy Laboratories Limited Polymorphic form of olmesartan medoxomil
WO2011021224A2 (en) * 2009-08-19 2011-02-24 Msn Laboratories Limited Process for (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-tetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate
CZ2010785A3 (cs) * 2010-10-29 2012-05-16 Zentiva, K.S. Zpusob výroby olmesartanu medoxomilu
KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN104447715B (zh) * 2014-11-28 2017-06-20 山东新华制药股份有限公司 奥美沙坦酯的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DK0573218T3 (da) * 1992-06-02 2001-06-18 Sankyo Co 4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
KR20090102883A (ko) * 2004-09-02 2009-09-30 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
JP4511550B2 (ja) * 2004-09-02 2010-07-28 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの調製法
GB2419592A (en) 2004-10-26 2006-05-03 Cipla Ltd Process for the preparation of irbesartan hydrochloride
US20060281800A1 (en) 2005-04-12 2006-12-14 Glenmark Pharmaceuticals Limited Polymorphic form of olmesartan and process for its preparation
EP1816131A1 (en) 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
EP1910343B1 (en) * 2005-07-29 2014-10-29 Krka Process for the preparation of olmesartan medoxomil
WO2007052301A2 (en) 2005-08-31 2007-05-10 Alembic Limited Process for the preparation of irbesartan
EP1801111B1 (en) 2005-12-20 2014-07-16 LEK Pharmaceuticals d.d. Novel polymorph forms of olmesartan medoxomil
ES2371910T3 (es) 2006-04-07 2012-01-11 Lek Pharmaceuticals D.D. Procedimiento para la preparación de irbesartán puro.
WO2007148344A2 (en) 2006-06-19 2007-12-27 Matrix Laboratories Limited Process for the preparation of olmesartan medoxomil
EP2074116A2 (en) 2006-10-09 2009-07-01 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
WO2009019304A1 (en) * 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation of olmesartan medoxomil

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102351849A (zh) * 2011-10-26 2012-02-15 齐鲁天和惠世制药有限公司 一种奥美沙坦酯的制备方法
CN102351849B (zh) * 2011-10-26 2013-10-02 齐鲁天和惠世制药有限公司 一种奥美沙坦酯的制备方法
CN103304550A (zh) * 2012-03-16 2013-09-18 湖南欧亚生物有限公司 一种奥美沙坦酯的制备方法
CN103304550B (zh) * 2012-03-16 2016-01-27 湖南欧亚生物有限公司 一种奥美沙坦酯的制备方法
CN103435602A (zh) * 2013-07-31 2013-12-11 山东省医学科学院药物研究所 一种奥美沙坦酯的制备方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104817546A (zh) * 2015-05-20 2015-08-05 浙江华海药业股份有限公司 一种奥美沙坦酯母液回收的方法
CN104817546B (zh) * 2015-05-20 2020-02-07 浙江华海药业股份有限公司 一种奥美沙坦酯母液回收的方法
CN107311990B (zh) * 2017-07-25 2021-09-03 浙江华海致诚药业有限公司 一种奥美沙坦酯的制备方法

Also Published As

Publication number Publication date
SI2176253T1 (sl) 2012-02-29
WO2009019303A2 (en) 2009-02-12
BRPI0815111A2 (pt) 2015-01-27
CN101778842B (zh) 2014-10-29
BRPI0815134A2 (pt) 2015-02-03
JP5685082B2 (ja) 2015-03-18
US20110263666A1 (en) 2011-10-27
JP2010535743A (ja) 2010-11-25
EP2173741B1 (en) 2013-10-02
EP2176253A2 (en) 2010-04-21
JP2010535742A (ja) 2010-11-25
WO2009019304A1 (en) 2009-02-12
EP2173741A1 (en) 2010-04-14
US8592474B2 (en) 2013-11-26
ATE528305T1 (de) 2011-10-15
EP2176253B1 (en) 2011-10-12
CA2707334A1 (en) 2009-02-12
CA2707334C (en) 2015-11-24
CA2707365A1 (en) 2009-02-12
CN101778842A (zh) 2010-07-14
WO2009019303A3 (en) 2009-04-02
US20110224271A1 (en) 2011-09-15

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