CN101450920A - 盐酸二甲双胍大颗粒结晶生产方法 - Google Patents
盐酸二甲双胍大颗粒结晶生产方法 Download PDFInfo
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- CN101450920A CN101450920A CNA2007101147658A CN200710114765A CN101450920A CN 101450920 A CN101450920 A CN 101450920A CN A2007101147658 A CNA2007101147658 A CN A2007101147658A CN 200710114765 A CN200710114765 A CN 200710114765A CN 101450920 A CN101450920 A CN 101450920A
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- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000013078 crystal Substances 0.000 title claims abstract description 28
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- 229960004329 metformin hydrochloride Drugs 0.000 title claims abstract description 18
- 239000002245 particle Substances 0.000 title claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000012043 crude product Substances 0.000 claims abstract description 25
- 239000008213 purified water Substances 0.000 claims abstract description 11
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims abstract description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 21
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000012266 salt solution Substances 0.000 claims description 16
- 239000012452 mother liquor Substances 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 9
- 238000009833 condensation Methods 0.000 claims description 8
- 230000005494 condensation Effects 0.000 claims description 8
- 230000006837 decompression Effects 0.000 claims description 8
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 8
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 4
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 abstract description 3
- 235000013923 monosodium glutamate Nutrition 0.000 abstract description 3
- 239000004223 monosodium glutamate Substances 0.000 abstract description 3
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000047 product Substances 0.000 description 12
- 229960004756 ethanol Drugs 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010060766 Heteroplasia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101147658A CN101450920B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍大颗粒结晶生产方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101147658A CN101450920B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍大颗粒结晶生产方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101450920A true CN101450920A (zh) | 2009-06-10 |
| CN101450920B CN101450920B (zh) | 2011-08-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101147658A Active CN101450920B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍大颗粒结晶生产方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101450920B (zh) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
| WO2016059507A1 (en) * | 2014-10-13 | 2016-04-21 | Kamavarapu Sarath Kumar | Improved process for the preparation of high pure metformine |
| CN106008277A (zh) * | 2016-06-12 | 2016-10-12 | 聊城大学 | 一种新型二甲双胍盐酸盐及其制备方法 |
| CN107337618A (zh) * | 2015-04-24 | 2017-11-10 | 青岛中科荣达新材料有限公司 | 一种同时提高盐酸二甲双胍纯度及收率的生产方法 |
| CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
| CN113248409A (zh) * | 2021-05-21 | 2021-08-13 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113292460A (zh) * | 2021-06-18 | 2021-08-24 | 天津应天成科技有限公司 | 一种盐酸二甲双胍的制备方法 |
| CN115108945A (zh) * | 2022-07-14 | 2022-09-27 | 山东省分析测试中心 | 一种盐酸二甲双胍晶体的制备方法及采用该方法得到的单分散、粒度均一棒状晶体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391939C (zh) * | 2006-05-10 | 2008-06-04 | 翟树军 | 盐酸二甲双胍的生产方法 |
-
2007
- 2007-11-30 CN CN2007101147658A patent/CN101450920B/zh active Active
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
| WO2016059507A1 (en) * | 2014-10-13 | 2016-04-21 | Kamavarapu Sarath Kumar | Improved process for the preparation of high pure metformine |
| CN106795104A (zh) * | 2014-10-13 | 2017-05-31 | 瑟勒特·库玛·卡玛瓦拉普 | 改进的制备高纯度二甲双胍的方法 |
| CN107337618A (zh) * | 2015-04-24 | 2017-11-10 | 青岛中科荣达新材料有限公司 | 一种同时提高盐酸二甲双胍纯度及收率的生产方法 |
| CN106008277A (zh) * | 2016-06-12 | 2016-10-12 | 聊城大学 | 一种新型二甲双胍盐酸盐及其制备方法 |
| CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
| CN113248409A (zh) * | 2021-05-21 | 2021-08-13 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113248409B (zh) * | 2021-05-21 | 2023-01-03 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113292460A (zh) * | 2021-06-18 | 2021-08-24 | 天津应天成科技有限公司 | 一种盐酸二甲双胍的制备方法 |
| CN115108945A (zh) * | 2022-07-14 | 2022-09-27 | 山东省分析测试中心 | 一种盐酸二甲双胍晶体的制备方法及采用该方法得到的单分散、粒度均一棒状晶体 |
| CN115108945B (zh) * | 2022-07-14 | 2024-05-17 | 山东省分析测试中心 | 一种盐酸二甲双胍晶体的制备方法及采用该方法得到的单分散、粒度均一棒状晶体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101450920B (zh) | 2011-08-10 |
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Address after: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee after: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Address before: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee before: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. |
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Denomination of invention: Method for producing metformin hydrochloride large particle crystal Effective date of registration: 20170120 Granted publication date: 20110810 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017990000057 |
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Denomination of invention: Method for producing metformin hydrochloride large particle crystal Effective date of registration: 20171114 Granted publication date: 20110810 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017320000049 |
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Date of cancellation: 20190115 Granted publication date: 20110810 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017320000049 |
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Denomination of invention: Method for producing metformin hydrochloride large particle crystal Effective date of registration: 20190121 Granted publication date: 20110810 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2019320000058 |
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Date of cancellation: 20191211 Granted publication date: 20110810 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: Jiangsu Deyuan Pharmaceutical Co., Ltd. Registration number: 2019320000058 |
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