KR101376013B1 - 기관 및 조직의 세포제거 및 재세포화 - Google Patents

기관 및 조직의 세포제거 및 재세포화 Download PDF

Info

Publication number
KR101376013B1
KR101376013B1 KR1020087007151A KR20087007151A KR101376013B1 KR 101376013 B1 KR101376013 B1 KR 101376013B1 KR 1020087007151 A KR1020087007151 A KR 1020087007151A KR 20087007151 A KR20087007151 A KR 20087007151A KR 101376013 B1 KR101376013 B1 KR 101376013B1
Authority
KR
South Korea
Prior art keywords
organ
cells
heart
cell
decellularized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020087007151A
Other languages
English (en)
Korean (ko)
Other versions
KR20080065970A (ko
Inventor
하랄트 오트
도리스 테일러
Original Assignee
리전츠 오브 더 유니버스티 오브 미네소타
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리전츠 오브 더 유니버스티 오브 미네소타 filed Critical 리전츠 오브 더 유니버스티 오브 미네소타
Publication of KR20080065970A publication Critical patent/KR20080065970A/ko
Application granted granted Critical
Publication of KR101376013B1 publication Critical patent/KR101376013B1/ko
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Sustainable Development (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
KR1020087007151A 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화 Active KR101376013B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US71150105P 2005-08-26 2005-08-26
US60/711,501 2005-08-26
US81524206P 2006-06-19 2006-06-19
US60/815,242 2006-06-19
PCT/US2006/033415 WO2007025233A1 (en) 2005-08-26 2006-08-28 Decellularization and recellularization of organs and tissues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020137028378A Division KR101420585B1 (ko) 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화

Publications (2)

Publication Number Publication Date
KR20080065970A KR20080065970A (ko) 2008-07-15
KR101376013B1 true KR101376013B1 (ko) 2014-03-19

Family

ID=37771950

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020087007151A Active KR101376013B1 (ko) 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화
KR1020137028378A Active KR101420585B1 (ko) 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화
KR1020147007674A Ceased KR20140040293A (ko) 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020137028378A Active KR101420585B1 (ko) 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화
KR1020147007674A Ceased KR20140040293A (ko) 2005-08-26 2006-08-28 기관 및 조직의 세포제거 및 재세포화

Country Status (15)

Country Link
US (5) US8470520B2 (enExample)
EP (3) EP2431063B1 (enExample)
JP (6) JP2009505752A (enExample)
KR (3) KR101376013B1 (enExample)
CN (2) CN101272815B (enExample)
AT (1) ATE552007T1 (enExample)
AU (1) AU2006282783B2 (enExample)
CA (1) CA2618731C (enExample)
ES (2) ES2547139T3 (enExample)
IL (2) IL189418A (enExample)
MX (3) MX369594B (enExample)
PL (2) PL2431063T3 (enExample)
RU (2) RU2463081C2 (enExample)
SG (1) SG170731A1 (enExample)
WO (1) WO2007025233A1 (enExample)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2547139T3 (es) 2005-08-26 2015-10-02 Regents Of The University Of Minnesota Descelularización y recelularización de órganos y tejidos
US20100093066A1 (en) * 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
US20110217274A1 (en) 2007-05-29 2011-09-08 Reld Christopher B Methods for production and uses of multipotent ,pluripotent, differentiated and disease-resistant cell populations
US20090180965A1 (en) * 2008-01-04 2009-07-16 Boston Scientific Scimed, Inc. Methods for repair and regeneration of bone marrow
EP2298866A4 (en) * 2008-07-02 2013-11-20 Otsuka Pharma Co Ltd ARTIFICIAL KIDNEY PROCESSORS AND MANUFACTURING METHOD THEREFOR
RU2521195C2 (ru) * 2008-08-20 2014-06-27 Орган Текнолоджиз Инк. Способ восстановления утраченного зуба и способ изготовления восстановительного материала
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
EP2393914B1 (en) * 2009-02-04 2017-01-04 Yale University Tissue engineering of lung
US8628572B2 (en) * 2009-02-26 2014-01-14 Wake Forest University Health Sciences Corneal endothelial scaffolds and methods of use
KR101029887B1 (ko) * 2009-03-04 2011-04-18 서울대학교산학협력단 탈세포화를 위한 돼지 각막의 가공방법
US20120183944A1 (en) * 2009-03-31 2012-07-19 Regents Of The Univeristy Of Minnesota Decellularization and recellularization of organs and tissues
ES2599828T3 (es) * 2009-06-04 2017-02-03 The General Hospital Corporation Pulmón bioartificial
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US20110045045A1 (en) * 2009-07-07 2011-02-24 Joaquin Cortiella Production of and uses for decellularized lung tissue
RU2407459C1 (ru) * 2009-07-27 2010-12-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт кардиологии Сибирского отделения РАМН Способ получения соединительно-тканного каркаса магистрального сосуда млекопитающих животных и человека
CA2770490C (en) * 2009-08-11 2024-04-16 The Johns Hopkins University Compositions and methods for implantation of processed adipose tissue and processed adipose tissue products
US20110236949A1 (en) * 2009-09-22 2011-09-29 Colorado State University Research Foundation Methods for Processing Biological Tissues
RU2012125263A (ru) * 2009-11-17 2013-12-27 Гарвард Байосайенс, Инк. Биореакторы, системы и способы для производства и/или исследования органов
US20110135706A1 (en) * 2009-12-03 2011-06-09 Lifecell Corporation Nerve treatment devices and methods
BR112012014603A2 (pt) 2009-12-17 2019-09-24 Univ Kingston método para descelularização de tecido adiposo, tecido adipose descelularizado, tecido adiposo descelularizado incluindo laminina, biosuporte, revestimento, esfera micro-transportadora e partícula
MX354068B (es) * 2010-01-14 2018-02-09 Organogenesis Inc Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas.
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
CN101850136B (zh) * 2010-06-11 2013-01-23 四川大学华西医院 一种植入式生物人工肝脏
EP2588592B1 (en) * 2010-06-30 2017-09-06 Miromatrix Medical Inc. Use of perfusion decellularized organs for matched recellularization
AU2011295779B2 (en) * 2010-09-01 2015-08-27 Miromatrix Medical Inc. Methods of recellularizing a tissue or organ for improved transplantability
KR101108983B1 (ko) * 2010-09-17 2012-01-31 강원대학교산학협력단 다장기 바이오스캐폴드의 제조방법
KR101273489B1 (ko) * 2011-04-08 2013-06-21 강원대학교산학협력단 심폐 동시 이식용 바이오스캐폴드의 제조방법
US10207025B2 (en) 2011-04-28 2019-02-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US9238793B2 (en) 2011-04-28 2016-01-19 Lifecell Corporation Method for enzymatic treatment of tissue products
KR102109309B1 (ko) 2011-04-28 2020-05-12 라이프셀 코포레이션 조직 생성물의 효소처리방법
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
CN103842497A (zh) * 2011-05-27 2014-06-04 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
US20130143323A1 (en) * 2011-06-01 2013-06-06 Geoffrey S. FROST Apparatus and method for decellularizing, recellularizing or treating organs
WO2012170490A2 (en) * 2011-06-06 2012-12-13 Invivosciences, Llc Engineered cardiac tissues and methods of using them
WO2013028968A1 (en) * 2011-08-25 2013-02-28 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
WO2013052138A2 (en) * 2011-10-03 2013-04-11 Fabrico. Inc. System and method for electrophoretic decellularization
KR101360226B1 (ko) * 2011-11-04 2014-02-12 강원대학교산학협력단 심폐 일체형 탈세포화기법
WO2013071096A1 (en) 2011-11-09 2013-05-16 The General Hospital Corporation Composite tissue graft and materials and methods for its production and use
JP6388831B2 (ja) * 2012-01-13 2018-09-12 ザ ジェネラル ホスピタル コーポレイション 単離ヒト肺前駆細胞およびその使用
EP2809152B1 (en) 2012-02-01 2019-11-20 Nayacure Therapeutics Ltd Method for inducing immune tolerance to organ transplants
AU2013234037A1 (en) 2012-03-16 2014-10-02 Novahep Ab Bioengineered allogeneic blood vessel
CN104379726A (zh) * 2012-04-18 2015-02-25 通用医疗公司 生物人工过滤器官
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
US20130344490A1 (en) * 2012-04-27 2013-12-26 Min Peter Kim Neoplastic cells grown on decellularized biomatrix
US9290738B2 (en) * 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
GB201212771D0 (en) 2012-07-18 2012-08-29 Northwick Park Inst For Medcal Res Ltd Implant and method for producing an implant
US9297806B2 (en) * 2012-08-01 2016-03-29 The Johns Hopkins University 5-hydroxymethylcytosine in human cancer
US10111740B2 (en) 2012-08-21 2018-10-30 Regents Of The University Of Minnesota Decellularized biologically-engineered tubular grafts
WO2014058175A1 (ko) * 2012-10-11 2014-04-17 강원대학교산학협력단 미산성 전해수를 유효성분으로 포함하는 바이오 스캐폴드 살균용 조성물 및 이를 이용한 바이오 스캐폴드의 살균 방법
EP2916800A4 (en) * 2012-11-07 2016-06-08 James Bennie Gandy TISSUE TRANSPLANTATION AND FABRICS MODIFIED BY DECELLULARIZATION AND REZELLULARIZATION OF DONATOR TISSUE FOR MINIMIZED OR PREVENTED FLUSHING REACTIONS
HK1217663A1 (zh) 2013-01-09 2017-01-20 Harvard Apparatus Regenerative Technology, Inc. 合成支架
WO2014110586A1 (en) * 2013-01-14 2014-07-17 Florida State University Research Foundation, Inc. Extracellular matrix derived from stem cells and methods for production
CN103127550A (zh) * 2013-02-26 2013-06-05 中国人民解放军第二军医大学 骨骼肌全器官脱细胞基质、制备方法及其衍生出的医疗产品
EP2964154A4 (en) 2013-03-07 2016-08-17 Allosource BONE ALLOTRANSPLATE SYSTEMS AND METHODS WITH CONSISTENT CALCIUM CONTENT
SG10201906304TA (en) 2013-03-15 2019-08-27 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
US9888680B2 (en) * 2013-04-04 2018-02-13 The Trustees Of Columbia University In The City Of New York Functional recovery of human lungs for transplantation
EP2983718A4 (en) * 2013-04-11 2016-12-07 Univ Of Vermont And State Agricultural College Decellularization and recellularization of whole organs
KR102161726B1 (ko) * 2013-04-12 2020-10-06 사베리오 라프란체스카 이식용 장기의 개선
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
WO2015017500A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
ES2846758T3 (es) 2013-11-04 2021-07-29 Lifecell Corp Métodos para eliminar la alfa-galactosa
KR101636954B1 (ko) 2013-11-04 2016-07-08 대한민국 재세포화된 바이오 스캐폴드 및 이의 제조방법
US10183097B2 (en) 2013-11-27 2019-01-22 The Johns Hopkins University Engineered cardiac derived compositions and methods of use
CN103736150B (zh) * 2013-12-31 2015-11-18 中山大学 褪黑素协同细胞外基质生物材料在制备促进间充质干细胞成骨分化药物中的应用
CN103750905B (zh) * 2014-01-20 2015-08-12 辽宁中医药大学 大动物离体工作心双通道灌流实验方法及设备
US11648335B2 (en) 2014-01-31 2023-05-16 Wake Forest University Health Sciences Organ/tissue decellularization, framework maintenance and recellularization
JP6271298B2 (ja) * 2014-02-28 2018-01-31 国立大学法人 東京医科歯科大学 脱細胞組織の製造方法
JP6271299B2 (ja) * 2014-02-28 2018-01-31 株式会社Adeka 脱細胞組織の製造方法
WO2015138832A1 (en) 2014-03-13 2015-09-17 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
EP3116311B1 (en) * 2014-03-14 2020-11-25 The General Hospital Corporation Lung bioreactor
CN104940997A (zh) * 2014-03-27 2015-09-30 复旦大学 一种组织工程化人类心肌组织
JP6580329B2 (ja) 2014-03-31 2019-09-25 シスメックス株式会社 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法
WO2015168528A1 (en) * 2014-05-02 2015-11-05 University Of Houston System Two stage cellularization strategy for the fabrication of bioartificial hearts
KR20180029274A (ko) * 2014-05-27 2018-03-20 노바헵 아브 생체공학적 동종성 판막
GB201409858D0 (en) * 2014-06-03 2014-07-16 Ucl Business Plc Human liver scaffolds
CN104208751A (zh) * 2014-08-19 2014-12-17 温州医科大学 一种新型肾脏去细胞生物支架的制备方法
CN107105639A (zh) 2014-09-02 2017-08-29 联合治疗学有限公司 自动生物反应器系统，自动实施器官去细胞方案系统，和废物净化系统
KR101693831B1 (ko) * 2014-09-03 2017-01-17 서울대학교산학협력단 스페이스 필러를 이용한 이종이식조직의 제조방법
EP3006557A1 (en) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Bile acids for inducing hepatic differentiation
EP3212247B1 (en) 2014-10-31 2021-04-07 The Administrators of the Tulane Educational Fund Surgical grafts for replacing the nipple and areola or damaged epidermis
CN104740684A (zh) * 2015-03-03 2015-07-01 上海市闸北区中心医院 一种犬子宫全器官脱细胞基质及其制备方法和应用
WO2016154447A1 (en) 2015-03-26 2016-09-29 Miromatrix Medical Inc. Gas filled decellularized extracellular matrix
JP2016185115A (ja) 2015-03-27 2016-10-27 シスメックス株式会社 臓器灌流方法および臓器灌流装置
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
RU2586952C1 (ru) * 2015-07-20 2016-06-10 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ лечения печеночной недостаточности
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CN105013014A (zh) * 2015-07-31 2015-11-04 武汉蓝普医品有限公司 一种无细胞基质生物材料的制备方法和用途
CN105031731B (zh) * 2015-08-18 2018-04-17 温州医科大学 一种快速去细胞单叶肝脏生物支架的制备方法
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CA2998130C (en) 2015-09-11 2024-02-13 The General Hospital Corporation Regeneration of a functional pulmonary vascular bed
EP3640321B1 (en) 2015-10-09 2022-04-06 DEKA Products Limited Partnership Method for generating a tissue for transplant
EP3184128B1 (en) 2015-12-21 2019-12-11 Heinrich-Heine-Universität Düsseldorf Method for producing a support device
KR101860798B1 (ko) * 2015-12-29 2018-05-25 포항공과대학교 산학협력단 뇌 조직 탈세포 방법 및 뇌 조직 배양 방법
WO2017176919A1 (en) 2016-04-05 2017-10-12 Regents Of The University Of Minnesota Engineered tissues having structural components embedded therein, and methods of making and using
KR102362222B1 (ko) 2016-05-16 2022-02-11 더 제너럴 하스피탈 코포레이션 폐 상피 공학에서 인간 기도 줄기 세포
CA3027505A1 (en) 2016-06-15 2017-12-21 The General Hospital Corporation Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
CN106075583B (zh) * 2016-07-07 2020-07-14 中国人民解放军第二军医大学 一种采用灌注-压差法制备脱细胞基质生物材料的方法
JP2019521769A (ja) 2016-07-14 2019-08-08 キドニ ラボズ, インク.Qidni Labs, Inc. 生体適合性且つ血液適合性の材料及びフィルタ
RU2639404C1 (ru) * 2016-08-24 2017-12-21 Государственное автономное учреждение здравоохранения Свердловской области "Центр специализированных видов медицинской помощи "Институт медицинских клеточных технологий" Способ восстановления лимфоидной ткани селезенки лабораторных животных
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering
FR3055805B1 (fr) 2016-09-09 2020-05-15 Assistance Publique - Hopitaux De Paris (Ap-Hp) Biomateriau a usage therapeutique
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
CN111544652A (zh) 2017-01-30 2020-08-18 生命细胞公司 转谷氨酰胺酶处理的产品
US10940184B2 (en) 2017-01-30 2021-03-09 Lifecell Corporation Tissue matrix materials and enzymatic adhesives
CN107096070B (zh) * 2017-03-09 2020-08-21 中国医学科学院阜外医院 一种脱细胞肺支架及其制备方法
RU2665962C1 (ru) 2017-03-17 2018-09-05 Общество с ограниченной ответственностью "Матрифлекс" Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN107137769A (zh) * 2017-06-06 2017-09-08 中国人民解放军军事医学科学院基础医学研究所 一种心脏全器官脱细胞基质的制备方法
EP3638019A4 (en) 2017-06-14 2020-08-26 The General Hospital Corporation VERY LOW TEMPERATURE CRYOPRESERVATION
EP3645068A4 (en) 2017-06-30 2021-04-07 Vascudyne Inc REGENERATIVE FABRIC AND NATURAL TISSUE IMPLANTS
EP3685661B1 (en) * 2017-09-19 2026-02-18 Pormedtec Co., Ltd. Method for developing organ lacking specific functional cell
WO2019094734A1 (en) 2017-11-09 2019-05-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Decellularization and functionalization of extracellular matrix biomaterials
JP7174984B2 (ja) * 2018-02-15 2022-11-18 学校法人自治医科大学 脱細胞化担体製造方法、脱細胞化担体保存方法、細胞充填方法、細胞シート作製方法、及び脱細胞化溶液キット
GB201807788D0 (en) * 2018-05-14 2018-06-27 Ucl Business Plc Method
WO2019232268A1 (en) 2018-05-30 2019-12-05 Mustafa Korkut Uygun Cryopreservation of tissues and organs
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
TWI712687B (zh) * 2018-09-11 2020-12-11 亞果生醫股份有限公司 去細胞器官及其製備方法
AU2020241583A1 (en) * 2019-03-21 2021-10-14 Miromatrix Medical Inc. Improved decellularization of isolated organs
US12465486B2 (en) 2019-05-28 2025-11-11 Regents Of The University Of Minnesota Engineered valve and method of making
CN110694113B (zh) * 2019-10-15 2022-02-01 南通大学附属医院 一种脑脱细胞支架的制备方法
US20230015009A1 (en) * 2019-12-04 2023-01-19 Miromatrix Medical Inc. Methods of Decellularization and Recellularization of Organs and Portions of Organs
JP7623017B2 (ja) 2020-02-14 2025-01-28 セルアートジェン インコーポレイテッド 臓器オルガノイドの培養及び移植のための脱細胞臓器組織由来の支持体及びその製造方法
KR102748928B1 (ko) * 2020-02-14 2025-01-02 주식회사 세라트젠 심장 오가노이드 배양 및 이식을 위한 탈세포 심장 조직 유래 지지체 및 이의 제조방법
CN111494718B (zh) * 2020-04-24 2021-05-14 四川大学华西医院 一种动物去细胞化肺生物支架材料的制备方法
KR102473682B1 (ko) * 2020-06-30 2022-12-02 서울대학교 산학협력단 개인 맞춤형 경피적 심장 반월판 스텐트 판막의 제조 방법
CN112354014A (zh) * 2020-10-20 2021-02-12 上海亚朋生物技术有限公司 一种清洗脱细胞试剂sds的方法
CN112274697A (zh) * 2020-11-04 2021-01-29 王寅 一种组织工程心肌补片制备方法
EP4052734B1 (en) * 2021-03-02 2024-04-24 Solidified Inc. Immunocompatible tissue scaffold and methods of forming the same
US12383657B1 (en) 2021-06-09 2025-08-12 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US20240415111A1 (en) * 2021-10-18 2024-12-19 Miromatrix Medical Inc. System for supporting biologically engineered organs
DE102021211875B3 (de) * 2021-10-21 2023-01-19 Friedrich-Alexander-Universität Erlangen-Nürnberg, Körperschaft des öffentlichen Rechts Bioreaktor und Verfahren zum Betrieb eines solchen
CA3253240A1 (en) * 2022-02-25 2023-08-31 Advanced Solutions Life Sciences, Llc BIOREACTOR ASSEMBLIES, PERFUSION BIOREACTOR SYSTEMS AND RELATED PROCESSES
WO2024006673A1 (en) * 2022-06-30 2024-01-04 Regenmedix Llc Stem cell and organ maturation system and method
CN115554472B (zh) * 2022-09-22 2023-08-18 舩本诚一 一种用于移植的生物组织处理方法
WO2024104780A1 (en) 2022-11-18 2024-05-23 Baxter Healthcare Sa Extracorporeal blood treatment for organ support
WO2026136912A2 (en) 2024-12-19 2026-06-25 Satellite Biosciences, Inc. Culture media and conditions for in vitro expansion and/or maturation of hepatocytes
EP4763211A1 (en) * 2024-12-20 2026-06-24 Fundación Instituto de Investigación Sanitaria Aragón Biofabrication of a functional vascular tree model and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416995B1 (en) 1999-11-22 2002-07-09 Bio Science Consultants, L.L.C. Bioreactor mediated recellularization of natural and tissue engineered vascular grafts
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US20030087428A1 (en) 1999-06-07 2003-05-08 Lloyd Wolfinbarger Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
WO2007025233A1 (en) 2005-08-26 2007-03-01 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545221A (en) 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
US3639084A (en) 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
DE2453363B2 (de) 1974-11-11 1976-08-26 Solco Basel AG, Birsfelden (Schweiz) Verfahren zur herstellung heterologer arterientransplantate
JPS5516016A (en) 1978-07-18 1980-02-04 Dai Ichi Kogyo Seiyaku Co Ltd Improved salt-resistant water-absorbing material
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
KR970705951A (ko) 1994-09-12 1997-11-03 가일 케이. 노우톤 심장 판막 구조에서 3차원 사람 세포 배양물과 이의 용도(three-dimensional human cell cultures on cardiac valve franeworks and their uses)
CA2286655C (en) * 1997-04-11 2009-02-24 Cryolife, Inc. Tissue decellularization
JPH1176400A (ja) 1997-09-09 1999-03-23 Masahito Nagaki 人工臓器
JP4222658B2 (ja) 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
US6448076B2 (en) * 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6376244B1 (en) * 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US20050249816A1 (en) 1999-12-29 2005-11-10 Wake Forest University Health Services Tissue engineered liver constructs
WO2001082992A1 (en) * 2000-04-28 2001-11-08 Emory University Decellularized vascular prostheses
DE10021627B4 (de) 2000-05-04 2009-11-19 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Verfahren zur Herstellung eines vaskularisierten bioartifiziellen Gewebes und zugehöriger Versuchsreaktor
CA2419817C (en) 2000-08-16 2014-11-18 Duke University Decellularized tissue engineered constructs and tissues
US6749064B1 (en) 2000-08-25 2004-06-15 Sanita L. Alrey Bag with article display aperture and support surface
AU2001292917A1 (en) 2000-09-20 2002-04-02 Regeneration Technologies, Inc. Method of preparing and processing transplant tissue
IL139708A0 (en) 2000-11-15 2002-02-10 Amiel Gilad Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
EP2338983B1 (en) * 2001-02-14 2015-10-07 Anthrogenesis Corporation Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
CA2445110A1 (en) 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
GB2375771A (en) 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
EP1317934A1 (de) * 2001-11-08 2003-06-11 Artiss GmbH Verfahren zur Herstellung einer azellularisierten Gewebematrix und damit erhältliche Gewebematrix
WO2003043675A1 (en) 2001-11-16 2003-05-30 Children's Medical Center Corporation Creation of tissue engineered female reproductive organs
EP2292278B1 (en) * 2001-11-16 2013-04-24 Children's Medical Center Corporation Augmentation of organ function
US20030180268A1 (en) 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
US6790475B2 (en) 2002-04-09 2004-09-14 Wafermasters Inc. Source gas delivery
JP4149897B2 (ja) 2002-11-07 2008-09-17 学校法人 聖マリアンナ医科大学 気管移植片の調製方法および気管移植片
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
JP2006514986A (ja) 2002-12-13 2006-05-18 シラグ・アクチエンゲゼルシヤフト トラマドールおよびトピラメートを含んでなる制御放出調製物
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP2006223101A (ja) * 2003-05-15 2006-08-31 Univ Waseda 生体組織の保持装置及びこれを用いた生体組織処理装置
WO2005118014A2 (en) * 2004-06-01 2005-12-15 Medtronic, Inc. Decellurisation processes for making bioprotheses
JP3773943B2 (ja) 2004-09-24 2006-05-10 国立大学法人 東京大学 把持状態判定システム及び方法
DE102005023599A1 (de) 2005-05-18 2006-11-23 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Bioartifizielles Herzgewebetransplantat und Verfahren zu seiner Herstellung
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
US7824912B2 (en) 2005-06-23 2010-11-02 Massachusetts Institute Of Technology Methods for ex vivo propagation of adult hepatic stem cells
US20100093066A1 (en) 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
AU2013224686B2 (en) 2005-08-26 2015-06-11 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
JP4599315B2 (ja) 2006-02-23 2010-12-15 クラレメディカル株式会社 バイオ人工臓器
CN101066477B (zh) 2007-05-17 2010-10-06 中国人民解放军第三军医大学 能在体捕获内皮祖细胞的生物人工血管
WO2009073594A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
US20120183944A1 (en) 2009-03-31 2012-07-19 Regents Of The Univeristy Of Minnesota Decellularization and recellularization of organs and tissues
EP2588592B1 (en) 2010-06-30 2017-09-06 Miromatrix Medical Inc. Use of perfusion decellularized organs for matched recellularization
AU2011295779B2 (en) 2010-09-01 2015-08-27 Miromatrix Medical Inc. Methods of recellularizing a tissue or organ for improved transplantability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
BR112015023641A2 (pt) 2013-03-15 2017-07-18 Miromatrix Medical Inc uso de micropartículas e células endotelial com descelularização de órgãos e tecidos
SG10201906304TA (en) 2013-03-15 2019-08-27 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
JP6340772B2 (ja) 2013-11-08 2018-06-13 東ソー株式会社 パラメータ変更履歴を管理可能な分析装置
WO2016154447A1 (en) 2015-03-26 2016-09-29 Miromatrix Medical Inc. Gas filled decellularized extracellular matrix
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030087428A1 (en) 1999-06-07 2003-05-08 Lloyd Wolfinbarger Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US6416995B1 (en) 1999-11-22 2002-07-09 Bio Science Consultants, L.L.C. Bioreactor mediated recellularization of natural and tissue engineered vascular grafts
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
WO2007025233A1 (en) 2005-08-26 2007-03-01 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues

Also Published As

Publication number Publication date
JP2017038948A (ja) 2017-02-23
PL2431063T3 (pl) 2015-11-30
US10220056B2 (en) 2019-03-05
RU2635478C9 (ru) 2018-06-05
JP2021120012A (ja) 2021-08-19
HK1220646A1 (en) 2017-05-12
EP1928519A1 (en) 2008-06-11
US8470520B2 (en) 2013-06-25
KR101420585B1 (ko) 2014-07-17
JP2015164549A (ja) 2015-09-17
CA2618731A1 (en) 2007-03-01
JP2009505752A (ja) 2009-02-12
US20090202977A1 (en) 2009-08-13
JP7286708B2 (ja) 2023-06-05
IL233821A (en) 2016-08-31
HK1168565A1 (en) 2013-01-04
US20130344599A1 (en) 2013-12-26
EP2431063B1 (en) 2015-06-17
JP6089062B2 (ja) 2017-03-01
EP1928519B1 (en) 2012-04-04
IL189418A0 (en) 2008-06-05
ES2384721T3 (es) 2012-07-11
WO2007025233A1 (en) 2007-03-01
CN101272815B (zh) 2012-09-26
KR20080065970A (ko) 2008-07-15
CN102861359A (zh) 2013-01-09
CA2618731C (en) 2021-12-28
PL1928519T3 (pl) 2012-08-31
ATE552007T1 (de) 2012-04-15
RU2008111503A (ru) 2009-10-10
US20190343877A1 (en) 2019-11-14
AU2006282783A1 (en) 2007-03-01
MX2008002589A (es) 2008-03-14
MX350338B (es) 2017-09-04
EP2431063A3 (en) 2012-07-11
EP1928519A4 (en) 2009-07-08
EP2431063A2 (en) 2012-03-21
RU2635478C2 (ru) 2017-11-13
US20200222456A1 (en) 2020-07-16
MX369594B (es) 2019-11-13
RU2012122055A (ru) 2013-12-10
EP2965769A1 (en) 2016-01-13
SG170731A1 (en) 2011-05-30
CN101272815A (zh) 2008-09-24
ES2547139T3 (es) 2015-10-02
AU2006282783B2 (en) 2013-06-06
US10441609B2 (en) 2019-10-15
RU2463081C2 (ru) 2012-10-10
IL189418A (en) 2014-08-31
KR20140040293A (ko) 2014-04-02
JP2013056183A (ja) 2013-03-28
EP2965769B1 (en) 2018-12-26
US20130109088A1 (en) 2013-05-02
CN102861359B (zh) 2015-04-01
JP2019088910A (ja) 2019-06-13
KR20130122701A (ko) 2013-11-07
IL233821A0 (en) 2014-09-30

Similar Documents

Publication Publication Date Title
JP7286708B2 (ja) 臓器および組織の脱細胞化および再細胞化
JP2022107023A (ja) 臓器および組織を脱細胞化および再細胞化する方法
AU2013224686B2 (en) Decellularization and recellularization of organs and tissues
AU2017272168B2 (en) Decellularization and recellularization of organs and tissues
HK1220646B (en) Decellularization and recellularization of organs and tissues
HK1168565B (en) Decellularization and recellularization of organs and tissues

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

A107 Divisional application of patent
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20170307

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20190228

Year of fee payment: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20200227

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 13

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 13