CN101437512A - 葡萄糖激酶活化剂 - Google Patents

葡萄糖激酶活化剂 Download PDF

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Publication number
CN101437512A
CN101437512A CNA2007800107261A CN200780010726A CN101437512A CN 101437512 A CN101437512 A CN 101437512A CN A2007800107261 A CNA2007800107261 A CN A2007800107261A CN 200780010726 A CN200780010726 A CN 200780010726A CN 101437512 A CN101437512 A CN 101437512A
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CN
China
Prior art keywords
alkyl
heteroaryl
saturated
aryl
partially unsaturated
Prior art date
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Pending
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CNA2007800107261A
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English (en)
Chinese (zh)
Inventor
T·D·艾彻尔
S·A·博伊德
M·J·奇卡雷利
K·R·孔德罗斯基
R·J·欣克林
A·辛格
T·M·特纳
F·G·拉斯塔姆
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Array Biopharma Inc
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Array Biopharma Inc
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Publication of CN101437512A publication Critical patent/CN101437512A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA2007800107261A 2006-01-27 2007-01-24 葡萄糖激酶活化剂 Pending CN101437512A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76317306P 2006-01-27 2006-01-27
US60/763,173 2006-01-27

Publications (1)

Publication Number Publication Date
CN101437512A true CN101437512A (zh) 2009-05-20

Family

ID=38109991

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800107261A Pending CN101437512A (zh) 2006-01-27 2007-01-24 葡萄糖激酶活化剂

Country Status (9)

Country Link
US (1) US8022222B2 (cg-RX-API-DMAC10.html)
EP (1) EP1986645B1 (cg-RX-API-DMAC10.html)
JP (1) JP5236499B2 (cg-RX-API-DMAC10.html)
CN (1) CN101437512A (cg-RX-API-DMAC10.html)
AT (1) ATE539748T1 (cg-RX-API-DMAC10.html)
CA (1) CA2637172A1 (cg-RX-API-DMAC10.html)
ES (1) ES2378704T3 (cg-RX-API-DMAC10.html)
TW (1) TW200740804A (cg-RX-API-DMAC10.html)
WO (1) WO2007089512A1 (cg-RX-API-DMAC10.html)

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CN102786517A (zh) * 2011-05-18 2012-11-21 中国医学科学院药物研究所 Gk和ppar双重激动活性的嘧啶噻唑胺类衍生物
CN108864151A (zh) * 2010-11-19 2018-11-23 利亘制药公司 杂环胺及其用途
CN110898049A (zh) * 2019-11-29 2020-03-24 华中师范大学 二硫化合物在制备药物中的应用、fbp酶抑制剂及用于预防和/或治疗糖尿病的药剂
CN113993859A (zh) * 2019-06-25 2022-01-28 益方生物科技(上海)股份有限公司 杂环化合物、其制备方法及其使用方法
CN115448916A (zh) * 2016-10-14 2022-12-09 林伯士拉克许米公司 Tyk2抑制剂及其用途

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EA019104B1 (ru) * 2007-09-21 2014-01-30 Эррей Биофарма Инк. Активаторы глюкокиназы
KR20100090250A (ko) 2007-10-09 2010-08-13 메르크 파텐트 게엠베하 글루코키나제 활성체로서 유용한 피리딘 유도체
ES2531396T3 (es) 2008-01-23 2015-03-13 Bristol Myers Squibb Co Proceso para preparar compuestos de piridinona
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
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EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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JP5748210B2 (ja) * 2011-05-26 2015-07-15 日本化薬株式会社 複素環化合物の製造方法
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108864151A (zh) * 2010-11-19 2018-11-23 利亘制药公司 杂环胺及其用途
CN102786517A (zh) * 2011-05-18 2012-11-21 中国医学科学院药物研究所 Gk和ppar双重激动活性的嘧啶噻唑胺类衍生物
CN102786517B (zh) * 2011-05-18 2017-06-06 中国医学科学院药物研究所 Gk和ppar双重激动活性的嘧啶噻唑胺类衍生物
CN115448916A (zh) * 2016-10-14 2022-12-09 林伯士拉克许米公司 Tyk2抑制剂及其用途
CN115448916B (zh) * 2016-10-14 2026-04-28 武田药品工业株式会社 Tyk2抑制剂及其用途
CN113993859A (zh) * 2019-06-25 2022-01-28 益方生物科技(上海)股份有限公司 杂环化合物、其制备方法及其使用方法
CN110898049A (zh) * 2019-11-29 2020-03-24 华中师范大学 二硫化合物在制备药物中的应用、fbp酶抑制剂及用于预防和/或治疗糖尿病的药剂
CN110898049B (zh) * 2019-11-29 2021-09-14 华中师范大学 二硫化合物在制备药物中的应用、fbp酶抑制剂及用于预防和/或治疗糖尿病的药剂

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ES2378704T3 (es) 2012-04-17
ATE539748T1 (de) 2012-01-15
CA2637172A1 (en) 2007-08-09
JP2009524670A (ja) 2009-07-02
US20090247526A1 (en) 2009-10-01
US8022222B2 (en) 2011-09-20
WO2007089512A1 (en) 2007-08-09
EP1986645A1 (en) 2008-11-05
TW200740804A (en) 2007-11-01
JP5236499B2 (ja) 2013-07-17
EP1986645B1 (en) 2012-01-04

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