WO2010098583A2 - 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물 - Google Patents

스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물 Download PDF

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Publication number
WO2010098583A2
WO2010098583A2 PCT/KR2010/001152 KR2010001152W WO2010098583A2 WO 2010098583 A2 WO2010098583 A2 WO 2010098583A2 KR 2010001152 W KR2010001152 W KR 2010001152W WO 2010098583 A2 WO2010098583 A2 WO 2010098583A2
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WO
WIPO (PCT)
Prior art keywords
salts
same
compounds
novel method
intermediate compounds
Prior art date
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PCT/KR2010/001152
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English (en)
French (fr)
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WO2010098583A3 (ko
Inventor
김희석
김희철
심재의
조성미
김원정
서귀현
이관순
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한미약품 주식회사
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Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Publication of WO2010098583A2 publication Critical patent/WO2010098583A2/ko
Publication of WO2010098583A3 publication Critical patent/WO2010098583A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 고지혈 관련 질환의 치료 및 예방에 유용한, 스타틴 화합물 또는 그의 염의 신규 제조방법, 및 이에 사용되는 신규 중간체에 관한 것으로, 본 발명에 따르면, 스타틴 화합물을 신규한 중간체들로부터 간편하고 효율적으로 제조할 수 있다.
PCT/KR2010/001152 2009-02-24 2010-02-24 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물 WO2010098583A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090015435A KR101160152B1 (ko) 2009-02-24 2009-02-24 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물
KR10-2009-0015435 2009-02-24

Publications (2)

Publication Number Publication Date
WO2010098583A2 true WO2010098583A2 (ko) 2010-09-02
WO2010098583A3 WO2010098583A3 (ko) 2011-01-06

Family

ID=42666047

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/001152 WO2010098583A2 (ko) 2009-02-24 2010-02-24 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물

Country Status (2)

Country Link
KR (1) KR101160152B1 (ko)
WO (1) WO2010098583A2 (ko)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102477032A (zh) * 2010-11-26 2012-05-30 上海医药工业研究院 一类2-环丙基-4-取代苯氧基喹啉衍生物、其制备方法、中间体及其应用
CN103058925A (zh) * 2011-11-02 2013-04-24 石药集团中奇制药技术（石家庄）有限公司 一种匹伐他汀钙的制备方法
EP2638013A1 (en) * 2010-11-12 2013-09-18 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
CN104447784A (zh) * 2014-12-02 2015-03-25 南京博优康远生物医药科技有限公司 一种他汀类药物中间体及其制备方法和应用
CN105198807A (zh) * 2015-10-24 2015-12-30 威海迪素制药有限公司 一种高纯度匹伐他钙的制备方法
CN105481838A (zh) * 2015-11-18 2016-04-13 北京万全德众医药生物技术有限公司 一种制备匹伐他汀内酯杂质的方法
CN105646369A (zh) * 2015-12-30 2016-06-08 安徽美诺华药物化学有限公司 一种瑞舒伐他汀的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260440A (en) * 1991-07-01 1993-11-09 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives
US5856336A (en) * 1987-08-20 1999-01-05 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones
WO2002081451A1 (fr) * 2001-04-05 2002-10-17 Nissan Chemical Industries, Ltd. Procede relatif a l'elaboration de 7-quinolinyl-3,5-dihydroxyhept-6-enoate
WO2003064392A1 (en) * 2002-01-31 2003-08-07 Novartis Ag Process for the manufacture of hmg-coa reductase inhibitors
WO2003087112A1 (en) * 2002-04-09 2003-10-23 Cls Laboratories, Inc. Chiral intermediate and process for the production thereof
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
WO2007041666A1 (en) * 2005-10-04 2007-04-12 Teva Pharmaceutical Industries Ltd. Preparation of rosuvastatin
WO2007132482A2 (en) * 2006-05-17 2007-11-22 Manne Satyanarayana Reddy Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856336A (en) * 1987-08-20 1999-01-05 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones
US5260440A (en) * 1991-07-01 1993-11-09 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives
WO2002081451A1 (fr) * 2001-04-05 2002-10-17 Nissan Chemical Industries, Ltd. Procede relatif a l'elaboration de 7-quinolinyl-3,5-dihydroxyhept-6-enoate
WO2003064392A1 (en) * 2002-01-31 2003-08-07 Novartis Ag Process for the manufacture of hmg-coa reductase inhibitors
WO2003087112A1 (en) * 2002-04-09 2003-10-23 Cls Laboratories, Inc. Chiral intermediate and process for the production thereof
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
WO2007041666A1 (en) * 2005-10-04 2007-04-12 Teva Pharmaceutical Industries Ltd. Preparation of rosuvastatin
WO2007132482A2 (en) * 2006-05-17 2007-11-22 Manne Satyanarayana Reddy Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2638013A1 (en) * 2010-11-12 2013-09-18 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
EP2638013A4 (en) * 2010-11-12 2014-03-26 Hetero Research Foundation NEW POLYMORPHS OF CALCIUM PIVASTATIN
EP3178812A1 (en) * 2010-11-12 2017-06-14 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
CN102477032A (zh) * 2010-11-26 2012-05-30 上海医药工业研究院 一类2-环丙基-4-取代苯氧基喹啉衍生物、其制备方法、中间体及其应用
CN102477032B (zh) * 2010-11-26 2015-04-01 上海医药工业研究院 一类2-环丙基-4-取代苯氧基喹啉衍生物、其制备方法、中间体及其应用
CN103058925A (zh) * 2011-11-02 2013-04-24 石药集团中奇制药技术（石家庄）有限公司 一种匹伐他汀钙的制备方法
CN103058925B (zh) * 2011-11-02 2015-09-02 石药集团中奇制药技术（石家庄）有限公司 一种匹伐他汀钙的制备方法
CN104447784A (zh) * 2014-12-02 2015-03-25 南京博优康远生物医药科技有限公司 一种他汀类药物中间体及其制备方法和应用
CN105198807A (zh) * 2015-10-24 2015-12-30 威海迪素制药有限公司 一种高纯度匹伐他钙的制备方法
CN105198807B (zh) * 2015-10-24 2018-11-20 威海迪素制药有限公司 一种低内酯含量的匹伐他汀钙的制备方法
CN105481838A (zh) * 2015-11-18 2016-04-13 北京万全德众医药生物技术有限公司 一种制备匹伐他汀内酯杂质的方法
CN105646369A (zh) * 2015-12-30 2016-06-08 安徽美诺华药物化学有限公司 一种瑞舒伐他汀的制备方法

Also Published As

Publication number Publication date
KR20100096526A (ko) 2010-09-02
WO2010098583A3 (ko) 2011-01-06
KR101160152B1 (ko) 2012-06-27

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