CN101272815B - 器官和组织的脱细胞化和再细胞化 - Google Patents

器官和组织的脱细胞化和再细胞化 Download PDF

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CN101272815B
CN101272815B CN2006800309254A CN200680030925A CN101272815B CN 101272815 B CN101272815 B CN 101272815B CN 2006800309254 A CN2006800309254 A CN 2006800309254A CN 200680030925 A CN200680030925 A CN 200680030925A CN 101272815 B CN101272815 B CN 101272815B
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organ
heart
tissue
perfusion
decellularized
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CN101272815A (zh
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H·奥特
D·泰勒
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University of Minnesota System
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    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Cardiology (AREA)
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  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
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  • Anesthesiology (AREA)
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CN2006800309254A 2005-08-26 2006-08-28 器官和组织的脱细胞化和再细胞化 Active CN101272815B (zh)

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US71150105P 2005-08-26 2005-08-26
US60/711,501 2005-08-26
US81524206P 2006-06-19 2006-06-19
US60/815,242 2006-06-19
PCT/US2006/033415 WO2007025233A1 (en) 2005-08-26 2006-08-28 Decellularization and recellularization of organs and tissues

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US (5) US8470520B2 (enExample)
EP (3) EP2431063B1 (enExample)
JP (6) JP2009505752A (enExample)
KR (3) KR101420585B1 (enExample)
CN (2) CN101272815B (enExample)
AT (1) ATE552007T1 (enExample)
AU (1) AU2006282783B2 (enExample)
CA (1) CA2618731C (enExample)
ES (2) ES2384721T3 (enExample)
IL (2) IL189418A (enExample)
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CN105013014A (zh) * 2015-07-31 2015-11-04 武汉蓝普医品有限公司 一种无细胞基质生物材料的制备方法和用途
US10220056B2 (en) 2005-08-26 2019-03-05 Miromatrix Medical, Inc. Decellularization and recellularization of solid organs
US11278643B2 (en) 2016-09-06 2022-03-22 Mayo Foundation For Medical Education And Research Use of resected liver serum for whole liver-engineering
US11414644B2 (en) 2010-09-01 2022-08-16 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US11452797B2 (en) 2013-03-15 2022-09-27 Miromatrix Medical Inc. Use of perfusion decellularized liver for islet cell recellularization
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
US12383657B1 (en) 2021-06-09 2025-08-12 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods

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