CN101646451B - 使用免疫球蛋白片段的促胰岛素缀合物 - Google Patents
使用免疫球蛋白片段的促胰岛素缀合物 Download PDFInfo
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- CN101646451B CN101646451B CN200880001766.4A CN200880001766A CN101646451B CN 101646451 B CN101646451 B CN 101646451B CN 200880001766 A CN200880001766 A CN 200880001766A CN 101646451 B CN101646451 B CN 101646451B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
实验材料 | 血液半衰期(小时) | 体外浓度(%) |
Exendin-4 | 0.7 | 100 |
Exendin-4(N)-PEG-Fc | 62 | <0.2 |
Exendin-4(Lys27)-PEG-Fc | 61 | 13.2 |
DM exendin-4(Lys27)-PEG-Fc | 69 | 2.6 |
DA exendin-4(Lys27)-PEG-Fc | 54 | 13.2 |
HY exendin-4(Lys27)-PEG-Fc | 52 | 7.6 |
CA exendin-4(Lys27)-PEG-Fc | 52 | 8.5 |
Ser12 DA exendin-4(Lys27)-PEG-Fc | N.D. | 2.6 |
DA exendin-4(Lys27)-白蛋白 | 2.0 | |
DA GLP-1(Lys20,28)-PEG-Fc | 27 | 2.0 |
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310309673.0A CN103435700B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2007-0001662 | 2007-01-05 | ||
KR1020070001662 | 2007-01-05 | ||
KR20070001662 | 2007-01-05 | ||
PCT/KR2008/000061 WO2008082274A1 (en) | 2007-01-05 | 2008-01-04 | An insulinotropic complex using an immunoglobulin fragment |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310309288.6A Division CN103435699B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
CN201310309673.0A Division CN103435700B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101646451A CN101646451A (zh) | 2010-02-10 |
CN101646451B true CN101646451B (zh) | 2014-03-26 |
Family
ID=39588830
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310309673.0A Active CN103435700B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
CN200880001766.4A Active CN101646451B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
CN201310309288.6A Active CN103435699B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310309673.0A Active CN103435700B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310309288.6A Active CN103435699B (zh) | 2007-01-05 | 2008-01-04 | 使用免疫球蛋白片段的促胰岛素缀合物 |
Country Status (21)
Country | Link |
---|---|
US (1) | US8476230B2 (zh) |
EP (1) | EP2114438B8 (zh) |
JP (2) | JP2008169195A (zh) |
KR (3) | KR101058290B1 (zh) |
CN (3) | CN103435700B (zh) |
AR (2) | AR065639A1 (zh) |
AU (1) | AU2008203574B2 (zh) |
BR (1) | BRPI0806262A2 (zh) |
CA (1) | CA2674538C (zh) |
DK (1) | DK2114438T3 (zh) |
ES (1) | ES2394121T3 (zh) |
HK (1) | HK1136504A1 (zh) |
IL (1) | IL199566A (zh) |
MX (1) | MX2009007267A (zh) |
MY (1) | MY164479A (zh) |
NZ (1) | NZ577812A (zh) |
PT (1) | PT2114438E (zh) |
RU (1) | RU2436589C2 (zh) |
TW (1) | TWI413528B (zh) |
WO (1) | WO2008082274A1 (zh) |
ZA (1) | ZA200904337B (zh) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8110665B2 (en) * | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
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US8263084B2 (en) | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
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US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
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AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
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AR096891A1 (es) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
AR096890A1 (es) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn |
MX369656B (es) | 2014-01-20 | 2019-11-15 | Hanmi Pharm Ind Co Ltd | Insulina de accion prolongada y uso de la misma. |
KR102385120B1 (ko) * | 2014-03-31 | 2022-04-12 | 한미약품 주식회사 | 면역글로불린 Fc 단편 결합을 이용한 단백질 및 펩타이드의 용해도를 개선시키는 방법 |
AR100639A1 (es) * | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
KR20150140177A (ko) | 2014-06-05 | 2015-12-15 | 한미약품 주식회사 | 단백질 및 펩타이드의 면역원성을 감소시키는 방법 |
TWI802396B (zh) | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
US10046058B2 (en) * | 2014-12-02 | 2018-08-14 | Rezolute, Inc. | Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates |
KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
WO2016108586A1 (ko) | 2014-12-30 | 2016-07-07 | 한미약품 주식회사 | 안정성이 증가된 글루카곤 유도체 |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
PE20180449A1 (es) | 2015-06-30 | 2018-03-05 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon y una composicion que comprende un conjugado de accion prolongada del mismo |
UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
KR102231217B1 (ko) * | 2015-09-24 | 2021-03-24 | 한미약품 주식회사 | 면역글로불린 단편의 특정 위치를 연결 부위로 이용한 단백질 결합체 |
HRP20220995T1 (hr) | 2015-12-31 | 2022-11-11 | Hanmi Pharm. Co., Ltd. | Trostruki aktivator koji aktivira glukagonski, glp-1 i gip receptore |
TN2018000452A1 (en) | 2016-06-29 | 2020-06-15 | Hanmi Pharm Ind Co Ltd | Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof |
KR20180033105A (ko) | 2016-09-23 | 2018-04-02 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된, 인슐린 아날로그 및 이의 용도 |
JOP20190095A1 (ar) * | 2016-10-27 | 2019-04-28 | Janssen Pharmaceutica Nv | مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y |
WO2018105988A1 (ko) | 2016-12-05 | 2018-06-14 | 한미약품 주식회사 | 면역반응이 약화된 결합체 |
EP3578204A4 (en) * | 2017-02-03 | 2021-01-06 | Hanmi Pharm. Co., Ltd. | BIOACTIVE SUBSTANCE CONJUGATE WITH ENHANCED DURABILITY AND ITS USE |
KR101941975B1 (ko) | 2017-03-17 | 2019-01-25 | 고려대학교 산학협력단 | Atpif1을 함유하는 당뇨 치료용 약학조성물 |
EP3604328A4 (en) | 2017-03-23 | 2021-01-06 | Hanmi Pharm. Co., Ltd. | REDUCED INSULIN ANALOGUE COMPLEX FOR INSULIN RECEPTOR AND ITS USE |
MX2020004453A (es) * | 2017-09-28 | 2020-07-24 | Hanmi Pharm Ind Co Ltd | Conjugados de accion prolongada de derivados de glp-2. |
WO2019066603A1 (ko) | 2017-09-29 | 2019-04-04 | 한미약품 주식회사 | 효력이 향상된 지속성 단백질 결합체 |
WO2022266467A2 (en) | 2021-06-17 | 2022-12-22 | Dana-Farber Cancer Institute, Inc. | Recombinant histone polypeptide and uses thereof |
KR20230000682A (ko) | 2021-06-25 | 2023-01-03 | 한미약품 주식회사 | 심혈관 질환 또는 신장 기능장애 발생의 위험을 감소시키기 위한 에페글레나타이드 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1723220A (zh) * | 2003-11-13 | 2006-01-18 | 韩美药品工业株式会社 | 含有免疫球蛋白fc区作为载体的药物组合物 |
WO2006107124A1 (en) * | 2005-04-08 | 2006-10-12 | Hanmi Pharmaceutical Co., Ltd. | Immunoglobulin fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
US5424686A (en) | 1994-04-20 | 1995-06-13 | Philips Electronics North America Corporation | Negative-resistance-compensated microwave buffer |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
WO1997034631A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
US7157555B1 (en) * | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
ES2311560T3 (es) | 2000-12-07 | 2009-02-16 | Eli Lilly And Company | Proteinas de fusion glp-1. |
RU2363707C2 (ru) | 2001-02-19 | 2009-08-10 | Мерк Патент Гмбх | Искусственные белки с пониженной иммуногенностью |
US7790681B2 (en) * | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
MXPA05009940A (es) | 2003-03-19 | 2005-12-05 | Lilly Co Eli | Compuestos de glp-1 de enlace de glicol polietilenico. |
AU2004251145C1 (en) | 2003-06-12 | 2011-04-14 | Eli Lilly And Company | GLP-1 analog fusion proteins |
DE10352479A1 (de) * | 2003-11-07 | 2005-06-09 | Basf Ag | Verfahren zur Herstellung von Polymerisatpulvern aus wässrigen Polymerisatdispersionen |
JP2006514649A (ja) * | 2003-12-17 | 2006-05-11 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 腎症の治療および予防のための組成物 |
CN101665538A (zh) | 2003-12-18 | 2010-03-10 | 诺沃挪第克公司 | 与白蛋白样物质相连的新glp-1类似物 |
EP1771573A4 (en) * | 2004-07-21 | 2009-02-18 | Ambrx Inc | BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS |
DE602005015257D1 (zh) * | 2004-12-22 | 2009-08-13 | Lilly Co Eli | |
WO2006076471A2 (en) | 2005-01-12 | 2006-07-20 | Nobex Corporation | Bnp conjugates and methods of use |
PT1881850E (pt) * | 2005-05-13 | 2010-11-26 | Lilly Co Eli | Compostos peguilados de glp-1 |
-
2007
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1723220A (zh) * | 2003-11-13 | 2006-01-18 | 韩美药品工业株式会社 | 含有免疫球蛋白fc区作为载体的药物组合物 |
WO2006107124A1 (en) * | 2005-04-08 | 2006-10-12 | Hanmi Pharmaceutical Co., Ltd. | Immunoglobulin fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same |
Non-Patent Citations (1)
Title |
---|
谭兴容 等.Exendin-4与糖尿病治疗.《重庆医学》.2006,第35卷(第10期),全文. * |
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