CN101489554A - 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 - Google Patents

脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 Download PDF

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Publication number
CN101489554A
CN101489554A CNA2007800273721A CN200780027372A CN101489554A CN 101489554 A CN101489554 A CN 101489554A CN A2007800273721 A CNA2007800273721 A CN A2007800273721A CN 200780027372 A CN200780027372 A CN 200780027372A CN 101489554 A CN101489554 A CN 101489554A
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substituted
compound
unsubstituted
formula
glucosidase
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Chinese (zh)
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T·D·巴特斯
R·A·德维克
G·W·J·弗利特
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United Therapeutics Corp
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United Therapeutics Corp
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Priority to CN201510202505.0A priority Critical patent/CN104876855A/zh
Publication of CN101489554A publication Critical patent/CN101489554A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800273721A 2006-05-24 2007-05-22 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 Pending CN101489554A (zh)

Priority Applications (1)

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CN201510202505.0A CN104876855A (zh) 2006-05-24 2007-05-22 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法

Applications Claiming Priority (2)

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US80277606P 2006-05-24 2006-05-24
US60/802,776 2006-05-24

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CN201510202505.0A Pending CN104876855A (zh) 2006-05-24 2007-05-22 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法

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US (1) US8975280B2 (enExample)
EP (1) EP2023927B1 (enExample)
JP (2) JP5241709B2 (enExample)
CN (2) CN101489554A (enExample)
CA (1) CA2652958C (enExample)
ES (1) ES2537572T3 (enExample)
HK (1) HK1214261A1 (enExample)
WO (1) WO2007140184A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102595895A (zh) * 2009-09-04 2012-07-18 联合治疗公司 亚氨基糖以及治疗丝状病毒性疾病的方法
CN102625801A (zh) * 2009-09-04 2012-08-01 联合治疗公司 治疗痘病毒感染的方法
CN102625796A (zh) * 2009-09-04 2012-08-01 联合治疗公司 治疗正粘病毒感染的方法
CN107207477A (zh) * 2014-11-05 2017-09-26 伊美根特病毒学公司 用于治疗病毒性疾病的亚氨基糖

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EP2356990A3 (en) * 2006-08-02 2011-10-19 University of Oxford Liposome treatment of viral infections
WO2009118658A2 (en) * 2008-03-26 2009-10-01 University Of Oxford Endoplasmic reticulum targeting liposomes
EP2398321B1 (en) * 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
WO2010099064A1 (en) * 2009-02-24 2010-09-02 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
EP2411526A4 (en) * 2009-03-27 2012-09-19 Zacharon Pharmaceuticals Inc MODULATORS OF GANGLIOSID BIOSYNTHESIS
US8703744B2 (en) * 2009-03-27 2014-04-22 The Chancellor, Masters And Scholars Of The University Of Oxford Cholesterol level lowering liposomes
ES2524361T3 (es) 2009-06-12 2014-12-05 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus
CN104703597A (zh) 2012-06-06 2015-06-10 尤尼特尔滤过性微生物学有限责任公司 新型亚氨基糖及它们的应用
CN105246478A (zh) * 2013-03-15 2016-01-13 优尼特尔病毒学公司 抗菌化合物
KR20160094848A (ko) * 2013-05-02 2016-08-10 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 이미노당을 사용한 당지질 억제
AP2016009125A0 (en) 2013-09-16 2016-04-30 Emergent Virology Llc Deoxynojirimycin derivatives and methods of their using
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases

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JPS54106477A (en) * 1978-02-03 1979-08-21 Nippon Shinyaku Co Ltd Moranoline derivative
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102595895A (zh) * 2009-09-04 2012-07-18 联合治疗公司 亚氨基糖以及治疗丝状病毒性疾病的方法
CN102625801A (zh) * 2009-09-04 2012-08-01 联合治疗公司 治疗痘病毒感染的方法
CN102625796A (zh) * 2009-09-04 2012-08-01 联合治疗公司 治疗正粘病毒感染的方法
CN102625796B (zh) * 2009-09-04 2015-03-11 联合治疗公司 治疗正粘病毒感染的方法
CN102625801B (zh) * 2009-09-04 2015-09-09 联合治疗公司 治疗痘病毒感染的方法
CN107207477A (zh) * 2014-11-05 2017-09-26 伊美根特病毒学公司 用于治疗病毒性疾病的亚氨基糖
CN107207477B (zh) * 2014-11-05 2022-11-01 伊美根特病毒学公司 用于治疗病毒性疾病的亚氨基糖

Also Published As

Publication number Publication date
HK1214261A1 (zh) 2016-07-22
EP2023927B1 (en) 2015-02-25
JP2013129662A (ja) 2013-07-04
WO2007140184A3 (en) 2008-11-27
CA2652958A1 (en) 2007-12-06
CA2652958C (en) 2015-11-17
JP2009538336A (ja) 2009-11-05
EP2023927A2 (en) 2009-02-18
CN104876855A (zh) 2015-09-02
US20070275998A1 (en) 2007-11-29
EP2023927A4 (en) 2013-04-10
ES2537572T3 (es) 2015-06-09
WO2007140184A2 (en) 2007-12-06
JP5241709B2 (ja) 2013-07-17
US8975280B2 (en) 2015-03-10

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Application publication date: 20090722