CN1014789B - 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法 - Google Patents

取代的桥式二氮二环烷基喹诺酮羧酸的制备方法

Info

Publication number
CN1014789B
CN1014789B CN86106385A CN86106385A CN1014789B CN 1014789 B CN1014789 B CN 1014789B CN 86106385 A CN86106385 A CN 86106385A CN 86106385 A CN86106385 A CN 86106385A CN 1014789 B CN1014789 B CN 1014789B
Authority
CN
China
Prior art keywords
diazabicyclo
compound
methyl
oxo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN86106385A
Other languages
English (en)
Chinese (zh)
Other versions
CN86106385A (zh
Inventor
马丁·雷蒙德·杰夫逊
保罗·罗伯特·麦夸克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CN86106385A publication Critical patent/CN86106385A/zh
Publication of CN1014789B publication Critical patent/CN1014789B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN86106385A 1985-09-18 1986-09-17 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法 Expired CN1014789B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77747185A 1985-09-18 1985-09-18
US777,471 1985-09-18

Publications (2)

Publication Number Publication Date
CN86106385A CN86106385A (zh) 1987-06-03
CN1014789B true CN1014789B (zh) 1991-11-20

Family

ID=25110350

Family Applications (1)

Application Number Title Priority Date Filing Date
CN86106385A Expired CN1014789B (zh) 1985-09-18 1986-09-17 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法

Country Status (42)

Country Link
US (3) US4861779A (OSRAM)
EP (1) EP0215650B1 (OSRAM)
JP (1) JPH0798819B2 (OSRAM)
KR (1) KR870000961B1 (OSRAM)
CN (1) CN1014789B (OSRAM)
AT (1) ATE72245T1 (OSRAM)
AU (1) AU576302B2 (OSRAM)
BG (2) BG49275A3 (OSRAM)
CA (1) CA1340734C (OSRAM)
CY (1) CY1774A (OSRAM)
CZ (1) CZ277825B6 (OSRAM)
DD (1) DD259190A5 (OSRAM)
DE (2) DE19675019I2 (OSRAM)
DK (1) DK171276B1 (OSRAM)
EG (1) EG18184A (OSRAM)
ES (1) ES2001428A6 (OSRAM)
FI (1) FI87565C (OSRAM)
GR (1) GR862363B (OSRAM)
HK (1) HK132795A (OSRAM)
HU (1) HU200462B (OSRAM)
IE (1) IE58966B1 (OSRAM)
IL (1) IL80033A (OSRAM)
IN (1) IN166416B (OSRAM)
LU (1) LU90356I2 (OSRAM)
MA (1) MA20770A1 (OSRAM)
MW (1) MW5886A1 (OSRAM)
MX (1) MX173358B (OSRAM)
MY (1) MY102518A (OSRAM)
NO (1) NO170335C (OSRAM)
NZ (1) NZ217614A (OSRAM)
OA (1) OA08410A (OSRAM)
PH (2) PH24048A (OSRAM)
PL (1) PL149987B1 (OSRAM)
PT (1) PT83388B (OSRAM)
SG (1) SG28094G (OSRAM)
SK (1) SK667886A3 (OSRAM)
SU (1) SU1482531A3 (OSRAM)
UA (1) UA6340A1 (OSRAM)
YU (1) YU45024B (OSRAM)
ZA (1) ZA867063B (OSRAM)
ZM (1) ZM8586A1 (OSRAM)
ZW (1) ZW19386A1 (OSRAM)

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US6114531A (en) * 1998-07-28 2000-09-05 Pfizer Inc. Process for preparing quinolone and naphthyridone carboxylic acids
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MXPA05002621A (es) * 2002-09-10 2005-05-05 Pfizer Prod Inc Compuestos diazabiciclos utiles en el tratamiento de transtornos del sistema nervioso central y otros trastornos.
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DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
PL1697378T3 (pl) 2003-12-22 2008-04-30 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania
US20050234095A1 (en) 2004-03-25 2005-10-20 Wenge Xie Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
WO2006001894A1 (en) * 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
US7632831B2 (en) * 2004-05-07 2009-12-15 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
JP2008525464A (ja) * 2004-12-22 2008-07-17 メモリー・ファーマシューティカルズ・コーポレイション α−７ニコチン性受容体リガンド並びにその製造及び使用
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
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Also Published As

Publication number Publication date
HK132795A (en) 1995-09-01
PH25338A (en) 1991-04-30
YU45024B (en) 1991-06-30
ATE72245T1 (de) 1992-02-15
CY1774A (en) 1995-10-20
LU90356I2 (fr) 1999-04-26
IL80033A (en) 1992-05-25
ZM8586A1 (en) 1987-03-27
YU161786A (en) 1987-10-31
DK445886D0 (da) 1986-09-17
AU6276886A (en) 1987-03-19
CN86106385A (zh) 1987-06-03
SK278605B6 (en) 1997-11-05
FI87565B (fi) 1992-10-15
DK171276B1 (da) 1996-08-19
FI863756L (fi) 1987-03-19
SK667886A3 (en) 1997-11-05
FI863756A0 (fi) 1986-09-17
DE19675019I2 (de) 2004-01-29
NO170335B (no) 1992-06-29
MW5886A1 (en) 1987-12-09
PL149987B1 (en) 1990-04-30
CA1340734C (en) 1999-09-14
AU576302B2 (en) 1988-08-18
NO863718L (no) 1987-03-19
EG18184A (en) 1992-12-30
NO863718D0 (no) 1986-09-17
DK445886A (da) 1987-05-27
MA20770A1 (fr) 1987-04-01
ZA867063B (en) 1988-04-27
UA6340A1 (uk) 1994-12-29
IL80033A0 (en) 1986-12-31
CZ277825B6 (en) 1993-06-16
CZ667886A3 (en) 1993-02-17
EP0215650A2 (en) 1987-03-25
US4861779A (en) 1989-08-29
PT83388A (en) 1986-10-01
PL261410A1 (en) 1987-11-16
IN166416B (OSRAM) 1990-05-05
KR870003106A (ko) 1987-04-15
US4775668A (en) 1988-10-04
SU1482531A3 (ru) 1989-05-23
SG28094G (en) 1994-10-28
JPS62103083A (ja) 1987-05-13
EP0215650B1 (en) 1992-01-29
GR862363B (en) 1987-01-19
IE58966B1 (en) 1993-12-01
NO170335C (no) 1992-10-07
HUT43070A (en) 1987-09-28
HU200462B (en) 1990-06-28
JPH0798819B2 (ja) 1995-10-25
OA08410A (fr) 1988-06-30
PH24048A (en) 1990-03-05
DE3683711D1 (de) 1992-03-12
EP0215650A3 (en) 1987-12-02
NZ217614A (en) 1989-11-28
BG61091B2 (bg) 1996-10-31
DD259190A5 (de) 1988-08-17
ES2001428A6 (es) 1988-05-16
ZW19386A1 (en) 1986-12-10
FI87565C (fi) 1993-01-25
PT83388B (pt) 1989-05-12
BG49275A3 (en) 1991-09-16
MX3751A (es) 1993-09-01
US5091383A (en) 1992-02-25
KR870000961B1 (ko) 1987-05-14
MX173358B (es) 1994-02-23
IE862479L (en) 1987-03-18
MY102518A (en) 1992-07-31

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