CN101657419A - 吡咯基庚酸衍生物的新晶型 - Google Patents

吡咯基庚酸衍生物的新晶型 Download PDF

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Publication number
CN101657419A
CN101657419A CN200880006877A CN200880006877A CN101657419A CN 101657419 A CN101657419 A CN 101657419A CN 200880006877 A CN200880006877 A CN 200880006877A CN 200880006877 A CN200880006877 A CN 200880006877A CN 101657419 A CN101657419 A CN 101657419A
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CN
China
Prior art keywords
crystal formation
compound
formula
alcohol
hydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880006877A
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English (en)
Chinese (zh)
Inventor
金文成
刘武姬
李在杰
金容稙
朴成镇
崔俊浩
成始荣
林弘珪
车大元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
East-Asia Pharmaceutical Co Ltd
Original Assignee
East-Asia Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by East-Asia Pharmaceutical Co Ltd filed Critical East-Asia Pharmaceutical Co Ltd
Publication of CN101657419A publication Critical patent/CN101657419A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CN200880006877A 2007-03-02 2008-03-03 吡咯基庚酸衍生物的新晶型 Pending CN101657419A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20070020999 2007-03-02
KR1020070020999 2007-03-02
KR1020080019764 2008-03-03

Publications (1)

Publication Number Publication Date
CN101657419A true CN101657419A (zh) 2010-02-24

Family

ID=40020978

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880006877A Pending CN101657419A (zh) 2007-03-02 2008-03-03 吡咯基庚酸衍生物的新晶型

Country Status (8)

Country Link
US (1) US7915302B2 (enExample)
EP (1) EP2132171A4 (enExample)
JP (1) JP2010520273A (enExample)
KR (1) KR101012917B1 (enExample)
CN (1) CN101657419A (enExample)
CA (1) CA2679317A1 (enExample)
RU (1) RU2421445C1 (enExample)
WO (1) WO2008108572A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011219437A (ja) * 2010-04-14 2011-11-04 Towa Yakuhin Kk 結晶性形態ｔｗ−１のアトルバスタチンヘミカルシウム水和物とその製造方法
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
RU2555360C2 (ru) * 2012-11-06 2015-07-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ определения воды в координационных соединениях

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE69634054T2 (de) * 1995-07-17 2005-12-08 Warner-Lambert Co. Kristalline (R-(R*, R*))-2-(4-Fluorophenyl)-β, δ-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-1H-Pyrrol-1-Heptancarbonsäure Hemi Calcium Salz (Atorvastatin)
DE19951107A1 (de) * 1999-10-23 2001-05-23 Zahnradfabrik Friedrichshafen Steuerung eines Automatgetriebes eines Kraftfahrzeuges
SI1535613T1 (sl) * 1999-11-17 2010-12-31 Teva Pharma Postopek za pripravo polimorfne oblike atorvastatin kalcija
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
EP1423364B1 (en) * 2001-06-29 2015-11-04 Warner-Lambert Company LLC Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
WO2003070702A1 (en) * 2002-02-15 2003-08-28 Teva Pharmaceutical Industries Ltd. Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix
EP1562583A1 (en) * 2002-09-03 2005-08-17 Morepen Laboratories Ltd. Atorvastatin calcium form vi or hydrates thereof
CA2508871C (en) * 2002-11-28 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline form f of atorvastatin hemi-calcium salt
WO2005090301A1 (en) * 2004-03-17 2005-09-29 Ranbaxy Laboratories Limited Crystalline form of atorvastatin hemi calcium
WO2006048894A1 (en) * 2004-11-05 2006-05-11 Morepen Laboratories Limited Novel crystalline forms of atorvastatin calcium and processes for preparing them.

Also Published As

Publication number Publication date
RU2421445C1 (ru) 2011-06-20
EP2132171A1 (en) 2009-12-16
KR20080080959A (ko) 2008-09-05
KR101012917B1 (ko) 2011-02-08
US20100113556A1 (en) 2010-05-06
US7915302B2 (en) 2011-03-29
EP2132171A4 (en) 2010-11-17
CA2679317A1 (en) 2008-09-12
WO2008108572A1 (en) 2008-09-12
RU2009136427A (ru) 2011-04-10
JP2010520273A (ja) 2010-06-10

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Open date: 20100224