ATE528305T1 - Verfahren zur herstellung oder reinigung von olmesartan-medoxomil oder von olmesartan- medoxomil-hydrohalid-salz - Google Patents

Verfahren zur herstellung oder reinigung von olmesartan-medoxomil oder von olmesartan- medoxomil-hydrohalid-salz

Info

Publication number
ATE528305T1
ATE528305T1 AT08786993T AT08786993T ATE528305T1 AT E528305 T1 ATE528305 T1 AT E528305T1 AT 08786993 T AT08786993 T AT 08786993T AT 08786993 T AT08786993 T AT 08786993T AT E528305 T1 ATE528305 T1 AT E528305T1
Authority
AT
Austria
Prior art keywords
olmesartan medoxomil
purification
production
hydrohalide salt
olmesartan
Prior art date
Application number
AT08786993T
Other languages
German (de)
English (en)
Inventor
Samo Pirc
Lovro Selic
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07114004A external-priority patent/EP2036904A1/en
Priority claimed from EP07114000A external-priority patent/EP2022790A1/en
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Application granted granted Critical
Publication of ATE528305T1 publication Critical patent/ATE528305T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT08786993T 2007-08-08 2008-08-07 Verfahren zur herstellung oder reinigung von olmesartan-medoxomil oder von olmesartan- medoxomil-hydrohalid-salz ATE528305T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07114004A EP2036904A1 (en) 2007-08-08 2007-08-08 A process for the preparation of olmesartan medoxomil
EP07114000A EP2022790A1 (en) 2007-08-08 2007-08-08 A process for the preparation or purification of olmesartan medoxomil
PCT/EP2008/060396 WO2009019303A2 (en) 2007-08-08 2008-08-07 A process for the preparation or purification of olmesartan medoxomil

Publications (1)

Publication Number Publication Date
ATE528305T1 true ATE528305T1 (de) 2011-10-15

Family

ID=39789494

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08786993T ATE528305T1 (de) 2007-08-08 2008-08-07 Verfahren zur herstellung oder reinigung von olmesartan-medoxomil oder von olmesartan- medoxomil-hydrohalid-salz

Country Status (9)

Country Link
US (2) US20110224271A1 (enExample)
EP (2) EP2176253B1 (enExample)
JP (2) JP2010535743A (enExample)
CN (2) CN101778842B (enExample)
AT (1) ATE528305T1 (enExample)
BR (2) BRPI0815111A2 (enExample)
CA (2) CA2707365A1 (enExample)
SI (1) SI2176253T1 (enExample)
WO (2) WO2009019304A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2707365A1 (en) * 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation of olmesartan medoxomil
KR101630885B1 (ko) 2008-06-09 2016-06-15 다이이찌 산쿄 가부시키가이샤 1-비페닐메틸이미다졸 화합물의 제조 방법
CA2760031C (en) * 2009-04-28 2015-03-10 Daiichi Sankyo Company, Limited Acetone solvate crystals of trityl olmesartan medoxomil
ES2527686T3 (es) 2009-04-28 2015-01-28 Daiichi Sankyo Company, Limited Procedimiento de producción de olmesartán medoxomil
WO2011007368A2 (en) * 2009-07-14 2011-01-20 Cadila Healthcare Limited An improved process for preparation of olmesartan
CA2769704A1 (en) * 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Polymorphic form of olmesartan medoxomil
WO2011021224A2 (en) * 2009-08-19 2011-02-24 Msn Laboratories Limited Process for (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-tetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate
CZ2010785A3 (cs) * 2010-10-29 2012-05-16 Zentiva, K.S. Zpusob výroby olmesartanu medoxomilu
KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
CN102351849B (zh) * 2011-10-26 2013-10-02 齐鲁天和惠世制药有限公司 一种奥美沙坦酯的制备方法
CN103304550B (zh) * 2012-03-16 2016-01-27 湖南欧亚生物有限公司 一种奥美沙坦酯的制备方法
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN103435602A (zh) * 2013-07-31 2013-12-11 山东省医学科学院药物研究所 一种奥美沙坦酯的制备方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104447715B (zh) * 2014-11-28 2017-06-20 山东新华制药股份有限公司 奥美沙坦酯的制备方法
CN104817546B (zh) * 2015-05-20 2020-02-07 浙江华海药业股份有限公司 一种奥美沙坦酯母液回收的方法
CN107311990B (zh) * 2017-07-25 2021-09-03 浙江华海致诚药业有限公司 一种奥美沙坦酯的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
ATE199548T1 (de) * 1992-06-02 2001-03-15 Sankyo Co 4-carboxyimidazolderivate als angiotensin-ii- antagonisten und ihre therapeutische verwendung
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
CN1993355A (zh) * 2004-09-02 2007-07-04 特瓦制药工业有限公司 奥美沙坦酯的纯化方法
JP4437141B2 (ja) * 2004-09-02 2010-03-24 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの精製法
GB2419592A (en) * 2004-10-26 2006-05-03 Cipla Ltd Process for the preparation of irbesartan hydrochloride
US20060281800A1 (en) 2005-04-12 2006-12-14 Glenmark Pharmaceuticals Limited Polymorphic form of olmesartan and process for its preparation
EA014026B1 (ru) 2005-07-29 2010-08-30 Крка, Товарна Здравил, Д.Д., Ново Место Способ получения олмесартан медоксомила
EP1816131A1 (en) 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
WO2007052301A2 (en) 2005-08-31 2007-05-10 Alembic Limited Process for the preparation of irbesartan
EP1801111B1 (en) * 2005-12-20 2014-07-16 LEK Pharmaceuticals d.d. Novel polymorph forms of olmesartan medoxomil
CA2654218C (en) * 2006-04-07 2014-07-22 Lek Pharmaceuticals D.D. Process for the preparation of pure irbesartan
US8048904B2 (en) 2006-06-19 2011-11-01 Matrix Laboratories Ltd. Process for the preparation of olmesartan medoxomil
US8076492B2 (en) * 2006-10-09 2011-12-13 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
CA2707365A1 (en) * 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation of olmesartan medoxomil

Also Published As

Publication number Publication date
US20110224271A1 (en) 2011-09-15
WO2009019303A3 (en) 2009-04-02
WO2009019303A2 (en) 2009-02-12
EP2176253A2 (en) 2010-04-21
CA2707334A1 (en) 2009-02-12
US8592474B2 (en) 2013-11-26
JP5685082B2 (ja) 2015-03-18
JP2010535743A (ja) 2010-11-25
CA2707365A1 (en) 2009-02-12
JP2010535742A (ja) 2010-11-25
BRPI0815111A2 (pt) 2015-01-27
US20110263666A1 (en) 2011-10-27
CN101778842B (zh) 2014-10-29
CN101778843A (zh) 2010-07-14
CA2707334C (en) 2015-11-24
EP2173741A1 (en) 2010-04-14
EP2173741B1 (en) 2013-10-02
CN101778842A (zh) 2010-07-14
EP2176253B1 (en) 2011-10-12
WO2009019304A1 (en) 2009-02-12
BRPI0815134A2 (pt) 2015-02-03
SI2176253T1 (sl) 2012-02-29

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