CN101743012B - 制备交联聚（烯丙胺）聚合物的一步法 - Google Patents

制备交联聚（烯丙胺）聚合物的一步法 Download PDF

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Publication number
CN101743012B
CN101743012B CN2008800248423A CN200880024842A CN101743012B CN 101743012 B CN101743012 B CN 101743012B CN 2008800248423 A CN2008800248423 A CN 2008800248423A CN 200880024842 A CN200880024842 A CN 200880024842A CN 101743012 B CN101743012 B CN 101743012B
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China
Prior art keywords
formula
allylamine
salt
water
polymer
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Expired - Fee Related
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CN2008800248423A
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English (en)
Chinese (zh)
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CN101743012A (zh
Inventor
S·彼安琪
V·卡斯托维妥
G·马拉斯
S·比洛米
G·卡斯托蒂
G·范迪米格丽亚
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Chemo Iberica SA
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Chemo Iberica SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C08F226/04—Diallylamine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
CN2008800248423A 2007-07-17 2008-07-16 制备交联聚（烯丙胺）聚合物的一步法 Expired - Fee Related CN101743012B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07112604.9 2007-07-17
EP07112604A EP2016947A1 (en) 2007-07-17 2007-07-17 Novel one step process for preparing cross-linked poly(allylamine) polymers
PCT/EP2008/059303 WO2009010531A1 (en) 2007-07-17 2008-07-16 Novel one step process for preparing cross-linked poly(allylamine) polymers

Publications (2)

Publication Number Publication Date
CN101743012A CN101743012A (zh) 2010-06-16
CN101743012B true CN101743012B (zh) 2012-07-04

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CN2008800248423A Expired - Fee Related CN101743012B (zh) 2007-07-17 2008-07-16 制备交联聚（烯丙胺）聚合物的一步法

Country Status (16)

Country Link
US (1) US8394416B2 (https=)
EP (2) EP2016947A1 (https=)
JP (1) JP2010533758A (https=)
KR (1) KR20100051616A (https=)
CN (1) CN101743012B (https=)
AT (1) ATE493136T1 (https=)
BR (1) BRPI0813829A2 (https=)
CA (1) CA2697130A1 (https=)
DE (1) DE602008004259D1 (https=)
DK (1) DK2175866T3 (https=)
ES (1) ES2358381T3 (https=)
HR (1) HRP20110181T1 (https=)
PL (1) PL2175866T3 (https=)
PT (1) PT2175866E (https=)
SI (1) SI2175866T1 (https=)
WO (1) WO2009010531A1 (https=)

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US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
WO2010146603A1 (en) * 2009-06-16 2010-12-23 Watson Pharma Private Limited Processes for the preparation of sevelamer carbonate
IT1404163B1 (it) 2011-02-01 2013-11-15 Chemi Spa Processo per la preparazione di poliallilamine reticolate o loro sali farmaceuticamente accettabili
CN102796259B (zh) * 2011-05-24 2014-11-12 北大方正集团有限公司 碳酸司维拉姆的制备方法
CN102796262B (zh) * 2011-05-24 2014-11-12 北大方正集团有限公司 一种碳酸司维拉姆的制备方法
CN103012789B (zh) * 2011-09-23 2015-02-25 北大方正集团有限公司 烟酸司维拉姆的制备方法
CN102675510B (zh) * 2012-05-28 2014-04-02 诚达药业股份有限公司 司维拉姆的合成工艺
CN102942646B (zh) * 2012-10-26 2016-06-29 青岛正大海尔制药有限公司 一种高分子聚合物的合成与分离纯化方法
SI3287133T1 (sl) 2013-06-05 2019-09-30 Tricida Inc. Polimeri, ki vežejo protone,za peroralno dajanje
CN104448139B (zh) * 2014-11-21 2016-08-17 新发药业有限公司 一种盐酸考来维仑的制备方法
LT3229816T (lt) 2014-12-10 2020-05-25 Tricida Inc. Protoną prijungiantys polimerai, skirti peroraliniam įvedimui
MA41202A (fr) * 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
WO2017193024A1 (en) 2016-05-06 2017-11-09 Tricida, Inc. Hcl-binding compositions for and method of treating acid-base disorders
CN106008813B (zh) * 2016-06-15 2017-11-14 新发药业有限公司 溶液聚合制备盐酸考来维仑的方法
KR101853260B1 (ko) * 2016-11-29 2018-06-14 주식회사 퍼슨 세벨라머 카보네이트의 제조방법
BR112019013364A2 (pt) 2016-12-28 2020-04-14 Fujifilm Corp emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas
WO2019009057A1 (ja) * 2017-07-05 2019-01-10 日東紡績株式会社 高純度アリルアミン（共）重合体及びその製造方法
US10934380B1 (en) 2017-09-25 2021-03-02 Tricida, Inc. Crosslinked poly(allylamine) polymer pharmaceutical compositions
CN111225674A (zh) 2017-10-16 2020-06-02 富士胶片株式会社 高磷血症治疗剂
IL319146A (en) 2017-11-03 2025-04-01 Tricida Inc Compositions for and method of treating acid-base disorders
CN108751208B (zh) * 2018-06-05 2020-06-30 山东师范大学 一种无表面活性剂微乳液制备的单分散二氧化硅纳米球及其制备方法
EP4164659B1 (en) 2021-08-24 2024-03-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Polymers, compositions and methods for treating hyperuricemia

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CN1150435A (zh) * 1994-06-10 1997-05-21 盖尔泰克斯药品有限公司 从病人体内除去胆汁盐的方法和由此产生的烷基化组合物

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JP3363143B2 (ja) * 1998-10-12 2003-01-08 中外製薬株式会社 リン酸結合性ポリマー粒子
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Also Published As

Publication number Publication date
EP2016947A1 (en) 2009-01-21
EP2175866B1 (en) 2010-12-29
CN101743012A (zh) 2010-06-16
KR20100051616A (ko) 2010-05-17
ATE493136T1 (de) 2011-01-15
DK2175866T3 (da) 2011-04-04
WO2009010531A1 (en) 2009-01-22
CA2697130A1 (en) 2009-01-22
PT2175866E (pt) 2011-04-01
HK1140945A1 (en) 2010-10-29
SI2175866T1 (sl) 2011-04-29
HRP20110181T1 (hr) 2011-04-30
US8394416B2 (en) 2013-03-12
US20100183732A1 (en) 2010-07-22
ES2358381T3 (es) 2011-05-10
PL2175866T3 (pl) 2011-05-31
JP2010533758A (ja) 2010-10-28
DE602008004259D1 (de) 2011-02-10
EP2175866A1 (en) 2010-04-21
BRPI0813829A2 (pt) 2015-01-06

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Granted publication date: 20120704

Termination date: 20130716