CA2652958C - Deoxynojirimycin and d-arabinitol analogs and methods of using - Google Patents
Deoxynojirimycin and d-arabinitol analogs and methods of using Download PDFInfo
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- CA2652958C CA2652958C CA2652958A CA2652958A CA2652958C CA 2652958 C CA2652958 C CA 2652958C CA 2652958 A CA2652958 A CA 2652958A CA 2652958 A CA2652958 A CA 2652958A CA 2652958 C CA2652958 C CA 2652958C
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
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- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80277606P | 2006-05-24 | 2006-05-24 | |
| US60/802,776 | 2006-05-24 | ||
| PCT/US2007/069448 WO2007140184A2 (en) | 2006-05-24 | 2007-05-22 | Deoxynojirimycin and d-arabinitol analogs and methods of using |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2652958A1 CA2652958A1 (en) | 2007-12-06 |
| CA2652958C true CA2652958C (en) | 2015-11-17 |
Family
ID=38779322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2652958A Expired - Fee Related CA2652958C (en) | 2006-05-24 | 2007-05-22 | Deoxynojirimycin and d-arabinitol analogs and methods of using |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8975280B2 (enExample) |
| EP (1) | EP2023927B1 (enExample) |
| JP (2) | JP5241709B2 (enExample) |
| CN (2) | CN104876855A (enExample) |
| CA (1) | CA2652958C (enExample) |
| ES (1) | ES2537572T3 (enExample) |
| HK (1) | HK1214261A1 (enExample) |
| WO (1) | WO2007140184A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2049126A2 (en) * | 2006-08-02 | 2009-04-22 | United Therapeutics Corporation | Liposome treatment of viral infections |
| US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| EP2398321B1 (en) * | 2009-02-23 | 2015-11-25 | United Therapeutics Corporation | Iminosugars and methods of treating viral diseases |
| CA2753194A1 (en) * | 2009-02-24 | 2010-09-02 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
| KR20120059447A (ko) * | 2009-03-27 | 2012-06-08 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 콜레스테롤 수준 저하 리포좀 |
| US20100248365A1 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
| CN102639133B (zh) * | 2009-06-12 | 2015-03-11 | 联合治疗公司 | 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法 |
| JP5752689B2 (ja) | 2009-09-04 | 2015-07-22 | ユナイテッド セラピューティクス コーポレイション | フィロウイルス疾患を治療するイミノ糖および方法 |
| US20110065752A1 (en) * | 2009-09-04 | 2011-03-17 | United Therapeutics Corporation | Methods of treating orthomyxoviral infections |
| CA2772807A1 (en) * | 2009-09-04 | 2011-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods of treating poxviral infections |
| JP2015518896A (ja) | 2012-06-06 | 2015-07-06 | ユニザー ヴィロロジー，エルエルシー | 新規イミノ糖およびそれらの用途 |
| EP2968300A4 (en) | 2013-03-15 | 2016-09-28 | Unither Virology Llc | ANTIBACTERIAL COMPOUNDS |
| US20160075651A1 (en) * | 2013-05-02 | 2016-03-17 | Unither Virology, Llc | Glycolipid inhibition using iminosugars |
| EP3046558B1 (en) | 2013-09-16 | 2019-08-14 | Emergent Virology LLC | Deoxynojirimycin derivatives and methods of their using |
| US10428022B2 (en) | 2014-11-05 | 2019-10-01 | Emergent Virology Llc | Iminosugars useful for the treatment of viral diseases |
| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
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| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| JPS54106477A (en) * | 1978-02-03 | 1979-08-21 | Nippon Shinyaku Co Ltd | Moranoline derivative |
| GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| JPS5943947B2 (ja) * | 1978-05-03 | 1984-10-25 | 日本新薬株式会社 | Ｎ−置換モラノリン誘導体 |
| JPS5943949B2 (ja) | 1978-09-29 | 1984-10-25 | 日本新薬株式会社 | モラノリンのｎ−置換誘導体 |
| JPS5943948B2 (ja) * | 1978-07-06 | 1984-10-25 | 日本新薬株式会社 | 置換モラノリン誘導体 |
| DE3007078A1 (de) | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3024901A1 (de) | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| DE3620645A1 (de) | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
| JPS62155291A (ja) | 1985-12-20 | 1987-07-10 | バイエル・アクチエンゲゼルシヤフト | ３−アミノ−４，５−ジヒドロキシピペリジン類、それらの製造方法及びそれらの使用 |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US4985445A (en) | 1988-02-12 | 1991-01-15 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitors and novel compounds |
| JPH0643306B2 (ja) * | 1988-02-12 | 1994-06-08 | 明治製菓株式会社 | 癌細胞転移抑制剤 |
| EP0350012A3 (en) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antiviral composition |
| ES2086323T3 (es) * | 1988-11-03 | 1996-07-01 | Searle & Co | Derivados del didesoxi-arabinitol como compuestos antiviricos. |
| US5256788A (en) | 1989-02-13 | 1993-10-26 | Nippon Shinyaku Co. Ltd. | Moranoline derivatives and their production and the use of moranoline and its derivatives as a stabilizing agent for enzymes |
| JPH0675510B2 (ja) | 1989-02-13 | 1994-09-28 | 日本新薬株式会社 | モラノリン誘導体の製法 |
| US5051401A (en) * | 1989-04-07 | 1991-09-24 | University Of South Alabama | Inhibition of mineral deposition by phosphorylated and related polyanionic peptides |
| DE4009561A1 (de) | 1990-03-24 | 1991-09-26 | Bayer Ag | Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| WO1992000277A1 (en) | 1990-06-29 | 1992-01-09 | Nippon Shinyaku Co., Ltd. | Piperidine derivative |
| US5290948A (en) | 1990-09-17 | 1994-03-01 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
| PT739205E (pt) | 1994-01-13 | 2000-04-28 | Monsanto Co | Utilizacao de derivados de 1,5-didesoxi-1,5-imino-d-glucitol para o tratamento de infeccoes com o virus da hepatite b |
| WO1995022975A1 (en) | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| ES2216327T3 (es) | 1997-11-10 | 2004-10-16 | G.D. SEARLE & CO. | Uso de iminoazucares alquilados para tratar la resistencia a multiples a farmacos. |
| DE69932154T2 (de) | 1998-02-12 | 2007-05-31 | G.D. Searle Llc, Chicago | Verwendung von n-substituirten-1,5-dideoxy-1,5-imino-d-glucitolen zur behandlung von hepatitis infektionen |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| EP1261339A1 (en) | 2000-02-14 | 2002-12-04 | Pharmacia Corporation | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| CA2479027A1 (en) * | 2002-03-13 | 2003-09-18 | Aarnoud C. Van Der Spoel | A non-hormonal approach to male contraception |
| JP4585851B2 (ja) * | 2002-07-17 | 2010-11-24 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
| JP2008545657A (ja) | 2005-05-17 | 2008-12-18 | アミカス セラピューティックス インコーポレイテッド | １−デオキシノジリマイシンおよび誘導体を用いるポンペ病の治療方法 |
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2007
- 2007-05-22 ES ES07797651.2T patent/ES2537572T3/es active Active
- 2007-05-22 JP JP2009512260A patent/JP5241709B2/ja not_active Expired - Fee Related
- 2007-05-22 CA CA2652958A patent/CA2652958C/en not_active Expired - Fee Related
- 2007-05-22 CN CN201510202505.0A patent/CN104876855A/zh active Pending
- 2007-05-22 CN CNA2007800273721A patent/CN101489554A/zh active Pending
- 2007-05-22 WO PCT/US2007/069448 patent/WO2007140184A2/en not_active Ceased
- 2007-05-22 EP EP07797651.2A patent/EP2023927B1/en not_active Not-in-force
- 2007-05-22 US US11/752,015 patent/US8975280B2/en not_active Expired - Fee Related
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2013
- 2013-02-28 JP JP2013039548A patent/JP2013129662A/ja active Pending
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2016
- 2016-03-02 HK HK16102398.6A patent/HK1214261A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009538336A (ja) | 2009-11-05 |
| US8975280B2 (en) | 2015-03-10 |
| JP5241709B2 (ja) | 2013-07-17 |
| EP2023927B1 (en) | 2015-02-25 |
| WO2007140184A3 (en) | 2008-11-27 |
| CN101489554A (zh) | 2009-07-22 |
| JP2013129662A (ja) | 2013-07-04 |
| WO2007140184A2 (en) | 2007-12-06 |
| CA2652958A1 (en) | 2007-12-06 |
| EP2023927A2 (en) | 2009-02-18 |
| ES2537572T3 (es) | 2015-06-09 |
| EP2023927A4 (en) | 2013-04-10 |
| CN104876855A (zh) | 2015-09-02 |
| HK1214261A1 (zh) | 2016-07-22 |
| US20070275998A1 (en) | 2007-11-29 |
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