CN101778842B - 制备或纯化奥美沙坦酯的方法 - Google Patents

制备或纯化奥美沙坦酯的方法 Download PDF

Info

Publication number
CN101778842B
CN101778842B CN200880102267.4A CN200880102267A CN101778842B CN 101778842 B CN101778842 B CN 101778842B CN 200880102267 A CN200880102267 A CN 200880102267A CN 101778842 B CN101778842 B CN 101778842B
Authority
CN
China
Prior art keywords
olmesartan medoxomil
acid
olmesartan
water
olmesartan medoxomill
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880102267.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN101778842A (zh
Inventor
S·皮尔茨
L·塞利奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07114004A external-priority patent/EP2036904A1/en
Priority claimed from EP07114000A external-priority patent/EP2022790A1/en
Application filed by Lek Pharmaceuticals dd filed Critical Lek Pharmaceuticals dd
Publication of CN101778842A publication Critical patent/CN101778842A/zh
Application granted granted Critical
Publication of CN101778842B publication Critical patent/CN101778842B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880102267.4A 2007-08-08 2008-08-07 制备或纯化奥美沙坦酯的方法 Expired - Fee Related CN101778842B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07114004.0 2007-08-08
EP07114000.8 2007-08-08
EP07114004A EP2036904A1 (en) 2007-08-08 2007-08-08 A process for the preparation of olmesartan medoxomil
EP07114000A EP2022790A1 (en) 2007-08-08 2007-08-08 A process for the preparation or purification of olmesartan medoxomil
PCT/EP2008/060396 WO2009019303A2 (en) 2007-08-08 2008-08-07 A process for the preparation or purification of olmesartan medoxomil

Publications (2)

Publication Number Publication Date
CN101778842A CN101778842A (zh) 2010-07-14
CN101778842B true CN101778842B (zh) 2014-10-29

Family

ID=39789494

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880102267.4A Expired - Fee Related CN101778842B (zh) 2007-08-08 2008-08-07 制备或纯化奥美沙坦酯的方法
CN200880102268A Pending CN101778843A (zh) 2007-08-08 2008-08-07 制备奥美沙坦酯的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880102268A Pending CN101778843A (zh) 2007-08-08 2008-08-07 制备奥美沙坦酯的方法

Country Status (9)

Country Link
US (2) US20110224271A1 (enExample)
EP (2) EP2176253B1 (enExample)
JP (2) JP2010535743A (enExample)
CN (2) CN101778842B (enExample)
AT (1) ATE528305T1 (enExample)
BR (2) BRPI0815111A2 (enExample)
CA (2) CA2707334C (enExample)
SI (1) SI2176253T1 (enExample)
WO (2) WO2009019303A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103304550B (zh) * 2012-03-16 2016-01-27 湖南欧亚生物有限公司 一种奥美沙坦酯的制备方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019303A2 (en) * 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation or purification of olmesartan medoxomil
CN102083823B (zh) 2008-06-09 2015-10-07 第一三共株式会社 1-联苯甲基咪唑化合物的制备方法
SG175296A1 (en) 2009-04-28 2011-11-28 Daiichi Sankyo Co Ltd Novel solvate crystals
WO2010126013A1 (ja) 2009-04-28 2010-11-04 第一三共株式会社 オルメサルタンメドキソミルの製造方法
WO2011007368A2 (en) * 2009-07-14 2011-01-20 Cadila Healthcare Limited An improved process for preparation of olmesartan
AU2010277221A1 (en) * 2009-07-31 2012-03-15 Ranbaxy Laboratories Limited Polymorphic form of olmesartan medoxomil
WO2011021224A2 (en) * 2009-08-19 2011-02-24 Msn Laboratories Limited Process for (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-tetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate
CZ303188B6 (cs) * 2010-10-29 2012-05-16 Zentiva, K.S. Zpusob výroby olmesartanu medoxomilu
KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
CN102351849B (zh) * 2011-10-26 2013-10-02 齐鲁天和惠世制药有限公司 一种奥美沙坦酯的制备方法
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN103435602A (zh) * 2013-07-31 2013-12-11 山东省医学科学院药物研究所 一种奥美沙坦酯的制备方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104447715B (zh) * 2014-11-28 2017-06-20 山东新华制药股份有限公司 奥美沙坦酯的制备方法
CN104817546B (zh) * 2015-05-20 2020-02-07 浙江华海药业股份有限公司 一种奥美沙坦酯母液回收的方法
CN107311990B (zh) * 2017-07-25 2021-09-03 浙江华海致诚药业有限公司 一种奥美沙坦酯的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co., Ltd. 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
US20060074117A1 (en) * 2004-09-02 2006-04-06 Lilach Hedvati Purification of olmesartan medoxomil
JP4511550B2 (ja) * 2004-09-02 2010-07-28 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの調製法
GB2419592A (en) * 2004-10-26 2006-05-03 Cipla Ltd Process for the preparation of irbesartan hydrochloride
US20060281800A1 (en) * 2005-04-12 2006-12-14 Glenmark Pharmaceuticals Limited Polymorphic form of olmesartan and process for its preparation
CA2616466A1 (en) 2005-07-29 2007-02-15 Krka Process for the preparation of olmesartan medoxomil
EP1816131A1 (en) 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
WO2007052301A2 (en) 2005-08-31 2007-05-10 Alembic Limited Process for the preparation of irbesartan
EP1801111B1 (en) 2005-12-20 2014-07-16 LEK Pharmaceuticals d.d. Novel polymorph forms of olmesartan medoxomil
ES2371910T3 (es) * 2006-04-07 2012-01-11 Lek Pharmaceuticals D.D. Procedimiento para la preparación de irbesartán puro.
WO2007148344A2 (en) 2006-06-19 2007-12-27 Matrix Laboratories Limited Process for the preparation of olmesartan medoxomil
EP2074116A2 (en) * 2006-10-09 2009-07-01 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
WO2009019303A2 (en) * 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation or purification of olmesartan medoxomil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103304550B (zh) * 2012-03-16 2016-01-27 湖南欧亚生物有限公司 一种奥美沙坦酯的制备方法

Also Published As

Publication number Publication date
US20110263666A1 (en) 2011-10-27
SI2176253T1 (sl) 2012-02-29
CA2707334A1 (en) 2009-02-12
ATE528305T1 (de) 2011-10-15
US8592474B2 (en) 2013-11-26
JP5685082B2 (ja) 2015-03-18
EP2173741A1 (en) 2010-04-14
CN101778843A (zh) 2010-07-14
EP2176253B1 (en) 2011-10-12
WO2009019303A3 (en) 2009-04-02
US20110224271A1 (en) 2011-09-15
JP2010535743A (ja) 2010-11-25
JP2010535742A (ja) 2010-11-25
CN101778842A (zh) 2010-07-14
BRPI0815111A2 (pt) 2015-01-27
CA2707365A1 (en) 2009-02-12
WO2009019303A2 (en) 2009-02-12
EP2176253A2 (en) 2010-04-21
EP2173741B1 (en) 2013-10-02
CA2707334C (en) 2015-11-24
WO2009019304A1 (en) 2009-02-12
BRPI0815134A2 (pt) 2015-02-03

Similar Documents

Publication Publication Date Title
CN101778842B (zh) 制备或纯化奥美沙坦酯的方法
RU2144536C1 (ru) Способ получения 2-н.бутил-3-[[2'-(тетразол-5-ил)бифенил-4-ил]метил]-1,3-диазаспиро[4.4]нон -1-ен-4-она в форме а или в форме в, способ получения формы в, форма в и фармацевтическая композиция на основе формы в
US7528258B2 (en) Preparation of olmesartan medoxomil
CA2575177A1 (en) Purification of olmesartan medoxomil
EP1556363A2 (en) Process for the preparation of valsartan and intermediates thereof
JP2004520446A (ja) ロサルタンカリウムの結晶化方法
JP2004520446A5 (enExample)
WO2011036674A1 (en) A new process for the preparation of olmesartan medoxomil
EP2016073B1 (en) Process for the preparation of pure irbesartan
US6350880B1 (en) Crystalline or crystallized acid addition salt of losartan and purification method of losartan
EP2036904A1 (en) A process for the preparation of olmesartan medoxomil
EP1984356B1 (en) An improved process for the preparation of candesartan cilexetil
EP2022790A1 (en) A process for the preparation or purification of olmesartan medoxomil
EP2152678A1 (en) Process for preparing valsartan
JP2010526126A (ja) バルサルタンの製造方法
WO2007020659A2 (en) A process for the preparation of irbesartan form a
WO2008041957A1 (en) Method for producing pure crystalline form of 2-n-butyl-3-((2-(1h-tetrazole-5-yl) (1,1'-biphenyl)-4-methyl)-1,3-diazapspiro (4,4') non -1- en-4-one

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20141029

CF01 Termination of patent right due to non-payment of annual fee