CN101679357A - 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途 - Google Patents

取代的杂环衍生物及其组合物和作为抗菌剂的药物用途 Download PDF

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Publication number
CN101679357A
CN101679357A CN200880020428A CN200880020428A CN101679357A CN 101679357 A CN101679357 A CN 101679357A CN 200880020428 A CN200880020428 A CN 200880020428A CN 200880020428 A CN200880020428 A CN 200880020428A CN 101679357 A CN101679357 A CN 101679357A
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alkyl
alkoxy
piperidine
carboxylic acid
cycloalkyl
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Pending
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CN200880020428A
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Chinese (zh)
Inventor
S·J·布里科纳
J·M·陈
Z·B·李
A·马法特
M·J·米顿-弗莱
U·赖利
M·A·普罗特金
S·罗宾逊
C·萨布拉曼亚姆
Z·张
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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Publication of CN101679357A publication Critical patent/CN101679357A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880020428A 2007-05-09 2008-04-29 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途 Pending CN101679357A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91690607P 2007-05-09 2007-05-09
US60/916,906 2007-05-09
PCT/IB2008/001076 WO2008139288A2 (en) 2007-05-09 2008-04-29 Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials

Publications (1)

Publication Number Publication Date
CN101679357A true CN101679357A (zh) 2010-03-24

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CN200880020428A Pending CN101679357A (zh) 2007-05-09 2008-04-29 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途

Country Status (17)

Country Link
US (3) US20080280879A1 (enExample)
EP (2) EP2481735A1 (enExample)
JP (1) JP2010526130A (enExample)
KR (2) KR20090130347A (enExample)
CN (1) CN101679357A (enExample)
AR (1) AR066478A1 (enExample)
AU (1) AU2008249745B2 (enExample)
CA (1) CA2685888A1 (enExample)
CL (1) CL2008001367A1 (enExample)
IL (1) IL201830A0 (enExample)
MX (1) MX2009012117A (enExample)
PA (1) PA8779801A1 (enExample)
PE (1) PE20090240A1 (enExample)
TW (1) TW200902518A (enExample)
UY (1) UY31071A1 (enExample)
WO (1) WO2008139288A2 (enExample)
ZA (1) ZA200907761B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112147257A (zh) * 2017-03-24 2020-12-29 上海安谱实验科技股份有限公司 Pet制品中多环芳烃的提取方法
CN113302175A (zh) * 2018-11-09 2021-08-24 维瓦斯治疗公司 双环化合物
US12103902B2 (en) 2019-04-16 2024-10-01 Vivace Therapeutics, Inc. Bicyclic compounds

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AU2017276627A1 (en) 2016-06-08 2018-12-20 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. New antibacterial compounds
JP6755775B2 (ja) * 2016-11-04 2020-09-16 富士アミドケミカル株式会社 ４−フルオロイソキノリンの製法
WO2019133605A1 (en) * 2017-12-26 2019-07-04 Astellas Pharma Inc. Process for the preparation of an amino-pyrimidine and intermediates thereof
CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
IL299612A (en) 2020-07-02 2023-03-01 Incyte Corp Tricyclic urea compounds as JAK2 V617F inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
US11958861B2 (en) 2021-02-25 2024-04-16 Incyte Corporation Spirocyclic lactams as JAK2 V617F inhibitors
AU2022380979A1 (en) 2021-11-02 2024-06-06 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof
EP4493558A1 (en) 2022-03-17 2025-01-22 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112147257A (zh) * 2017-03-24 2020-12-29 上海安谱实验科技股份有限公司 Pet制品中多环芳烃的提取方法
CN113302175A (zh) * 2018-11-09 2021-08-24 维瓦斯治疗公司 双环化合物
US11866431B2 (en) 2018-11-09 2024-01-09 Vivace Therapeutics, Inc. Bicyclic compounds
US12103902B2 (en) 2019-04-16 2024-10-01 Vivace Therapeutics, Inc. Bicyclic compounds

Also Published As

Publication number Publication date
WO2008139288A3 (en) 2009-03-26
US20110092480A1 (en) 2011-04-21
KR20090130347A (ko) 2009-12-22
EP2155716A2 (en) 2010-02-24
AR066478A1 (es) 2009-08-19
AU2008249745A1 (en) 2008-11-20
US20120065188A1 (en) 2012-03-15
JP2010526130A (ja) 2010-07-29
TW200902518A (en) 2009-01-16
UY31071A1 (es) 2009-01-05
PE20090240A1 (es) 2009-03-19
AU2008249745B2 (en) 2012-01-12
US20080280879A1 (en) 2008-11-13
EP2481735A1 (en) 2012-08-01
PA8779801A1 (es) 2009-01-23
MX2009012117A (es) 2009-11-23
ZA200907761B (en) 2010-08-25
IL201830A0 (en) 2010-06-16
KR20120011093A (ko) 2012-02-06
WO2008139288A2 (en) 2008-11-20
CL2008001367A1 (es) 2008-11-07
CA2685888A1 (en) 2008-11-20

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