PE20090240A1 - Derivados heterociclicos sustituidos y su uso farmaceutico y composiciones - Google Patents
Derivados heterociclicos sustituidos y su uso farmaceutico y composicionesInfo
- Publication number
- PE20090240A1 PE20090240A1 PE2008000800A PE2008000800A PE20090240A1 PE 20090240 A1 PE20090240 A1 PE 20090240A1 PE 2008000800 A PE2008000800 A PE 2008000800A PE 2008000800 A PE2008000800 A PE 2008000800A PE 20090240 A1 PE20090240 A1 PE 20090240A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- carboxyl
- alkyl
- piperidin
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE X1, X2, X3, X4, X5 Y X6 SON CADA UNO N, N-OXIDO O CR1, DONDE R1 ES H, HALOGENO, CN, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS; R2 ES H, OH, HALOGENO, ALQUILO(C1-C6), ALQUILTIO(C1-C6), ENTRE OTROS; X7 ES O, CH2, S, SO, ENTRE OTROS; R4 ES H, OH, ALCOXI(C1-C6), F, NH2, ENTRE OTROS; D ES UN COMPUESTO DE FORMULA (a) EN DONDE R9 ES CARBOXILO, ALCOXI(C1-C6)CARBONILO, AMINOCARBONILO, TETRAZOL, ENTRE OTROS; R10 ES H, HALOGENO, OH, ENTRE OTROS; n ES DE 0 A 3; p ES 0 O 1; C ES UN COMPUESTO DE FORMULA (b) EN DONDE Y1 ES CR6 O N, DONDE R6 ES H, OH, HALOGENO, ENTRE OTROS; R7 ES H, HALOGENO, OH, ALQUILO(C1-C6), ENTRE OTROS; R8 ES ARILO(C6-C10), CICLOALQUILO(C3-C10), ARIL(C6-C10)-ALQUILO(C1-C6), ENTRE OTROS; m ES DE 0 A 3; q ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: ACIDO (3R,4R)-4-(3-HIDROXI-3-(6-METOXIQUINOLIN-4-IL)PROPIL)-1-(3-FENILCICLOBUTIL)PIPERIDIN-3-CARBOXILICO, ACIDO (3R,4R)-4-(3-(3-FLUORO-6-METOXIQUINOLIN-4-IL)-3-HIDROXIPROPIL)-1-(3-FENILCICLOBUTIL)PIPERIDIN-3-CARBOXILICO, ACIDO (3R,4R)-4-(3-(3-CLORO-6-METOXIQUINOLIN-4-IL)-3-HIDROXIPROPIL)-1-(3-FENILCICLOBUTIL)PIPERIDIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91690607P | 2007-05-09 | 2007-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090240A1 true PE20090240A1 (es) | 2009-03-19 |
Family
ID=39865577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000800A PE20090240A1 (es) | 2007-05-09 | 2008-05-07 | Derivados heterociclicos sustituidos y su uso farmaceutico y composiciones |
Country Status (17)
Country | Link |
---|---|
US (3) | US20080280879A1 (es) |
EP (2) | EP2481735A1 (es) |
JP (1) | JP2010526130A (es) |
KR (2) | KR20120011093A (es) |
CN (1) | CN101679357A (es) |
AR (1) | AR066478A1 (es) |
AU (1) | AU2008249745B2 (es) |
CA (1) | CA2685888A1 (es) |
CL (1) | CL2008001367A1 (es) |
IL (1) | IL201830A0 (es) |
MX (1) | MX2009012117A (es) |
PA (1) | PA8779801A1 (es) |
PE (1) | PE20090240A1 (es) |
TW (1) | TW200902518A (es) |
UY (1) | UY31071A1 (es) |
WO (1) | WO2008139288A2 (es) |
ZA (1) | ZA200907761B (es) |
Families Citing this family (16)
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JP2012532834A (ja) * | 2009-07-11 | 2012-12-20 | バイエル ファーマ アクチエンゲゼルシャフト | シクロアルキル基を用いる放射性標識方法 |
MA41169A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
JP2019517545A (ja) | 2016-06-08 | 2019-06-24 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニAziende Chimiche Riunite Angelini Francesco A.C.R.A.F.Societa Per Azioni | 新しい抗菌性化合物 |
JP6755775B2 (ja) * | 2016-11-04 | 2020-09-16 | 富士アミドケミカル株式会社 | 4−フルオロイソキノリンの製法 |
CN112147257B (zh) * | 2017-03-24 | 2022-06-03 | 上海安谱实验科技股份有限公司 | Pet制品中多环芳烃的提取方法 |
EP3732166A4 (en) * | 2017-12-26 | 2021-09-01 | Cytokinetics, Incorporated | PROCESS FOR THE MANUFACTURING OF AN AMINO-PYRIMIDINE AND INTERMEDIATES THEREOF |
CN113302175A (zh) * | 2018-11-09 | 2021-08-24 | 维瓦斯治疗公司 | 双环化合物 |
CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药(上海)有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
AU2021300429A1 (en) | 2020-07-02 | 2023-02-16 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
TW202302589A (zh) | 2021-02-25 | 2023-01-16 | 美商英塞特公司 | 作為jak2 v617f抑制劑之螺環內醯胺 |
WO2023078252A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
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-
2008
- 2008-04-29 EP EP12165102A patent/EP2481735A1/en not_active Withdrawn
- 2008-04-29 EP EP08737576A patent/EP2155716A2/en not_active Withdrawn
- 2008-04-29 CA CA002685888A patent/CA2685888A1/en not_active Abandoned
- 2008-04-29 KR KR1020127000612A patent/KR20120011093A/ko not_active Application Discontinuation
- 2008-04-29 JP JP2010507014A patent/JP2010526130A/ja not_active Withdrawn
- 2008-04-29 CN CN200880020428A patent/CN101679357A/zh active Pending
- 2008-04-29 MX MX2009012117A patent/MX2009012117A/es not_active Application Discontinuation
- 2008-04-29 WO PCT/IB2008/001076 patent/WO2008139288A2/en active Application Filing
- 2008-04-29 KR KR1020097025640A patent/KR20090130347A/ko not_active Application Discontinuation
- 2008-04-29 AU AU2008249745A patent/AU2008249745B2/en not_active Ceased
- 2008-05-07 AR ARP080101937A patent/AR066478A1/es not_active Application Discontinuation
- 2008-05-07 PE PE2008000800A patent/PE20090240A1/es not_active Application Discontinuation
- 2008-05-08 US US12/117,071 patent/US20080280879A1/en not_active Abandoned
- 2008-05-08 TW TW097117046A patent/TW200902518A/zh unknown
- 2008-05-08 UY UY31071A patent/UY31071A1/es not_active Application Discontinuation
- 2008-05-09 PA PA20088779801A patent/PA8779801A1/es unknown
- 2008-05-09 CL CL2008001367A patent/CL2008001367A1/es unknown
-
2009
- 2009-10-29 IL IL201830A patent/IL201830A0/en unknown
- 2009-11-04 ZA ZA200907761A patent/ZA200907761B/xx unknown
-
2010
- 2010-12-20 US US12/972,620 patent/US20110092480A1/en not_active Abandoned
-
2011
- 2011-11-22 US US13/302,151 patent/US20120065188A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2008249745A1 (en) | 2008-11-20 |
EP2155716A2 (en) | 2010-02-24 |
US20080280879A1 (en) | 2008-11-13 |
EP2481735A1 (en) | 2012-08-01 |
US20120065188A1 (en) | 2012-03-15 |
KR20090130347A (ko) | 2009-12-22 |
AR066478A1 (es) | 2009-08-19 |
CL2008001367A1 (es) | 2008-11-07 |
IL201830A0 (en) | 2010-06-16 |
AU2008249745B2 (en) | 2012-01-12 |
KR20120011093A (ko) | 2012-02-06 |
JP2010526130A (ja) | 2010-07-29 |
CN101679357A (zh) | 2010-03-24 |
MX2009012117A (es) | 2009-11-23 |
CA2685888A1 (en) | 2008-11-20 |
US20110092480A1 (en) | 2011-04-21 |
TW200902518A (en) | 2009-01-16 |
WO2008139288A2 (en) | 2008-11-20 |
WO2008139288A3 (en) | 2009-03-26 |
ZA200907761B (en) | 2010-08-25 |
UY31071A1 (es) | 2009-01-05 |
PA8779801A1 (es) | 2009-01-23 |
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