CN101631546A - 螺-吲哚酮化合物作为治疗剂的用途 - Google Patents

螺-吲哚酮化合物作为治疗剂的用途 Download PDF

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Publication number
CN101631546A
CN101631546A CN200780038111A CN200780038111A CN101631546A CN 101631546 A CN101631546 A CN 101631546A CN 200780038111 A CN200780038111 A CN 200780038111A CN 200780038111 A CN200780038111 A CN 200780038111A CN 101631546 A CN101631546 A CN 101631546A
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alkyl
heteroaryl
cyclic hydrocarbon
heterocyclic radical
aryl
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Pending
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CN200780038111A
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Chinese (zh)
Inventor
麦克海里·乔威夫
苏鲁旦·乔德亨瑞
罗伯特·法瑟
傅建民
雷杰德·坎柏
侯端杰
刘世峰
玛瑞·赛德巴哈萨德
歇吉瑞·史瑞威多
孙绍毅
孙建宇
娜贾司瑞·恰卡
谢瀚霄
凡德娜·瑞娜
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of CN101631546A publication Critical patent/CN101631546A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200780038111A 2006-10-12 2007-10-12 螺-吲哚酮化合物作为治疗剂的用途 Pending CN101631546A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85178706P 2006-10-12 2006-10-12
US60/851,787 2006-10-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2013101646702A Division CN103271906A (zh) 2006-10-12 2007-10-12 螺-吲哚酮化合物作为治疗剂的用途

Publications (1)

Publication Number Publication Date
CN101631546A true CN101631546A (zh) 2010-01-20

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CN2013101646702A Pending CN103271906A (zh) 2006-10-12 2007-10-12 螺-吲哚酮化合物作为治疗剂的用途
CN200780038111A Pending CN101631546A (zh) 2006-10-12 2007-10-12 螺-吲哚酮化合物作为治疗剂的用途

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Country Link
US (1) US8466188B2 (enExample)
EP (1) EP2073806B1 (enExample)
JP (2) JP5460324B2 (enExample)
CN (2) CN103271906A (enExample)
AR (1) AR063280A1 (enExample)
AT (1) ATE545416T1 (enExample)
AU (1) AU2007319580B2 (enExample)
BR (1) BRPI0719210A2 (enExample)
CA (1) CA2665698A1 (enExample)
CL (1) CL2007002950A1 (enExample)
MX (1) MX2009003876A (enExample)
RU (1) RU2009117642A (enExample)
TW (1) TW200833695A (enExample)
WO (1) WO2008060789A2 (enExample)

Cited By (4)

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CN105008351B (zh) * 2013-03-14 2017-03-15 伊莱利利公司 Cdc7抑制剂
CN112334192A (zh) * 2018-07-12 2021-02-05 Ucb生物制药有限责任公司 作为il-17调节剂的螺环茚满类似物
CN112442042A (zh) * 2019-08-30 2021-03-05 广东东阳光药业有限公司 一种螺环吲哚化合物的制备方法
CN115160331A (zh) * 2022-08-04 2022-10-11 青岛农业大学 一种氧化吲哚螺烯丙基取代色满骨架及其制备方法

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CN103664973B (zh) * 2008-10-17 2017-04-19 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
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